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ORMDL3 but not neighboring 17q21 gene LRRC3C is expressed in human lungs and lung cells of asthmatics.

Hur GY, Pham A, Miller M, Weng N, Hu J, Kurten RC, Broide DH.

Allergy. 2020 Feb 22. doi: 10.1111/all.14243. [Epub ahead of print] No abstract available.


Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses.

Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E.

Elife. 2020 Feb 4;9. pii: e49416. doi: 10.7554/eLife.49416.


Unconventional ST2- and CD127-negative lung ILC2 populations are induced by the fungal allergen Alternaria alternata.

Cavagnero KJ, Badrani JH, Naji LH, Amadeo MB, Shah VS, Gasparian S, Pham A, Wang AW, Seumois G, Croft M, Broide DH, Doherty TA.

J Allergy Clin Immunol. 2019 Nov;144(5):1432-1435.e9. doi: 10.1016/j.jaci.2019.07.018. Epub 2019 Jul 29. No abstract available.


Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma.

Hur GY, Broide DH.

Allergy Asthma Immunol Res. 2019 Sep;11(5):604-621. doi: 10.4168/aair.2019.11.5.604. Review.


Platelets attach to lung type 2 innate lymphoid cells (ILC2s) expressing P-selectin glycoprotein ligand 1 and influence ILC2 function.

Karta MR, Cavagnero K, Miller M, Badrani J, Naji L, Doherty TA, Broide DH.

J Allergy Clin Immunol. 2019 Oct;144(4):1112-1115.e8. doi: 10.1016/j.jaci.2019.06.001. Epub 2019 Jun 12. No abstract available.


Airway innate lymphoid cells in the induction and regulation of allergy.

Doherty TA, Broide DH.

Allergol Int. 2019 Jan;68(1):9-16. doi: 10.1016/j.alit.2018.11.001. Epub 2018 Nov 23. Review.


Why Is ORMDL3 on Chromosome 17q21 Highly Linked to Asthma?

Miller M, Broide DH.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):404-406. doi: 10.1164/rccm.201810-1941ED. No abstract available.


Does reduced zona pellucida binding protein 2 (ZPBP2) expression on chromosome 17q21 protect against asthma?

Miller M, Vuong C, Garcia MF, Rosenthal P, Das S, Weng N, Pham A, Kim YJ, Broide DH.

J Allergy Clin Immunol. 2018 Aug;142(2):706-709.e4. doi: 10.1016/j.jaci.2018.04.011. Epub 2018 Apr 28. No abstract available.


Lipid regulation of group 2 innate lymphoid cell function: Moving beyond epithelial cytokines.

Doherty TA, Broide DH.

J Allergy Clin Immunol. 2018 May;141(5):1587-1589. doi: 10.1016/j.jaci.2018.02.034. Epub 2018 Mar 6. No abstract available.


Activating transcription factor 6α (ATF6α) regulates airway hyperreactivity, smooth muscle proliferation, and contractility.

Unno H, Miller M, Rosenthal P, Beppu A, Das S, Broide DH.

J Allergy Clin Immunol. 2018 Jan;141(1):439-442.e4. doi: 10.1016/j.jaci.2017.07.053. Epub 2017 Sep 27. No abstract available.


Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca2+ oscillations in asthma.

Chen J, Miller M, Unno H, Rosenthal P, Sanderson MJ, Broide DH.

J Allergy Clin Immunol. 2018 Jul;142(1):207-218.e6. doi: 10.1016/j.jaci.2017.08.015. Epub 2017 Sep 7.


Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation.

Song DJ, Miller M, Beppu A, Rosenthal P, Das S, Karta M, Vuong C, Mehta AK, Croft M, Broide DH.

J Immunol. 2017 Oct 1;199(7):2215-2224. doi: 10.4049/jimmunol.1601412. Epub 2017 Aug 21.


Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune Diseases.

Das S, Miller M, Broide DH.

Adv Immunol. 2017;135:1-52. doi: 10.1016/ Epub 2017 Jul 19. Review.


Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation.

Lund SJ, Portillo A, Cavagnero K, Baum RE, Naji LH, Badrani JH, Mehta A, Croft M, Broide DH, Doherty TA.

J Immunol. 2017 Aug 1;199(3):1096-1104. doi: 10.4049/jimmunol.1601569. Epub 2017 Jun 30.


Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma.

Liu T, Liu Y, Miller M, Cao L, Zhao J, Wu J, Wang J, Liu L, Li S, Zou M, Xu J, Broide DH, Dong L.

Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L27-L40. doi: 10.1152/ajplung.00510.2016. Epub 2017 May 4.


β2 integrins rather than β1 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung.

Karta MR, Rosenthal PS, Beppu A, Vuong CY, Miller M, Das S, Kurten RC, Doherty TA, Broide DH.

J Allergy Clin Immunol. 2018 Jan;141(1):329-338.e12. doi: 10.1016/j.jaci.2017.03.010. Epub 2017 Mar 30.


Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease.

Eastman JJ, Cavagnero KJ, Deconde AS, Kim AS, Karta MR, Broide DH, Zuraw BL, White AA, Christiansen SC, Doherty TA.

J Allergy Clin Immunol. 2017 Jul;140(1):101-108.e3. doi: 10.1016/j.jaci.2016.11.023. Epub 2017 Mar 6.


Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.

Miller M, Tam AB, Mueller JL, Rosenthal P, Beppu A, Gordillo R, McGeough MD, Vuong C, Doherty TA, Hoffman HM, Niwa M, Broide DH.

J Immunol. 2017 Apr 15;198(8):3017-3022. doi: 10.4049/jimmunol.1601848. Epub 2017 Mar 8.


Hypoxia-inducible factor-1α inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma.

Dewitz C, McEachern E, Shin S, Akong K, Nagle DG, Broide DH, Akuthota P, Crotty Alexander LE.

Clin Immunol. 2017 Mar;176:94-99. doi: 10.1016/j.clim.2017.01.002. Epub 2017 Jan 14.


Pathways to limit group 2 innate lymphoid cell activation.

Doherty TA, Broide DH.

J Allergy Clin Immunol. 2017 May;139(5):1465-1467. doi: 10.1016/j.jaci.2016.12.003. Epub 2017 Jan 10. No abstract available.


Acute renal dysfunction caused by nonsucrose intravenous immunoglobulin in common variable immunodeficiency.

Kim AS, Broide DH.

Ann Allergy Asthma Immunol. 2017 Feb;118(2):231-233. doi: 10.1016/j.anai.2016.11.009. Epub 2016 Dec 23. No abstract available.


Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide.

Miller M, Rosenthal P, Beppu A, Gordillo R, Broide DH.

J Allergy Clin Immunol. 2017 Apr;139(4):1373-1376.e4. doi: 10.1016/j.jaci.2016.08.053. Epub 2016 Nov 5. No abstract available.


GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.

Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide DH.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13132-13137. Epub 2016 Oct 31.


Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma.

Seumois G, Zapardiel-Gonzalo J, White B, Singh D, Schulten V, Dillon M, Hinz D, Broide DH, Sette A, Peters B, Vijayanand P.

J Immunol. 2016 Jul 15;197(2):655-64. doi: 10.4049/jimmunol.1600397. Epub 2016 Jun 6.


TGF-β1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis.

Rawson R, Yang T, Newbury RO, Aquino M, Doshi A, Bell B, Broide DH, Dohil R, Kurten R, Aceves SS.

J Allergy Clin Immunol. 2016 Sep;138(3):791-800.e4. doi: 10.1016/j.jaci.2016.02.028. Epub 2016 Apr 8.


Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis.

Kim AS, Doherty TA, Karta MR, Das S, Baum R, Rosenthal P, Beppu A, Miller M, Kurten R, Broide DH.

J Allergy Clin Immunol. 2016 Oct;138(4):1192-1195.e5. doi: 10.1016/j.jaci.2016.03.017. Epub 2016 Apr 6. No abstract available.


Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma.

Miller M, Esnault S, Kurten RC, Kelly EA, Beppu A, Das S, Rosenthal P, Ramsdell J, Croft M, Zuraw B, Jarjour N, Hamid Q, Broide DH.

J Allergy Clin Immunol. 2016 Aug;138(2):596-599.e4. doi: 10.1016/j.jaci.2016.01.019. Epub 2016 Apr 20. No abstract available.


miR-23∼27∼24 clusters control effector T cell differentiation and function.

Cho S, Wu CJ, Yasuda T, Cruz LO, Khan AA, Lin LL, Nguyen DT, Miller M, Lee HM, Kuo ML, Broide DH, Rajewsky K, Rudensky AY, Lu LF.

J Exp Med. 2016 Feb 8;213(2):235-49. doi: 10.1084/jem.20150990. Epub 2016 Feb 1.


Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.

Karta MR, Broide DH, Doherty TA.

Curr Allergy Asthma Rep. 2016 Jan;16(1):8. doi: 10.1007/s11882-015-0581-6. Review.


Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with the allergen-specific modulation of immune reactivity.

Hinz D, Seumois G, Gholami AM, Greenbaum JA, Lane J, White B, Broide DH, Schulten V, Sidney J, Bakhru P, Oseroff C, Wambre E, James EA, Kwok WW, Peters B, Vijayanand P, Sette A.

Clin Exp Allergy. 2016 May;46(5):705-19. doi: 10.1111/cea.12692.


The TGFβ1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis.

Rawson R, Anilkumar A, Newbury RO, Bafna V, Aquino M, Palmquist J, Hoffman HM, Mueller JL, Dohil R, Broide DH, Aceves SS.

PLoS One. 2015 Dec 14;10(12):e0144651. doi: 10.1371/journal.pone.0144651. eCollection 2015.


Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses.

Zhou W, Toki S, Zhang J, Goleniewksa K, Newcomb DC, Cephus JY, Dulek DE, Bloodworth MH, Stier MT, Polosuhkin V, Gangula RD, Mallal SA, Broide DH, Peebles RS Jr.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):31-42. doi: 10.1164/rccm.201410-1793OC.


Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M.

Miller M, Beppu A, Rosenthal P, Pham A, Das S, Karta M, Song DJ, Vuong C, Doherty T, Croft M, Zuraw B, Zhang X, Gao X, Aceves S, Chouiali F, Hamid Q, Broide DH.

J Immunol. 2015 Oct 15;195(8):3546-56. doi: 10.4049/jimmunol.1501105. Epub 2015 Sep 9.


Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis.

Doherty TA, Baum R, Newbury RO, Yang T, Dohil R, Aquino M, Doshi A, Walford HH, Kurten RC, Broide DH, Aceves S.

J Allergy Clin Immunol. 2015 Sep;136(3):792-794.e3. doi: 10.1016/j.jaci.2015.05.048. Epub 2015 Jul 30. No abstract available.


Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids.

Rajan J, Newbury RO, Anilkumar A, Dohil R, Broide DH, Aceves SS.

J Allergy Clin Immunol. 2016 Jan;137(1):147-156.e8. doi: 10.1016/j.jaci.2015.05.045. Epub 2015 Jul 30.


Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33.

Mehta AK, Duan W, Doerner AM, Traves SL, Broide DH, Proud D, Zuraw BL, Croft M.

J Allergy Clin Immunol. 2016 Jan;137(1):278-288.e6. doi: 10.1016/j.jaci.2015.05.007. Epub 2015 Jun 19.


Group 2 innate lymphoid cells: new players in human allergic diseases.

Doherty TA, Broide DH.

J Investig Allergol Clin Immunol. 2015;25(1):1-11; quiz 2p following 11. Review.


Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma.

Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1529-34. doi: 10.1073/pnas.1417972112. Epub 2015 Jan 20.


MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy.

Beppu L, Yang T, Luk M, Newbury RO, Palmquist J, Dohil R, Kurten RC, Broide DH, Aceves SS.

J Pediatr Gastroenterol Nutr. 2015 Aug;61(2):194-9. doi: 10.1097/MPG.0000000000000668.


Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness.

Walford HH, Lund SJ, Baum RE, White AA, Bergeron CM, Husseman J, Bethel KJ, Scott DR, Khorram N, Miller M, Broide DH, Doherty TA.

Clin Immunol. 2014 Nov;155(1):126-35. doi: 10.1016/j.clim.2014.09.007. Epub 2014 Sep 16.


Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease.

Miyazaki M, Miyazaki K, Chen S, Itoi M, Miller M, Lu LF, Varki N, Chang AN, Broide DH, Murre C.

Nat Immunol. 2014 Aug;15(8):767-76. doi: 10.1038/ni.2928. Epub 2014 Jun 29.


TGF-β1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis.

Beppu LY, Anilkumar AA, Newbury RO, Dohil R, Broide DH, Aceves SS.

J Allergy Clin Immunol. 2014 Nov;134(5):1100-1107.e4. doi: 10.1016/j.jaci.2014.04.004. Epub 2014 May 13.


Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites.

Nonaka M, Bao X, Matsumura F, Götze S, Kandasamy J, Kononov A, Broide DH, Nakayama J, Seeberger PH, Fukuda M.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8173-8. doi: 10.1073/pnas.1319870111. Epub 2014 May 16.


ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.

Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty TA, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide DH.

J Immunol. 2014 Apr 15;192(8):3475-87. doi: 10.4049/jimmunol.1303047. Epub 2014 Mar 12.


Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84.

Doherty TA, Scott D, Walford HH, Khorram N, Lund S, Baum R, Chang J, Rosenthal P, Beppu A, Miller M, Broide DH.

J Allergy Clin Immunol. 2014 Apr;133(4):1203-5. doi: 10.1016/j.jaci.2013.12.1086. Epub 2014 Feb 28. No abstract available.


Targeting AMCase reduces esophageal eosinophilic inflammation and remodeling in a mouse model of egg induced eosinophilic esophagitis.

Cho JY, Rosenthal P, Miller M, Pham A, Aceves S, Sakuda S, Broide DH.

Int Immunopharmacol. 2014 Jan;18(1):35-42. doi: 10.1016/j.intimp.2013.10.026. Epub 2013 Nov 13.


Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production.

Doherty TA, Khorram N, Lund S, Mehta AK, Croft M, Broide DH.

J Allergy Clin Immunol. 2013 Jul;132(1):205-13. doi: 10.1016/j.jaci.2013.03.048. Epub 2013 May 17.


Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis.

Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, Broide DH, Aceves SS.

J Allergy Clin Immunol. 2013 Jun;131(6):1576-82. doi: 10.1016/j.jaci.2013.02.042. Epub 2013 Apr 25.


Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance.

Soroosh P, Doherty TA, Duan W, Mehta AK, Choi H, Adams YF, Mikulski Z, Khorram N, Rosenthal P, Broide DH, Croft M.

J Exp Med. 2013 Apr 8;210(4):775-88. doi: 10.1084/jem.20121849. Epub 2013 Apr 1.


Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model.

Baek KJ, Cho JY, Rosenthal P, Alexander LEC, Nizet V, Broide DH.

Clin Immunol. 2013 Apr;147(1):27-37. doi: 10.1016/j.clim.2013.02.004. Epub 2013 Feb 21.

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