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Items: 1 to 50 of 213

1.

Synaptic vesicle fusion: today and beyond.

Brose N, Brunger A, Cafiso D, Chapman ER, Diao J, Hughson FM, Jackson MB, Jahn R, Lindau M, Ma C, Rizo J, Shin YK, Söllner TH, Tamm L, Yoon TY, Zhang Y.

Nat Struct Mol Biol. 2019 Aug;26(8):663-668. doi: 10.1038/s41594-019-0277-z. No abstract available.

PMID:
31384060
2.

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.

Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M.

Neuron. 2019 Jul 17;103(2):217-234.e4. doi: 10.1016/j.neuron.2019.05.002. Epub 2019 Jun 3.

PMID:
31171447
3.

An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.

Rhee HJ, Shaib AH, Rehbach K, Lee C, Seif P, Thomas C, Gideons E, Guenther A, Krutenko T, Hebisch M, Peitz M, Brose N, Brüstle O, Rhee JS.

Cell Rep. 2019 May 14;27(7):2212-2228.e7. doi: 10.1016/j.celrep.2019.04.059.

4.

Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release.

López-Murcia FJ, Reim K, Jahn O, Taschenberger H, Brose N.

Cell Rep. 2019 Mar 5;26(10):2521-2530.e5. doi: 10.1016/j.celrep.2019.02.030.

5.

Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.

Scholz N, Ehmann N, Sachidanandan D, Imig C, Cooper BH, Jahn O, Reim K, Brose N, Meyer J, Lamberty M, Altrichter S, Bormann A, Hallermann S, Pauli M, Heckmann M, Stigloher C, Langenhan T, Kittel RJ.

J Cell Biol. 2019 Mar 4;218(3):1011-1026. doi: 10.1083/jcb.201806155. Epub 2019 Feb 19.

6.

IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses.

Babaev O, Cruces-Solis H, Piletti Chatain C, Hammer M, Wenger S, Ali H, Karalis N, de Hoz L, Schlüter OM, Yanagawa Y, Ehrenreich H, Taschenberger H, Brose N, Krueger-Burg D.

Nat Commun. 2018 Dec 20;9(1):5400. doi: 10.1038/s41467-018-07762-1.

7.

Dynamically Primed Synaptic Vesicle States: Key to Understand Synaptic Short-Term Plasticity.

Neher E, Brose N.

Neuron. 2018 Dec 19;100(6):1283-1291. doi: 10.1016/j.neuron.2018.11.024. Review.

8.

Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons.

Bhouri M, Morishita W, Temkin P, Goswami D, Kawabe H, Brose N, Südhof TC, Craig AM, Siddiqui TJ, Malenka R.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5382-E5389. doi: 10.1073/pnas.1803280115. Epub 2018 May 21.

9.

Response: Commentary: Analysis of SUMO1-conjugation at synapses.

Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M.

Front Cell Neurosci. 2018 May 1;12:117. doi: 10.3389/fncel.2018.00117. eCollection 2018. No abstract available.

10.

Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.

Zhang B, Gokce O, Hale WD, Brose N, Südhof TC.

J Exp Med. 2018 Jun 4;215(6):1543-1553. doi: 10.1084/jem.20172162. Epub 2018 May 3.

11.

BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology.

Peters F, Salihoglu H, Rodrigues E, Herzog E, Blume T, Filser S, Dorostkar M, Shimshek DR, Brose N, Neumann U, Herms J.

Acta Neuropathol. 2018 May;135(5):695-710. doi: 10.1007/s00401-017-1804-9. Epub 2018 Jan 11.

12.

Building Bridges through Science.

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.

Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.

13.

Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.

Unichenko P, Yang JW, Kirischuk S, Kolbaev S, Kilb W, Hammer M, Krueger-Burg D, Brose N, Luhmann HJ.

Cereb Cortex. 2018 Aug 1;28(8):2873-2886. doi: 10.1093/cercor/bhx165.

PMID:
29106499
14.

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

Lai Y, Choi UB, Leitz J, Rhee HJ, Lee C, Altas B, Zhao M, Pfuetzner RA, Wang AL, Brose N, Rhee J, Brunger AT.

Neuron. 2017 Aug 2;95(3):591-607.e10. doi: 10.1016/j.neuron.2017.07.004.

15.

Analysis of SUMO1-conjugation at synapses.

Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M.

Elife. 2017 Jun 9;6. pii: e26338. doi: 10.7554/eLife.26338.

16.

Organizers of inhibitory synapses come of age.

Krueger-Burg D, Papadopoulos T, Brose N.

Curr Opin Neurobiol. 2017 Aug;45:66-77. doi: 10.1016/j.conb.2017.04.003. Epub 2017 Apr 28. Review.

PMID:
28460365
17.

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.

Chehab T, Santos NC, Holthenrich A, Koerdt SN, Disse J, Schuberth C, Nazmi AR, Neeft M, Koch H, Man KNM, Wojcik SM, Martin TFJ, van der Sluijs P, Brose N, Gerke V.

Mol Biol Cell. 2017 Jun 15;28(12):1688-1700. doi: 10.1091/mbc.E17-02-0128. Epub 2017 Apr 27.

18.

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.

Sigler A, Oh WC, Imig C, Altas B, Kawabe H, Cooper BH, Kwon HB, Rhee JS, Brose N.

Neuron. 2017 Apr 19;94(2):304-311.e4. doi: 10.1016/j.neuron.2017.03.029.

19.

Correction: ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.

Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N.

J Cell Biol. 2017 Apr 3;216(4):1205. doi: 10.1083/jcb.20160608603092017c. Epub 2017 Mar 13. No abstract available.

20.

ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.

Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N.

J Cell Biol. 2017 Apr 3;216(4):1143-1161. doi: 10.1083/jcb.201606086. Epub 2017 Mar 6. Erratum in: J Cell Biol. 2017 Apr 3;216(4):1205.

21.

Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.

Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, Toselli M, Brose N, Parenti M, Rhee J.

Elife. 2017 Feb 23;6. pii: e22466. doi: 10.7554/eLife.22466.

22.

Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder.

Lipstein N, Verhoeven-Duif NM, Michelassi FE, Calloway N, van Hasselt PM, Pienkowska K, van Haaften G, van Haelst MM, van Empelen R, Cuppen I, van Teeseling HC, Evelein AM, Vorstman JA, Thoms S, Jahn O, Duran KJ, Monroe GR, Ryan TA, Taschenberger H, Dittman JS, Rhee JS, Visser G, Jans JJ, Brose N.

J Clin Invest. 2017 Mar 1;127(3):1005-1018. doi: 10.1172/JCI90259. Epub 2017 Feb 13.

23.

Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.

Lahut S, Gispert S, Ömür Ö, Depboylu C, Seidel K, Domínguez-Bautista JA, Brehm N, Tireli H, Hackmann K, Pirkevi C, Leube B, Ries V, Reim K, Brose N, den Dunnen WF, Johnson M, Wolf Z, Schindewolf M, Schrempf W, Reetz K, Young P, Vadasz D, Frangakis AS, Schröck E, Steinmetz H, Jendrach M, Rüb U, Başak AN, Oertel W, Auburger G.

Dis Model Mech. 2017 May 1;10(5):619-631. doi: 10.1242/dmm.028035. Epub 2017 Jan 20.

24.

Synapse biology in the 'circuit-age'-paths toward molecular connectomics.

Schreiner D, Savas JN, Herzog E, Brose N, de Wit J.

Curr Opin Neurobiol. 2017 Feb;42:102-110. doi: 10.1016/j.conb.2016.12.004. Epub 2016 Dec 26. Review.

25.

Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses.

Papadopoulos T, Rhee HJ, Subramanian D, Paraskevopoulou F, Mueller R, Schultz C, Brose N, Rhee JS, Betz H.

J Biol Chem. 2017 Jan 27;292(4):1160-1177. doi: 10.1074/jbc.M116.771592. Epub 2016 Dec 9.

26.

Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.

Strenzke N, Chakrabarti R, Al-Moyed H, Müller A, Hoch G, Pangrsic T, Yamanbaeva G, Lenz C, Pan KT, Auge E, Geiss-Friedlander R, Urlaub H, Brose N, Wichmann C, Reisinger E.

EMBO J. 2016 Dec 1;35(23):2519-2535. Epub 2016 Oct 11.

27.

Systematic Localization and Identification of SUMOylation Substrates in Knock-In Mice Expressing Affinity-Tagged SUMO1.

Tirard M, Brose N.

Methods Mol Biol. 2016;1475:291-301. doi: 10.1007/978-1-4939-6358-4_20.

PMID:
27631813
28.

Photoswitchable diacylglycerols enable optical control of protein kinase C.

Frank JA, Yushchenko DA, Hodson DJ, Lipstein N, Nagpal J, Rutter GA, Rhee JS, Gottschalk A, Brose N, Schultz C, Trauner D.

Nat Chem Biol. 2016 Sep;12(9):755-62. doi: 10.1038/nchembio.2141. Epub 2016 Jul 25.

29.

Functional Roles of Complexin 3 and Complexin 4 at Mouse Photoreceptor Ribbon Synapses.

Babai N, Sendelbeck A, Regus-Leidig H, Fuchs M, Mertins J, Reim K, Brose N, Feigenspan A, Brandstätter JH.

J Neurosci. 2016 Jun 22;36(25):6651-67. doi: 10.1523/JNEUROSCI.4335-15.2016. Erratum in: J Neurosci. 2017 Aug 9;37(32):7796.

30.

Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses.

Mortensen LS, Park SJH, Ke JB, Cooper BH, Zhang L, Imig C, Löwel S, Reim K, Brose N, Demb JB, Rhee JS, Singer JH.

Cell Rep. 2016 Jun 7;15(10):2239-2250. doi: 10.1016/j.celrep.2016.05.012. Epub 2016 May 26.

31.

Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice.

Okamoto Y, Lipstein N, Hua Y, Lin KH, Brose N, Sakaba T, Midorikawa M.

Elife. 2016 May 7;5. pii: e14643. doi: 10.7554/eLife.14643.

32.

Selective expression of a constitutively active erythropoietin receptor in GABAergic neurons alters hippocampal network properties without affecting cognition.

Wüstefeld L, Winkler D, Janc OA, Hassouna I, Ronnenberg A, Ostmeier K, Müller M, Brose N, Ehrenreich H, Wojcik SM.

J Neurochem. 2016 Feb;136(4):698-705. doi: 10.1111/jnc.13445. Epub 2016 Jan 7.

33.

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.

Man KN, Imig C, Walter AM, Pinheiro PS, Stevens DR, Rettig J, Sørensen JB, Cooper BH, Brose N, Wojcik SM.

Elife. 2015 Nov 17;4. pii: e10635. doi: 10.7554/eLife.10635.

34.

Specificity of Collybistin-Phosphoinositide Interactions: IMPACT OF THE INDIVIDUAL PROTEIN DOMAINS.

Ludolphs M, Schneeberger D, Soykan T, Schäfer J, Papadopoulos T, Brose N, Schindelin H, Steinem C.

J Biol Chem. 2016 Jan 1;291(1):244-54. doi: 10.1074/jbc.M115.673400. Epub 2015 Nov 6.

35.

Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.

Hammer M, Krueger-Burg D, Tuffy LP, Cooper BH, Taschenberger H, Goswami SP, Ehrenreich H, Jonas P, Varoqueaux F, Rhee JS, Brose N.

Cell Rep. 2015 Oct 20;13(3):516-523. doi: 10.1016/j.celrep.2015.09.011. Epub 2015 Oct 8.

36.

Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission.

Lipina TV, Prasad T, Yokomaku D, Luo L, Connor SA, Kawabe H, Wang YT, Brose N, Roder JC, Craig AM.

Neuropsychopharmacology. 2016 Feb;41(3):802-10. doi: 10.1038/npp.2015.206. Epub 2015 Jul 14.

37.

Neuroligin 2 deletion alters inhibitory synapse function and anxiety-associated neuronal activation in the amygdala.

Babaev O, Botta P, Meyer E, Müller C, Ehrenreich H, Brose N, Lüthi A, Krueger-Burg D.

Neuropharmacology. 2016 Jan;100:56-65. doi: 10.1016/j.neuropharm.2015.06.016. Epub 2015 Jun 30.

PMID:
26142252
38.

Correction: Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.

Schotten S, Meijer M, Walter AM, Huson V, Mamer L, Kalogreades L, Veer MT, Ruiter M, Brose N, Rosenmund C, Sørensen JB, Verhage M, Cornelisse LN.

Elife. 2015 Jun 4;4. doi: 10.7554/eLife.09036. No abstract available.

39.

Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse.

Chang S, Reim K, Pedersen M, Neher E, Brose N, Taschenberger H.

J Neurosci. 2015 May 27;35(21):8272-90. doi: 10.1523/JNEUROSCI.4841-14.2015.

40.

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.

Schotten S, Meijer M, Walter AM, Huson V, Mamer L, Kalogreades L, ter Veer M, Ruiter M, Brose N, Rosenmund C, Sørensen JB, Verhage M, Cornelisse LN.

Elife. 2015 Apr 14;4:e05531. doi: 10.7554/eLife.05531. Erratum in: Elife. 2015;4. doi: 10.7554/eLife.09036.

41.

Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo.

Jedlicka P, Vnencak M, Krueger DD, Jungenitz T, Brose N, Schwarzacher SW.

Brain Struct Funct. 2015 Jan;220(1):47-58.

PMID:
25713840
42.

Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability.

Papadopoulos T, Schemm R, Grubmüller H, Brose N.

J Biol Chem. 2015 Mar 27;290(13):8256-70. doi: 10.1074/jbc.M114.633024. Epub 2015 Feb 12.

43.

Fast cerebellar reflex circuitry requires synaptic vesicle priming by munc13-3.

Netrakanti PR, Cooper BH, Dere E, Poggi G, Winkler D, Brose N, Ehrenreich H.

Cerebellum. 2015 Jun;14(3):264-83. doi: 10.1007/s12311-015-0645-0.

44.

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.

Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C.

J Cell Sci. 2015 Feb 15;128(4):638-44. doi: 10.1242/jcs.162099. Epub 2015 Jan 20.

45.

Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain.

Nguyen Truong CQ, Nestvogel D, Ratai O, Schirra C, Stevens DR, Brose N, Rhee J, Rettig J.

Cell Rep. 2014 Nov 6;9(3):902-9. doi: 10.1016/j.celrep.2014.09.050. Epub 2014 Oct 23.

46.

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.

Imig C, Min SW, Krinner S, Arancillo M, Rosenmund C, Südhof TC, Rhee J, Brose N, Cooper BH.

Neuron. 2014 Oct 22;84(2):416-31. doi: 10.1016/j.neuron.2014.10.009. Epub 2014 Oct 22. Erratum in: Neuron. 2014 Nov 19;84(4):882.

47.

Munc13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum.

Ishiyama S, Schmidt H, Cooper BH, Brose N, Eilers J.

J Neurosci. 2014 Oct 29;34(44):14687-96. doi: 10.1523/JNEUROSCI.2060-14.2014.

48.

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

Hsia HE, Kumar R, Luca R, Takeda M, Courchet J, Nakashima J, Wu S, Goebbels S, An W, Eickholt BJ, Polleux F, Rotin D, Wu H, Rossner MJ, Bagni C, Rhee JS, Brose N, Kawabe H.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13205-10. doi: 10.1073/pnas.1400737111. Epub 2014 Aug 25.

49.

A conformational switch in collybistin determines the differentiation of inhibitory postsynapses.

Soykan T, Schneeberger D, Tria G, Buechner C, Bader N, Svergun D, Tessmer I, Poulopoulos A, Papadopoulos T, Varoqueaux F, Schindelin H, Brose N.

EMBO J. 2014 Sep 17;33(18):2113-33. doi: 10.15252/embj.201488143. Epub 2014 Jul 30.

50.

Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.

Ju A, Hammerschmidt K, Tantra M, Krueger D, Brose N, Ehrenreich H.

Behav Brain Res. 2014 Aug 15;270:159-64. doi: 10.1016/j.bbr.2014.05.019. Epub 2014 May 20.

PMID:
24855039

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