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Items: 30


Cellular Uptake and Efflux of Palbociclib In Vitro in Single Cell and Spheroid Models.

Jove M, Spencer JA, Hubbard ME, Holden EC, O'Dea RD, Brook BS, Phillips RM, Smye SW, Loadman PM, Twelves CJ.

J Pharmacol Exp Ther. 2019 Aug;370(2):242-251. doi: 10.1124/jpet.119.256693. Epub 2019 Jun 12.


DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.

Saunders R, Kaul H, Berair R, Gonem S, Singapuri A, Sutcliffe AJ, Chachi L, Biddle MS, Kaur D, Bourne M, Pavord ID, Wardlaw AJ, Siddiqui SH, Kay RA, Brook BS, Smallwood RH, Brightling CE.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaao6451. doi: 10.1126/scitranslmed.aao6451.


Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices.

Maarsingh H, Bidan CM, Brook BS, Zuidhof AB, Elzinga CRS, Smit M, Oldenburger A, Gosens R, Timens W, Meurs H.

Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L537-L546. doi: 10.1152/ajplung.00325.2018. Epub 2019 Jan 10.


Chemokine Transport Dynamics and Emerging Recognition of Their Role in Immune Function.

Moore JE Jr, Brook BS, Nibbs RJB.

Curr Opin Biomed Eng. 2018 Mar;5:90-95. doi: 10.1016/j.cobme.2018.03.001. Epub 2018 Mar 20.


A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling.

Hill MR, Philp CJ, Billington CK, Tatler AL, Johnson SR, O'Dea RD, Brook BS.

Biomech Model Mechanobiol. 2018 Oct;17(5):1451-1470. doi: 10.1007/s10237-018-1037-4. Epub 2018 Jul 2.


Effect of Loading History on Airway Smooth Muscle Cell-Matrix Adhesions.

Irons L, Owen MR, O'Dea RD, Brook BS.

Biophys J. 2018 Jun 5;114(11):2679-2690. doi: 10.1016/j.bpj.2018.04.026.


In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss.

Chernyavsky IL, Russell RJ, Saunders RM, Morris GE, Berair R, Singapuri A, Chachi L, Mansur AH, Howarth PH, Dennison P, Chaudhuri R, Bicknell S, Rose FRAJ, Siddiqui S, Brook BS, Brightling CE.

Eur Respir J. 2018 May 24;51(5). pii: 1701680. doi: 10.1183/13993003.01680-2017. Print 2018 May.


Repeated airway constrictions in mice do not alter respiratory function.

Mailhot-Larouche S, DeschĂȘnes L, Gazzola M, Lortie K, Henry C, Brook BS, Morissette MC, BossĂ© Y.

J Appl Physiol (1985). 2018 Jun 1;124(6):1483-1490. doi: 10.1152/japplphysiol.01073.2017. Epub 2018 Feb 22.


A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4.

Jafarnejad M, Zawieja DC, Brook BS, Nibbs RJB, Moore JE Jr.

J Immunol. 2017 Oct 1;199(7):2291-2304. doi: 10.4049/jimmunol.1700377. Epub 2017 Aug 14.


Corrigendum: Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice.

Hiorns JE, Bidan CM, Jensen OE, Gosens R, Kistemaker LE, Fredberg JJ, Butler JP, Krishnan R, Brook BS.

Front Physiol. 2017 Feb 28;8:117. doi: 10.3389/fphys.2017.00117. eCollection 2017.


Mathematical modelling of cytokines, MMPs and fibronectin fragments in osteoarthritic cartilage.

Baker M, Brook BS, Owen MR.

J Math Biol. 2017 Oct;75(4):985-1024. doi: 10.1007/s00285-017-1104-y. Epub 2017 Feb 17.


Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice.

Hiorns JE, Bidan CM, Jensen OE, Gosens R, Kistemaker LE, Fredberg JJ, Butler JP, Krishnan R, Brook BS.

Front Physiol. 2016 Jul 21;7:309. doi: 10.3389/fphys.2016.00309. eCollection 2016. Erratum in: Front Physiol. 2017 Feb 28;8:117.


Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall.

Hiorns JE, Jensen OE, Brook BS.

J Appl Physiol (1985). 2016 Jul 1;121(1):233-47. doi: 10.1152/japplphysiol.00715.2015. Epub 2016 May 19.


Ryanodine receptor sensitization results in abnormal calcium signaling in airway smooth muscle cells.

Croisier H, Tan X, Chen J, Sneyd J, Sanderson MJ, Brook BS.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):703-11. doi: 10.1165/rcmb.2014-0386OC.


Nonlinear compliance modulates dynamic bronchoconstriction in a multiscale airway model.

Hiorns JE, Jensen OE, Brook BS.

Biophys J. 2014 Dec 16;107(12):3030-3042. doi: 10.1016/j.bpj.2014.10.067.


Airway smooth muscle in asthma: linking contraction and mechanotransduction to disease pathogenesis and remodelling.

Noble PB, Pascoe CD, Lan B, Ito S, Kistemaker LE, Tatler AL, Pera T, Brook BS, Gosens R, West AR.

Pulm Pharmacol Ther. 2014 Dec;29(2):96-107. doi: 10.1016/j.pupt.2014.07.005. Epub 2014 Jul 23. Review.


STI-GMaS: an open-source environment for simulation of sexually-transmitted infections.

Nelson MR, Sutton KJ, Brook BS, Mallet DG, Simpson DP, Rank RG.

BMC Syst Biol. 2014 Jun 12;8:66. doi: 10.1186/1752-0509-8-66.


The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model.

Chernyavsky IL, Croisier H, Chapman LA, Kimpton LS, Hiorns JE, Brook BS, Jensen OE, Billington CK, Hall IP, Johnson SR.

PLoS One. 2014 Mar 14;9(3):e90162. doi: 10.1371/journal.pone.0090162. eCollection 2014.


Emergence of airway smooth muscle mechanical behavior through dynamic reorganization of contractile units and force transmission pathways.

Brook BS.

J Appl Physiol (1985). 2014 Apr 15;116(8):980-97. doi: 10.1152/japplphysiol.01209.2013. Epub 2014 Jan 30.


Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model.

Croisier H, Tan X, Perez-Zoghbi JF, Sanderson MJ, Sneyd J, Brook BS.

PLoS One. 2013 Jul 25;8(7):e69598. doi: 10.1371/journal.pone.0069598. Print 2013.


The role of contractile unit reorganization in force generation in airway smooth muscle.

Brook BS, Jensen OE.

Math Med Biol. 2014 Jun;31(2):99-124. doi: 10.1093/imammb/dqs031. Epub 2013 Jan 28.


Mathematical modelling of cytokine-mediated inflammation in rheumatoid arthritis.

Baker M, Denman-Johnson S, Brook BS, Gaywood I, Owen MR.

Math Med Biol. 2013 Dec;30(4):311-37. doi: 10.1093/imammb/dqs026. Epub 2012 Sep 20.


Towards the virtual physiological human: mathematical and computational case studies.

Brook BS, Kohl P, King JR.

Philos Trans A Math Phys Eng Sci. 2011 Nov 13;369(1954):4145-8. doi: 10.1098/rsta.2011.0278. No abstract available.


A biomechanical model of agonist-initiated contraction in the asthmatic airway.

Brook BS, Peel SE, Hall IP, Politi AZ, Sneyd J, Bai Y, Sanderson MJ, Jensen OE.

Respir Physiol Neurobiol. 2010 Jan 31;170(1):44-58. doi: 10.1016/j.resp.2009.11.006. Epub 2009 Nov 22.


A computer model of the artificially ventilated human respiratory system in adult intensive care.

Wilson AJ, Murphy CM, Brook BS, Breen D, Miles AW, Tilley DG.

Med Eng Phys. 2009 Nov;31(9):1118-33. doi: 10.1016/j.medengphy.2009.07.009. Epub 2009 Aug 20.


Mathematical challenges in integrative physiology.

Brook BS, Waters SL.

J Math Biol. 2008 Jun;56(6):893-6. doi: 10.1007/s00285-008-0159-1. No abstract available.


Quantification of lung injury using ventilation and perfusion distributions obtained from gamma scintigraphy.

Brook BS, Murphy CM, Breen D, Miles AW, Tilley DG, Wilson AJ.

Physiol Meas. 2007 Dec;28(12):1451-64. Epub 2007 Oct 31.


Radiological imaging as the basis for a simulation software of ventilation in the tracheo-bronchial tree.

Ley S, Mayer D, Brook BS, van Beek EJ, Heussel CP, Rinck D, Hose R, Markstaller K, Kauczor HU.

Eur Radiol. 2002 Sep;12(9):2218-28. Epub 2002 May 25.


A model for time-dependent flow in (giraffe jugular) veins: uniform tube properties.

Brook BS, Pedley TJ.

J Biomech. 2002 Jan;35(1):95-107.


Blood pressure and flow rate in the giraffe jugular vein.

Pedley TJ, Brook BS, Seymour RS.

Philos Trans R Soc Lond B Biol Sci. 1996 Jul 29;351(1342):855-66.


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