Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 66

1.

Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents.

Geyer BC, Kannan L, Garnaud PE, Broomfield CA, Cadieux CL, Cherni I, Hodgins SM, Kasten SA, Kelley K, Kilbourne J, Oliver ZP, Otto TC, Puffenberger I, Reeves TE, Robbins N 2nd, Woods RR, Soreq H, Lenz DE, Cerasoli DM, Mor TS.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20251-6. doi: 10.1073/pnas.1009021107. Epub 2010 Nov 8.

2.

Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation.

Cadieux CL, Broomfield CA, Kirkpatrick MG, Kazanski ME, Lenz DE, Cerasoli DM.

Chem Biol Interact. 2010 Sep 6;187(1-3):229-33. doi: 10.1016/j.cbi.2010.04.020. Epub 2010 Apr 28.

PMID:
20433814
3.

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters.

Masson P, Nachon F, Broomfield CA, Lenz DE, Verdier L, Schopfer LM, Lockridge O.

Chem Biol Interact. 2008 Sep 25;175(1-3):273-80. doi: 10.1016/j.cbi.2008.04.005. Epub 2008 Apr 16.

PMID:
18508040
4.

TNF-alpha expression patterns as potential molecular biomarker for human skin cells exposed to vesicant chemical warfare agents: sulfur mustard (HD) and Lewisite (L).

Arroyo CM, Burman DL, Kahler DW, Nelson MR, Corun CM, Guzman JJ, Smith MA, Purcell ED, Hackley BE Jr, Soni SD, Broomfield CA.

Cell Biol Toxicol. 2004 Nov;20(6):345-59.

PMID:
15868479
5.

A review of multi-threat medical countermeasures against chemical warfare and terrorism.

Cowan FM, Broomfield CA, Stojiljkovic MP, Smith WJ.

Mil Med. 2004 Nov;169(11):850-5. Review.

PMID:
15605928
6.

Neutralization effects of interleukin-6 (IL-6) antibodies on sulfur mustard (HD)-induced IL-6 secretion on human epidermal keratinocytes.

Arroyo CM, Burman DL, Sweeney RE, Broomfield CA, Ross MC, Hackley BE Jr.

Environ Toxicol Pharmacol. 2004 Jun;17(2):87-94. doi: 10.1016/j.etap.2004.03.004.

PMID:
21782718
7.
8.

Regulation of 1-alpha, 25-dihydroxyvitamin D3 on interleukin-6 and interleukin-8 induced by sulfur mustard (HD) on human skin cells.

Arroyo CM, Kan RK, Burman DL, Kahler DW, Nelson MR, Corun CM, Guzman JJ, Broomfield CA.

Pharmacol Toxicol. 2003 May;92(5):204-13.

PMID:
12753408
10.

Sulfur mustard-stimulated protease: a target for antivesicant drugs.

Ray P, Chakrabarti AK, Broomfield CA, Ray R.

J Appl Toxicol. 2002 Mar-Apr;22(2):139-40.

PMID:
11920939
11.

Progress on the road to new nerve agent treatments.

Broomfield CA, Kirby SD.

J Appl Toxicol. 2001 Dec;21 Suppl 1:S43-6.

PMID:
11920919
12.

The role of interleukin-6 (IL-6) in human sulfur mustard (HD) toxicology.

Arroyo CM, Broomfield CA, Hackley BE Jr.

Int J Toxicol. 2001 Sep-Oct;20(5):281-96.

PMID:
11766126
13.

Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality.

Duysen EG, Li B, Xie W, Schopfer LM, Anderson RS, Broomfield CA, Lockridge O.

J Pharmacol Exp Ther. 2001 Nov;299(2):528-35.

PMID:
11602663
14.

Protective action of the serine protease inhibitor N-tosyl-L-lysine chloromethyl ketone (TLCK) against acute soman poisoning.

Cowan FM, Broomfield CA, Lenz DE, Shih TM.

J Appl Toxicol. 2001 Jul-Aug;21(4):293-6.

PMID:
11481662
16.

Response of normal human keratinocytes to sulfur mustard: cytokine release.

Arroyo CM, Schafer RJ, Kurt EM, Broomfield CA, Carmichael AJ.

J Appl Toxicol. 2000 Dec;20 Suppl 1:S63-72.

PMID:
11428645
17.

Serum paraoxonase (PON1) isozymes: the quantitative analysis of isozymes affecting individual sensitivity to environmental chemicals.

La Du BN, Billecke S, Hsu C, Haley RW, Broomfield CA.

Drug Metab Dispos. 2001 Apr;29(4 Pt 2):566-9.

PMID:
11259353
18.

Expression of biologically active human butyrylcholinesterase in the cabbage looper (Trichoplusia ni).

Platteborze PL, Broomfield CA.

Biotechnol Appl Biochem. 2000 Jun;31 ( Pt 3):225-9.

PMID:
10814593
19.

Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization.

Broomfield CA, Lockridge O, Millard CB.

Chem Biol Interact. 1999 May 14;119-120:413-8.

PMID:
10421478
20.

Characterization of a soluble mouse liver enzyme capable of hydrolyzing diisopropyl phosphorofluoridate.

Billecke SS, Primo-Parmo SL, Dunlop CS, Doorn JA, La Du BN, Broomfield CA.

Chem Biol Interact. 1999 May 14;119-120:251-6.

PMID:
10421459
21.

Response of normal human keratinocytes to sulfur mustard (HD): cytokine release using a non-enzymatic detachment procedure.

Arroyo CM, Schafer RJ, Kurt EM, Broomfield CA, Carmichael AJ.

Hum Exp Toxicol. 1999 Jan;18(1):1-11.

PMID:
10025362
22.

Purification and characterization of protease activated by sulfur mustard in normal human epidermal keratinocytes.

Chakrabarti AK, Ray P, Broomfield CA, Ray R.

Biochem Pharmacol. 1998 Aug 15;56(4):467-72.

PMID:
9763222
24.

Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase.

Millard CB, Lockridge O, Broomfield CA.

Biochemistry. 1998 Jan 6;37(1):237-47.

PMID:
9425044
25.

Identification of a recombinant synaptobrevin-thioredoxin fusion protein by capillary zone electrophoresis using laser-induced fluorescence detection.

Asermely KE, Broomfield CA, Nowakowski J, Courtney BC, Adler M.

J Chromatogr B Biomed Sci Appl. 1997 Jul 18;695(1):67-75.

PMID:
9271130
26.
27.

A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase.

Lockridge O, Blong RM, Masson P, Froment MT, Millard CB, Broomfield CA.

Biochemistry. 1997 Jan 28;36(4):786-95.

PMID:
9020776
28.

The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin.

Davies HG, Richter RJ, Keifer M, Broomfield CA, Sowalla J, Furlong CE.

Nat Genet. 1996 Nov;14(3):334-6.

PMID:
8896566
29.

Temperature effects in cyanolysis using elemental sulfur.

Lieske CN, Clark CR, Zoeffel LD, von Tersch RL, Lowe JR, Smith CD, Broomfield CA, Baskin SI, Maxwell DM.

J Appl Toxicol. 1996 Mar-Apr;16(2):171-5.

PMID:
8935794
30.

Mustard gas crosslinking of proteins through preferential alkylation of cysteines.

Byrne MP, Broomfield CA, Stites WE.

J Protein Chem. 1996 Feb;15(2):131-6.

PMID:
8924198
31.

Hypothesis for synergistic toxicity of organophosphorus poisoning-induced cholinergic crisis and anaphylactoid reactions.

Cowan FM, Shih TM, Lenz DE, Madsen JM, Broomfield CA.

J Appl Toxicol. 1996 Jan-Feb;16(1):25-33. Review.

PMID:
8821672
32.

Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase.

Millard CB, Lockridge O, Broomfield CA.

Biochemistry. 1995 Dec 12;34(49):15925-33.

PMID:
8519749
33.
34.

Anticholinesterases: medical applications of neurochemical principles.

Millard CB, Broomfield CA.

J Neurochem. 1995 May;64(5):1909-18. Review.

PMID:
7722478
35.

The distribution of [125I]ricin in mice following aerosol inhalation exposure.

Doebler JA, Wiltshire ND, Mayer TW, Estep JE, Moeller RB, Traub RK, Broomfield CA, Calamaio CA, Thompson WL, Pitt ML.

Toxicology. 1995 Apr 12;98(1-3):137-49.

PMID:
7740542
36.

Exposure of human lymphocytes to bis-(2-chloroethyl)sulfide solubilizes truncated and intact core histones.

Millard CB, Meier HL, Broomfield CA.

Biochim Biophys Acta. 1994 Dec 30;1224(3):389-94.

PMID:
7803495
37.

Behavioral decrements persist in rhesus monkeys trained on a serial probe recognition task despite protection against soman lethality by butyrylcholinesterase.

Castro CA, Gresham VC, Finger AV, Maxwell DM, Solana RP, Lenz DE, Broomfield CA.

Neurotoxicol Teratol. 1994 Mar-Apr;16(2):145-8.

PMID:
8052188
38.

Inhibition of bioenergetics alters intracellular calcium, membrane composition, and fluidity in a neuronal cell line.

Ray P, Ray R, Broomfield CA, Berman JD.

Neurochem Res. 1994 Jan;19(1):57-63.

PMID:
8139764
39.

Sulfur mustard-increased proteolysis following in vitro and in vivo exposures.

Cowan FM, Yourick JJ, Hurst CG, Broomfield CA, Smith WJ.

Cell Biol Toxicol. 1993 Jul-Sep;9(3):269-77.

PMID:
8299005
40.

Putative roles of inflammation in the dermatopathology of sulfur mustard.

Cowan FM, Broomfield CA.

Cell Biol Toxicol. 1993 Jul-Sep;9(3):201-13. Review. No abstract available.

PMID:
8299000
41.

A purified recombinant organophosphorus acid anhydrase protects mice against soman.

Broomfield CA.

Chem Biol Interact. 1993 Jun;87(1-3):279-84.

PMID:
8393744
42.

Catalytic antibodies hydrolysing organophosphorus esters.

Brimfield AA, Lenz DE, Maxwell DM, Broomfield CA.

Chem Biol Interact. 1993 Jun;87(1-3):95-102.

PMID:
8344006
43.

C-terminal substance P fragments elicit histamine release from a murine mast cell line.

Krumins SA, Broomfield CA.

Neuropeptides. 1993 Jan;24(1):5-10.

PMID:
7679211
44.

A computer model of glycosylated human butyrylcholinesterase.

Millard CB, Broomfield CA.

Biochem Biophys Res Commun. 1992 Dec 30;189(3):1280-6.

PMID:
1482344
45.

Inhibition of sulfur mustard-increased protease activity by niacinamide, N-acetyl-L-cysteine or dexamethasone.

Cowan FM, Broomfield CA, Smith WJ.

Cell Biol Toxicol. 1992 Apr-Jun;8(2):129-38.

PMID:
1422923
46.
47.

A purified recombinant organophosphorus acid anhydrase protects mice against soman.

Broomfield CA.

Pharmacol Toxicol. 1992 Jan;70(1):65-6.

PMID:
1317565
48.

Cholinesterase studies with (R) (+)- and (S)(-)-5-(1,3,3-trimethylindolinyl)-N-(1-phenylethyl)carbamate.

Lieske CN, Gepp RT, Maxwell DM, Clark JH, Broomfield CA, Blumbergs P, Tseng CC.

J Enzyme Inhib. 1992;6(4):283-91.

PMID:
1284965
49.

Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates.

Broomfield CA, Maxwell DM, Solana RP, Castro CA, Finger AV, Lenz DE.

J Pharmacol Exp Ther. 1991 Nov;259(2):633-8.

PMID:
1941611
50.

Effect of sulfur exposure on protease activity in human peripheral blood lymphocytes.

Cowan FM, Broomfield CA, Smith WJ.

Cell Biol Toxicol. 1991 Jul;7(3):239-48.

PMID:
1933515

Supplemental Content

Loading ...
Support Center