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Items: 1 to 50 of 171

1.
2.

ESX/Type VII Secretion Systems-An Important Way Out for Mycobacterial Proteins.

Vaziri F, Brosch R.

Microbiol Spectr. 2019 Jul;7(4). doi: 10.1128/microbiolspec.PSIB-0029-2019.

PMID:
31298207
3.

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis.

Machelart A, Salzano G, Li X, Demars A, Debrie AS, Menendez-Miranda M, Pancani E, Jouny S, Hoffmann E, Deboosere N, Belhaouane I, Rouanet C, Simar S, Talahari S, Giannini V, Villemagne B, Flipo M, Brosch R, Nesslany F, Deprez B, Muraille E, Locht C, Baulard AR, Willand N, Majlessi L, Gref R, Brodin P.

ACS Nano. 2019 Apr 23;13(4):3992-4007. doi: 10.1021/acsnano.8b07902. Epub 2019 Mar 8.

PMID:
30822386
4.

Update on the virulence factors of the obligate pathogen Mycobacterium tuberculosis and related tuberculosis-causing mycobacteria.

Madacki J, Mas Fiol G, Brosch R.

Infect Genet Evol. 2019 Aug;72:67-77. doi: 10.1016/j.meegid.2018.12.013. Epub 2018 Dec 10.

PMID:
30543938
5.

[The most ancestral mycobacterial ESX-4 secretion system is essential for intracellular growth of Mycobacterium abscessus within environmental and human phagocytes].

Girard-Misguich F, Laencina L, Dubois V, Le Moigne V, Kremer L, Maljessi L, Brosch R, Herrmann JL.

Med Sci (Paris). 2018 Oct;34(10):795-797. doi: 10.1051/medsci/2018196. Epub 2018 Nov 19. French. No abstract available.

PMID:
30451667
6.

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.

Gil M, Lima A, Rivera B, Rossello J, Urdániz E, Cascioferro A, Carrión F, Wehenkel A, Bellinzoni M, Batthyány C, Pritsch O, Denicola A, Alvarez MN, Carvalho PC, Lisa MN, Brosch R, Piuri M, Alzari PM, Durán R.

J Proteomics. 2019 Feb 10;192:321-333. doi: 10.1016/j.jprot.2018.09.013. Epub 2018 Sep 27.

PMID:
30267874
7.

Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity.

Ates LS, Dippenaar A, Sayes F, Pawlik A, Bouchier C, Ma L, Warren RM, Sougakoff W, Majlessi L, van Heijst JWJ, Brossier F, Brosch R.

Genome Biol Evol. 2018 Aug 1;10(8):1858-1874. doi: 10.1093/gbe/evy145.

8.

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.

Ates LS, Sayes F, Frigui W, Ummels R, Damen MPM, Bottai D, Behr MA, van Heijst JWJ, Bitter W, Majlessi L, Brosch R.

PLoS Pathog. 2018 Jun 18;14(6):e1007139. doi: 10.1371/journal.ppat.1007139. eCollection 2018 Jun.

9.

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors.

Sayes F, Blanc C, Ates LS, Deboosere N, Orgeur M, Le Chevalier F, Gröschel MI, Frigui W, Song OR, Lo-Man R, Brossier F, Sougakoff W, Bottai D, Brodin P, Charneau P, Brosch R, Majlessi L.

Cell Rep. 2018 Apr 24;23(4):1072-1084. doi: 10.1016/j.celrep.2018.03.125.

10.

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus.

Laencina L, Dubois V, Le Moigne V, Viljoen A, Majlessi L, Pritchard J, Bernut A, Piel L, Roux AL, Gaillard JL, Lombard B, Loew D, Rubin EJ, Brosch R, Kremer L, Herrmann JL, Girard-Misguich F.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1002-E1011. doi: 10.1073/pnas.1713195115. Epub 2018 Jan 17.

11.

Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis.

Ates LS, Dippenaar A, Ummels R, Piersma SR, van der Woude AD, van der Kuij K, Le Chevalier F, Mata-Espinosa D, Barrios-Payán J, Marquina-Castillo B, Guapillo C, Jiménez CR, Pain A, Houben ENG, Warren RM, Brosch R, Hernández-Pando R, Bitter W.

Nat Microbiol. 2018 Feb;3(2):181-188. doi: 10.1038/s41564-017-0090-6. Epub 2018 Jan 15.

PMID:
29335553
12.

The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis.

Queval CJ, Brosch R, Simeone R.

Front Microbiol. 2017 Nov 23;8:2284. doi: 10.3389/fmicb.2017.02284. eCollection 2017. Review.

13.

Evolution of virulence in the Mycobacterium tuberculosis complex.

Orgeur M, Brosch R.

Curr Opin Microbiol. 2018 Feb;41:68-75. doi: 10.1016/j.mib.2017.11.021. Epub 2017 Dec 5. Review.

PMID:
29216510
14.

Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation.

Levillain F, Poquet Y, Mallet L, Mazères S, Marceau M, Brosch R, Bange FC, Supply P, Magalon A, Neyrolles O.

PLoS Pathog. 2017 Nov 27;13(11):e1006752. doi: 10.1371/journal.ppat.1006752. eCollection 2017 Nov.

15.

The Biology and Epidemiology of Mycobacterium canettii.

Supply P, Brosch R.

Adv Exp Med Biol. 2017;1019:27-41. doi: 10.1007/978-3-319-64371-7_2. Review.

PMID:
29116628
16.

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.

Queval CJ, Song OR, Carralot JP, Saliou JM, Bongiovanni A, Deloison G, Deboosère N, Jouny S, Iantomasi R, Delorme V, Debrie AS, Park SJ, Gouveia JC, Tomavo S, Brosch R, Yoshimura A, Yeramian E, Brodin P.

Cell Rep. 2017 Sep 26;20(13):3188-3198. doi: 10.1016/j.celrep.2017.08.101.

17.

What we 'see' when we read: Visualization and vividness in reading fictional narratives.

Brosch R.

Cortex. 2018 Aug;105:135-143. doi: 10.1016/j.cortex.2017.08.020. Epub 2017 Aug 24. Review.

PMID:
28916259
18.

Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells.

Blischak JD, Tailleux L, Myrthil M, Charlois C, Bergot E, Dinh A, Morizot G, Chény O, Platen CV, Herrmann JL, Brosch R, Barreiro LB, Gilad Y.

Sci Rep. 2017 Jul 18;7(1):5702. doi: 10.1038/s41598-017-05878-w.

19.

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar-Adler NR, Bottrill AR, le Chevalier F, Frigui W, Bellinzoni M, Lisa MN, Alzari PM, Nguyen L, Brosch R, Sauer U, Manganelli R, O'Hare HM.

PLoS Pathog. 2017 May 17;13(5):e1006399. doi: 10.1371/journal.ppat.1006399. eCollection 2017 May.

20.

Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: 'Aethiops vetus'.

Nebenzahl-Guimaraes H, Yimer SA, Holm-Hansen C, de Beer J, Brosch R, van Soolingen D.

Microb Genom. 2016 Jun 24;2(6):e000063. doi: 10.1099/mgen.0.000063. eCollection 2016 Jun.

21.

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection.

Gröschel MI, Sayes F, Shin SJ, Frigui W, Pawlik A, Orgeur M, Canetti R, Honoré N, Simeone R, van der Werf TS, Bitter W, Cho SN, Majlessi L, Brosch R.

Cell Rep. 2017 Mar 14;18(11):2752-2765. doi: 10.1016/j.celrep.2017.02.057.

22.

Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis.

Majlessi L, Sayes F, Bureau JF, Pawlik A, Michel V, Jouvion G, Huerre M, Severgnini M, Consolandi C, Peano C, Brosch R, Touati E, Leclerc C.

Mucosal Immunol. 2017 Sep;10(5):1178-1189. doi: 10.1038/mi.2016.140. Epub 2017 Feb 1.

23.

Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions.

Conrad WH, Osman MM, Shanahan JK, Chu F, Takaki KK, Cameron J, Hopkinson-Woolley D, Brosch R, Ramakrishnan L.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1371-1376. doi: 10.1073/pnas.1620133114. Epub 2017 Jan 24.

24.

Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384.

Halloum I, Viljoen A, Khanna V, Craig D, Bouchier C, Brosch R, Coxon G, Kremer L.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02509-16. doi: 10.1128/AAC.02509-16. Print 2017 Apr.

25.

ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis.

Augenstreich J, Arbues A, Simeone R, Haanappel E, Wegener A, Sayes F, Le Chevalier F, Chalut C, Malaga W, Guilhot C, Brosch R, Astarie-Dequeker C.

Cell Microbiol. 2017 Jul;19(7). doi: 10.1111/cmi.12726. Epub 2017 Feb 15.

PMID:
28095608
26.

The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages.

Roux AL, Viljoen A, Bah A, Simeone R, Bernut A, Laencina L, Deramaudt T, Rottman M, Gaillard JL, Majlessi L, Brosch R, Girard-Misguich F, Vergne I, de Chastellier C, Kremer L, Herrmann JL.

Open Biol. 2016 Nov;6(11). pii: 160185.

27.

Discovery of the type VII ESX-1 secretion needle?

Ates LS, Brosch R.

Mol Microbiol. 2017 Jan;103(1):7-12. doi: 10.1111/mmi.13579. Epub 2016 Nov 25.

28.

Leprosy in red squirrels.

Stinear TP, Brosch R.

Science. 2016 Nov 11;354(6313):702-703. No abstract available.

PMID:
27846589
29.

Evolution of Mycobacterium tuberculosis: New Insights into Pathogenicity and Drug Resistance.

Boritsch EC, Brosch R.

Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.TBTB2-0020-2016. Review.

PMID:
27787194
30.

A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts.

Singh VK, Berry L, Bernut A, Singh S, Carrère-Kremer S, Viljoen A, Alibaud L, Majlessi L, Brosch R, Chaturvedi V, Geurtsen J, Drancourt M, Kremer L.

Cell Microbiol. 2016 Nov;18(11):1489-1507. doi: 10.1111/cmi.12606. Epub 2016 Jun 1.

PMID:
27120981
31.

ESX secretion systems: mycobacterial evolution to counter host immunity.

Gröschel MI, Sayes F, Simeone R, Majlessi L, Brosch R.

Nat Rev Microbiol. 2016 Nov;14(11):677-691. doi: 10.1038/nrmicro.2016.131. Epub 2016 Sep 26. Review.

PMID:
27665717
32.

pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence.

Boritsch EC, Frigui W, Cascioferro A, Malaga W, Etienne G, Laval F, Pawlik A, Le Chevalier F, Orgeur M, Ma L, Bouchier C, Stinear TP, Supply P, Majlessi L, Daffé M, Guilhot C, Brosch R.

Nat Microbiol. 2016 Jan 27;1:15019. doi: 10.1038/nmicrobiol.2015.19.

PMID:
27571976
33.

Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria.

Boritsch EC, Khanna V, Pawlik A, Honoré N, Navas VH, Ma L, Bouchier C, Seemann T, Supply P, Stinear TP, Brosch R.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9876-81. doi: 10.1073/pnas.1604921113. Epub 2016 Aug 15.

34.

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection.

Sayes F, Pawlik A, Frigui W, Gröschel MI, Crommelynck S, Fayolle C, Cia F, Bancroft GJ, Bottai D, Leclerc C, Brosch R, Majlessi L.

PLoS Pathog. 2016 Jul 28;12(7):e1005770. doi: 10.1371/journal.ppat.1005770. eCollection 2016 Jul.

35.

Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access.

Simeone R, Majlessi L, Enninga J, Brosch R.

Cell Microbiol. 2016 Aug;18(8):1070-7. doi: 10.1111/cmi.12622. Epub 2016 Jun 29. Review.

PMID:
27247079
36.

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

Dupont C, Viljoen A, Dubar F, Blaise M, Bernut A, Pawlik A, Bouchier C, Brosch R, Guérardel Y, Lelièvre J, Ballell L, Herrmann JL, Biot C, Kremer L.

Mol Microbiol. 2016 Aug;101(3):515-29. doi: 10.1111/mmi.13406. Epub 2016 Jun 1.

37.

ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo.

Kupz A, Zedler U, Stäber M, Perdomo C, Dorhoi A, Brosch R, Kaufmann SH.

J Clin Invest. 2016 Jun 1;126(6):2109-22. doi: 10.1172/JCI84978. Epub 2016 Apr 25.

38.

The BCG Strain Pool: Diversity Matters.

Bottai D, Brosch R.

Mol Ther. 2016 Feb;24(2):201-203. doi: 10.1038/mt.2016.18. No abstract available.

39.

Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications.

Sapriel G, Konjek J, Orgeur M, Bouri L, Frézal L, Roux AL, Dumas E, Brosch R, Bouchier C, Brisse S, Vandenbogaert M, Thiberge JM, Caro V, Ngeow YF, Tan JL, Herrmann JL, Gaillard JL, Heym B, Wirth T.

BMC Genomics. 2016 Feb 17;17:118. doi: 10.1186/s12864-016-2448-1.

40.

Type VII Secretion Systems in Gram-Positive Bacteria.

Bottai D, Gröschel MI, Brosch R.

Curr Top Microbiol Immunol. 2017;404:235-265. doi: 10.1007/82_2015_5015. Review.

PMID:
26847354
41.

Mycobacterial Pan-Genome Analysis Suggests Important Role of Plasmids in the Radiation of Type VII Secretion Systems.

Dumas E, Christina Boritsch E, Vandenbogaert M, Rodríguez de la Vega RC, Thiberge JM, Caro V, Gaillard JL, Heym B, Girard-Misguich F, Brosch R, Sapriel G.

Genome Biol Evol. 2016 Jan 8;8(2):387-402. doi: 10.1093/gbe/evw001.

42.

Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis.

Le Chevalier F, Cascioferro A, Frigui W, Pawlik A, Boritsch EC, Bottai D, Majlessi L, Herrmann JL, Brosch R.

Sci Rep. 2015 Nov 25;5:16918. doi: 10.1038/srep16918.

43.

Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions.

Etna MP, Giacomini E, Pardini M, Severa M, Bottai D, Cruciani M, Rizzo F, Calogero R, Brosch R, Coccia EM.

Sci Rep. 2015 Nov 25;5:17078. doi: 10.1038/srep17078.

44.

Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members.

Bernut A, Viljoen A, Dupont C, Sapriel G, Blaise M, Bouchier C, Brosch R, de Chastellier C, Herrmann JL, Kremer L.

Mol Microbiol. 2016 Mar;99(5):866-83. doi: 10.1111/mmi.13283. Epub 2015 Dec 18.

45.

The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis.

Slama N, Jamet S, Frigui W, Pawlik A, Bottai D, Laval F, Constant P, Lemassu A, Cam K, Daffé M, Brosch R, Eynard N, Quémard A.

Mol Microbiol. 2016 Feb;99(4):794-807. doi: 10.1111/mmi.13266. Epub 2015 Nov 27.

46.

Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations.

Abdallah AM, Hill-Cawthorne GA, Otto TD, Coll F, Guerra-Assunção JA, Gao G, Naeem R, Ansari H, Malas TB, Adroub SA, Verboom T, Ummels R, Zhang H, Panigrahi AK, McNerney R, Brosch R, Clark TG, Behr MA, Bitter W, Pain A.

Sci Rep. 2015 Oct 21;5:15443. doi: 10.1038/srep15443.

47.

Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity.

Majlessi L, Brosch R.

Cell Host Microbe. 2015 Jun 10;17(6):733-5. doi: 10.1016/j.chom.2015.05.017.

48.

Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system.

Bottai D, Frigui W, Clark S, Rayner E, Zelmer A, Andreu N, de Jonge MI, Bancroft GJ, Williams A, Brodin P, Brosch R.

Vaccine. 2015 May 28;33(23):2710-8. doi: 10.1016/j.vaccine.2015.03.083. Epub 2015 Apr 11.

PMID:
25869896
49.

[Bovine tubercle bacilli: evolution associated with loss of transmission capacity in humans].

Brosch R, Guilhot C.

Med Sci (Paris). 2015 Feb;31(2):123-6. doi: 10.1051/medsci/20153102003. Epub 2015 Mar 4. French. No abstract available.

50.

ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection.

Simeone R, Bottai D, Frigui W, Majlessi L, Brosch R.

Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S150-4. doi: 10.1016/j.tube.2015.02.019. Epub 2015 Feb 13.

PMID:
25732627

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