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Items: 1 to 50 of 95


High-intensity exercise to promote accelerated improvements in cardiorespiratory fitness (HI-PACE): study protocol for a randomized controlled trial.

McGee JE, Barefoot SG, Gniewek NR, Brophy PM, Clark A, Dubis GS, Ryan TE, Houmard JA, Vos P, Raedeke TD, Swift DL.

Trials. 2019 Aug 8;20(1):484. doi: 10.1186/s13063-019-3611-1.


The importance of extracellular vesicle purification for downstream analysis: A comparison of differential centrifugation and size exclusion chromatography for helminth pathogens.

Davis CN, Phillips H, Tomes JJ, Swain MT, Wilkinson TJ, Brophy PM, Morphew RM.

PLoS Negl Trop Dis. 2019 Feb 27;13(2):e0007191. doi: 10.1371/journal.pntd.0007191. eCollection 2019 Feb.


X-ray structure of Fasciola hepatica Sigma class glutathione transferase 1 reveals a disulfide bond to support stability in gastro-intestinal environment.

Line K, Isupov MN, LaCourse EJ, Cutress DJ, Morphew RM, Brophy PM, Littlechild JA.

Sci Rep. 2019 Jan 29;9(1):902. doi: 10.1038/s41598-018-37531-5.


Smell of Infection: A Novel, Noninvasive Method for Detection of Fish Excretory-Secretory Proteins.

Pawluk RJ, Stuart R, Garcia de Leaniz C, Cable J, Morphew RM, Brophy PM, Consuegra S.

J Proteome Res. 2019 Mar 1;18(3):1371-1379. doi: 10.1021/acs.jproteome.8b00953. Epub 2019 Jan 9.


Polyomic tools for an emerging livestock parasite, the rumen fluke Calicophoron daubneyi; identifying shifts in rumen functionality.

Huson KM, Morphew RM, Allen NR, Hegarty MJ, Worgan HJ, Girdwood SE, Jones EL, Phillips HC, Vickers M, Swain M, Smith D, Kingston-Smith AH, Brophy PM.

Parasit Vectors. 2018 Dec 4;11(1):617. doi: 10.1186/s13071-018-3225-6.


Detection of Galba truncatula, Fasciola hepatica and Calicophoron daubneyi environmental DNA within water sources on pasture land, a future tool for fluke control?

Jones RA, Brophy PM, Davis CN, Davies TE, Emberson H, Rees Stevens P, Williams HW.

Parasit Vectors. 2018 Jun 8;11(1):342. doi: 10.1186/s13071-018-2928-z.


Purification of native Sigma class glutathione transferase from Fasciola hepatica.

Duncan J, Cutress D, Morphew RM, Brophy PM.

Mol Biochem Parasitol. 2018 Jun;222:45-50. doi: 10.1016/j.molbiopara.2018.04.006. Epub 2018 Apr 27.


Inducible glutathione S-transferase (IrGST1) from the tick Ixodes ricinus is a haem-binding protein.

Perner J, Kotál J, Hatalová T, Urbanová V, Bartošová-Sojková P, Brophy PM, Kopáček P.

Insect Biochem Mol Biol. 2018 Apr;95:44-54. doi: 10.1016/j.ibmb.2018.02.002. Epub 2018 Mar 9.


Worms at the Royal Welsh Show.

Tyson F, Brophy PM, Morphew RM, Allen T, Pennington C, Thomas E.

Vet Rec. 2017 Oct 7;181(14):376-377. doi: 10.1136/vr.j4548. No abstract available.


Greater Oxidative Capacity in Primary Myotubes from Endurance-trained Women.

Heden TD, Ryan TE, Ferrara PJ, Hickner RC, Brophy PM, Neufer PD, McClung JM, Funai K.

Med Sci Sports Exerc. 2017 Nov;49(11):2151-2157. doi: 10.1249/MSS.0000000000001352.


The prevalence and development of digenean parasites within their intermediate snail host, Galba truncatula, in a geographic area where the presence of Calicophoron daubneyi has recently been confirmed.

Jones RA, Williams HW, Dalesman S, Ayodeji S, Thomas RK, Brophy PM.

Vet Parasitol. 2017 Jun 15;240:68-74. doi: 10.1016/j.vetpar.2017.03.021. Epub 2017 Mar 27.


Rumen fluke (Calicophoron daubneyi) on Welsh farms: prevalence, risk factors and observations on co-infection with Fasciola hepatica.

Jones RA, Brophy PM, Mitchell ES, Williams HW.

Parasitology. 2017 Feb;144(2):237-247. doi: 10.1017/S0031182016001797.


Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species.

Morphew RM, Wilkinson TJ, Mackintosh N, Jahndel V, Paterson S, McVeigh P, Abbas Abidi SM, Saifullah K, Raman M, Ravikumar G, LaCourse J, Maule A, Brophy PM.

J Proteome Res. 2016 Sep 2;15(9):3308-21. doi: 10.1021/acs.jproteome.6b00331. Epub 2016 Aug 16.


Calmodulin disruption impacts growth and motility in juvenile liver fluke.

McCammick EM, McVeigh P, McCusker P, Timson DJ, Morphew RM, Brophy PM, Marks NJ, Mousley A, Maule AG.

Parasit Vectors. 2016 Jan 27;9:46. doi: 10.1186/s13071-016-1324-9.


The intervention composed of aerobic training and non-exercise physical activity (I-CAN) study: Rationale, design and methods.

Swift DL, Dover SE, Nevels TR, Solar CA, Brophy PM, Hall TR, Houmard JA, Lutes LD.

Contemp Clin Trials. 2015 Nov;45(Pt B):435-442. doi: 10.1016/j.cct.2015.11.005. Epub 2015 Nov 2.


A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus.

Hart EH, Brophy PM, Prescott M, Bartley DJ, Wolf BT, Hamilton JV.

Vet Parasitol. 2015 Jan 30;207(3-4):266-75. doi: 10.1016/j.vetpar.2014.12.003. Epub 2014 Dec 15.


RNAi dynamics in Juvenile Fasciola spp. Liver flukes reveals the persistence of gene silencing in vitro.

McVeigh P, McCammick EM, McCusker P, Morphew RM, Mousley A, Abidi A, Saifullah KM, Muthusamy R, Gopalakrishnan R, Spithill TW, Dalton JP, Brophy PM, Marks NJ, Maule AG.

PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3185. doi: 10.1371/journal.pntd.0003185. eCollection 2014 Sep.


Time-dependent tegumental surface changes in juvenile Fasciola gigantica in response to triclabendazole treatment in goat.

Shareef PA, Brennan GP, McVeigh P, Khan MA, Morphew RM, Mousley A, Marks NJ, Saifullah MK, Brophy PM, Maule AG, Abidi SM.

Acta Trop. 2014 Aug;136:108-17. doi: 10.1016/j.actatropica.2014.04.011. Epub 2014 Apr 15.


Mitochondrial respiratory capacity and content are normal in young insulin-resistant obese humans.

Fisher-Wellman KH, Weber TM, Cathey BL, Brophy PM, Gilliam LA, Kane CL, Maples JM, Gavin TP, Houmard JA, Neufer PD.

Diabetes. 2014 Jan;63(1):132-41. doi: 10.2337/db13-0940. Epub 2013 Aug 23.


Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes.

Geyer KK, Chalmers IW, Mackintosh N, Hirst JE, Geoghegan R, Badets M, Brophy PM, Brehm K, Hoffmann KF.

BMC Genomics. 2013 Jul 9;14:462. doi: 10.1186/1471-2164-14-462.


Early hepatic and peritoneal changes and immune response in goats vaccinated with a recombinant glutathione transferase sigma class and challenged with Fasciola hepatica.

Zafra R, Pérez-Écija RA, Buffoni L, Pacheco IL, Martínez-Moreno A, LaCourse EJ, Perally S, Brophy PM, Pérez J.

Res Vet Sci. 2013 Jun;94(3):602-9. doi: 10.1016/j.rvsc.2012.10.026. Epub 2012 Dec 20.


Proteomics and in silico approaches to extend understanding of the glutathione transferase superfamily of the tropical liver fluke Fasciola gigantica.

Morphew RM, Eccleston N, Wilkinson TJ, McGarry J, Perally S, Prescott M, Ward D, Williams D, Paterson S, Raman M, Ravikumar G, Khalid Saifullah M, Abbas Abidi SM, McVeigh P, Maule AG, Brophy PM, LaCourse EJ.

J Proteome Res. 2012 Dec 7;11(12):5876-89. doi: 10.1021/pr300654w. Epub 2012 Nov 28.


Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40.

Morphew RM, Hamilton CM, Wright HA, Dowling DJ, O'Neill SM, Brophy PM.

Vet Parasitol. 2013 Jan 31;191(3-4):379-85. doi: 10.1016/j.vetpar.2012.08.029. Epub 2012 Sep 11.


The soluble proteome phenotypes of ivermectin resistant and ivermectin susceptible Haemonchus contortus females compared.

Hart EH, Morphew RM, Bartley DJ, Millares P, Wolf BT, Brophy PM, Hamilton JV.

Vet Parasitol. 2012 Nov 23;190(1-2):104-13. doi: 10.1016/j.vetpar.2012.06.009. Epub 2012 Jun 17.


Anthelmintic metabolism in parasitic helminths: proteomic insights.

Brophy PM, MacKintosh N, Morphew RM.

Parasitology. 2012 Aug;139(9):1205-17. doi: 10.1017/S003118201200087X. Epub 2012 Jul 10. Review.


The Sigma class glutathione transferase from the liver fluke Fasciola hepatica.

LaCourse EJ, Perally S, Morphew RM, Moxon JV, Prescott M, Dowling DJ, O'Neill SM, Kipar A, Hetzel U, Hoey E, Zafra R, Buffoni L, Pérez Arévalo J, Brophy PM.

PLoS Negl Trop Dis. 2012;6(5):e1666. doi: 10.1371/journal.pntd.0001666. Epub 2012 May 29.


Proteomic profiling and protein identification by MALDI-TOF mass spectrometry in unsequenced parasitic nematodes.

Millares P, Lacourse EJ, Perally S, Ward DA, Prescott MC, Hodgkinson JE, Brophy PM, Rees HH.

PLoS One. 2012;7(3):e33590. doi: 10.1371/journal.pone.0033590. Epub 2012 Mar 29.


Comparison of a field-based test to estimate functional threshold power and power output at lactate threshold.

Gavin TP, Van Meter JB, Brophy PM, Dubis GS, Potts KN, Hickner RC.

J Strength Cond Res. 2012 Feb;26(2):416-21. doi: 10.1519/JSC.0b013e318220b4eb.


Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle.

Perry CG, Kane DA, Lin CT, Kozy R, Cathey BL, Lark DS, Kane CL, Brophy PM, Gavin TP, Anderson EJ, Neufer PD.

Biochem J. 2011 Jul 15;437(2):215-22. doi: 10.1042/BJ20110366.


Towards delineating functions within the fasciola secreted cathepsin l protease family by integrating in vivo based sub-proteomics and phylogenetics.

Morphew RM, Wright HA, Lacourse EJ, Porter J, Barrett J, Woods DJ, Brophy PM.

PLoS Negl Trop Dis. 2011 Jan 4;5(1):e937. doi: 10.1371/journal.pntd.0000937.


Progesterone increases skeletal muscle mitochondrial H2O2 emission in nonmenopausal women.

Kane DA, Lin CT, Anderson EJ, Kwak HB, Cox JH, Brophy PM, Hickner RC, Neufer PD, Cortright RN.

Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E528-35. doi: 10.1152/ajpendo.00389.2010. Epub 2010 Dec 28.


Comparative proteomic analysis of triclabendazole response in the liver fluke Fasciola hepatica.

Chemale G, Perally S, LaCourse EJ, Prescott MC, Jones LM, Ward D, Meaney M, Hoey E, Brennan GP, Fairweather I, Trudgett A, Brophy PM.

J Proteome Res. 2010 Oct 1;9(10):4940-51. doi: 10.1021/pr1000785.


Proteomic analyses of Caenorhabditis elegans dauer larvae and long-lived daf-2 mutants implicates a shared detoxification system in longevity assurance.

Jones LM, Staffa K, Perally S, LaCourse EJ, Brophy PM, Hamilton JV.

J Proteome Res. 2010 Jun 4;9(6):2871-81. doi: 10.1021/pr9009639.


Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus.

Zhan B, Perally S, Brophy PM, Xue J, Goud G, Liu S, Deumic V, de Oliveira LM, Bethony J, Bottazzi ME, Jiang D, Gillespie P, Xiao SH, Gupta R, Loukas A, Ranjit N, Lustigman S, Oksov Y, Hotez P.

Infect Immun. 2010 Apr;78(4):1552-63. doi: 10.1128/IAI.00848-09. Epub 2010 Feb 9.


Proteomic analysis of embryonic Fasciola hepatica: characterization and antigenic potential of a developmentally regulated heat shock protein.

Moxon JV, LaCourse EJ, Wright HA, Perally S, Prescott MC, Gillard JL, Barrett J, Hamilton JV, Brophy PM.

Vet Parasitol. 2010 Apr 19;169(1-2):62-75. doi: 10.1016/j.vetpar.2009.12.031. Epub 2010 Jan 4.


Immune responses directed at egg proteins during experimental infection with the liver fluke Fasciola hepatica.

Moxon JV, Flynn RJ, Golden O, Hamilton JV, Mulcahy G, Brophy PM.

Parasite Immunol. 2010 Feb;32(2):111-24. doi: 10.1111/j.1365-3024.2009.01171.x.


Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses.

Dowling DJ, Hamilton CM, Donnelly S, La Course J, Brophy PM, Dalton J, O'Neill SM.

Infect Immun. 2010 Feb;78(2):793-801. doi: 10.1128/IAI.00573-09. Epub 2009 Nov 16.


Glutathione transferase (GST) as a candidate molecular-based biomarker for soil toxin exposure in the earthworm Lumbricus rubellus.

LaCourse EJ, Hernandez-Viadel M, Jefferies JR, Svendsen C, Spurgeon DJ, Barrett J, Morgan AJ, Kille P, Brophy PM.

Environ Pollut. 2009 Aug-Sep;157(8-9):2459-69. doi: 10.1016/j.envpol.2009.03.015. Epub 2009 Apr 5.


The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function.

Hamilton CM, Dowling DJ, Loscher CE, Morphew RM, Brophy PM, O'Neill SM.

Infect Immun. 2009 Jun;77(6):2488-98. doi: 10.1128/IAI.00919-08. Epub 2009 Mar 30.


Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin.

Jones TE, Basilio JL, Brophy PM, McCammon MR, Hickner RC.

Obesity (Silver Spring). 2009 Jun;17(6):1189-95. doi: 10.1038/oby.2009.11. Epub 2009 Feb 26.


Heme transport and detoxification in nematodes: subproteomics evidence of differential role of glutathione transferases.

Perally S, Lacourse EJ, Campbell AM, Brophy PM.

J Proteome Res. 2008 Oct;7(10):4557-65. doi: 10.1021/pr800395x. Epub 2008 Aug 23.


A proteomics approach to quantify protein levels following RNA interference: case study with glutathione transferase superfamily from the model metazoan Caenorhabditis elegans.

Lacourse EJ, Perally S, Hernandez-Viadel M, Wright HA, Brophy PM.

J Proteome Res. 2008 Aug;7(8):3314-8. doi: 10.1021/pr8001035. Epub 2008 Jun 27.


The Aedes aegypti glutathione transferase family.

Lumjuan N, Stevenson BJ, Prapanthadara LA, Somboon P, Brophy PM, Loftus BJ, Severson DW, Ranson H.

Insect Biochem Mol Biol. 2007 Oct;37(10):1026-35. Epub 2007 Jun 13.


Understanding triclabendazole resistance.

Brennan GP, Fairweather I, Trudgett A, Hoey E, McCoy, McConville M, Meaney M, Robinson M, McFerran N, Ryan L, Lanusse C, Mottier L, Alvarez L, Solana H, Virkel G, Brophy PM.

Exp Mol Pathol. 2007 Apr;82(2):104-9. Epub 2007 Feb 15. Review.


Comparative proteomics of excretory-secretory proteins released by the liver fluke Fasciola hepatica in sheep host bile and during in vitro culture ex host.

Morphew RM, Wright HA, LaCourse EJ, Woods DJ, Brophy PM.

Mol Cell Proteomics. 2007 Jun;6(6):963-72. Epub 2007 Feb 17.


Proteomic analysis of glutathione transferases from the liver fluke parasite, Fasciola hepatica.

Chemale G, Morphew R, Moxon JV, Morassuti AL, Lacourse EJ, Barrett J, Johnston DA, Brophy PM.

Proteomics. 2006 Dec;6(23):6263-73.


Plasticity demonstrated in the proteome of a parasitic nematode within the intestine of different host strains.

Morgan C, LaCourse EJ, Rushbrook BJ, Greetham D, Hamilton JV, Barrett J, Bailey K, Brophy PM.

Proteomics. 2006 Aug;6(16):4633-45.


Crystal structure of a new class of glutathione transferase from the model human hookworm nematode Heligmosomoides polygyrus.

Schuller DJ, Liu Q, Kriksunov IA, Campbell AM, Barrett J, Brophy PM, Hao Q.

Proteins. 2005 Dec 1;61(4):1024-31.


Analysing proteomic data.

Barrett J, Brophy PM, Hamilton JV.

Int J Parasitol. 2005 Apr 30;35(5):543-53. Review.


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