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Evaluating single-particle tracking by photo-activation localization microscopy (sptPALM) in Lactococcus lactis.

van Beljouw SPB, van der Els S, Martens KJA, Kleerebezem M, Bron PA, Hohlbein J.

Phys Biol. 2019 Mar 8;16(3):035001. doi: 10.1088/1478-3975/ab0162.


Transcriptome Analysis of a Spray Drying-Resistant Subpopulation Reveals a Zinc-Dependent Mechanism for Robustness in L. lactis SK11.

Dijkstra AR, Starrenburg MJC, Todt T, van Hijum SAFT, Hugenholtz J, Bron PA.

Front Microbiol. 2018 Oct 15;9:2418. doi: 10.3389/fmicb.2018.02418. eCollection 2018.


Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria.

Bron PA, Marcelli B, Mulder J, van der Els S, Morawska LP, Kuipers OP, Kok J, Kleerebezem M.

Curr Opin Biotechnol. 2019 Apr;56:61-68. doi: 10.1016/j.copbio.2018.09.004. Epub 2018 Oct 11. Review.


Understanding mode of action can drive the translational pipeline towards more reliable health benefits for probiotics.

Kleerebezem M, Binda S, Bron PA, Gross G, Hill C, van Hylckama Vlieg JE, Lebeer S, Satokari R, Ouwehand AC.

Curr Opin Biotechnol. 2019 Apr;56:55-60. doi: 10.1016/j.copbio.2018.09.007. Epub 2018 Oct 5. Review.


Lactic Acid Bacteria for Delivery of Endogenous or Engineered Therapeutic Molecules.

Bron PA, Kleerebezem M.

Front Microbiol. 2018 Aug 3;9:1821. doi: 10.3389/fmicb.2018.01821. eCollection 2018. Review.


Versatile Cas9-Driven Subpopulation Selection Toolbox for Lactococcus lactis.

van der Els S, James JK, Kleerebezem M, Bron PA.

Appl Environ Microbiol. 2018 Apr 2;84(8). pii: e02752-17. doi: 10.1128/AEM.02752-17. Print 2018 Apr 15.


Identification of probiotic effector molecules: present state and future perspectives.

Lebeer S, Bron PA, Marco ML, Van Pijkeren JP, O'Connell Motherway M, Hill C, Pot B, Roos S, Klaenhammer T.

Curr Opin Biotechnol. 2018 Feb;49:217-223. doi: 10.1016/j.copbio.2017.10.007. Epub 2017 Nov 16. Review.


Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells.

de Vos P, Mujagic Z, de Haan BJ, Siezen RJ, Bron PA, Meijerink M, Wells JM, Masclee AAM, Boekschoten MV, Faas MM, Troost FJ.

Front Immunol. 2017 Aug 23;8:1000. doi: 10.3389/fimmu.2017.01000. eCollection 2017.


Unleashing Natural Competence in Lactococcus lactis by Induction of the Competence Regulator ComX.

Mulder J, Wels M, Kuipers OP, Kleerebezem M, Bron PA.

Appl Environ Microbiol. 2017 Sep 29;83(20). pii: e01320-17. doi: 10.1128/AEM.01320-17. Print 2017 Oct 15.


Can probiotics modulate human disease by impacting intestinal barrier function?

Bron PA, Kleerebezem M, Brummer RJ, Cani PD, Mercenier A, MacDonald TT, Garcia-Ródenas CL, Wells JM.

Br J Nutr. 2017 Jan;117(1):93-107. doi: 10.1017/S0007114516004037. Review.


The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial.

Mujagic Z, de Vos P, Boekschoten MV, Govers C, Pieters HH, de Wit NJ, Bron PA, Masclee AA, Troost FJ.

Sci Rep. 2017 Jan 3;7:40128. doi: 10.1038/srep40128.


Strain-Dependent Transcriptome Signatures for Robustness in Lactococcus lactis.

Dijkstra AR, Alkema W, Starrenburg MJ, Hugenholtz J, van Hijum SA, Bron PA.

PLoS One. 2016 Dec 14;11(12):e0167944. doi: 10.1371/journal.pone.0167944. eCollection 2016.


Draft Genome Sequence of Lactobacillus delbrueckii subsp. bulgaricus LBB.B5.

Urshev Z, Hajo K, Lenoci L, Bron PA, Dijkstra A, Alkema W, Wels M, Siezen RJ, Minkova S, van Hijum SA.

Genome Announc. 2016 Oct 6;4(5). pii: e01090-16. doi: 10.1128/genomeA.01090-16.


Protease and lipase activities of fungal and bacterial strains derived from an artisanal raw ewe's milk cheese.

Ozturkoglu-Budak S, Wiebenga A, Bron PA, de Vries RP.

Int J Food Microbiol. 2016 Nov 21;237:17-27. doi: 10.1016/j.ijfoodmicro.2016.08.007. Epub 2016 Aug 13.


Stress Physiology of Lactic Acid Bacteria.

Papadimitriou K, Alegría Á, Bron PA, de Angelis M, Gobbetti M, Kleerebezem M, Lemos JA, Linares DM, Ross P, Stanton C, Turroni F, van Sinderen D, Varmanen P, Ventura M, Zúñiga M, Tsakalidou E, Kok J.

Microbiol Mol Biol Rev. 2016 Jul 27;80(3):837-90. doi: 10.1128/MMBR.00076-15. Print 2016 Sep. Review.


Volatile compound profiling of Turkish Divle Cave cheese during production and ripening.

Ozturkoglu-Budak S, Gursoy A, Aykas DP, Koçak C, Dönmez S, de Vries RP, Bron PA.

J Dairy Sci. 2016 Jul;99(7):5120-5131. doi: 10.3168/jds.2015-10828. Epub 2016 Apr 20.


Strain-Specific Features of Extracellular Polysaccharides and Their Impact on Lactobacillus plantarum-Host Interactions.

Lee IC, Caggianiello G, van Swam II, Taverne N, Meijerink M, Bron PA, Spano G, Kleerebezem M.

Appl Environ Microbiol. 2016 Jun 13;82(13):3959-3970. doi: 10.1128/AEM.00306-16. Print 2016 Jul 1.


Draft Genome Sequence of Lactobacillus plantarum SF2A35B.

Bron PA, Lee IC, Backus L, van Hijum SA, Wels M, Kleerebezem M.

Genome Announc. 2016 Feb 25;4(1). pii: e01638-15. doi: 10.1128/genomeA.01638-15.


Characterization of the transcriptional regulation of the tarIJKL locus involved in ribitol-containing wall teichoic acid biosynthesis in Lactobacillus plantarum.

Tomita S, Lee IC, van Swam II, Boeren S, Vervoort J, Bron PA, Kleerebezem M.

Microbiology. 2016 Feb;162(2):420-32. doi: 10.1099/mic.0.000229. Epub 2015 Dec 17.


TLR signaling-induced CD103-expressing cells protect against intestinal inflammation.

Wittmann A, Bron PA, van Swam II, Kleerebezem M, Adam P, Gronbach K, Menz S, Flade I, Bender A, Schäfer A, Korkmaz AG, Parusel R, Autenrieth IB, Frick JS.

Inflamm Bowel Dis. 2015 Mar;21(3):507-19. doi: 10.1097/MIB.0000000000000292.


Use of non-growing Lactococcus lactis cell suspensions for production of volatile metabolites with direct relevance for flavour formation during dairy fermentations.

van de Bunt B, Bron PA, Sijtsma L, de Vos WM, Hugenholtz J.

Microb Cell Fact. 2014 Dec 10;13:176. doi: 10.1186/s12934-014-0176-2.


Fermentation-induced variation in heat and oxidative stress phenotypes of Lactococcus lactis MG1363 reveals transcriptome signatures for robustness.

Dijkstra AR, Alkema W, Starrenburg MJ, Hugenholtz J, van Hijum SA, Bron PA.

Microb Cell Fact. 2014 Nov 4;13:148. doi: 10.1186/s12934-014-0148-6.


GtfA and GtfB are both required for protein O-glycosylation in Lactobacillus plantarum.

Lee IC, van Swam II, Tomita S, Morsomme P, Rolain T, Hols P, Kleerebezem M, Bron PA.

J Bacteriol. 2014 May;196(9):1671-82. doi: 10.1128/JB.01401-13. Epub 2014 Feb 14.


Transcriptome signatures of class I and III stress response deregulation in Lactobacillus plantarum reveal pleiotropic adaptation.

Van Bokhorst-van de Veen H, Bongers RS, Wels M, Bron PA, Kleerebezem M.

Microb Cell Fact. 2013 Nov 18;12:112. doi: 10.1186/1475-2859-12-112.


Diversity in robustness of Lactococcus lactis strains during heat stress, oxidative stress, and spray drying stress.

Dijkstra AR, Setyawati MC, Bayjanov JR, Alkema W, van Hijum SA, Bron PA, Hugenholtz J.

Appl Environ Microbiol. 2014 Jan;80(2):603-11. doi: 10.1128/AEM.03434-13. Epub 2013 Nov 8.


Genotypic adaptations associated with prolonged persistence of Lactobacillus plantarum in the murine digestive tract.

van Bokhorst-van de Veen H, Smelt MJ, Wels M, van Hijum SA, de Vos P, Kleerebezem M, Bron PA.

Biotechnol J. 2013 Aug;8(8):895-904.


Transcriptome-based characterization of interactions between Saccharomyces cerevisiae and Lactobacillus delbrueckii subsp. bulgaricus in lactose-grown chemostat cocultures.

Mendes F, Sieuwerts S, de Hulster E, Almering MJ, Luttik MA, Pronk JT, Smid EJ, Bron PA, Daran-Lapujade P.

Appl Environ Microbiol. 2013 Oct;79(19):5949-61. doi: 10.1128/AEM.01115-13. Epub 2013 Jul 19.


Probiotics can generate FoxP3 T-cell responses in the small intestine and simultaneously inducing CD4 and CD8 T cell activation in the large intestine.

Smelt MJ, de Haan BJ, Bron PA, van Swam I, Meijerink M, Wells JM, Faas MM, de Vos P.

PLoS One. 2013 Jul 4;8(7):e68952. doi: 10.1371/journal.pone.0068952. Print 2013.


Cell surface-associated compounds of probiotic lactobacilli sustain the strain-specificity dogma.

Bron PA, Tomita S, Mercenier A, Kleerebezem M.

Curr Opin Microbiol. 2013 Jun;16(3):262-9. doi: 10.1016/j.mib.2013.06.001. Epub 2013 Jun 28. Review.


O-glycosylation as a novel control mechanism of peptidoglycan hydrolase activity.

Rolain T, Bernard E, Beaussart A, Degand H, Courtin P, Egge-Jacobsen W, Bron PA, Morsomme P, Kleerebezem M, Chapot-Chartier MP, Dufrêne YF, Hols P.

J Biol Chem. 2013 Aug 2;288(31):22233-47. doi: 10.1074/jbc.M113.470716. Epub 2013 Jun 12.


The impact of Lactobacillus plantarum WCFS1 teichoic acid D-alanylation on the generation of effector and regulatory T-cells in healthy mice.

Smelt MJ, de Haan BJ, Bron PA, van Swam I, Meijerink M, Wells JM, Kleerebezem M, Faas MM, de Vos P.

PLoS One. 2013 Apr 30;8(4):e63099. doi: 10.1371/journal.pone.0063099. Print 2013.


The structure of an alternative wall teichoic acid produced by a Lactobacillus plantarum WCFS1 mutant contains a 1,5-linked poly(ribitol phosphate) backbone with 2-α-D-glucosyl substitutions.

Tomita S, de Waard P, Bakx EJ, Schols HA, Kleerebezem M, Bron PA.

Carbohydr Res. 2013 Apr 5;370:67-71. doi: 10.1016/j.carres.2013.01.018. Epub 2013 Feb 1.


Impact of Lactobacillus plantarum sortase on target protein sorting, gastrointestinal persistence, and host immune response modulation.

Remus DM, Bongers RS, Meijerink M, Fusetti F, Poolman B, de Vos P, Wells JM, Kleerebezem M, Bron PA.

J Bacteriol. 2013 Feb;195(3):502-9. doi: 10.1128/JB.01321-12. Epub 2012 Nov 21.


Impact of 4 Lactobacillus plantarum capsular polysaccharide clusters on surface glycan composition and host cell signaling.

Remus DM, van Kranenburg R, van Swam II, Taverne N, Bongers RS, Wels M, Wells JM, Bron PA, Kleerebezem M.

Microb Cell Fact. 2012 Nov 21;11:149. doi: 10.1186/1475-2859-11-149.


Identification of key peptidoglycan hydrolases for morphogenesis, autolysis, and peptidoglycan composition of Lactobacillus plantarum WCFS1.

Rolain T, Bernard E, Courtin P, Bron PA, Kleerebezem M, Chapot-Chartier MP, Hols P.

Microb Cell Fact. 2012 Oct 15;11:137. doi: 10.1186/1475-2859-11-137.


The quest for probiotic effector molecules--unraveling strain specificity at the molecular level.

Lee IC, Tomita S, Kleerebezem M, Bron PA.

Pharmacol Res. 2013 Mar;69(1):61-74. doi: 10.1016/j.phrs.2012.09.010. Epub 2012 Oct 8. Review.


L. plantarum, L. salivarius, and L. lactis attenuate Th2 responses and increase Treg frequencies in healthy mice in a strain dependent manner.

Smelt MJ, de Haan BJ, Bron PA, van Swam I, Meijerink M, Wells JM, Faas MM, de Vos P.

PLoS One. 2012;7(10):e47244. doi: 10.1371/journal.pone.0047244. Epub 2012 Oct 9.


Congruent strain specific intestinal persistence of Lactobacillus plantarum in an intestine-mimicking in vitro system and in human volunteers.

van Bokhorst-van de Veen H, van Swam I, Wels M, Bron PA, Kleerebezem M.

PLoS One. 2012;7(9):e44588. doi: 10.1371/journal.pone.0044588. Epub 2012 Sep 6.


Lactobacillus plantarum possesses the capability for wall teichoic acid backbone alditol switching.

Bron PA, Tomita S, van Swam II, Remus DM, Meijerink M, Wels M, Okada S, Wells JM, Kleerebezem M.

Microb Cell Fact. 2012 Sep 11;11:123. doi: 10.1186/1475-2859-11-123.


Modulation of Lactobacillus plantarum gastrointestinal robustness by fermentation conditions enables identification of bacterial robustness markers.

van Bokhorst-van de Veen H, Lee IC, Marco ML, Wels M, Bron PA, Kleerebezem M.

PLoS One. 2012;7(7):e39053. doi: 10.1371/journal.pone.0039053. Epub 2012 Jul 3.


Transcriptomes reveal genetic signatures underlying physiological variations imposed by different fermentation conditions in Lactobacillus plantarum.

Bron PA, Wels M, Bongers RS, van Bokhorst-van de Veen H, Wiersma A, Overmars L, Marco ML, Kleerebezem M.

PLoS One. 2012;7(7):e38720. doi: 10.1371/journal.pone.0038720. Epub 2012 Jul 3.


Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa.

Bron PA, van Baarlen P, Kleerebezem M.

Nat Rev Microbiol. 2011 Nov 21;10(1):66-78. doi: 10.1038/nrmicro2690. Review.


The major autolysin Acm2 from Lactobacillus plantarum undergoes cytoplasmic O-glycosylation.

Fredriksen L, Mathiesen G, Moen A, Bron PA, Kleerebezem M, Eijsink VG, Egge-Jacobsen W.

J Bacteriol. 2012 Jan;194(2):325-33. doi: 10.1128/JB.06314-11. Epub 2011 Nov 11.


An intimate tête-à-tête - how probiotic lactobacilli communicate with the host.

Remus DM, Kleerebezem M, Bron PA.

Eur J Pharmacol. 2011 Sep;668 Suppl 1:S33-42. doi: 10.1016/j.ejphar.2011.07.012. Epub 2011 Jul 27. Review.


Short- and long-term adaptation to ethanol stress and its cross-protective consequences in Lactobacillus plantarum.

van Bokhorst-van de Veen H, Abee T, Tempelaars M, Bron PA, Kleerebezem M, Marco ML.

Appl Environ Microbiol. 2011 Aug;77(15):5247-56. doi: 10.1128/AEM.00515-11. Epub 2011 Jun 24.


Engineering lactic acid bacteria for increased industrial functionality.

Bron PA, Kleerebezem M.

Bioeng Bugs. 2011 Mar-Apr;2(2):80-7. doi: 10.4161/bbug.2.2.13910. Review.


Fluorescence and atomic force microscopy imaging of wall teichoic acids in Lactobacillus plantarum.

Andre G, Deghorain M, Bron PA, van Swam II, Kleerebezem M, Hols P, Dufrene YF.

ACS Chem Biol. 2011 Apr 15;6(4):366-76. doi: 10.1021/cb1003509. Epub 2011 Feb 4.


Identification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells.

van Hemert S, Meijerink M, Molenaar D, Bron PA, de Vos P, Kleerebezem M, Wells JM, Marco ML.

BMC Microbiol. 2010 Nov 16;10:293. doi: 10.1186/1471-2180-10-293.


Identification of genetic loci in Lactobacillus plantarum that modulate the immune response of dendritic cells using comparative genome hybridization.

Meijerink M, van Hemert S, Taverne N, Wels M, de Vos P, Bron PA, Savelkoul HF, van Bilsen J, Kleerebezem M, Wells JM.

PLoS One. 2010 May 13;5(5):e10632. doi: 10.1371/journal.pone.0010632.


The extracellular biology of the lactobacilli.

Kleerebezem M, Hols P, Bernard E, Rolain T, Zhou M, Siezen RJ, Bron PA.

FEMS Microbiol Rev. 2010 Mar;34(2):199-230. doi: 10.1111/j.1574-6976.2010.00208.x. Epub 2010 Jan 19. Review.

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