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Fluorescent labelling of membrane fatty acid transporter CD36 (SR-B2) in the extracellular loop.

Liu Y, Rodriguez-Calvo R, Wang S, Zhu X, Broers JLV, Glatz JFC, Luiken JJFP, Neumann D.

PLoS One. 2019 Jan 23;14(1):e0210704. doi: 10.1371/journal.pone.0210704. eCollection 2019.


Assessment of fibroblast nuclear morphology aids interpretation of LMNA variants.

van Tienen FHJ, Lindsey PJ, Kamps MAF, Krapels IP, Ramaekers FCS, Brunner HG, van den Wijngaard A, Broers JLV.

Eur J Hum Genet. 2019 Mar;27(3):389-399. doi: 10.1038/s41431-018-0294-0. Epub 2018 Nov 12.


The 180 splice variant of NCAM-containing exon 18-is specifically expressed in small cell lung cancer cells.

Vander Borght A, Duysinx M, Broers JLV, Ummelen M, Falkenberg FW, Hahnel C, van der Zeijst BAM.

Transl Lung Cancer Res. 2018 Jun;7(3):376-388. doi: 10.21037/tlcr.2018.03.03.


A rare missense mutation in GJB3 (Cx31G45E) is associated with a unique cellular phenotype resulting in necrotic cell death.

Easton JA, Albuloushi AK, Kamps MAF, Brouns GHMR, Broers JLV, Coull BJ, Oji V, van Geel M, van Steensel MAM, Martin PE.

Exp Dermatol. 2019 Oct;28(10):1106-1113. doi: 10.1111/exd.13542. Epub 2018 May 10.


Lamin A/C-Related Cardiac Disease: Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation.

Hoorntje ET, Bollen IA, Barge-Schaapveld DQ, van Tienen FH, Te Meerman GJ, Jansweijer JA, van Essen AJ, Volders PG, Constantinescu AA, van den Akker PC, van Spaendonck-Zwarts KY, Oldenburg RA, Marcelis CL, van der Smagt JJ, Hennekam EA, Vink A, Bootsma M, Aten E, Wilde AA, van den Wijngaard A, Broers JL, Jongbloed JD, van der Velden J, van den Berg MP, van Tintelen JP.

Circ Cardiovasc Genet. 2017 Aug;10(4). pii: e001631. doi: 10.1161/CIRCGENETICS.116.001631.


Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts.

van Loosdregt IAEW, Kamps MAF, Oomens CWJ, Loerakker S, Broers JLV, Bouten CVC.

Integr Biol (Camb). 2017 Aug 14;9(8):709-721. doi: 10.1039/c7ib00069c.


Cellular strain avoidance is mediated by a functional actin cap - observations in an Lmna-deficient cell model.

Tamiello C, Halder M, Kamps MA, Baaijens FP, Broers JL, Bouten CV.

J Cell Sci. 2017 Feb 15;130(4):779-790. doi: 10.1242/jcs.184838. Epub 2017 Jan 6.


Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments.

Tamiello C, Buskermolen ABC, Baaijens FPT, Broers JLV, Bouten CVC.

Cell Mol Bioeng. 2016;9:12-37. doi: 10.1007/s12195-015-0422-7. Epub 2015 Nov 2. Review.


Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates.

Sieprath T, Corne TD, Nooteboom M, Grootaert C, Rajkovic A, Buysschaert B, Robijns J, Broers JL, Ramaekers FC, Koopman WJ, Willems PH, De Vos WH.

Nucleus. 2015;6(3):236-46. doi: 10.1080/19491034.2015.1050568. Epub 2015 May 21.


The role of the nuclear lamina in cancer and apoptosis.

Broers JL, Ramaekers FC.

Adv Exp Med Biol. 2014;773:27-48. doi: 10.1007/978-1-4899-8032-8_2. Review.


Birt-Hogg-Dube syndrome is a novel ciliopathy.

Luijten MN, Basten SG, Claessens T, Vernooij M, Scott CL, Janssen R, Easton JA, Kamps MA, Vreeburg M, Broers JL, van Geel M, Menko FH, Harbottle RP, Nookala RK, Tee AR, Land SC, Giles RH, Coull BJ, van Steensel MA.

Hum Mol Genet. 2013 Nov 1;22(21):4383-97. doi: 10.1093/hmg/ddt288. Epub 2013 Jun 19.


Soft substrates normalize nuclear morphology and prevent nuclear rupture in fibroblasts from a laminopathy patient with compound heterozygous LMNA mutations.

Tamiello C, Kamps MA, van den Wijngaard A, Verstraeten VL, Baaijens FP, Broers JL, Bouten CC.

Nucleus. 2013 Jan-Feb;4(1):61-73. doi: 10.4161/nucl.23388. Epub 2013 Jan 1.


Overexpression of vesicle-associated membrane protein (VAMP) 3, but not VAMP2, protects glucose transporter (GLUT) 4 protein translocation in an in vitro model of cardiac insulin resistance.

Schwenk RW, Angin Y, Steinbusch LK, Dirkx E, Hoebers N, Coumans WA, Bonen A, Broers JL, van Eys GJ, Glatz JF, Luiken JJ.

J Biol Chem. 2012 Oct 26;287(44):37530-9. doi: 10.1074/jbc.M112.363630. Epub 2012 Aug 30.


Cytoplasmic localization of PML particles in laminopathies.

Houben F, De Vos WH, Krapels IP, Coorens M, Kierkels GJ, Kamps MA, Verstraeten VL, Marcelis CL, van den Wijngaard A, Ramaekers FC, Broers JL.

Histochem Cell Biol. 2013 Jan;139(1):119-34. doi: 10.1007/s00418-012-1005-5. Epub 2012 Aug 25.


Effects of ethanol and acetaldehyde on tight junction integrity: in vitro study in a three dimensional intestinal epithelial cell culture model.

Elamin E, Jonkers D, Juuti-Uusitalo K, van Ijzendoorn S, Troost F, Duimel H, Broers J, Verheyen F, Dekker J, Masclee A.

PLoS One. 2012;7(4):e35008. doi: 10.1371/journal.pone.0035008. Epub 2012 Apr 19.


Health reform: a community experience using design research as a guide.

Severson MA, Wood DL, Chastain CN, Lee LG, Rees AC, Agerter DC, Holtz CP, Broers JK, Savoleinen KH, Spurrier BR, Larusso NF.

Mayo Clin Proc. 2011 Oct;86(10):973-80. doi: 10.4065/mcp.2011.0225.


Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies.

De Vos WH, Houben F, Kamps M, Malhas A, Verheyen F, Cox J, Manders EM, Verstraeten VL, van Steensel MA, Marcelis CL, van den Wijngaard A, Vaux DJ, Ramaekers FC, Broers JL.

Hum Mol Genet. 2011 Nov 1;20(21):4175-86. doi: 10.1093/hmg/ddr344. Epub 2011 Aug 10.


Multiplexed profiling of secreted proteins for the detection of potential space biomarkers.

Dieriks B, De Vos WH, Moreels M, Ghardi M, Hennekam R, Broers JL, Baatout S, van Oostveldt P.

Mol Med Rep. 2011 Jan-Feb;4(1):17-23. doi: 10.3892/mmr.2010.405. Epub 2010 Nov 30.


Reorganization of the nuclear lamina and cytoskeleton in adipogenesis.

Verstraeten VL, Renes J, Ramaekers FC, Kamps M, Kuijpers HJ, Verheyen F, Wabitsch M, Steijlen PM, van Steensel MA, Broers JL.

Histochem Cell Biol. 2011 Mar;135(3):251-61. doi: 10.1007/s00418-011-0792-4. Epub 2011 Feb 25.


Electrical signals affect the cardiomyocyte transcriptome independently of contraction.

Martherus RS, Vanherle SJ, Timmer ED, Zeijlemaker VA, Broers JL, Smeets HJ, Geraedts JP, Ayoubi TA.

Physiol Genomics. 2010 Nov 29;42A(4):283-9. doi: 10.1152/physiolgenomics.00182.2009. Epub 2010 Sep 21.


Building a home. Twenty tips for creating a medical home.

Dehnel P, Peitso M, Golnik A, Harvieux G, Kopski K, Broers J, Jewett T, Walters S, Coy H.

Minn Med. 2010 Jan;93(1):32-5. No abstract available.


Increased plasticity of the nuclear envelope and hypermobility of telomeres due to the loss of A-type lamins.

De Vos WH, Houben F, Hoebe RA, Hennekam R, van Engelen B, Manders EM, Ramaekers FC, Broers JL, Van Oostveldt P.

Biochim Biophys Acta. 2010 Apr;1800(4):448-58. doi: 10.1016/j.bbagen.2010.01.002. Epub 2010 Jan 14.


Absence of platelet-dependent fibrin formation in a patient with Scott syndrome.

Wielders SJ, Broers J, ten Cate H, Collins PW, Bevers EM, Lindhout T.

Thromb Haemost. 2009 Jul;102(1):76-82. doi: 10.1160/TH08-11-0719.


The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress.

Verstraeten VL, Caputo S, van Steensel MA, Duband-Goulet I, Zinn-Justin S, Kamps M, Kuijpers HJ, Ostlund C, Worman HJ, Briedé JJ, Le Dour C, Marcelis CL, van Geel M, Steijlen PM, van den Wijngaard A, Ramaekers FC, Broers JL.

J Cell Mol Med. 2009 May;13(5):959-71. doi: 10.1111/j.1582-4934.2009.00690.x. Epub 2009 Feb 11.


Disturbed nuclear orientation and cellular migration in A-type lamin deficient cells.

Houben F, Willems CH, Declercq IL, Hochstenbach K, Kamps MA, Snoeckx LH, Ramaekers FC, Broers JL.

Biochim Biophys Acta. 2009 Feb;1793(2):312-24. doi: 10.1016/j.bbamcr.2008.10.003. Epub 2008 Oct 25.


A newly identified splice site mutation in ZMPSTE24 causes restrictive dermopathy in the Middle East.

Sander CS, Salman N, van Geel M, Broers JL, Al-Rahmani A, Chedid F, Hausser I, Oji V, Al Nuaimi K, Berger TG, Verstraeten VL.

Br J Dermatol. 2008 Sep;159(4):961-7. doi: 10.1111/j.1365-2133.2008.08772.x. Epub 2008 Jul 30.


The nuclear envelope, a key structure in cellular integrity and gene expression.

Verstraeten VL, Broers JL, Ramaekers FC, van Steensel MA.

Curr Med Chem. 2007;14(11):1231-48. Review.


Dual roles of intermediate filaments in apoptosis.

Marceau N, Schutte B, Gilbert S, Loranger A, Henfling ME, Broers JL, Mathew J, Ramaekers FC.

Exp Cell Res. 2007 Jun 10;313(10):2265-81. Epub 2007 Apr 11. Review.


Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts.

Pekovic V, Harborth J, Broers JL, Ramaekers FC, van Engelen B, Lammens M, von Zglinicki T, Foisner R, Hutchison C, Markiewicz E.

J Cell Biol. 2007 Jan 15;176(2):163-72.


Role of nuclear lamina-cytoskeleton interactions in the maintenance of cellular strength.

Houben F, Ramaekers FC, Snoeckx LH, Broers JL.

Biochim Biophys Acta. 2007 May;1773(5):675-86. Epub 2006 Sep 19. Review.


The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.

Markiewicz E, Tilgner K, Barker N, van de Wetering M, Clevers H, Dorobek M, Hausmanowa-Petrusewicz I, Ramaekers FC, Broers JL, Blankesteijn WM, Salpingidou G, Wilson RG, Ellis JA, Hutchison CJ.

EMBO J. 2006 Jul 26;25(14):3275-85. Epub 2006 Jul 20.


Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation.

Verstraeten VL, Broers JL, van Steensel MA, Zinn-Justin S, Ramaekers FC, Steijlen PM, Kamps M, Kuijpers HJ, Merckx D, Smeets HJ, Hennekam RC, Marcelis CL, van den Wijngaard A.

Hum Mol Genet. 2006 Aug 15;15(16):2509-22. Epub 2006 Jul 6.


Nuclear lamins: laminopathies and their role in premature ageing.

Broers JL, Ramaekers FC, Bonne G, Yaou RB, Hutchison CJ.

Physiol Rev. 2006 Jul;86(3):967-1008. Review.


A-type lamins are essential for TGF-beta1 induced PP2A to dephosphorylate transcription factors.

Van Berlo JH, Voncken JW, Kubben N, Broers JL, Duisters R, van Leeuwen RE, Crijns HJ, Ramaekers FC, Hutchison CJ, Pinto YM.

Hum Mol Genet. 2005 Oct 1;14(19):2839-49. Epub 2005 Aug 22.


Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization.

Broers JL, Kuijpers HJ, Ostlund C, Worman HJ, Endert J, Ramaekers FC.

Exp Cell Res. 2005 Apr 1;304(2):582-92. Epub 2004 Dec 20.


Dynamics of nuclear lamina assembly and disassembly.

Broers JL, Ramaekers FC.

Symp Soc Exp Biol. 2004;(56):177-92. Review.



Broers JL, Hutchison CJ, Ramaekers FC.

J Pathol. 2004 Nov;204(4):478-88. Review.


Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.

Broers JL, Peeters EA, Kuijpers HJ, Endert J, Bouten CV, Oomens CW, Baaijens FP, Ramaekers FC.

Hum Mol Genet. 2004 Nov 1;13(21):2567-80. Epub 2004 Sep 14.


Principal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation.

Lecut C, Schoolmeester A, Kuijpers MJ, Broers JL, van Zandvoort MA, Vanhoorelbeke K, Deckmyn H, Jandrot-Perrus M, Heemskerk JW.

Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1727-33. Epub 2004 Jul 1.


Electric discharge plasmas influence attachment of cultured CHO K1 cells.

Kieft IE, Broers JL, Caubet-Hilloutou V, Slaaf DW, Ramaekers FC, Stoffels E.

Bioelectromagnetics. 2004 Jul;25(5):362-8.


Facilitating roles of murine platelet glycoprotein Ib and alphaIIbbeta3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formation.

Kuijpers MJ, Schulte V, Oury C, Lindhout T, Broers J, Hoylaerts MF, Nieswandt B, Heemskerk JW.

J Physiol. 2004 Jul 15;558(Pt 2):403-15. Epub 2004 May 21.


Partial cleavage of A-type lamins concurs with their total disintegration from the nuclear lamina during apoptosis.

Broers JL, Bronnenberg NM, Kuijpers HJ, Schutte B, Hutchison CJ, Ramaekers FC.

Eur J Cell Biol. 2002 Dec;81(12):677-91.


Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma.

Tilli CM, Ramaekers FC, Broers JL, Hutchison CJ, Neumann HA.

Br J Dermatol. 2003 Jan;148(1):102-9.


Glutathione oxidation in calcium- and p38 MAPK-dependent membrane blebbing of endothelial cells.

van Gorp RM, Heeneman S, Broers JL, Bronnenberg NM, van Dam-Mieras MC, Heemskerk JW.

Biochim Biophys Acta. 2002 Aug 19;1591(1-3):129-138.


Quantification of cytoskeletal deformation in living cells based on hierarchical feature vector matching.

Delhaas T, Van Engeland S, Broers J, Bouten C, Kuijpers N, Ramaekers F, Snoeckx LH.

Am J Physiol Cell Physiol. 2002 Aug;283(2):C639-45.


Discrimination of DNA and RNA in cells by a vital fluorescent probe: lifetime imaging of SYTO13 in healthy and apoptotic cells.

van Zandvoort MA, de Grauw CJ, Gerritsen HC, Broers JL, oude Egbrink MG, Ramaekers FC, Slaaf DW.

Cytometry. 2002 Apr 1;47(4):226-35.


The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion.

Gruijthuijsen YK, Casarosa P, Kaptein SJ, Broers JL, Leurs R, Bruggeman CA, Smit MJ, Vink C.

J Virol. 2002 Feb;76(3):1328-38.


Both emerin and lamin C depend on lamin A for localization at the nuclear envelope.

Vaughan A, Alvarez-Reyes M, Bridger JM, Broers JL, Ramaekers FC, Wehnert M, Morris GE, Whitfield WGF, Hutchison CJ.

J Cell Sci. 2001 Jul;114(Pt 14):2577-90.


Disease management strategies: managing care giving in managed care.

Nesse RE, Hagedorn SD, Scheitel SM, Nyman MA, Broers JK.

Qual Manag Health Care. 2000 Fall;9(1):42-8.


Improving hypertension control: a team approach in a primary care setting.

Stroebel RJ, Broers JK, Houle SK, Scott CG, Naessens JM.

Jt Comm J Qual Improv. 2000 Nov;26(11):623-32.


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