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Items: 35


The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability.

Pérez V, Bermedo-Garcia F, Zelada D, Court FA, Pérez MÁ, Fuenzalida M, Ábrigo J, Cabello-Verrugio C, Moya-Alvarado G, Tapia JC, Valenzuela V, Hetz C, Bronfman FC, Henríquez JP.

Acta Neuropathol Commun. 2019 Sep 12;7(1):147. doi: 10.1186/s40478-019-0802-7.


c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling.

Escudero CA, Cabeza C, Moya-Alvarado G, Maloney MT, Flores CM, Wu C, Court FA, Mobley WC, Bronfman FC.

Sci Rep. 2019 Apr 15;9(1):6070. doi: 10.1038/s41598-019-42420-6.


Brain-Derived Neurotrophic Factor (BDNF) Regulates Rab5-Positive Early Endosomes in Hippocampal Neurons to Induce Dendritic Branching.

Moya-Alvarado G, Gonzalez A, Stuardo N, Bronfman FC.

Front Cell Neurosci. 2018 Dec 17;12:493. doi: 10.3389/fncel.2018.00493. eCollection 2018.


Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis.

Hernández DE, Salvadores NA, Moya-Alvarado G, Catalán RJ, Bronfman FC, Court FA.

J Cell Sci. 2018 Nov 19;131(22). pii: jcs214684. doi: 10.1242/jcs.214684.


Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor.

Gonzalez A, Moya-Alvarado G, Gonzalez-Billaut C, Bronfman FC.

Cytoskeleton (Hoboken). 2016 Oct;73(10):612-628. doi: 10.1002/cm.21312. Epub 2016 Jun 13. Review.


Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B.

Villarroel-Campos D, Henríquez DR, Bodaleo FJ, Oguchi ME, Bronfman FC, Fukuda M, Gonzalez-Billault C.

J Neurosci. 2016 Jul 6;36(27):7298-313. doi: 10.1523/JNEUROSCI.4064-15.2016.


Rab GTPase signaling in neurite outgrowth and axon specification.

Villarroel-Campos D, Bronfman FC, Gonzalez-Billault C.

Cytoskeleton (Hoboken). 2016 Sep;73(9):498-507. doi: 10.1002/cm.21303. Epub 2016 May 31. Review.


Venlafaxine treatment after endothelin-1-induced cortical stroke modulates growth factor expression and reduces tissue damage in rats.

Zepeda R, Contreras V, Pissani C, Stack K, Vargas M, Owen GI, Lazo OM, Bronfman FC.

Neuropharmacology. 2016 Aug;107:131-145. doi: 10.1016/j.neuropharm.2016.03.011. Epub 2016 Mar 8.


Neurodegeneration and Alzheimer's disease (AD). What Can Proteomics Tell Us About the Alzheimer's Brain?

Moya-Alvarado G, Gershoni-Emek N, Perlson E, Bronfman FC.

Mol Cell Proteomics. 2016 Feb;15(2):409-25. doi: 10.1074/mcp.R115.053330. Epub 2015 Dec 11. Review.


Axonal PPARγ promotes neuronal regeneration after injury.

Lezana JP, Dagan SY, Robinson A, Goldstein RS, Fainzilber M, Bronfman FC, Bronfman M.

Dev Neurobiol. 2016 Jun;76(6):688-701. doi: 10.1002/dneu.22353. Epub 2015 Oct 26.


Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production.

Langjahr P, Díaz-Jiménez D, De la Fuente M, Rubio E, Golenbock D, Bronfman FC, Quera R, González MJ, Hermoso MA.

PLoS One. 2014 Dec 22;9(12):e104624. doi: 10.1371/journal.pone.0104624. eCollection 2014.


Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway.

Larios JA, Jausoro I, Benitez ML, Bronfman FC, Marzolo MP.

BMC Neurosci. 2014 Sep 19;15:108. doi: 10.1186/1471-2202-15-108.


Spatiotemporal intracellular dynamics of neurotrophin and its receptors. Implications for neurotrophin signaling and neuronal function.

Bronfman FC, Lazo OM, Flores C, Escudero CA.

Handb Exp Pharmacol. 2014;220:33-65. doi: 10.1007/978-3-642-45106-5_3. Review.


The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release.

Escudero CA, Lazo OM, Galleguillos C, Parraguez JI, Lopez-Verrilli MA, Cabeza C, Leon L, Saeed U, Retamal C, Gonzalez A, Marzolo MP, Carter BD, Court FA, Bronfman FC.

J Cell Sci. 2014 May 1;127(Pt 9):1966-79. doi: 10.1242/jcs.141754. Epub 2014 Feb 25.


BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching.

Lazo OM, Gonzalez A, Ascaño M, Kuruvilla R, Couve A, Bronfman FC.

J Neurosci. 2013 Apr 3;33(14):6112-22. doi: 10.1523/JNEUROSCI.4630-12.2013.


Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease.

Cabeza C, Figueroa A, Lazo OM, Galleguillos C, Pissani C, Klein A, Gonzalez-Billault C, Inestrosa NC, Alvarez AR, Zanlungo S, Bronfman FC.

Mol Neurodegener. 2012 Mar 29;7:11. doi: 10.1186/1750-1326-7-11.


p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17.

Kenchappa RS, Tep C, Korade Z, Urra S, Bronfman FC, Yoon SO, Carter BD.

J Biol Chem. 2010 Jun 25;285(26):20358-68. doi: 10.1074/jbc.M109.082834. Epub 2010 Apr 26.


Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons.

Lazo OM, Mauna JC, Pissani CA, Inestrosa NC, Bronfman FC.

Mol Neurodegener. 2010 Jan 19;5:5. doi: 10.1186/1750-1326-5-5.


An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot and interactions with p75 coreceptors.

Guillemard V, Ivanisevic L, Garcia AG, Scholten V, Lazo OM, Bronfman FC, Saragovi HU.

Dev Neurobiol. 2010 Feb 15;70(3):150-64. doi: 10.1002/dneu.20776.


Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease.

Alvarez AR, Klein A, Castro J, Cancino GI, Amigo J, Mosqueira M, Vargas LM, Yévenes LF, Bronfman FC, Zanlungo S.

FASEB J. 2008 Oct;22(10):3617-27. doi: 10.1096/fj.07-102715. Epub 2008 Jun 30.


Commuting within the cell-mind the GAPs. Workshop on Systems Dynamics of Intracellular Communication: overcoming Distance in Signalling Networks.

Bronfman FC, Kapon R.

EMBO Rep. 2007 Nov;8(11):1011-5. Epub 2007 Oct 19. Review. No abstract available.


Endosomal transport of neurotrophins: roles in signaling and neurodegenerative diseases.

Bronfman FC, Escudero CA, Weis J, Kruttgen A.

Dev Neurobiol. 2007 Aug;67(9):1183-203. Review.


TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain.

Urra S, Escudero CA, Ramos P, Lisbona F, Allende E, Covarrubias P, Parraguez JI, Zampieri N, Chao MV, Annaert W, Bronfman FC.

J Biol Chem. 2007 Mar 9;282(10):7606-15. Epub 2007 Jan 9.


Peroxisome proliferator-activated receptor gamma is a novel target of the nerve growth factor signaling pathway in PC12 cells.

Fuenzalida KM, Aguilera MC, Piderit DG, Ramos PC, Contador D, Quiñones V, Rigotti A, Bronfman FC, Bronfman M.

J Biol Chem. 2005 Mar 11;280(10):9604-9. Epub 2005 Jan 4.


Multi-tasking by the p75 neurotrophin receptor: sortilin things out?

Bronfman FC, Fainzilber M.

EMBO Rep. 2004 Sep;5(9):867-71. Review.


Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome.

Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M.

J Neurosci. 2003 Apr 15;23(8):3209-20.


The p75 neurotrophin receptor interacts with multiple MAGE proteins.

Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E, Fainzilber M.

J Biol Chem. 2002 Dec 20;277(51):49101-4. Epub 2002 Oct 31.


No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice.

Bronfman FC, Tesseur I, Hofker MH, Havekens LM, Van Leuven F.

Neuroscience. 2000;97(3):411-8.


Laminin blocks the assembly of wild-type A beta and the Dutch variant peptide into Alzheimer's fibrils.

Bronfman FC, Alvarez A, Morgan C, Inestrosa NC.

Amyloid. 1998 Mar;5(1):16-23.


Laminin inhibits amyloid-beta-peptide fibrillation.

Bronfman FC, Garrido J, Alvarez A, Morgan C, Inestrosa NC.

Neurosci Lett. 1996 Nov 8;218(3):201-3.


Extracellular matrix regulates the amount of the beta-amyloid precursor protein and its amyloidogenic fragments.

Bronfman FC, Soto C, Tapia L, Tapia V, Inestrosa NC.

J Cell Physiol. 1996 Feb;166(2):360-9.


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