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Items: 1 to 50 of 80

1.

New Targets and Emergent Therapies for Osteoporosis.

Brommage R.

Handb Exp Pharmacol. 2019 Dec 10. doi: 10.1007/164_2019_329. [Epub ahead of print]

PMID:
31820174
2.

MicroCT analyses of mouse femoral neck architecture.

Brommage R, Jeter-Jones S, Xiong W, Liu J.

Bone. 2019 Aug 19:115040. doi: 10.1016/j.bone.2019.115040. [Epub ahead of print]

PMID:
31437568
3.

Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns.

Brommage R, Powell DR, Vogel P.

Dis Model Mech. 2019 May 7;12(5). pii: dmm038224. doi: 10.1242/dmm.038224. Review.

4.

NOTUM inhibition increases endocortical bone formation and bone strength.

Brommage R, Liu J, Vogel P, Mseeh F, Thompson AY, Potter DG, Shadoan MK, Hansen GM, Jeter-Jones S, Cui J, Bright D, Bardenhagen JP, Doree DD, Movérare-Skrtic S, Nilsson KH, Henning P, Lerner UH, Ohlsson C, Sands AT, Tarver JE, Powell DR, Zambrowicz B, Liu Q.

Bone Res. 2019 Jan 8;7:2. doi: 10.1038/s41413-018-0038-3. eCollection 2019.

5.

Translational studies provide insights for the etiology and treatment of cortical bone osteoporosis.

Brommage R, Ohlsson C.

Best Pract Res Clin Endocrinol Metab. 2018 Jun;32(3):329-340. doi: 10.1016/j.beem.2018.02.006. Epub 2018 Feb 27. Review.

PMID:
29779585
6.

Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice.

Funck-Brentano T, Nilsson KH, Brommage R, Henning P, Lerner UH, Koskela A, Tuukkanen J, Cohen-Solal M, Movérare-Skrtic S, Ohlsson C.

J Endocrinol. 2018 Jul;238(1):13-23. doi: 10.1530/JOE-18-0153. Epub 2018 May 2.

7.

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H; IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M.

Nat Commun. 2018 Jan 18;9(1):288. doi: 10.1038/s41467-017-01995-2.

8.

Genetic and Molecular Insights Into Genotype-Phenotype Relationships in Osteopathia Striata With Cranial Sclerosis (OSCS) Through the Analysis of Novel Mouse Wtx Mutant Alleles.

Comai G, Boutet A, Tanneberger K, Massa F, Rocha AS, Charlet A, Panzolini C, Jian Motamedi F, Brommage R, Hans W, Funck-Brentano T, Hrabe de Angelis M, Hartmann C, Cohen-Solal M, Behrens J, Schedl A.

J Bone Miner Res. 2018 May;33(5):875-887. doi: 10.1002/jbmr.3387. Epub 2018 Mar 1.

9.

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH.

Cell Metab. 2017 Oct 3;26(4):620-632.e6. doi: 10.1016/j.cmet.2017.08.023. Epub 2017 Sep 21.

10.

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice.

Kumar S, Rathkolb B, Sabrautzki S, Krebs S, Kemter E, Becker L, Beckers J, Bekeredjian R, Brommage R, Calzada-Wack J, Garrett L, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Moreth K, Neff F, Rozman J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Aigner B.

J Biomed Sci. 2017 Aug 17;24(1):57. doi: 10.1186/s12929-017-0365-5.

11.

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel JA, Amarie OV, Becker L, Brommage R, Garrett L, Henzel KS, Hölter SM, Janik D, Lehmann I, Moreth K, Pearson BL, Racz I, Rathkolb B, Ryan DP, Schröder S, Treise I, Bekeredjian R, Busch DH, Graw J, Ehninger G, Klingenspor M, Klopstock T, Ollert M, Sandholzer M, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Ehninger D.

Nat Commun. 2017 Jul 24;8(1):155. doi: 10.1038/s41467-017-00178-3.

12.

Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.

Sabrautzki S, Sandholzer MA, Lorenz-Depiereux B, Brommage R, Przemeck G, Vargas Panesso IL, Vernaleken A, Garrett L, Baron K, Yildirim AO, Rozman J, Rathkolb B, Gau C, Hans W, Hoelter SM, Marschall S, Stoeger C, Becker L, Fuchs H, Gailus-Durner V, Klingenspor M, Klopstock T, Lengger C, Stefanie L, Wolf E, Strom TM, Wurst W, de Angelis MH.

Mamm Genome. 2016 Dec;27(11-12):587-598. Epub 2016 Sep 26.

13.

Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease.

Kiper POS, Saito H, Gori F, Unger S, Hesse E, Yamana K, Kiviranta R, Solban N, Liu J, Brommage R, Boduroglu K, Bonafé L, Campos-Xavier B, Dikoglu E, Eastell R, Gossiel F, Harshman K, Nishimura G, Girisha KM, Stevenson BJ, Takita H, Rivolta C, Superti-Furga A, Baron R.

N Engl J Med. 2016 Jun 30;374(26):2553-2562. doi: 10.1056/NEJMoa1509342.

14.

Dentin Dysplasia in Notum Knockout Mice.

Vogel P, Read RW, Hansen GM, Powell DR, Kantaputra PN, Zambrowicz B, Brommage R.

Vet Pathol. 2016 Jul;53(4):853-62. doi: 10.1177/0300985815626778. Epub 2016 Feb 29.

PMID:
26926082
15.

Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase.

Tarver JE Jr, Pabba PK, Barbosa J, Han Q, Gardyan MW, Brommage R, Thompson AY, Schmidt JM, Wilson AGE, He W, Lombardo VK, Carson KG.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1525-1528. doi: 10.1016/j.bmcl.2016.02.021. Epub 2016 Feb 10.

PMID:
26897593
16.

4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase.

Han Q, Pabba PK, Barbosa J, Mabon R, Healy JP, Gardyan MW, Terranova KM, Brommage R, Thompson AY, Schmidt JM, Wilson AG, Xu X, Tarver JE Jr, Carson KG.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1184-7. doi: 10.1016/j.bmcl.2016.01.038. Epub 2016 Jan 18.

PMID:
26821819
17.

Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness.

Brommage R, Liu J, Doree D, Yu W, Powell DR, Melissa Yang Q.

Bonekey Rep. 2015 Jul 15;4:718. doi: 10.1038/bonekey.2015.87. eCollection 2015.

18.

Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice.

Powell DR, Gay JP, Wilganowski N, Doree D, Savelieva KV, Lanthorn TH, Read R, Vogel P, Hansen GM, Brommage R, Ding ZM, Desai U, Zambrowicz B.

Front Endocrinol (Lausanne). 2015 Jun 2;6:86. doi: 10.3389/fendo.2015.00086. eCollection 2015.

19.

Genetic Approaches To Identifying Novel Osteoporosis Drug Targets.

Brommage R.

J Cell Biochem. 2015 Oct;116(10):2139-45. doi: 10.1002/jcb.25179. Review.

PMID:
25833316
20.

Role of WNT16 in the regulation of periosteal bone formation in female mice.

Wergedal JE, Kesavan C, Brommage R, Das S, Mohan S.

Endocrinology. 2015 Mar;156(3):1023-32. doi: 10.1210/en.2014-1702. Epub 2014 Dec 18.

21.

Reply to Lrp5 regulation of bone mass and gut serotonin synthesis.

Cui Y, Niziolek PJ, MacDonald BT, Alenina N, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Powell DR, He X, Bader M, Williams BO, Warman ML, Robling AG.

Nat Med. 2014 Nov;20(11):1229-30. doi: 10.1038/nm.3697. No abstract available.

22.

Malformation of incisor teeth in Grem2⁻/⁻ mice.

Vogel P, Liu J, Platt KA, Read RW, Thiel M, Vance RB, Brommage R.

Vet Pathol. 2015 Jan;52(1):224-9. doi: 10.1177/0300985814528218. Epub 2014 Mar 31.

PMID:
24686385
23.

High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.

Brommage R, Liu J, Hansen GM, Kirkpatrick LL, Potter DG, Sands AT, Zambrowicz B, Powell DR, Vogel P.

Bone Res. 2014 Oct 28;2:14034. doi: 10.1038/boneres.2014.34. eCollection 2014.

24.

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.

Xing W, Liu J, Cheng S, Vogel P, Mohan S, Brommage R.

J Bone Miner Res. 2013 Sep;28(9):1962-74. doi: 10.1002/jbmr.1935.

25.

Improved glycemic control in mice lacking Sglt1 and Sglt2.

Powell DR, DaCosta CM, Gay J, Ding ZM, Smith M, Greer J, Doree D, Jeter-Jones S, Mseeh F, Rodriguez LA, Harris A, Buhring L, Platt KA, Vogel P, Brommage R, Shadoan MK, Sands AT, Zambrowicz B.

Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E117-30. doi: 10.1152/ajpendo.00439.2012. Epub 2012 Nov 13.

26.

WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.

Zheng HF, Tobias JH, Duncan E, Evans DM, Eriksson J, Paternoster L, Yerges-Armstrong LM, Lehtimäki T, Bergström U, Kähönen M, Leo PJ, Raitakari O, Laaksonen M, Nicholson GC, Viikari J, Ladouceur M, Lyytikäinen LP, Medina-Gomez C, Rivadeneira F, Prince RL, Sievanen H, Leslie WD, Mellström D, Eisman JA, Movérare-Skrtic S, Goltzman D, Hanley DA, Jones G, St Pourcain B, Xiao Y, Timpson NJ, Smith GD, Reid IR, Ring SM, Sambrook PN, Karlsson M, Dennison EM, Kemp JP, Danoy P, Sayers A, Wilson SG, Nethander M, McCloskey E, Vandenput L, Eastell R, Liu J, Spector T, Mitchell BD, Streeten EA, Brommage R, Pettersson-Kymmer U, Brown MA, Ohlsson C, Richards JB, Lorentzon M.

PLoS Genet. 2012 Jul;8(7):e1002745. doi: 10.1371/journal.pgen.1002745. Epub 2012 Jul 5.

27.

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

Medina-Gomez C, Kemp JP, Estrada K, Eriksson J, Liu J, Reppe S, Evans DM, Heppe DH, Vandenput L, Herrera L, Ring SM, Kruithof CJ, Timpson NJ, Zillikens MC, Olstad OK, Zheng HF, Richards JB, St Pourcain B, Hofman A, Jaddoe VW, Smith GD, Lorentzon M, Gautvik KM, Uitterlinden AG, Brommage R, Ohlsson C, Tobias JH, Rivadeneira F.

PLoS Genet. 2012 Jul;8(7):e1002718. doi: 10.1371/journal.pgen.1002718. Epub 2012 Jul 5.

28.

Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice.

Vogel P, Hansen GM, Read RW, Vance RB, Thiel M, Liu J, Wronski TJ, Smith DD, Jeter-Jones S, Brommage R.

Vet Pathol. 2012 Nov;49(6):998-1017. doi: 10.1177/0300985812453177. Epub 2012 Jun 25.

PMID:
22732358
29.

Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation.

Linares GR, Brommage R, Powell DR, Xing W, Chen ST, Alshbool FZ, Lau KH, Wergedal JE, Mohan S.

J Bone Miner Res. 2012 Jul;27(7):1553-65. doi: 10.1002/jbmr.1600.

30.

Lrp5 functions in bone to regulate bone mass.

Cui Y, Niziolek PJ, MacDonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, Zambrowicz B, Gerrits H, Gossen JA, He X, Bader M, Williams BO, Warman ML, Robling AG.

Nat Med. 2011 Jun;17(6):684-91. doi: 10.1038/nm.2388. Epub 2011 May 22.

31.

High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes.

Brommage R, Desai U, Revelli JP, Donoviel DB, Fontenot GK, Dacosta CM, Smith DD, Kirkpatrick LL, Coker KJ, Donoviel MS, Eberhart DE, Holt KH, Kelly MR, Paradee WJ, Philips AV, Platt KA, Suwanichkul A, Hansen GM, Sands AT, Zambrowicz BP, Powell DR.

Obesity (Silver Spring). 2008 Oct;16(10):2362-7. doi: 10.1038/oby.2008.361. Epub 2008 Jul 31.

32.

Effects of lasofoxifene on the uterus, vagina, and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis).

Cline JM, Botts S, Lees CJ, Brommage R.

Am J Obstet Gynecol. 2008 Aug;199(2):158.e1-8. doi: 10.1016/j.ajog.2008.02.020. Epub 2008 May 23.

PMID:
18501325
33.

Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract.

Liu Q, Yang Q, Sun W, Vogel P, Heydorn W, Yu XQ, Hu Z, Yu W, Jonas B, Pineda R, Calderon-Gay V, Germann M, O'Neill E, Brommage R, Cullinan E, Platt K, Wilson A, Powell D, Sands A, Zambrowicz B, Shi ZC.

J Pharmacol Exp Ther. 2008 Apr;325(1):47-55. doi: 10.1124/jpet.107.132670. Epub 2008 Jan 11.

PMID:
18192499
34.

PTH stimulates bone formation in mice deficient in Lrp5.

Iwaniec UT, Wronski TJ, Liu J, Rivera MF, Arzaga RR, Hansen G, Brommage R.

J Bone Miner Res. 2007 Mar;22(3):394-402.

35.

Effects of lasofoxifene on bone in surgically postmenopausal cynomolgus monkeys.

Lees C, Shen V, Brommage R.

Menopause. 2007 Jan-Feb;14(1):97-105.

PMID:
17075430
36.
37.

Teriparatide [PTH(1-34)] strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity.

Sato M, Westmore M, Ma YL, Schmidt A, Zeng QQ, Glass EV, Vahle J, Brommage R, Jerome CP, Turner CH.

J Bone Miner Res. 2004 Apr;19(4):623-9. Epub 2004 Jan 12.

38.

Validation and calibration of DEXA body composition in mice.

Brommage R.

Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E454-9. Epub 2003 May 20.

39.

The effects of PTH (1-34) on bone structure and strength in ovariectomized monkeys.

Turner CH, Burr DB, Hock JM, Brommage R, Sato M.

Adv Exp Med Biol. 2001;496:165-79. No abstract available.

PMID:
11783618
40.

Levormeloxifene prevents increased bone turnover and vertebral bone loss following ovariectomy in cynomolgus monkeys.

Hotchkiss CE, Stavisky R, Nowak J, Brommage R, Lees CJ, Kaplan J.

Bone. 2001 Jul;29(1):7-15.

PMID:
11472885
41.

Rapid embedding protocol for visualizing bone mineral and matrix.

Brommage R, Vafai H.

Calcif Tissue Int. 2000 Dec;67(6):479. No abstract available.

PMID:
11289698
42.

Three-dimensional modeling of the effects of parathyroid hormone on bone distribution in lumbar vertebrae of ovariectomized cynomolgus macaques.

Sato M, Westmore M, Clendenon J, Smith S, Hannum B, Zeng GQ, Brommage R, Turner CH.

Osteoporos Int. 2000;11(10):871-80.

PMID:
11199192
46.

Measurement of serum bone-specific alkaline phosphatase activity in cynomolgus macaques.

Brommage R, Allison C, Stavisky R, Kaplan J.

J Med Primatol. 1999 Dec;28(6):329-33.

PMID:
10733205
47.

Changes in bone turnover during the menstrual cycle in cynomolgus monkeys.

Hotchkiss CE, Brommage R.

Calcif Tissue Int. 2000 Mar;66(3):224-8.

PMID:
10666499
48.

Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys.

Brommage R, Hotchkiss CE, Lees CJ, Stancill MW, Hock JM, Jerome CP.

J Clin Endocrinol Metab. 1999 Oct;84(10):3757-63.

PMID:
10523026
49.
50.

Genes in idiopathic calcium oxalate stone disease.

Goodman HO, Brommage R, Assimos DG, Holmes RP.

World J Urol. 1997;15(3):186-94. Review.

PMID:
9228726

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