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Items: 1 to 50 of 182

1.

Holding All the Cards-How Fanconi Anemia Proteins Deal with Replication Stress and Preserve Genomic Stability.

Datta A, Brosh RM Jr.

Genes (Basel). 2019 Feb 22;10(2). pii: E170. doi: 10.3390/genes10020170. Review.

2.

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).

Sommers JA, Kulikowicz T, Croteau DL, Dexheimer T, Dorjsuren D, Jadhav A, Maloney DJ, Simeonov A, Bohr VA, Brosh RM Jr.

PLoS One. 2019 Jan 9;14(1):e0210525. doi: 10.1371/journal.pone.0210525. eCollection 2019.

3.

Warsaw breakage syndrome: Further clinical and genetic delineation.

Alkhunaizi E, Shaheen R, Bharti SK, Joseph-George AM, Chong K, Abdel-Salam GMH, Alowain M, Blaser SI, Papsin BC, Butt M, Hashem M, Martin N, Godoy R, Brosh RM Jr, Alkuraya FS, Chitayat D.

Am J Med Genet A. 2018 Nov;176(11):2404-2418. doi: 10.1002/ajmg.a.40482. Epub 2018 Sep 14.

PMID:
30216658
4.

BLM's balancing act and the involvement of FANCJ in DNA repair.

Dhar S, Brosh RM.

Cell Cycle. 2018;17(18):2207-2220. doi: 10.1080/15384101.2018.1520567. Epub 2018 Sep 23.

PMID:
30209988
5.

New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy.

Datta A, Brosh RM Jr.

Front Mol Biosci. 2018 Jun 26;5:59. doi: 10.3389/fmolb.2018.00059. eCollection 2018. Review.

6.

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair.

Bharti SK, Sommers JA, Awate S, Bellani MA, Khan I, Bradley L, King GA, Seol Y, Vidhyasagar V, Wu Y, Abe T, Kobayashi K, Shin-Ya K, Kitao H, Wold MS, Branzei D, Neuman KC, Brosh RM Jr.

Nucleic Acids Res. 2018 Jul 6;46(12):6238-6256. doi: 10.1093/nar/gky403.

7.

RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.

Estep KN, Brosh RM Jr.

Biochem Soc Trans. 2018 Feb 19;46(1):77-95. doi: 10.1042/BST20170044. Epub 2017 Dec 22. Review.

8.

Replication checkpoint-mediated symmetric DNA synthesis: beginning to understand mechanism.

Brosh RM Jr, Matson SW.

Cell Cycle. 2018;17(3):271-272. doi: 10.1080/15384101.2017.1408234. Epub 2018 Feb 19. No abstract available.

9.

G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets.

Estep KN, Butler TJ, Ding J, Brosh RM Jr.

Curr Med Chem. 2017 Nov 16. doi: 10.2174/0929867324666171116123345. [Epub ahead of print]

PMID:
29149833
10.

Interactive Roles of DNA Helicases and Translocases with the Single-Stranded DNA Binding Protein RPA in Nucleic Acid Metabolism.

Awate S, Brosh RM Jr.

Int J Mol Sci. 2017 Jun 8;18(6). pii: E1233. doi: 10.3390/ijms18061233. Review.

11.

Mechanistic insights into how CMG helicase facilitates replication past DNA roadblocks.

Trakselis MA, Seidman MM, Brosh RM Jr.

DNA Repair (Amst). 2017 Jul;55:76-82. doi: 10.1016/j.dnarep.2017.05.005. Epub 2017 May 20. Review.

PMID:
28554039
12.

Detection of G-quadruplex DNA in mammalian cells.

Henderson A, Wu Y, Huang YC, Chavez EA, Platt J, Johnson FB, Brosh RM Jr, Sen D, Lansdorp PM.

Nucleic Acids Res. 2017 Jun 2;45(10):6252. doi: 10.1093/nar/gkx300. No abstract available.

13.

Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism.

Crouch JD, Brosh RM Jr.

Free Radic Biol Med. 2017 Jun;107:245-257. doi: 10.1016/j.freeradbiomed.2016.11.022. Epub 2016 Nov 22. Review.

14.

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.

Scheibye-Knudsen M, Tseng A, Borch Jensen M, Scheibye-Alsing K, Fang EF, Iyama T, Bharti SK, Marosi K, Froetscher L, Kassahun H, Eckley DM, Maul RW, Bastian P, De S, Ghosh S, Nilsen H, Goldberg IG, Mattson MP, Wilson DM 3rd, Brosh RM Jr, Gorospe M, Bohr VA.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12502-12507. Epub 2016 Oct 18.

15.

Editorial.

Brosh RM Jr.

Ageing Res Rev. 2017 Jan;33:1-2. doi: 10.1016/j.arr.2016.09.009. Epub 2016 Sep 29. No abstract available.

16.

CDK1 phosphorylates WRN at collapsed replication forks.

Palermo V, Rinalducci S, Sanchez M, Grillini F, Sommers JA, Brosh RM Jr, Zolla L, Franchitto A, Pichierri P.

Nat Commun. 2016 Sep 16;7:12880. doi: 10.1038/ncomms12880.

17.

Special Methods collection on DNA helicases.

Brosh RM Jr.

Methods. 2016 Oct 1;108:1-3. doi: 10.1016/j.ymeth.2016.08.009. Epub 2016 Aug 24.

18.

A Long Noncoding RNA Regulates Sister Chromatid Cohesion.

Marchese FP, Grossi E, Marín-Béjar O, Bharti SK, Raimondi I, González J, Martínez-Herrera DJ, Athie A, Amadoz A, Brosh RM Jr, Huarte M.

Mol Cell. 2016 Aug 4;63(3):397-407. doi: 10.1016/j.molcel.2016.06.031. Epub 2016 Jul 28.

19.

Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles.

Bharti SK, Awate S, Banerjee T, Brosh RM.

Genes (Basel). 2016 Jul 1;7(7). pii: E31. doi: 10.3390/genes7070031. Review.

20.

Fine-tuning DNA repair by protein acetylation.

Bharti SK, Brosh RM Jr.

Cell Cycle. 2016 Aug 2;15(15):1952-3. doi: 10.1080/15384101.2016.1191250. Epub 2016 Jun 13. No abstract available.

21.

A dual molecular analogue tuner for dissecting protein function in mammalian cells.

Brosh R, Hrynyk I, Shen J, Waghray A, Zheng N, Lemischka IR.

Nat Commun. 2016 May 27;7:11742. doi: 10.1038/ncomms11742.

22.

Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING.

Khan I, Crouch JD, Bharti SK, Sommers JA, Carney SM, Yakubovskaya E, Garcia-Diaz M, Trakselis MA, Brosh RM Jr.

J Biol Chem. 2016 Jul 1;291(27):14324-39. doi: 10.1074/jbc.M115.712026. Epub 2016 May 11.

23.

Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging.

Brosh RM Jr, Bellani M, Liu Y, Seidman MM.

Ageing Res Rev. 2017 Jan;33:67-75. doi: 10.1016/j.arr.2016.05.005. Epub 2016 May 17. Review.

24.

Biochemical and cell biological assays to identify and characterize DNA helicase inhibitors.

Banerjee T, Aggarwal M, Sommers JA, Brosh RM Jr.

Methods. 2016 Oct 1;108:130-41. doi: 10.1016/j.ymeth.2016.04.007. Epub 2016 Apr 7. Review.

25.

G-quadruplexes and helicases.

Mendoza O, Bourdoncle A, Boulé JB, Brosh RM Jr, Mergny JL.

Nucleic Acids Res. 2016 Mar 18;44(5):1989-2006. doi: 10.1093/nar/gkw079. Epub 2016 Feb 15. Review.

26.

Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway.

Calì F, Bharti SK, Di Perna R, Brosh RM Jr, Pisani FM.

Nucleic Acids Res. 2016 Jan 29;44(2):705-17. doi: 10.1093/nar/gkv1112. Epub 2015 Oct 25.

27.

Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.

Banerjee T, Sommers JA, Huang J, Seidman MM, Brosh RM Jr.

Curr Biol. 2015 Nov 2;25(21):2830-2838. doi: 10.1016/j.cub.2015.09.026. Epub 2015 Oct 8.

28.

Close encounters for the first time: Helicase interactions with DNA damage.

Khan I, Sommers JA, Brosh RM Jr.

DNA Repair (Amst). 2015 Sep;33:43-59. doi: 10.1016/j.dnarep.2015.06.003. Epub 2015 Jun 16. Review.

29.

RECQL: a new breast cancer susceptibility gene.

Banerjee T, Brosh RM Jr.

Cell Cycle. 2015;14(22):3540-3. doi: 10.1080/15384101.2015.1066539.

30.

Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm.

Waghray A, Saiz N, Jayaprakash AD, Freire AG, Papatsenko D, Pereira CF, Lee DF, Brosh R, Chang B, Darr H, Gingold J, Kelley K, Schaniel C, Hadjantonakis AK, Lemischka IR.

Stem Cell Reports. 2015 Jul 14;5(1):97-110. doi: 10.1016/j.stemcr.2015.05.009. Epub 2015 Jun 18.

31.

Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stability.

Sommers JA, Suhasini AN, Brosh RM Jr.

Biomolecules. 2015 Apr 21;5(2):590-616. doi: 10.3390/biom5020590. Review.

32.

What is wrong with Fanconi anemia cells?

Cantor SB, Brosh RM Jr.

Cell Cycle. 2014;13(24):3823-7. doi: 10.4161/15384101.2014.980633. Review.

33.

Impact of age-associated cyclopurine lesions on DNA repair helicases.

Khan I, Suhasini AN, Banerjee T, Sommers JA, Kaplan DL, Kuper J, Kisker C, Brosh RM Jr.

PLoS One. 2014 Nov 19;9(11):e113293. doi: 10.1371/journal.pone.0113293. eCollection 2014.

34.

Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia.

Brosh RM Jr, Cantor SB.

Front Genet. 2014 Oct 21;5:372. doi: 10.3389/fgene.2014.00372. eCollection 2014. Review.

35.

DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.

Bharti SK, Sommers JA, Zhou J, Kaplan DL, Spelbrink JN, Mergny JL, Brosh RM Jr.

J Biol Chem. 2014 Oct 24;289(43):29975-93. doi: 10.1074/jbc.M114.567073. Epub 2014 Sep 5.

36.

Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.

Sommers JA, Banerjee T, Hinds T, Wan B, Wold MS, Lei M, Brosh RM Jr.

J Biol Chem. 2014 Jul 18;289(29):19928-41. doi: 10.1074/jbc.M113.542456. Epub 2014 Jun 3.

37.

UvrD helicase: the little engine that could.

Brosh RM Jr.

Cell Cycle. 2014;13(8):1213-5. doi: 10.4161/cc.28382. Epub 2014 Mar 4. No abstract available.

38.

Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome.

Bharti SK, Khan I, Banerjee T, Sommers JA, Wu Y, Brosh RM Jr.

Cell Mol Life Sci. 2014 Jul;71(14):2625-39. doi: 10.1007/s00018-014-1569-4. Epub 2014 Feb 1. Review.

39.

Detection of G-quadruplex DNA in mammalian cells.

Henderson A, Wu Y, Huang YC, Chavez EA, Platt J, Johnson FB, Brosh RM Jr, Sen D, Lansdorp PM.

Nucleic Acids Res. 2014 Jan;42(2):860-9. doi: 10.1093/nar/gkt957. Epub 2013 Oct 24.

40.

Targeting an Achilles' heel of cancer with a WRN helicase inhibitor.

Aggarwal M, Banerjee T, Sommers JA, Brosh RM Jr.

Cell Cycle. 2013 Oct 15;12(20):3329-35. doi: 10.4161/cc.26320. Epub 2013 Sep 12.

41.

Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.

Bharti SK, Sommers JA, George F, Kuper J, Hamon F, Shin-ya K, Teulade-Fichou MP, Kisker C, Brosh RM Jr.

J Biol Chem. 2013 Sep 27;288(39):28217-29. doi: 10.1074/jbc.M113.496463. Epub 2013 Aug 9.

42.

Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.

Aggarwal M, Banerjee T, Sommers JA, Iannascoli C, Pichierri P, Shoemaker RH, Brosh RM Jr.

Cancer Res. 2013 Sep 1;73(17):5497-507. doi: 10.1158/0008-5472.CAN-12-2975. Epub 2013 Jul 18.

43.

DNA helicases involved in DNA repair and their roles in cancer.

Brosh RM Jr.

Nat Rev Cancer. 2013 Aug;13(8):542-58. doi: 10.1038/nrc3560. Epub 2013 Jul 11. Review.

44.

Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks.

Parvathaneni S, Stortchevoi A, Sommers JA, Brosh RM Jr, Sharma S.

PLoS One. 2013 May 1;8(5):e62481. doi: 10.1371/journal.pone.0062481. Print 2013.

45.

Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response.

Suhasini AN, Sommers JA, Muniandy PA, Coulombe Y, Cantor SB, Masson JY, Seidman MM, Brosh RM Jr.

Mol Cell Biol. 2013 Jun;33(11):2212-27. doi: 10.1128/MCB.01256-12. Epub 2013 Mar 25.

46.

A new development in DNA repair modulation: discovery of a BLM helicase inhibitor.

Banerjee T, Aggarwal M, Brosh RM Jr.

Cell Cycle. 2013 Mar 1;12(5):713-4. doi: 10.4161/cc.23953. Epub 2013 Feb 19. No abstract available.

47.

Disease-causing missense mutations in human DNA helicase disorders.

Suhasini AN, Brosh RM Jr.

Mutat Res. 2013 Apr-Jun;752(2):138-52. doi: 10.1016/j.mrrev.2012.12.004. Epub 2012 Dec 28. Review.

48.

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.

Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM Jr, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, Robbiani DF.

J Exp Med. 2013 Jan 14;210(1):115-23. doi: 10.1084/jem.20121975. Epub 2012 Dec 17.

49.

DNA helicases associated with genetic instability, cancer, and aging.

Suhasini AN, Brosh RM Jr.

Adv Exp Med Biol. 2013;767:123-44. doi: 10.1007/978-1-4614-5037-5_6.

50.

RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures.

Popuri V, Croteau DL, Brosh RM Jr, Bohr VA.

Cell Cycle. 2012 Nov 15;11(22):4252-65. doi: 10.4161/cc.22581. Epub 2012 Oct 24.

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