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Items: 11

1.

DNA sequence analysis of the conserved region around the SOD1 gene locus in recessively inherited ALS.

Broom WJ, Johnson DV, Garber M, Andersen PM, Lennon N, Landers J, Nusbaum C, Russ C, Brown RH Jr.

Neurosci Lett. 2009 Sep 29;463(1):64-9. doi: 10.1016/j.neulet.2009.07.010. Epub 2009 Jul 9.

PMID:
19596401
2.

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.

Landers JE, Melki J, Meininger V, Glass JD, van den Berg LH, van Es MA, Sapp PC, van Vught PW, McKenna-Yasek DM, Blauw HM, Cho TJ, Polak M, Shi L, Wills AM, Broom WJ, Ticozzi N, Silani V, Ozoguz A, Rodriguez-Leyva I, Veldink JH, Ivinson AJ, Saris CG, Hosler BA, Barnes-Nessa A, Couture N, Wokke JH, Kwiatkowski TJ Jr, Ophoff RA, Cronin S, Hardiman O, Diekstra FP, Leigh PN, Shaw CE, Simpson CL, Hansen VK, Powell JF, Corcia P, Salachas F, Heath S, Galan P, Georges F, Horvitz HR, Lathrop M, Purcell S, Al-Chalabi A, Brown RH Jr.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9004-9. doi: 10.1073/pnas.0812937106. Epub 2009 May 18.

3.

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.

Simpson CL, Lemmens R, Miskiewicz K, Broom WJ, Hansen VK, van Vught PW, Landers JE, Sapp P, Van Den Bosch L, Knight J, Neale BM, Turner MR, Veldink JH, Ophoff RA, Tripathi VB, Beleza A, Shah MN, Proitsi P, Van Hoecke A, Carmeliet P, Horvitz HR, Leigh PN, Shaw CE, van den Berg LH, Sham PC, Powell JF, Verstreken P, Brown RH Jr, Robberecht W, Al-Chalabi A.

Hum Mol Genet. 2009 Feb 1;18(3):472-81. doi: 10.1093/hmg/ddn375. Epub 2008 Nov 7.

4.

50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis.

Broom WJ, Greenway M, Sadri-Vakili G, Russ C, Auwarter KE, Glajch KE, Dupre N, Swingler RJ, Purcell S, Hayward C, Sapp PC, McKenna-Yasek D, Valdmanis PN, Bouchard JP, Meininger V, Hosler BA, Glass JD, Polack M, Rouleau GA, Cha JH, Hardiman O, Brown RH Jr.

Amyotroph Lateral Scler. 2008 Aug;9(4):229-37. doi: 10.1080/17482960802103107.

PMID:
18608091
5.

SOD1A4V-mediated ALS: absence of a closely linked modifier gene and origination in Asia.

Broom WJ, Johnson DV, Auwarter KE, Iafrate AJ, Russ C, Al-Chalabi A, Sapp PC, McKenna-Yasek D, Andersen PM, Brown RH Jr.

Neurosci Lett. 2008 Jan 17;430(3):241-5. Epub 2007 Nov 6.

PMID:
18055113
6.
7.

Two approaches to drug discovery in SOD1-mediated ALS.

Broom WJ, Auwarter KE, Ni J, Russel DE, Yeh LA, Maxwell MM, Glicksman M, Kazantsev AG, Brown RH Jr.

J Biomol Screen. 2006 Oct;11(7):729-35. Epub 2006 Aug 23.

PMID:
16928982
8.

Inhibition of SOD1 expression by mitomycin C is a non-specific consequence of cellular toxicity.

Broom WJ, Ay I, Pasinelli P, Brown RH Jr.

Neurosci Lett. 2006 Jan 30;393(2-3):184-8. Epub 2005 Oct 19.

PMID:
16242241
9.

Variants in candidate ALS modifier genes linked to Cu/Zn superoxide dismutase do not explain divergent survival phenotypes.

Broom WJ, Russ C, Sapp PC, McKenna-Yasek D, Hosler BA, Andersen PM, Brown RH Jr.

Neurosci Lett. 2006 Jan 9;392(1-2):52-7. Epub 2005 Sep 19. Erratum in: Neurosci Lett. 2006 May 22;399(3):273.

PMID:
16174551
10.

No association of the SOD1 locus and disease susceptibility or phenotype in sporadic ALS.

Broom WJ, Parton MJ, Vance CA, Russ C, Andersen PM, Hansen V, Leigh PN, Powell JF, Al-Chalabi A, Shaw CE.

Neurology. 2004 Dec 28;63(12):2419-22.

PMID:
15623718
11.

Compound heterozygosity and variable penetrance in SOD1 amyotrophic lateral sclerosis pedigrees.

Parton MJ, Andersen PM, Broom WJ, Shaw CE.

Ann Neurol. 2001 Oct;50(4):553-4. No abstract available.

PMID:
11601511

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