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HBD3 Induces PD-L1 Expression on Head and Neck Squamous Cell Carcinoma Cell Lines.

Gomez Hernandez MP, Bates AM, Starman EE, Lanzel EA, Comnick C, Xie XJ, Brogden KA.

Antibiotics (Basel). 2019 Sep 24;8(4). pii: E161. doi: 10.3390/antibiotics8040161.


Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer.

Fischer CL, Bates AM, Lanzel EA, Guthmiller JM, Johnson GK, Singh NK, Kumar A, Vidva R, Abbasi T, Vali S, Xie XJ, Zeng E, Brogden KA.

Sci Rep. 2019 Jul 26;9(1):10877. doi: 10.1038/s41598-019-47381-4.


255-nm Light-emitting Diode Kills Enterococcus faecalis and Induces the Production of Cellular Biomarkers in Human Embryonic Palatal Mesenchyme Cells and Gingival Fibroblasts.

Morio K, Thayer EL, Bates AM, Brogden KA.

J Endod. 2019 Jun;45(6):774-783.e6. doi: 10.1016/j.joen.2019.02.016. Epub 2019 Mar 29.


Dataset on the chemokine and cytokine responses of multi-cell cultures treated with Porphyromonas gingivalis hemagglutinin B.

Abhyankar VP, Bates AM, Fischer CL, Johnson GK, Guthmiller JM, Progulske-Fox A, Brogden KA.

Data Brief. 2018 Dec 31;22:964-970. doi: 10.1016/j.dib.2018.12.087. eCollection 2019 Feb.


Matrix Metalloproteinase Response of Dendritic Cell, Gingival Epithelial Keratinocyte, and T-Cell Transwell Co-Cultures Treated with Porphyromonas gingivalis Hemagglutinin-B.

Bates AM, Fischer CL, Abhyankar VP, Johnson GK, Guthmiller JM, Progulske-Fox A, Brogden KA.

Int J Mol Sci. 2018 Dec 7;19(12). pii: E3923. doi: 10.3390/ijms19123923.


Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines.

Bates AM, Gomez Hernandez MP, Lanzel EA, Qian F, Brogden KA.

Transl Cancer Res. 2018 Jun;7(3):533-542. doi: 10.21037/tcr.2018.05.09.


Correction to: Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy.

Brogden KA, Parashar D, Hallier AR, Braun T, Qian F, Rizvi NA, Bossler AD, Milhem MM, Chan TA, Abbasi T, Vali S.

BMC Cancer. 2018 Apr 12;18(1):413. doi: 10.1186/s12885-018-4200-5.


Human beta defensin 3 alters matrix metalloproteinase production in human dendritic cells exposed to Porphyromonas gingivalis hemagglutinin B.

Raina M, Bates AM, Fischer CL, Progulske-Fox A, Abbasi T, Vali S, Brogden KA.

J Periodontol. 2018 Mar;89(3):361-369. doi: 10.1002/JPER.17-0366.


Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy.

Brogden KA, Parashar D, Hallier AR, Braun T, Qian F, Rizvi NA, Bossler AD, Milhem MM, Chan TA, Abbasi T, Vali S.

BMC Cancer. 2018 Feb 27;18(1):225. doi: 10.1186/s12885-018-4134-y. Erratum in: BMC Cancer. 2018 Apr 12;18(1):413.


Cell genomics and immunosuppressive biomarker expression influence PD-L1 immunotherapy treatment responses in HNSCC-a computational study.

Bates AM, Lanzel EA, Qian F, Abbasi T, Vali S, Brogden KA.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Aug;124(2):157-164. doi: 10.1016/j.oooo.2017.05.474. Epub 2017 May 25.


Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice.

Li K, Wohlford-Lenane CL, Channappanavar R, Park JE, Earnest JT, Bair TB, Bates AM, Brogden KA, Flaherty HA, Gallagher T, Meyerholz DK, Perlman S, McCray PB Jr.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3119-E3128. doi: 10.1073/pnas.1619109114. Epub 2017 Mar 27.


PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression.

Brogden KA, Vali S, Abbasi T.

Transl Cancer Res. 2016 Dec;5(Suppl 7):S1396-S1399. doi: 10.21037/tcr.2016.12.43. No abstract available.


Diminished Antimicrobial Peptide and Antifungal Antibiotic Activities against Candida albicans in Denture Adhesive.

Bates AM, Garaicoa JL, Fischer CL, Brogden KA.

Antibiotics (Basel). 2017 Feb 6;6(1). pii: E6. doi: 10.3390/antibiotics6010006.


Correction: MicroRNA-200c Represses IL-6, IL-8, and CCL-5 Expression and Enhances Osteogenic Differentiation.

Hong L, Sharp T, Khorsand B, Fischer C, Eliason S, Salem AK, Akkouch A, Brogden K, Amendt BA.

PLoS One. 2016 Dec 29;11(12):e0169381. doi: 10.1371/journal.pone.0169381. eCollection 2016.


Promise of Combining Antifungal Agents in Denture Adhesives to Fight Candida Species Infections.

Garaicoa JL, Fischer CL, Bates AM, Holloway J, Avila-Ortiz G, Guthmiller JM, Johnson GK, Stanford C, Brogden KA.

J Prosthodont. 2018 Oct;27(8):755-762. doi: 10.1111/jopr.12565. Epub 2016 Nov 21.


Expression of Membrane-Bound Mucins and p63 in Distinguishing Mucoepidermoid Carcinoma from Papillary Cystadenoma.

Lanzel EA, Pourian A, Sousa Melo SL, Brogden KA, Hellstein JW.

Head Neck Pathol. 2016 Dec;10(4):521-526. Epub 2016 Jun 9.


Predicting PD-L1 expression on human cancer cells using next-generation sequencing information in computational simulation models.

Lanzel EA, Paula Gomez Hernandez M, Bates AM, Treinen CN, Starman EE, Fischer CL, Parashar D, Guthmiller JM, Johnson GK, Abbasi T, Vali S, Brogden KA.

Cancer Immunol Immunother. 2016 Dec;65(12):1511-1522. Epub 2016 Sep 29.


MicroRNA-200c Represses IL-6, IL-8, and CCL-5 Expression and Enhances Osteogenic Differentiation.

Hong L, Sharp T, Khorsand B, Fischer C, Eliason S, Salem A, Akkouch A, Brogden K, Amendt BA.

PLoS One. 2016 Aug 16;11(8):e0160915. doi: 10.1371/journal.pone.0160915. eCollection 2016. Erratum in: PLoS One. 2016 Dec 29;11(12 ):e0169381.


Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells.

Mehalick LA, Poulsen C, Fischer CL, Lanzel EA, Bates AM, Walters KS, Cavanaugh JE, Guthmiller JM, Johnson GK, Wertz PW, Brogden KA.

Data Brief. 2015 Sep 7;5:285-91. doi: 10.1016/j.dib.2015.08.025. eCollection 2015 Dec.


Protein Analysis of Sapienic Acid-Treated Porphyromonas gingivalis Suggests Differential Regulation of Multiple Metabolic Pathways.

Fischer CL, Dawson DV, Blanchette DR, Drake DR, Wertz PW, Brogden KA.

J Bacteriol. 2015 Oct 19;198(1):157-67. doi: 10.1128/JB.00665-15. Print 2016 Jan 1.


Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial keratinocytes in cell culture conditions.

Leelakanok N, Fischer CL, Bates AM, Guthmiller JM, Johnson GK, Salem AK, Brogden KA, Brogden NK.

Toxicol Lett. 2015 Dec 3;239(2):90-6. doi: 10.1016/j.toxlet.2015.09.006. Epub 2015 Sep 11.


Novel biomarkers of periodontitis and/or obesity in saliva-An exploratory analysis.

Recker EN, Brogden KA, Avila-Ortiz G, Fischer CL, Pagan-Rivera K, Dawson DV, Smith KM, Elangovan S.

Arch Oral Biol. 2015 Oct;60(10):1503-9. doi: 10.1016/j.archoralbio.2015.07.006. Epub 2015 Jul 14.


Age-dependent variation in cytokines, chemokines, and biologic analytes rinsed from the surface of healthy human skin.

Kinn PM, Holdren GO, Westermeyer BA, Abuissa M, Fischer CL, Fairley JA, Brogden KA, Brogden NK.

Sci Rep. 2015 Jun 2;5:10472. doi: 10.1038/srep10472.


Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells.

Poulsen C, Mehalick LA, Fischer CL, Lanzel EA, Bates AM, Walters KS, Cavanaugh JE, Guthmiller JM, Johnson GK, Wertz PW, Brogden KA.

Toxicol Lett. 2015 Aug 19;237(1):21-9. doi: 10.1016/j.toxlet.2015.05.012. Epub 2015 May 21.


Antimicrobial Activity of Chemokine CXCL10 for Dermal and Oral Microorganisms.

Holdren GO, Rosenthal DJ, Yang J, Bates AM, Fischer CL, Zhang Y, Brogden NK, Brogden KA.

Antibiotics (Basel). 2014 Oct 23;3(4):527-39. doi: 10.3390/antibiotics3040527.


Body fat indices and biomarkers of inflammation: a cross-sectional study with implications for obesity and peri-implant oral health.

Elangovan S, Brogden KA, Dawson DV, Blanchette D, Pagan-Rivera K, Stanford CM, Johnson GK, Recker E, Bowers R, Haynes WG, Avila-Ortiz G.

Int J Oral Maxillofac Implants. 2014 Nov-Dec;29(6):1429-34. doi: 10.11607/jomi.3758.


A cross-sectional assessment of biomarker levels around implants versus natural teeth in periodontal maintenance patients.

Recker EN, Avila-Ortiz G, Fischer CL, Pagan-Rivera K, Brogden KA, Dawson DV, Elangovan S.

J Periodontol. 2015 Feb;86(2):264-72. doi: 10.1902/jop.2014.140354. Epub 2014 Sep 30.


Human β-defensin HBD3 binds to immobilized Bla g2 from the German cockroach (Blattella germanica).

Dietrich DE, Martin AD, Brogden KA.

Peptides. 2014 Mar;53:265-9. doi: 10.1016/j.peptides.2014.01.017. Epub 2014 Feb 2.


Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses.

Borgwardt DS, Martin AD, Van Hemert JR, Yang J, Fischer CL, Recker EN, Nair PR, Vidva R, Chandrashekaraiah S, Progulske-Fox A, Drake D, Cavanaugh JE, Vali S, Zhang Y, Brogden KA.

Sci Rep. 2014 Jan 29;4:3904. doi: 10.1038/srep03904.


Comparison of pro-inflammatory cytokines and bone metabolism mediators around titanium and zirconia dental implant abutments following a minimum of 6 months of clinical function.

Barwacz CA, Brogden KA, Stanford CM, Dawson DV, Recker EN, Blanchette D.

Clin Oral Implants Res. 2015 Apr;26(4):e35-e41. doi: 10.1111/clr.12326. Epub 2014 Jan 13.


Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.

Cassel SL, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, Iwakura Y, Shayakhmetov DM, Bassuk AG, Abu-Amer Y, Brogden KA, Burns TL, Sutterwala FS, Ferguson PJ.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1072-7. doi: 10.1073/pnas.1318685111. Epub 2014 Jan 6.


Oral inflammation, a role for antimicrobial peptide modulation of cytokine and chemokine responses.

Brogden KA, Johnson GK, Vincent SD, Abbasi T, Vali S.

Expert Rev Anti Infect Ther. 2013 Oct;11(10):1097-113. doi: 10.1586/14787210.2013.836059. Review.


The roles of cutaneous lipids in host defense.

Fischer CL, Blanchette DR, Brogden KA, Dawson DV, Drake DR, Hill JR, Wertz PW.

Biochim Biophys Acta. 2014 Mar;1841(3):319-22. doi: 10.1016/j.bbalip.2013.08.012. Epub 2013 Aug 29. Review.


Oral mucosal lipids are antibacterial against Porphyromonas gingivalis, induce ultrastructural damage, and alter bacterial lipid and protein compositions.

Fischer CL, Walters KS, Drake DR, Dawson DV, Blanchette DR, Brogden KA, Wertz PW.

Int J Oral Sci. 2013 Sep;5(3):130-40. doi: 10.1038/ijos.2013.28. Epub 2013 Jul 19.


Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus.

Harvey LE, Kohlgraf KG, Mehalick LA, Raina M, Recker EN, Radhakrishnan S, Prasad SA, Vidva R, Progulske-Fox A, Cavanaugh JE, Vali S, Brogden KA.

Sci Rep. 2013;3:1232. doi: 10.1038/srep01232. Epub 2013 Feb 6.


Organization, barrier function and antimicrobial lipids of the oral mucosa.

Dawson DV, Drake DR, Hill JR, Brogden KA, Fischer CL, Wertz PW.

Int J Cosmet Sci. 2013 Jun;35(3):220-3. doi: 10.1111/ics.12038. Epub 2013 Feb 9. Review.


Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage.

Fischer CL, Walters KS, Drake DR, Blanchette DR, Dawson DV, Brogden KA, Wertz PW.

Skin Pharmacol Physiol. 2013;26(1):36-44. doi: 10.1159/000343175. Epub 2012 Oct 30.


Human β-defensin-3 alters, but does not inhibit, the binding of Porphyromonas gingivalis haemagglutinin B to the surface of human dendritic cells.

Van Hemert JR, Recker EN, Dietrich D, Progulske-Fox A, Kurago ZB, Walters KS, Cavanaugh JE, Brogden KA.

Int J Antimicrob Agents. 2012 Jul;40(1):75-9. doi: 10.1016/j.ijantimicag.2012.03.007. Epub 2012 May 9.


The emerging role of peptides and lipids as antimicrobial epidermal barriers and modulators of local inflammation.

Brogden NK, Mehalick L, Fischer CL, Wertz PW, Brogden KA.

Skin Pharmacol Physiol. 2012;25(4):167-81. doi: 10.1159/000337927. Epub 2012 Apr 26. Review.


Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria.

Fischer CL, Drake DR, Dawson DV, Blanchette DR, Brogden KA, Wertz PW.

Antimicrob Agents Chemother. 2012 Mar;56(3):1157-61. doi: 10.1128/AAC.05151-11. Epub 2011 Dec 12.


Inflammatory mediators in fluid extracted from the coronal occlusal dentine of trimmed teeth.

Geraldeli S, Li Y, Hogan MM, Tjaderhane LS, Pashley DH, Morgan TA, Zimmerman MB, Brogden KA.

Arch Oral Biol. 2012 Mar;57(3):264-70. doi: 10.1016/j.archoralbio.2011.08.012. Epub 2011 Sep 18.


Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay.

Kohlgraf KG, Ackermann AR, Burnell KK, Srikantha RN, Joly SA, Bartlett JA, Gakhar L, Johnson GK, McCray PB Jr, Guthmiller JM, Brogden KA.

Arch Oral Biol. 2012 Feb;57(2):197-204. doi: 10.1016/j.archoralbio.2011.08.013. Epub 2011 Sep 16.


Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?

Brogden NK, Brogden KA.

Int J Antimicrob Agents. 2011 Sep;38(3):217-25. doi: 10.1016/j.ijantimicag.2011.05.004. Epub 2011 Jul 5. Review.


Streptococcus mutans strains recovered from caries-active or caries-free individuals differ in sensitivity to host antimicrobial peptides.

Phattarataratip E, Olson B, Broffitt B, Qian F, Brogden KA, Drake DR, Levy SM, Banas JA.

Mol Oral Microbiol. 2011 Jun;26(3):187-99. doi: 10.1111/j.2041-1014.2011.00607.x. Epub 2011 Jan 31.


Presence of wax esters and squalene in human saliva.

Brasser AJ, Barwacz CA, Dawson DV, Brogden KA, Drake DR, Wertz PW.

Arch Oral Biol. 2011 Jun;56(6):588-91. doi: 10.1016/j.archoralbio.2010.12.002. Epub 2011 Jan 17.


Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis.

Tymkiw KD, Thunell DH, Johnson GK, Joly S, Burnell KK, Cavanaugh JE, Brogden KA, Guthmiller JM.

J Clin Periodontol. 2011 Mar;38(3):219-28. doi: 10.1111/j.1600-051X.2010.01684.x. Epub 2010 Dec 29.


Communication: Antimicrobial Activity of SMAP28 with a Targeting Domain for Porphyromonas gingivalis.

Bratt CL, Kohlgraf KG, Yohnke K, Kummet C, Dawson DV, Brogden KA.

Probiotics Antimicrob Proteins. 2010 Mar 1;2(1):21-5. doi: 10.1007/s12602-009-9028-5.


Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.

Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA 4th, Chang EH, Taft PJ, Ludwig PS, Estin M, Hornick EE, Launspach JL, Samuel M, Rokhlina T, Karp PH, Ostedgaard LS, Uc A, Starner TD, Horswill AR, Brogden KA, Prather RS, Richter SS, Shilyansky J, McCray PB Jr, Zabner J, Welsh MJ.

Sci Transl Med. 2010 Apr 28;2(29):29ra31. doi: 10.1126/scitranslmed.3000928.


Defensins attenuate cytokine responses yet enhance antibody responses to Porphyromonas gingivalis adhesins in mice.

Kohlgraf KG, Ackermann A, Lu X, Burnell K, Bélanger M, Cavanaugh JE, Xie H, Progulske-Fox A, Brogden KA.

Future Microbiol. 2010 Jan;5(1):115-25. doi: 10.2217/fmb.09.107.


Defensins as anti-inflammatory compounds and mucosal adjuvants.

Kohlgraf KG, Pingel LC, Dietrich DE, Brogden KA.

Future Microbiol. 2010 Jan;5(1):99-113. doi: 10.2217/fmb.09.104. Review.

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