Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 37

1.

Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells.

Marusiak AA, Prelowska MK, Mehlich D, Lazniewski M, Kaminska K, Gorczynski A, Korwat A, Sokolowska O, Kedzierska H, Golab J, Biernat W, Plewczynski D, Brognard J, Nowis D.

Oncogene. 2019 Apr;38(15):2860-2875. doi: 10.1038/s41388-018-0618-0. Epub 2018 Dec 14.

2.

Orange is the new black: Kinases are the new master regulators of tumor suppression.

An E, Brognard J.

IUBMB Life. 2019 Jun;71(6):738-748. doi: 10.1002/iub.1981. Epub 2018 Dec 11. Review.

3.

Shipping Out MEK Inhibitor Resistance with SHP2 Inhibitors.

Torres-Ayuso P, Brognard J.

Cancer Discov. 2018 Oct;8(10):1210-1212. doi: 10.1158/2159-8290.CD-18-0915.

4.

Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin.

Torres-Ayuso P, Sahoo S, Ashton G, An E, Simms N, Galvin M, Leong HS, Frese KK, Simpson K, Cook N, Hughes A, Miller CJ, Marais R, Dive C, Krebs MG, Brognard J.

NPJ Genom Med. 2018 Jun 20;3:15. doi: 10.1038/s41525-018-0055-6. eCollection 2018.

5.

Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.

Callender JA, Yang Y, Lordén G, Stephenson NL, Jones AC, Brognard J, Newton AC.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5497-E5505. doi: 10.1073/pnas.1805046115. Epub 2018 May 29.

6.

Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases.

Hudson AM, Stephenson NL, Li C, Trotter E, Fletcher AJ, Katona G, Bieniasz-Krzywiec P, Howell M, Wirth C, Furney S, Miller CJ, Brognard J.

Sci Signal. 2018 Apr 17;11(526). pii: eaan6776. doi: 10.1126/scisignal.aan6776.

PMID:
29666306
7.

Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53.

Edwards ZC, Trotter EW, Torres-Ayuso P, Chapman P, Wood HM, Nyswaner K, Brognard J.

Cancer Res. 2017 Sep 15;77(18):4961-4972. doi: 10.1158/0008-5472.CAN-17-0267. Epub 2017 Jul 31.

8.

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma.

Girotti MR, Lopes F, Preece N, Niculescu-Duvaz D, Zambon A, Davies L, Whittaker S, Saturno G, Viros A, Pedersen M, Suijkerbuijk BMJM, Menard D, McLeary R, Johnson L, Fish L, Ejiama S, Sanchez-Laorden B, Hohloch J, Carragher N, Macleod K, Ashton G, Marusiak AA, Fusi A, Brognard J, Frame M, Lorigan P, Marais R, Springer C.

Cancer Cell. 2017 Mar 13;31(3):466. doi: 10.1016/j.ccell.2017.02.007. No abstract available.

9.

Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor.

Newton AC, Brognard J.

Trends Pharmacol Sci. 2017 May;38(5):438-447. doi: 10.1016/j.tips.2017.02.002. Epub 2017 Mar 8. Review.

10.

Somatically mutated ABL1 is an actionable and essential NSCLC survival gene.

Testoni E, Stephenson NL, Torres-Ayuso P, Marusiak AA, Trotter EW, Hudson A, Hodgkinson CL, Morrow CJ, Dive C, Brognard J.

EMBO Mol Med. 2016 Feb 1;8(2):105-16. doi: 10.15252/emmm.201505456.

11.

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.

Marusiak AA, Stephenson NL, Baik H, Trotter EW, Li Y, Blyth K, Mason S, Chapman P, Puto LA, Read JA, Brassington C, Pollard HK, Phillips C, Green I, Overman R, Collier M, Testoni E, Miller CJ, Hunter T, Sansom OJ, Brognard J.

Cancer Res. 2016 Feb 1;76(3):724-35. doi: 10.1158/0008-5472.CAN-15-0701-T. Epub 2015 Dec 4.

12.

Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges.

Hudson AM, Wirth C, Stephenson NL, Fawdar S, Brognard J, Miller CJ.

Pharmacogenomics. 2015;16(10):1149-60. doi: 10.2217/pgs.15.60. Epub 2015 Jul 31. Review.

13.

Transcriptional Repressor DAXX Promotes Prostate Cancer Tumorigenicity via Suppression of Autophagy.

Puto LA, Brognard J, Hunter T.

J Biol Chem. 2015 Jun 19;290(25):15406-20. doi: 10.1074/jbc.M115.658765. Epub 2015 Apr 22.

14.

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.

Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC.

Cell. 2015 Jan 29;160(3):489-502. doi: 10.1016/j.cell.2015.01.001. Epub 2015 Jan 22.

15.

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.

Girotti MR, Lopes F, Preece N, Niculescu-Duvaz D, Zambon A, Davies L, Whittaker S, Saturno G, Viros A, Pedersen M, Suijkerbuijk BM, Menard D, McLeary R, Johnson L, Fish L, Ejiama S, Sanchez-Laorden B, Hohloch J, Carragher N, Macleod K, Ashton G, Marusiak AA, Fusi A, Brognard J, Frame M, Lorigan P, Marais R, Springer C.

Cancer Cell. 2015 Jan 12;27(1):85-96. doi: 10.1016/j.ccell.2014.11.006. Epub 2014 Dec 11. Erratum in: Cancer Cell. 2017 Mar 13;31(3):466.

16.

Discrepancies in cancer genomic sequencing highlight opportunities for driver mutation discovery.

Hudson AM, Yates T, Li Y, Trotter EW, Fawdar S, Chapman P, Lorigan P, Biankin A, Miller CJ, Brognard J.

Cancer Res. 2014 Nov 15;74(22):6390-6396. doi: 10.1158/0008-5472.CAN-14-1020. Epub 2014 Sep 25.

17.

Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.

Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3957-65. doi: 10.1073/pnas.1404221111. Epub 2014 Sep 8.

18.

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors.

Marusiak AA, Edwards ZC, Hugo W, Trotter EW, Girotti MR, Stephenson NL, Kong X, Gartside MG, Fawdar S, Hudson A, Breitwieser W, Hayward NK, Marais R, Lo RS, Brognard J.

Nat Commun. 2014 May 22;5:3901. doi: 10.1038/ncomms4901.

19.

Reply: To PMID 23666743.

Belot A, Brognard J, Crow YJ, Bonnefoy N.

Arthritis Rheumatol. 2014 Jan;66(1):229-30. doi: 10.1002/art.38234. No abstract available.

20.

Druggable drivers of lung cancer.

Fawdar S, Edwards ZC, Brognard J.

Oncotarget. 2013 Sep;4(9):1334-5. No abstract available.

21.

Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer.

Fawdar S, Trotter EW, Li Y, Stephenson NL, Hanke F, Marusiak AA, Edwards ZC, Ientile S, Waszkowycz B, Miller CJ, Brognard J.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12426-31. doi: 10.1073/pnas.1305207110. Epub 2013 Jul 8.

22.

Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation.

Belot A, Kasher PR, Trotter EW, Foray AP, Debaud AL, Rice GI, Szynkiewicz M, Zabot MT, Rouvet I, Bhaskar SS, Daly SB, Dickerson JE, Mayer J, O'Sullivan J, Juillard L, Urquhart JE, Fawdar S, Marusiak AA, Stephenson N, Waszkowycz B, W Beresford M, Biesecker LG, C M Black G, René C, Eliaou JF, Fabien N, Ranchin B, Cochat P, Gaffney PM, Rozenberg F, Lebon P, Malcus C, Crow YJ, Brognard J, Bonnefoy N.

Arthritis Rheum. 2013 Aug;65(8):2161-71. doi: 10.1002/art.38008.

23.

Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase.

Brognard J, Zhang YW, Puto LA, Hunter T.

Cancer Res. 2011 Apr 15;71(8):3152-61. doi: 10.1158/0008-5472.CAN-10-3543. Epub 2011 Apr 12.

24.

Protein kinase signaling networks in cancer.

Brognard J, Hunter T.

Curr Opin Genet Dev. 2011 Feb;21(1):4-11. doi: 10.1016/j.gde.2010.10.012. Epub 2010 Nov 29. Review.

25.

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

Zhang YW, Brognard J, Coughlin C, You Z, Dolled-Filhart M, Aslanian A, Manning G, Abraham RT, Hunter T.

Mol Cell. 2009 Aug 28;35(4):442-53. doi: 10.1016/j.molcel.2009.06.030.

26.

Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.

Brognard J, Niederst M, Reyes G, Warfel N, Newton AC.

J Biol Chem. 2009 May 29;284(22):15215-23. doi: 10.1074/jbc.M901468200. Epub 2009 Mar 26.

27.

PHLiPPing the switch on Akt and protein kinase C signaling.

Brognard J, Newton AC.

Trends Endocrinol Metab. 2008 Aug;19(6):223-30. doi: 10.1016/j.tem.2008.04.001. Epub 2008 May 27. Review.

28.

The phosphatase PHLPP controls the cellular levels of protein kinase C.

Gao T, Brognard J, Newton AC.

J Biol Chem. 2008 Mar 7;283(10):6300-11. Epub 2007 Dec 27.

29.
30.

Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.

Tsurutani J, Castillo SS, Brognard J, Granville CA, Zhang C, Gills JJ, Sayyah J, Dennis PA.

Carcinogenesis. 2005 Jul;26(7):1182-95. Epub 2005 Mar 24.

PMID:
15790591
31.

The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.

Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT.

Mol Cell. 2004 Jun 4;14(5):585-98.

32.

Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo.

West KA, Linnoila IR, Brognard J, Belinsky S, Harris C, Dennis PA.

Chest. 2004 May;125(5 Suppl):101S-2S. No abstract available.

PMID:
15136436
33.

Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues.

Castillo SS, Brognard J, Petukhov PA, Zhang C, Tsurutani J, Granville CA, Li M, Jung M, West KA, Gills JG, Kozikowski AP, Dennis PA.

Cancer Res. 2004 Apr 15;64(8):2782-92.

34.

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

Kozikowski AP, Sun H, Brognard J, Dennis PA.

J Am Chem Soc. 2003 Feb 5;125(5):1144-5.

PMID:
12553797
35.

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.

West KA, Brognard J, Clark AS, Linnoila IR, Yang X, Swain SM, Harris C, Belinsky S, Dennis PA.

J Clin Invest. 2003 Jan;111(1):81-90.

Supplemental Content

Loading ...
Support Center