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Items: 1 to 50 of 63

1.

PET-based dosimetry of [68Ga]Ga-NODAGA-exendin-4 in humans, a tracer for beta cell imaging.

Boss M, Buitinga M, Jansen TJ, Brom M, Visser EP, Gotthardt M.

J Nucl Med. 2019 Sep 13. pii: jnumed.119.228627. doi: 10.2967/jnumed.119.228627. [Epub ahead of print]

PMID:
31519801
2.

Incidence of cancer in a cohort of patients with primary Sjögren syndrome in Argentina.

Brom M, Moyano S, Gandino IJ, Scolnik M, Soriano ER.

Rheumatol Int. 2019 Oct;39(10):1697-1702. doi: 10.1007/s00296-019-04433-2. Epub 2019 Aug 30.

PMID:
31471716
3.

Measuring the Pancreatic β Cell Mass in Vivo with Exendin SPECT during Hyperglycemia and Severe Insulitis.

Joosten L, Brom M, Peeters H, Bos D, Himpe E, Bouwens L, Boerman O, Gotthardt M.

Mol Pharm. 2019 Sep 3;16(9):4024-4030. doi: 10.1021/acs.molpharmaceut.9b00728. Epub 2019 Aug 8.

PMID:
31345042
4.

Exendin-4 analogs in insulinoma theranostics.

Jansen TJP, van Lith SAM, Boss M, Brom M, Joosten L, Béhé M, Buitinga M, Gotthardt M.

J Labelled Comp Radiopharm. 2019 Aug;62(10):656-672. doi: 10.1002/jlcr.3750.

5.

Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients.

Buitinga M, Jansen T, van der Kroon I, Woliner-van der Weg W, Boss M, Janssen M, Aarntzen E, Béhé M, Wild D, Visser E, Brom M, Gotthardt M.

J Nucl Med. 2019 Jun;60(6):812-816. doi: 10.2967/jnumed.118.219980. Epub 2018 Nov 30.

PMID:
30504139
6.

Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer.

Gotthardt M, Eizirik DL, Aanstoot HJ, Korsgren O, Mul D, Martin F, Boss M, Jansen TJP, van Lith SAM, Buitinga M, Eriksson O, Cnop M, Brom M.

Diabetologia. 2018 Dec;61(12):2516-2519. doi: 10.1007/s00125-018-4745-5. Epub 2018 Oct 3.

7.

Clinical description of patients with cytoplasmic discrete dots pattern (lysosome) on indirect immunofluorescence on HEp-2 cells.

Brom M, Carrizo CE, Arana RM, Pisoni CN.

Clin Rheumatol. 2018 Dec;37(12):3435-3437. doi: 10.1007/s10067-018-4305-x. Epub 2018 Sep 20.

PMID:
30238378
8.

Validation of 111In-Exendin SPECT for the Determination of the β-Cell Mass in BioBreeding Diabetes-Prone Rats.

Brom M, Joosten L, Frielink C, Peeters H, Bos D, van Zanten M, Boerman O, Gotthardt M.

Diabetes. 2018 Oct;67(10):2012-2018. doi: 10.2337/db17-1312. Epub 2018 Jul 25.

9.

Characterization of 111In-labeled Glucose-Dependent Insulinotropic Polypeptide as a Radiotracer for Neuroendocrine Tumors.

Willekens SMA, Joosten L, Boerman OC, Brom M, Gotthardt M.

Sci Rep. 2018 Feb 13;8(1):2948. doi: 10.1038/s41598-018-21259-3.

10.

Enhanced Specific Activity by Multichelation of Exendin-3 Leads To Improved Image Quality and In Vivo Beta Cell Imaging.

Joosten L, Brom M, Peeters H, Heskamp S, Béhé M, Boerman O, Gotthardt M.

Mol Pharm. 2018 Feb 5;15(2):486-494. doi: 10.1021/acs.molpharmaceut.7b00853. Epub 2017 Dec 21.

11.

Non-invasive in vivo determination of viable islet graft volume by 111In-exendin-3.

Eter WA, Van der Kroon I, Andralojc K, Buitinga M, Willekens SMA, Frielink C, Bos D, Joosten L, Boerman OC, Brom M, Gotthardt M.

Sci Rep. 2017 Aug 3;7(1):7232. doi: 10.1038/s41598-017-07815-3.

12.

Preclinical evaluation of PAC1 targeting with radiolabeled Maxadilan.

Joosten L, Brom M, Schäfer MKH, Boerman OC, Weihe E, Gotthardt M.

Sci Rep. 2017 May 11;7(1):1751. doi: 10.1038/s41598-017-01852-8.

13.

Whole organ and islet of Langerhans dosimetry for calculation of absorbed doses resulting from imaging with radiolabeled exendin.

van der Kroon I, Woliner-van der Weg W, Brom M, Joosten L, Frielink C, Konijnenberg MW, Visser EP, Gotthardt M.

Sci Rep. 2017 Jan 9;7:39800. doi: 10.1038/srep39800.

14.

Quantitative and longitudinal imaging of intramuscular transplanted islets of Langerhans with SPECT using [ 123 I]IBZM.

Willekens SM, van der Kroon I, Bos D, Joosten L, Frielink C, Boerman OC, Brom M, Gotthardt M.

Diabetes Obes Metab. 2017 Apr;19(4):604-608. doi: 10.1111/dom.12857. Epub 2017 Jan 30.

PMID:
27987245
15.

Improved Quantification of the Beta Cell Mass after Pancreas Visualization with 99mTc-demobesin-4 and Beta Cell Imaging with 111In-exendin-3 in Rodents.

van der Kroon I, Joosten L, Nock BA, Maina T, Boerman OC, Brom M, Gotthardt M.

Mol Pharm. 2016 Oct 3;13(10):3478-3483. Epub 2016 Aug 31.

PMID:
27537699
16.

The effect of purification of Ga-68-labeled exendin on in vivo distribution.

Brom M, Franssen GM, Joosten L, Gotthardt M, Boerman OC.

EJNMMI Res. 2016 Dec;6(1):65. doi: 10.1186/s13550-016-0221-8. Epub 2016 Aug 12.

17.

In vivo imaging of beta cells with radiotracers: state of the art, prospects and recommendations for development and use.

Eriksson O, Laughlin M, Brom M, Nuutila P, Roden M, Hwa A, Bonadonna R, Gotthardt M.

Diabetologia. 2016 Jul;59(7):1340-1349. doi: 10.1007/s00125-016-3959-7. Epub 2016 Apr 19. Review.

PMID:
27094935
18.

SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for β-cell mass assessments.

Eter WA, Parween S, Joosten L, Frielink C, Eriksson M, Brom M, Ahlgren U, Gotthardt M.

Sci Rep. 2016 Apr 15;6:24576. doi: 10.1038/srep24576.

19.

Strain Differences Determine the Suitability of Animal Models for Noninvasive In Vivo Beta Cell Mass Determination with Radiolabeled Exendin.

Willekens SM, Joosten L, Boerman OC, Balhuizen A, Eizirik DL, Gotthardt M, Brom M.

Mol Imaging Biol. 2016 Oct;18(5):705-14. doi: 10.1007/s11307-016-0936-y.

20.

The effect of a dopamine antagonist on conditioning of sexual arousal in women.

Brom M, Laan E, Everaerd W, Spinhoven P, Trimbos B, Both S.

Psychopharmacology (Berl). 2016 Apr;233(7):1179-89. doi: 10.1007/s00213-015-4201-x. Epub 2016 Feb 2.

21.

Noninvasive Imaging of Islet Transplants with 111In-Exendin-3 SPECT/CT.

van der Kroon I, Andralojc K, Willekens SM, Bos D, Joosten L, Boerman OC, Brom M, Gotthardt M.

J Nucl Med. 2016 May;57(5):799-804. doi: 10.2967/jnumed.115.166330. Epub 2016 Jan 21.

22.

The Influence of Emotion Upregulation on the Expectation of Sexual Reward.

Brom M, Laan E, Everaerd W, Spinhoven P, Trimbos B, Both S.

J Sex Med. 2016 Jan;13(1):105-19. doi: 10.1016/j.jsxm.2015.11.003.

PMID:
26755093
23.

SPECT of Transplanted Islets of Langerhans by Dopamine 2 Receptor Targeting in a Rat Model.

Willekens SM, van der Kroon I, Joosten L, Frielink C, Boerman OC, van den Broek SA, Brom M, Gotthardt M.

Mol Pharm. 2016 Jan 4;13(1):85-91. doi: 10.1021/acs.molpharmaceut.5b00518. Epub 2015 Dec 4.

PMID:
26607139
24.

Graft revascularization is essential for non-invasive monitoring of transplanted islets with radiolabeled exendin.

Eter WA, Bos D, Frielink C, Boerman OC, Brom M, Gotthardt M.

Sci Rep. 2015 Oct 22;5:15521. doi: 10.1038/srep15521.

25.

d-Cycloserine reduces context specificity of sexual extinction learning.

Brom M, Laan E, Everaerd W, Spinhoven P, Trimbos B, Both S.

Neurobiol Learn Mem. 2015 Nov;125:202-10. doi: 10.1016/j.nlm.2015.09.010. Epub 2015 Oct 9.

PMID:
26456134
26.

Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers.

Berclaz C, Pache C, Bouwens A, Szlag D, Lopez A, Joosten L, Ekim S, Brom M, Gotthardt M, Grapin-Botton A, Lasser T.

Sci Rep. 2015 May 19;5:10385. doi: 10.1038/srep10385.

27.

The influence of emotion down-regulation on the expectation of sexual reward.

Brom M, Laan E, Everaerd W, Spinhoven P, Cousijn J, Both S.

Behav Ther. 2015 May;46(3):379-94. doi: 10.1016/j.beth.2015.01.005. Epub 2015 Feb 17.

PMID:
25892173
28.

Extinction of aversive classically conditioned human sexual response.

Brom M, Laan E, Everaerd W, Spinhoven P, Both S.

J Sex Med. 2015 Apr;12(4):916-35. doi: 10.1111/jsm.12800. Epub 2014 Dec 17.

PMID:
25515383
29.

(111)In-exendin uptake in the pancreas correlates with the β-cell mass and not with the α-cell mass.

Brom M, Joosten L, Frielink C, Boerman O, Gotthardt M.

Diabetes. 2015 Apr;64(4):1324-8. doi: 10.2337/db14-1212. Epub 2014 Nov 19.

30.

Extinction and renewal of conditioned sexual responses.

Brom M, Laan E, Everaerd W, Spinhoven P, Both S.

PLoS One. 2014 Aug 29;9(8):e105955. doi: 10.1371/journal.pone.0105955. eCollection 2014.

31.

A standardized method for in vivo mouse pancreas imaging and semiquantitative β cell mass measurement by dual isotope SPECT.

Mathijs I, Xavier C, Peleman C, Caveliers V, Brom M, Gotthardt M, Herrera PL, Lahoutte T, Bouwens L.

Mol Imaging Biol. 2015 Feb;17(1):58-66. doi: 10.1007/s11307-014-0771-y.

PMID:
25070262
32.

Preclinical studies of SPECT and PET tracers for NET.

Brom M, Boerman O, Gotthardt M, Oyen WJ.

PET Clin. 2014 Jan;9(1):63-9. doi: 10.1016/j.cpet.2013.08.012. Epub 2013 Oct 4. Review.

PMID:
25029935
33.

A comparison of three (67/68)Ga-labelled exendin-4 derivatives for β-cell imaging on the GLP-1 receptor: the influence of the conjugation site of NODAGA as chelator.

Jodal A, Lankat-Buttgereit B, Brom M, Schibli R, Béhé M.

EJNMMI Res. 2014 Jun 22;4:31. doi: 10.1186/s13550-014-0031-9. eCollection 2014.

34.

Beta cell imaging - a key tool in optimized diabetes prevention and treatment.

Gotthardt M, Eizirik DL, Cnop M, Brom M.

Trends Endocrinol Metab. 2014 Aug;25(8):375-7. doi: 10.1016/j.tem.2014.02.002. Epub 2014 Apr 11.

PMID:
24726483
35.

Non-invasive quantification of the beta cell mass by SPECT with ¹¹¹In-labelled exendin.

Brom M, Woliner-van der Weg W, Joosten L, Frielink C, Bouckenooghe T, Rijken P, Andralojc K, Göke BJ, de Jong M, Eizirik DL, Béhé M, Lahoutte T, Oyen WJ, Tack CJ, Janssen M, Boerman OC, Gotthardt M.

Diabetologia. 2014 May;57(5):950-9. doi: 10.1007/s00125-014-3166-3. Epub 2014 Feb 1.

PMID:
24488022
36.

The role of conditioning, learning and dopamine in sexual behavior: a narrative review of animal and human studies.

Brom M, Both S, Laan E, Everaerd W, Spinhoven P.

Neurosci Biobehav Rev. 2014 Jan;38:38-59. doi: 10.1016/j.neubiorev.2013.10.014. Epub 2013 Nov 6. Review.

PMID:
24211372
37.

Surveillance Programme of Work-related Diseases (WRD) in France.

Valenty M, Homère J, Mevel M, Dourlat T, Garras L, Brom M, Imbernon E.

Saf Health Work. 2012 Mar;3(1):67-70. doi: 10.5491/SHAW.2012.3.1.67. Epub 2012 Mar 8.

38.

Radiolabelled GLP-1 analogues for in vivo targeting of insulinomas.

Brom M, Joosten L, Oyen WJ, Gotthardt M, Boerman OC.

Contrast Media Mol Imaging. 2012 Mar-Apr;7(2):160-6. doi: 10.1002/cmmi.475.

39.

Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis.

Andralojc K, Srinivas M, Brom M, Joosten L, de Vries IJ, Eizirik DL, Boerman OC, Meda P, Gotthardt M.

Diabetologia. 2012 May;55(5):1247-57. doi: 10.1007/s00125-012-2491-7. Epub 2012 Feb 23. Review.

40.

Improved labelling of DTPA- and DOTA-conjugated peptides and antibodies with 111In in HEPES and MES buffer.

Brom M, Joosten L, Oyen WJ, Gotthardt M, Boerman OC.

EJNMMI Res. 2012 Jan 27;2:4. doi: 10.1186/2191-219X-2-4.

41.

[Report on Salmonella isolates submitted to the German National Reference Laboratory for running analyses and tests on zoonoses (Salmonella) in the year 2009].

Friedrich A, Szabo I, Dorn C, Schroeter A, Jaber M, Berendonk G, Brom M, Ledwolorz J, Malorny B, Helmuth R.

Berl Munch Tierarztl Wochenschr. 2011 Sep-Oct;124(9-10):401-10. German.

PMID:
21950218
42.

Preclinical evaluation of 68Ga-DOTA-minigastrin for the detection of cholecystokinin-2/gastrin receptor-positive tumors.

Brom M, Joosten L, Laverman P, Oyen WJ, Béhé M, Gotthardt M, Boerman OC.

Mol Imaging. 2011 Apr;10(2):144-52.

43.

Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice.

Vegt E, Melis M, Eek A, de Visser M, Brom M, Oyen WJ, Gotthardt M, de Jong M, Boerman OC.

Eur J Nucl Med Mol Imaging. 2011 Apr;38(4):623-32. doi: 10.1007/s00259-010-1685-9. Epub 2010 Dec 18.

44.

[Report on Salmonella isolates in livestock, food and feed, received at the German national reference laboratory for Salmonella during 2004-2008].

Friedrich A, Dorn C, Schroeter A, Szabo I, Jaber M, Berendonk G, Brom M, Ledwolorz J, Helmuth R.

Berl Munch Tierarztl Wochenschr. 2010 Jul-Aug;123(7-8):265-77. German.

PMID:
20690538
45.

Vectorial transport of nucleoside analogs from the apical to the basolateral membrane in double-transfected cells expressing the human concentrative nucleoside transporter hCNT3 and the export pump ABCC4.

Rius M, Keller D, Brom M, Hummel-Eisenbeiss J, Lyko F, Keppler D.

Drug Metab Dispos. 2010 Jul;38(7):1054-63. doi: 10.1124/dmd.110.032664. Epub 2010 Apr 1.

PMID:
20360301
46.

Image-quality assessment for several positron emitters using the NEMA NU 4-2008 standards in the Siemens Inveon small-animal PET scanner.

Disselhorst JA, Brom M, Laverman P, Slump CH, Boerman OC, Oyen WJ, Gotthardt M, Visser EP.

J Nucl Med. 2010 Apr;51(4):610-7. doi: 10.2967/jnumed.109.068858. Epub 2010 Mar 17.

47.

Development of radiotracers for the determination of the beta-cell mass in vivo.

Brom M, Andrałojć K, Oyen WJ, Boerman OC, Gotthardt M.

Curr Pharm Des. 2010 May;16(14):1561-7. Review.

PMID:
20146667
48.

68Ga-labelled exendin-3, a new agent for the detection of insulinomas with PET.

Brom M, Oyen WJ, Joosten L, Gotthardt M, Boerman OC.

Eur J Nucl Med Mol Imaging. 2010 Jul;37(7):1345-55. doi: 10.1007/s00259-009-1363-y. Epub 2010 Jan 29.

49.

Autofluorescent proteins as photosensitizer in eukaryontes.

Waldeck W, Mueller G, Wiessler M, Brom M, Tóth K, Braun K.

Int J Med Sci. 2009 Dec 1;6(6):365-73.

50.

Spatial resolution and sensitivity of the Inveon small-animal PET scanner.

Visser EP, Disselhorst JA, Brom M, Laverman P, Gotthardt M, Oyen WJ, Boerman OC.

J Nucl Med. 2009 Jan;50(1):139-47. doi: 10.2967/jnumed.108.055152.

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