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Formate concentrations in maternal plasma during pregnancy and in cord blood in a cohort of pregnant Canadian women: relations to genetic polymorphisms and plasma metabolites.

Brosnan JT, Plumptre L, Brosnan ME, Pongnopparat T, Masih SP, Visentin CE, Berger H, Lamers Y, Caudill MA, Malysheva OV, O'Connor DL, Kim YI.

Am J Clin Nutr. 2019 Jul 27. pii: nqz152. doi: 10.1093/ajcn/nqz152. [Epub ahead of print]


The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites.

O'Reilly J, Pangilinan F, Hokamp K, Ueland PM, Brosnan JT, Brosnan ME, Brody LC, Molloy AM.

Mol Genet Metab Rep. 2018 Jun 11;16:20-22. doi: 10.1016/j.ymgmr.2018.05.006. eCollection 2018 Sep.


Lifestyle, metabolite, and genetic determinants of formate concentrations in a cross-sectional study in young, healthy adults.

Brosnan JT, Mills JL, Ueland PM, Shane B, Fan R, Chiu CY, Pangilinan F, Brody LC, Brosnan ME, Pongnopparat T, Molloy AM.

Am J Clin Nutr. 2018 Mar 1;107(3):345-354. doi: 10.1093/ajcn/nqx065.


Cobalamin Deficiency Results in Increased Production of Formate Secondary to Decreased Mitochondrial Oxidation of One-Carbon Units in Rats.

MacMillan L, Tingley G, Young SK, Clow KA, Randell EW, Brosnan ME, Brosnan JT.

J Nutr. 2018 Mar 1;148(3):358-363. doi: 10.1093/jn/nxx057.


Several Pesticides Influence the Nutritional Content of Sweet Corn.

Cutulle MA, Armel GR, Kopsell DA, Wilson HP, Brosnan JT, Vargas JJ, Hines TE, Koepke-Hill RM.

J Agric Food Chem. 2018 Mar 28;66(12):3086-3092. doi: 10.1021/acs.jafc.7b05885. Epub 2018 Feb 22.


Genotypic and phenotypic evaluation of off-type grasses in hybrid Bermudagrass [Cynodon dactylon (L.) Pers. x C. transvaalensis Burtt-Davy] putting greens using genotyping-by-sequencing and morphological characterization.

Reasor EH, Brosnan JT, Staton ME, Lane T, Trigiano RN, Wadl PA, Conner JA, Schwartz BM.

Hereditas. 2017 Aug 18;155:8. doi: 10.1186/s41065-017-0043-3. eCollection 2018.


Physiological levels of formate activate mitochondrial superoxide/hydrogen peroxide release from mouse liver mitochondria.

Young A, Gardiner D, Brosnan ME, Brosnan JT, Mailloux RJ.

FEBS Lett. 2017 Aug;591(16):2426-2438. doi: 10.1002/1873-3468.12777. Epub 2017 Aug 15.


Riboflavin Deficiency in Rats Decreases de novo Formate Production but Does Not Affect Plasma Formate Concentration.

MacMillan L, Lamarre SG, daSilva RP, Jacobs RL, Brosnan ME, Brosnan JT.

J Nutr. 2017 Mar;147(3):346-352. doi: 10.3945/jn.116.243535. Epub 2017 Jan 25.


Changes in the arabinoxylan fraction of wheat grain during alcohol production.

Kosik O, Powers SJ, Chatzifragkou A, Prabhakumari PC, Charalampopoulos D, Hess L, Brosnan J, Shewry PR, Lovegrove A.

Food Chem. 2017 Apr 15;221:1754-1762. doi: 10.1016/j.foodchem.2016.10.109. Epub 2016 Oct 24.


Comparing Dislodgeable 2,4-D Residues across Athletic Field Turfgrass Species and Time.

Jeffries MD, Gannon TW, Brosnan JT, Breeden GK.

PLoS One. 2016 Dec 9;11(12):e0168086. doi: 10.1371/journal.pone.0168086. eCollection 2016.


A Systematic Review of Biomarkers and Risk of Incident Type 2 Diabetes: An Overview of Epidemiological, Prediction and Aetiological Research Literature.

Abbasi A, Sahlqvist AS, Lotta L, Brosnan JM, Vollenweider P, Giabbanelli P, Nunez DJ, Waterworth D, Scott RA, Langenberg C, Wareham NJ.

PLoS One. 2016 Oct 27;11(10):e0163721. doi: 10.1371/journal.pone.0163721. eCollection 2016. Review.


Choline and dimethylglycine produce superoxide/hydrogen peroxide from the electron transport chain in liver mitochondria.

Mailloux RJ, Young A, Chalker J, Gardiner D, O'Brien M, Slade L, Brosnan JT.

FEBS Lett. 2016 Dec;590(23):4318-4328. doi: 10.1002/1873-3468.12461. Epub 2016 Nov 9.


The genetic and phenotypic variability of interspecific hybrid bermudagrasses (Cynodon dactylon (L.) Pers. × C. transvaalensis Burtt-Davy) used on golf course putting greens.

Reasor EH, Brosnan JT, Trigiano RN, Elsner JE, Henry GM, Schwartz BM.

Planta. 2016 Oct;244(4):761-73. doi: 10.1007/s00425-016-2573-8. Epub 2016 Jul 22. Review.


Formate: The Neglected Member of One-Carbon Metabolism.

Brosnan ME, Brosnan JT.

Annu Rev Nutr. 2016 Jul 17;36:369-88. doi: 10.1146/annurev-nutr-071715-050738. Review.


Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects.

Sudiwala S, De Castro SC, Leung KY, Brosnan JT, Brosnan ME, Mills K, Copp AJ, Greene ND.

Biochimie. 2016 Jul;126:63-70. doi: 10.1016/j.biochi.2016.02.010. Epub 2016 Feb 23.


The role of dietary creatine.

Brosnan ME, Brosnan JT.

Amino Acids. 2016 Aug;48(8):1785-91. doi: 10.1007/s00726-016-2188-1. Epub 2016 Feb 13. Review.


Factors Influencing Dislodgeable 2, 4-D Plant Residues from Hybrid Bermudagrass (Cynodon dactylon L. x C. transvaalensis) Athletic Fields.

Jeffries MD, Gannon TW, Brosnan JT, Ahmed KA, Breeden GK.

PLoS One. 2016 Feb 10;11(2):e0148992. doi: 10.1371/journal.pone.0148992. eCollection 2016.


Creatine supplementation as a possible new therapeutic approach for fatty liver disease: early findings.

Deminice R, de Castro GS, Brosnan ME, Brosnan JT.

Amino Acids. 2016 Aug;48(8):1983-91. doi: 10.1007/s00726-016-2183-6. Epub 2016 Jan 30. Review.


Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?

Brosnan ME, MacMillan L, Stevens JR, Brosnan JT.

Biochem J. 2015 Dec 1;472(2):135-46. doi: 10.1042/BJ20150837. Review.


Definitions of Metabolic Health and Risk of Future Type 2 Diabetes in BMI Categories: A Systematic Review and Network Meta-analysis.

Lotta LA, Abbasi A, Sharp SJ, Sahlqvist AS, Waterworth D, Brosnan JM, Scott RA, Langenberg C, Wareham NJ.

Diabetes Care. 2015 Nov;38(11):2177-87. doi: 10.2337/dc15-1218. Review.


A new amino acid substitution (Ala-205-Phe) in acetolactate synthase (ALS) confers broad spectrum resistance to ALS-inhibiting herbicides.

Brosnan JT, Vargas JJ, Breeden GK, Grier L, Aponte RA, Tresch S, Laforest M.

Planta. 2016 Jan;243(1):149-59. doi: 10.1007/s00425-015-2399-9. Epub 2015 Sep 9.


Cytochrome P450 Inhibitors Reduce Creeping Bentgrass (Agrostis stolonifera) Tolerance to Topramezone.

Elmore MT, Brosnan JT, Armel GR, Kopsell DA, Best MD, Mueller TC, Sorochan JC.

PLoS One. 2015 Jul 17;10(7):e0130947. doi: 10.1371/journal.pone.0130947. eCollection 2015.


Effects of Two Football Stud Types on Knee and Ankle Kinetics of Single-Leg Land-Cut and 180° Cut Movements on Infilled Synthetic Turf.

Bennett HJ, Brock E, Brosnan JT, Sorochan JC, Zhang S.

J Appl Biomech. 2015 Oct;31(5):309-17. doi: 10.1123/jab.2014-0203. Epub 2015 May 7.


Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.

Deac OM, Mills JL, Shane B, Midttun Ø, Ueland PM, Brosnan JT, Brosnan ME, Laird E, Gibney ER, Fan R, Wang Y, Brody LC, Molloy AM.

J Nutr. 2015 Apr;145(4):701-7. doi: 10.3945/jn.114.203091. Epub 2015 Feb 18.


Formate metabolism in fetal and neonatal sheep.

Washburn SE, Caudill MA, Malysheva O, MacFarlane AJ, Behan NA, Harnett B, MacMillan L, Pongnopparat T, Brosnan JT, Brosnan ME.

Am J Physiol Endocrinol Metab. 2015 May 15;308(10):E921-7. doi: 10.1152/ajpendo.00046.2015. Epub 2015 Mar 24.


Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice.

Pai YJ, Leung KY, Savery D, Hutchin T, Prunty H, Heales S, Brosnan ME, Brosnan JT, Copp AJ, Greene ND.

Nat Commun. 2015 Mar 4;6:6388. doi: 10.1038/ncomms7388.


Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism.

Deminice R, da Silva RP, Lamarre SG, Kelly KB, Jacobs RL, Brosnan ME, Brosnan JT.

Amino Acids. 2015 Apr;47(4):839-46. doi: 10.1007/s00726-014-1913-x. Epub 2015 Jan 11.


Understanding the challenges of palliative care in everyday clinical practice: an example from a COPD action research project.

Hynes G, Kavanagh F, Hogan C, Ryan K, Rogers L, Brosnan J, Coghlan D.

Nurs Inq. 2015 Sep;22(3):249-60. doi: 10.1111/nin.12089. Epub 2014 Dec 16.


In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats.

Morrow GP, MacMillan L, Lamarre SG, Young SK, MacFarlane AJ, Brosnan ME, Brosnan JT.

J Biol Chem. 2015 Jan 23;290(4):2244-50. doi: 10.1074/jbc.M114.600718. Epub 2014 Dec 5.


Effects of two football stud configurations on biomechanical characteristics of single-leg landing and cutting movements on infilled synthetic turf.

Brock E, Zhang S, Milner C, Liu X, Brosnan JT, Sorochan JC.

Sports Biomech. 2014 Nov;13(4):362-79. doi: 10.1080/14763141.2014.965727. Epub 2014 Oct 10.


Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency.

Field MS, Kamynina E, Agunloye OC, Liebenthal RP, Lamarre SG, Brosnan ME, Brosnan JT, Stover PJ.

J Biol Chem. 2014 Oct 24;289(43):29642-50. doi: 10.1074/jbc.M114.599589. Epub 2014 Sep 11.


Is there a relationship between dietary MSG and [corrected] obesity in animals or humans?

Brosnan JT, Drewnowski A, Friedman MI.

Amino Acids. 2014 Sep;46(9):2075-87. doi: 10.1007/s00726-014-1771-6. Epub 2014 Jun 14. Review. Erratum in: Amino Acids. 2014 Sep;46(9):2089.


An isotope-dilution, GC-MS assay for formate and its application to human and animal metabolism.

Lamarre SG, MacMillan L, Morrow GP, Randell E, Pongnopparat T, Brosnan ME, Brosnan JT.

Amino Acids. 2014 Aug;46(8):1885-91. doi: 10.1007/s00726-014-1738-7. Epub 2014 Apr 10.


Stability, across environments, of grain and alcohol yield, in soft wheat varieties grown for grain distilling or bioethanol production.

Swanston JS, Smith PL, Thomas WT, Sylvester-Bradley R, Kindred D, Brosnan JM, Bringhurst TA, Agu RC.

J Sci Food Agric. 2014 Dec;94(15):3234-40. doi: 10.1002/jsfa.6675. Epub 2014 Apr 22.


Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.

Flannick J, Thorleifsson G, Beer NL, Jacobs SB, Grarup N, Burtt NP, Mahajan A, Fuchsberger C, Atzmon G, Benediktsson R, Blangero J, Bowden DW, Brandslund I, Brosnan J, Burslem F, Chambers J, Cho YS, Christensen C, Douglas DA, Duggirala R, Dymek Z, Farjoun Y, Fennell T, Fontanillas P, Forsén T, Gabriel S, Glaser B, Gudbjartsson DF, Hanis C, Hansen T, Hreidarsson AB, Hveem K, Ingelsson E, Isomaa B, Johansson S, Jørgensen T, Jørgensen ME, Kathiresan S, Kong A, Kooner J, Kravic J, Laakso M, Lee JY, Lind L, Lindgren CM, Linneberg A, Masson G, Meitinger T, Mohlke KL, Molven A, Morris AP, Potluri S, Rauramaa R, Ribel-Madsen R, Richard AM, Rolph T, Salomaa V, Segrè AV, Skärstrand H, Steinthorsdottir V, Stringham HM, Sulem P, Tai ES, Teo YY, Teslovich T, Thorsteinsdottir U, Trimmer JK, Tuomi T, Tuomilehto J, Vaziri-Sani F, Voight BF, Wilson JG, Boehnke M, McCarthy MI, Njølstad PR, Pedersen O; Go-T2D Consortium; T2D-GENES Consortium, Groop L, Cox DR, Stefansson K, Altshuler D.

Nat Genet. 2014 Apr;46(4):357-63. doi: 10.1038/ng.2915. Epub 2014 Mar 2.


Synthesis and evaluation of heterocyclic analogues of bromoxynil.

Cutulle MA, Armel GR, Brosnan JT, Best MD, Kopsell DA, Bruce BD, Bostic HE, Layton DS.

J Agric Food Chem. 2014 Jan 15;62(2):329-36. doi: 10.1021/jf404209d. Epub 2013 Dec 27.


Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy.

Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer JK, Brosnan J, Rothman DL, Petersen KF, Shulman GI.

Nat Med. 2014 Jan;20(1):98-102. doi: 10.1038/nm.3415. Epub 2013 Dec 8.


Amino acids and proteins important for all; from stem cells, to the critically ill patient and even general bone health.

Rooyackers O, Brosnan JT.

Curr Opin Clin Nutr Metab Care. 2014 Jan;17(1):59-60. doi: 10.1097/MCO.0000000000000021. No abstract available.


Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas.

da Silva RP, Clow K, Brosnan JT, Brosnan ME.

Br J Nutr. 2014 Feb;111(4):571-7. doi: 10.1017/S0007114513003012. Epub 2013 Oct 8.


Pancreatic cancer genomics: insights and opportunities for clinical translation.

Makohon-Moore A, Brosnan JA, Iacobuzio-Donahue CA.

Genome Med. 2013 Mar 28;5(3):26. doi: 10.1186/gm430. eCollection 2013. Review.


The effect of portacaval anastomosis on the expression of glutamine synthetase and ornithine aminotransferase in perivenous hepatocytes.

da Silva R, Levillain O, Brosnan JT, Araneda S, Brosnan ME.

Can J Physiol Pharmacol. 2013 May;91(5):362-8. doi: 10.1139/cjpp-2012-0060. Epub 2012 Dec 19.


Creatine and guanidinoacetate content of human milk and infant formulas: implications for creatine deficiency syndromes and amino acid metabolism.

Edison EE, Brosnan ME, Aziz K, Brosnan JT.

Br J Nutr. 2013 Sep 28;110(6):1075-8. doi: 10.1017/S000711451300010X. Epub 2013 Feb 7.


Formate: an essential metabolite, a biomarker, or more?

Lamarre SG, Morrow G, Macmillan L, Brosnan ME, Brosnan JT.

Clin Chem Lab Med. 2013 Mar 1;51(3):571-8. doi: 10.1515/cclm-2012-0552. Review.


Amino acids: the most versatile nutrients.

Brosnan JT, Rooyackers O.

Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):56. doi: 10.1097/MCO.0b013e32835b4ec4. No abstract available.


Norethisterone acetate alters coagulation gene expression in vitro in human cell culture.

Brosnan JF, Sheppard BL, Kelly LA, O'Leary JJ, Norris LA.

Thromb Res. 2013 Jan;131(1):72-7. doi: 10.1016/j.thromres.2012.09.006. Epub 2012 Sep 19.


Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors.

Yachida S, White CM, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM, Morgan RA, Saunders T, Laheru DA, Herman JM, Hruban RH, Klein AP, Jones S, Velculescu V, Wolfgang CL, Iacobuzio-Donahue CA.

Clin Cancer Res. 2012 Nov 15;18(22):6339-47. doi: 10.1158/1078-0432.CCR-12-1215. Epub 2012 Sep 18.


Effect of germination temperatures on proteolysis of the gluten-free grains rice and buckwheat during malting and mashing.

Agu RC, Chiba Y, Goodfellow V, MacKinlay J, Brosnan JM, Bringhurst TA, Jack FR, Harrison B, Pearson SY, Bryce JH.

J Agric Food Chem. 2012 Oct 10;60(40):10147-54. doi: 10.1021/jf3028039. Epub 2012 Oct 2.


Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.

Cui Y, Brosnan JA, Blackford AL, Sur S, Hruban RH, Kinzler KW, Vogelstein B, Maitra A, Diaz LA Jr, Iacobuzio-Donahue CA, Eshleman JR.

Clin Cancer Res. 2012 Dec 1;18(23):6519-30. doi: 10.1158/1078-0432.CCR-12-0827. Epub 2012 Jul 2.


The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.

Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KA, Grützmann R, Aust D, Rümmele P, Knösel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve JJ, de Ridder J, Klein AP, Goggins M, Hruban RH, Chang DK, Biankin AV, Grimmond SM; Australian Pancreatic Cancer Genome Initiative, Wessels LF, Wood SA, Iacobuzio-Donahue CA, Pilarsky C, Largaespada DA, Adams DJ, Tuveson DA.

Nature. 2012 Apr 29;486(7402):266-70. doi: 10.1038/nature11114. Erratum in: Nature. 2013 Feb 21;494(7437):390. Scarlett, Christopher J [added]; Kaplan, Warren [added]; Scarpa, Aldo [added], Das, Amithabad [corrected to Das, Amitabha].


Glutamate: a truly functional amino acid.

Brosnan JT, Brosnan ME.

Amino Acids. 2013 Sep;45(3):413-8. doi: 10.1007/s00726-012-1280-4. Epub 2012 Apr 18. Review.


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