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An ultrasound-based referential of body height-adjusted normal liver organometry in school children from Bokito in rural Cameroon.

Kamdem SD, Kuemkon EM, Kamguia LM, Tchanana GK, Konhawa F, Nche F, Oumarou A, Hamza M, Essomba RG, Kengne M, Ondigui BE, Assoumou MCO, Brombacher F, Nono JK.

Sci Rep. 2020 Feb 17;10(1):2773. doi: 10.1038/s41598-020-59613-z.


Inflammatory Dendritic Cells, Regulated by IL-4 Receptor Alpha Signaling, Control Replication, and Dissemination of Leishmania major in Mice.

Hurdayal R, Nieuwenhuizen NE, Khutlang R, Brombacher F.

Front Cell Infect Microbiol. 2020 Jan 24;9:479. doi: 10.3389/fcimb.2019.00479. eCollection 2019.


Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon.

Kamdem SD, Konhawa F, Kuemkon EM, Meyo Kamguia L, Tchanana GK, Nche F, Oumarou A, Hamza M, Ouratou Y, Tcheutchoua MN, Ghislain Essomba R, Ngogang MP, Kengne M, Netongo PM, Ondigui BE, Okomo Assoumou MC, Brombacher F, Nono JK.

Front Immunol. 2019 Dec 3;10:2827. doi: 10.3389/fimmu.2019.02827. eCollection 2019.


Environment and Host-Genetic Determinants in Early Development of Allergic Asthma: Contribution of Fungi.

Hadebe S, Brombacher F.

Front Immunol. 2019 Nov 20;10:2696. doi: 10.3389/fimmu.2019.02696. eCollection 2019. Review.


Therapeutic and prophylactic deletion of IL-4Rα signaling ameliorates established ovalbumin-induced allergic asthma.

Khumalo J, Kirstein F, Scibiorek M, Hadebe S, Brombacher F.

Allergy. 2019 Nov 29. doi: 10.1111/all.14137. [Epub ahead of print]


Increasing Influenza Vaccination Rates in People With Chronic Illness.

Sanftenberg L, Brombacher F, Schelling J, Klug SJ, Gensichen J.

Dtsch Arztebl Int. 2019 Sep 27;116(39):645-652. doi: 10.3238/arztebl.2019.0645.


IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Rα Signaling via T Cells.

McFarlane E, Mokgethi T, Kaye PM, Hurdayal R, Brombacher F, Alexander J, Carter KC.

Front Immunol. 2019 Aug 16;10:1957. doi: 10.3389/fimmu.2019.01957. eCollection 2019.


Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring.

Darby MG, Chetty A, Mrjden D, Rolot M, Smith K, Mackowiak C, Sedda D, Nyangahu D, Jaspan H, Toellner KM, Waisman A, Quesniaux V, Ryffel B, Cunningham AF, Dewals BG, Brombacher F, Horsnell WGC.

Sci Adv. 2019 May 29;5(5):eaav3058. doi: 10.1126/sciadv.aav3058. eCollection 2019 May.


Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion.

Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS.

Immunity. 2019 May 21;50(5):1262-1275.e4. doi: 10.1016/j.immuni.2019.03.023. Epub 2019 Apr 23.


Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages.

Tamgue O, Gcanga L, Ozturk M, Whitehead L, Pillay S, Jacobs R, Roy S, Schmeier S, Davids M, Medvedeva YA, Dheda K, Suzuki H, Brombacher F, Guler R.

Front Immunol. 2019 Mar 19;10:421. doi: 10.3389/fimmu.2019.00421. eCollection 2019.


Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection.

Denisenko E, Guler R, Mhlanga M, Suzuki H, Brombacher F, Schmeier S.

BMC Genomics. 2019 Jan 22;20(1):71. doi: 10.1186/s12864-019-5450-6.


Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis.

Ogrinc Wagner A, Friedrich V, Barthels C, Marconi P, Blutke A, Brombacher F, Brocker T.

PLoS One. 2019 Jan 17;14(1):e0210998. doi: 10.1371/journal.pone.0210998. eCollection 2019.


Interleukin-4 Receptor Alpha Expressing B Cells Are Essential to Down-Modulate Host Granulomatous Inflammation During Schistosomasis.

Ndlovu H, Nono JK, Abdel Aziz N, Nieuwenhuizen NE, Brombacher F.

Front Immunol. 2018 Dec 18;9:2928. doi: 10.3389/fimmu.2018.02928. eCollection 2018.


Host Regulators of Liver Fibrosis During Human Schistosomiasis.

Kamdem SD, Moyou-Somo R, Brombacher F, Nono JK.

Front Immunol. 2018 Nov 28;9:2781. doi: 10.3389/fimmu.2018.02781. eCollection 2018. Review.


Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases.

Guler R, Mpotje T, Ozturk M, Nono JK, Parihar SP, Chia JE, Abdel Aziz N, Hlaka L, Kumar S, Roy S, Penn-Nicholson A, Hanekom WA, Zak DE, Scriba TJ, Suzuki H, Brombacher F.

Mucosal Immunol. 2019 Mar;12(2):390-402. doi: 10.1038/s41385-018-0108-2. Epub 2018 Dec 12.


IL-4Rα-expressing CD11c+ cells contribute to driving optimal cellular responses during Schistosoma mansoni infection in mice.

Ndlovu H, Nono JK, Nieuwenhuizen NE, Brombacher F.

J Leukoc Biol. 2019 Feb;105(2):307-316. doi: 10.1002/JLB.MA0318-115R. Epub 2018 Nov 30.


Statins: a viable candidate for host-directed therapy against infectious diseases.

Parihar SP, Guler R, Brombacher F.

Nat Rev Immunol. 2019 Feb;19(2):104-117. doi: 10.1038/s41577-018-0094-3. Review.


The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections.

Abdel Aziz N, Nono JK, Mpotje T, Brombacher F.

PLoS Biol. 2018 Oct 31;16(10):e2005850. doi: 10.1371/journal.pbio.2005850. eCollection 2018 Oct.


Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.

Rolot M, Dougall AM, Chetty A, Javaux J, Chen T, Xiao X, Machiels B, Selkirk ME, Maizels RM, Hokke C, Denis O, Brombacher F, Vanderplasschen A, Gillet L, Horsnell WGC, Dewals BG.

Nat Commun. 2018 Oct 30;9(1):4516. doi: 10.1038/s41467-018-06978-5.


Schistosomiasis Burden and Its Association With Lower Measles Vaccine Responses in School Children From Rural Cameroon.

Nono JK, Kamdem SD, Netongo PM, Dabee S, Schomaker M, Oumarou A, Brombacher F, Moyou-Somo R.

Front Immunol. 2018 Oct 9;9:2295. doi: 10.3389/fimmu.2018.02295. eCollection 2018.


Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis.

De Oliveira T, Ramakrishnan M, Diamanti MA, Ziegler PK, Brombacher F, Greten FR.

Oncogene. 2019 Mar;38(11):1787-1801. doi: 10.1038/s41388-018-0551-2. Epub 2018 Oct 23.


Deletion of Interleukin-4 Receptor Alpha-Responsive Keratinocytes in BALB/c Mice Does Not Alter Susceptibility to Cutaneous Leishmaniasis.

Govender M, Hurdayal R, Martinez-Salazar B, Gqada K, Pillay S, Gcanga L, Passelli K, Nieuwenhuizen NE, Tacchini-Cottier F, Guler R, Brombacher F.

Infect Immun. 2018 Nov 20;86(12). pii: e00710-18. doi: 10.1128/IAI.00710-18. Print 2018 Dec.


Viral Apoptosis Evasion via the MAPK Pathway by Use of a Host Long Noncoding RNA.

Barichievy S, Naidoo J, Boullé M, Scholefield J, Parihar SP, Coussens AK, Brombacher F, Sigal A, Mhlanga MM.

Front Cell Infect Microbiol. 2018 Aug 3;8:263. doi: 10.3389/fcimb.2018.00263. eCollection 2018.


Chronic schistosomiasis suppresses HIV-specific responses to DNA-MVA and MVA-gp140 Env vaccine regimens despite antihelminthic treatment and increases helminth-associated pathology in a mouse model.

Dzhivhuho GA, Rehrl SA, Ndlovu H, Horsnell WGC, Brombacher F, Williamson AL, Chege GK.

PLoS Pathog. 2018 Jul 26;14(7):e1007182. doi: 10.1371/journal.ppat.1007182. eCollection 2018 Jul.


Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages.

Roy S, Schmeier S, Kaczkowski B, Arner E, Alam T, Ozturk M, Tamgue O, Parihar SP, Kawaji H, Itoh M, Lassmann T, Carninci P, Hayashizaki Y, Forrest ARR, Guler R, Bajic VB, Brombacher F, Suzuki H.

Sci Rep. 2018 Apr 30;8(1):6758. doi: 10.1038/s41598-018-24509-6.


C-Type Lectin Receptors in Asthma.

Hadebe S, Brombacher F, Brown GD.

Front Immunol. 2018 Apr 11;9:733. doi: 10.3389/fimmu.2018.00733. eCollection 2018. Review.


Author Correction: House dust mite induced allergic airway disease is attenuated in CD11ccreIL-4Rα-/l°x mice.

Nieuwenhuizen NE, Kirstein F, Hoving JC, Brombacher F.

Sci Rep. 2018 Apr 11;8(1):6054. doi: 10.1038/s41598-018-23432-0.


IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.

Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J.

Elife. 2018 Mar 9;7. pii: e35074. doi: 10.7554/eLife.35074.


IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal.

Weng SY, Wang X, Vijayan S, Tang Y, Kim YO, Padberg K, Regen T, Molokanova O, Chen T, Bopp T, Schild H, Brombacher F, Crosby JR, McCaleb ML, Waisman A, Bockamp E, Schuppan D.

EBioMedicine. 2018 Mar;29:92-103. doi: 10.1016/j.ebiom.2018.01.028. Epub 2018 Feb 17.


Nippostrongylus brasiliensis infection leads to impaired reference memory and myeloid cell interference.

Brombacher TM, De Gouveia KS, Cruywagen L, Makena N, Booley F, Tamgue O, Brombacher F.

Sci Rep. 2018 Feb 13;8(1):2958. doi: 10.1038/s41598-018-20770-x.


Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection.

Firacative C, Gressler AE, Schubert K, Schulze B, Müller U, Brombacher F, von Bergen M, Alber G.

Sci Rep. 2018 Feb 8;8(1):2681. doi: 10.1038/s41598-018-21039-z.


Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.

Parihar SP, Ozturk M, Marakalala MJ, Loots DT, Hurdayal R, Beukes D, Van Reenen M, Zak DE, Mbandi SK, Darboe F, Penn-Nicholson A, Hanekom WA, Leitges M, Scriba TJ, Guler R, Brombacher F.

Mucosal Immunol. 2018 Mar;11(2):579-580. doi: 10.1038/mi.2017.108. Epub 2017 Dec 20.


House dust mite induced allergic airway disease is attenuated in CD11ccreIL-4Rα-/l°x mice.

Nieuwenhuizen NE, Kirstein F, Hoving JC, Brombacher F.

Sci Rep. 2018 Jan 17;8(1):885. doi: 10.1038/s41598-017-19060-9. Erratum in: Sci Rep. 2018 Apr 11;8(1):6054.


Interleukin-4 Receptor Alpha: From Innate to Adaptive Immunity in Murine Models of Cutaneous Leishmaniasis.

Hurdayal R, Brombacher F.

Front Immunol. 2017 Nov 10;8:1354. doi: 10.3389/fimmu.2017.01354. eCollection 2017. Review.


IL-4Rα Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major-Infected C57BL/6 Mice.

Descatoire M, Hurrell BP, Govender M, Passelli K, Martinez-Salazar B, Hurdayal R, Brombacher F, Guler R, Tacchini-Cottier F.

Front Immunol. 2017 Oct 10;8:1265. doi: 10.3389/fimmu.2017.01265. eCollection 2017.


Genome-wide profiling of transcribed enhancers during macrophage activation.

Denisenko E, Guler R, Mhlanga MM, Suzuki H, Brombacher F, Schmeier S.

Epigenetics Chromatin. 2017 Oct 23;10(1):50. doi: 10.1186/s13072-017-0158-9.


Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy.

Hlaka L, Rosslee MJ, Ozturk M, Kumar S, Parihar SP, Brombacher F, Khalaf AI, Carter KC, Scott FJ, Suckling CJ, Guler R.

J Antimicrob Chemother. 2017 Dec 1;72(12):3334-3341. doi: 10.1093/jac/dkx326.


IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases.

Hurdayal R, Ndlovu HH, Revaz-Breton M, Parihar SP, Nono JK, Govender M, Brombacher F.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8430-E8439. doi: 10.1073/pnas.1708125114. Epub 2017 Sep 15.


Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS.

Cell. 2017 Sep 21;171(1):217-228.e13. doi: 10.1016/j.cell.2017.08.006. Epub 2017 Sep 7.


FANTOM5 CAGE profiles of human and mouse samples.

Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Ishikawa-Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manabe RI, Murata M, Nagao-Sato S, Nakazato K, Ninomiya N, Nishiyori-Sueki H, Noma S, Saijyo E, Saka A, Sakai M, Simon C, Suzuki N, Tagami M, Watanabe S, Yoshida S, Arner P, Axton RA, Babina M, Baillie JK, Barnett TC, Beckhouse AG, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Carlisle AJ, Clevers HC, Davis CA, Detmar M, Dohi T, Edge ASB, Edinger M, Ehrlund A, Ekwall K, Endoh M, Enomoto H, Eslami A, Fagiolini M, Fairbairn L, Farach-Carson MC, Faulkner GJ, Ferrai C, Fisher ME, Forrester LM, Fujita R, Furusawa JI, Geijtenbeek TB, Gingeras T, Goldowitz D, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Hasegawa Y, Herlyn M, Heutink P, Hitchens KJ, Hume DA, Ikawa T, Ishizu Y, Kai C, Kawamoto H, Kawamura YI, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klein S, Klinken SP, Knox AJ, Kojima S, Koseki H, Koyasu S, Lee W, Lennartsson A, Mackay-Sim A, Mejhert N, Mizuno Y, Morikawa H, Morimoto M, Moro K, Morris KJ, Motohashi H, Mummery CL, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nozaki T, Ogishima S, Ohkura N, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Passier R, Patrikakis M, Pombo A, Pradhan-Bhatt S, Qin XY, Rehli M, Rizzu P, Roy S, Sajantila A, Sakaguchi S, Sato H, Satoh H, Savvi S, Saxena A, Schmidl C, Schneider C, Schulze-Tanzil GG, Schwegmann A, Sheng G, Shin JW, Sugiyama D, Sugiyama T, Summers KM, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tomoiu A, Toyoda H, van de Wetering M, van den Berg LM, Verardo R, Vijayan D, Wells CA, Winteringham LN, Wolvetang E, Yamaguchi Y, Yamamoto M, Yanagi-Mizuochi C, Yoneda M, Yonekura Y, Zhang PG, Zucchelli S, Abugessaisa I, Arner E, Harshbarger J, Kondo A, Lassmann T, Lizio M, Sahin S, Sengstag T, Severin J, Shimoji H, Suzuki M, Suzuki H, Kawai J, Kondo N, Itoh M, Daub CO, Kasukawa T, Kawaji H, Carninci P, Forrest ARR, Hayashizaki Y.

Sci Data. 2017 Aug 29;4:170112. doi: 10.1038/sdata.2017.112.


Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.

Parihar SP, Ozturk M, Marakalala MJ, Loots DT, Hurdayal R, Maasdorp DB, Van Reenen M, Zak DE, Darboe F, Penn-Nicholson A, Hanekom WA, Leitges M, Scriba TJ, Guler R, Brombacher F.

Mucosal Immunol. 2018 Mar;11(2):496-511. doi: 10.1038/mi.2017.68. Epub 2017 Aug 9. Erratum in: Mucosal Immunol. 2017 Dec 20;:.


Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha.

Nono JK, Ndlovu H, Aziz NA, Mpotje T, Hlaka L, Brombacher F.

PLoS Negl Trop Dis. 2017 Aug 21;11(8):e0005861. doi: 10.1371/journal.pntd.0005861. eCollection 2017 Aug.


A type 2 cytokine axis for thymus emigration.

White AJ, Baik S, Parnell SM, Holland AM, Brombacher F, Jenkinson WE, Anderson G.

J Exp Med. 2017 Aug 7;214(8):2205-2216. doi: 10.1084/jem.20170271. Epub 2017 Jul 10.


Interleukin-4 receptor alpha is still required after Th2 polarization for the maintenance and the recall of protective immunity to Nematode infection.

Nono JK, Ndlovu H, Abdel Aziz N, Mpotje T, Hlaka L, Brombacher F.

PLoS Negl Trop Dis. 2017 Jun 26;11(6):e0005675. doi: 10.1371/journal.pntd.0005675. eCollection 2017 Jun.


An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics.

Scott FJ, Nichol RJO, Khalaf AI, Giordani F, Gillingwater K, Ramu S, Elliott A, Zuegg J, Duffy P, Rosslee MJ, Hlaka L, Kumar S, Ozturk M, Brombacher F, Barrett M, Guler R, Suckling CJ.

Eur J Med Chem. 2017 Aug 18;136:561-572. doi: 10.1016/j.ejmech.2017.05.039. Epub 2017 May 17.


Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths.

Pelly VS, Coomes SM, Kannan Y, Gialitakis M, Entwistle LJ, Perez-Lloret J, Czieso S, Okoye IS, Rückerl D, Allen JE, Brombacher F, Wilson MS.

J Exp Med. 2017 Jun 5;214(6):1809-1826. doi: 10.1084/jem.20161104. Epub 2017 May 15.


Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis.

Fischer K, Ruiz HH, Jhun K, Finan B, Oberlin DJ, van der Heide V, Kalinovich AV, Petrovic N, Wolf Y, Clemmensen C, Shin AC, Divanovic S, Brombacher F, Glasmacher E, Keipert S, Jastroch M, Nagler J, Schramm KW, Medrikova D, Collden G, Woods SC, Herzig S, Homann D, Jung S, Nedergaard J, Cannon B, Tschöp MH, Müller TD, Buettner C.

Nat Med. 2017 May;23(5):623-630. doi: 10.1038/nm.4316. Epub 2017 Apr 17.


Interleukin 13-mediated colitis in the absence of IL-4Rα signalling.

Hoving JC, Cutler AJ, Leeto M, Horsnell WGC, Dewals BG, Nieuwenhuizen NE, Brombacher F.

Gut. 2017 Nov;66(11):2037-2039. doi: 10.1136/gutjnl-2016-313208. Epub 2017 Feb 28. No abstract available.


Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells.

Ng Kuet Leong N, Brombacher F, Dalpke AH, Weitnauer M.

Immunobiology. 2017 May;222(5):759-767. doi: 10.1016/j.imbio.2017.02.003. Epub 2017 Feb 9.


IL-13-Mediated Regulation of Learning and Memory.

Brombacher TM, Nono JK, De Gouveia KS, Makena N, Darby M, Womersley J, Tamgue O, Brombacher F.

J Immunol. 2017 Apr 1;198(7):2681-2688. doi: 10.4049/jimmunol.1601546. Epub 2017 Feb 15.

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