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Leucinostatin acts as a co-inducer for heat shock protein 70 in cultured canine retinal pigment epithelial cells.

Lyu Q, Ludwig IS, Kooten PJS, Sijts AJAM, Rutten VPMG, van Eden W, Broere F.

Cell Stress Chaperones. 2020 Jan 15. doi: 10.1007/s12192-019-01066-z. [Epub ahead of print]


Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis.

Spiering R, Jansen MAA, Wood MJ, Fath AA, Eltherington O, Anderson AE, Pratt AG, van Eden W, Isaacs JD, Broere F, Hilkens CMU.

J Transl Med. 2019 Nov 14;17(1):375. doi: 10.1186/s12967-019-2128-4.


Matured Tolerogenic Dendritic Cells Effectively Inhibit Autoantigen Specific CD4+ T Cells in a Murine Arthritis Model.

Jansen MAA, Spiering R, Ludwig IS, van Eden W, Hilkens CMU, Broere F.

Front Immunol. 2019 Aug 28;10:2068. doi: 10.3389/fimmu.2019.02068. eCollection 2019.


Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model.

Jansen MAA, Klausen LH, Thanki K, Lyngsø J, Skov Pedersen J, Franzyk H, Nielsen HM, van Eden W, Dong M, Broere F, Foged C, Zeng X.

Eur J Pharm Biopharm. 2019 Sep;142:38-48. doi: 10.1016/j.ejpb.2019.06.009. Epub 2019 Jun 11.


Heat Shock Proteins Can Be Surrogate Autoantigens for Induction of Antigen Specific Therapeutic Tolerance in Rheumatoid Arthritis.

van Eden W, Jansen MAA, Ludwig IS, Leufkens P, van der Goes MC, van Laar JM, Broere F.

Front Immunol. 2019 Feb 22;10:279. doi: 10.3389/fimmu.2019.00279. eCollection 2019. Review.


The bacterial and fungal microbiome of the skin of healthy dogs and dogs with atopic dermatitis and the impact of topical antimicrobial therapy, an exploratory study.

Chermprapai S, Ederveen THA, Broere F, Broens EM, Schlotter YM, van Schalkwijk S, Boekhorst J, van Hijum SAFT, Rutten VPMG.

Vet Microbiol. 2019 Feb;229:90-99. doi: 10.1016/j.vetmic.2018.12.022. Epub 2018 Dec 21.


Immunization of young heifers with staphylococcal immune evasion proteins before natural exposure to Staphylococcus aureus induces a humoral immune response in serum and milk.

Benedictus L, Ravesloot L, Poppe K, Daemen I, Boerhout E, van Strijp J, Broere F, Rutten V, Koets A, Eisenberg S.

BMC Vet Res. 2019 Jan 7;15(1):15. doi: 10.1186/s12917-018-1765-9.


A canine keratinocyte cell line expresses antimicrobial peptide and cytokine genes upon stimulation with bacteria, microbial ligands and recombinant cytokines.

Chermprapai S, Broere F, Schlotter YM, Veldhuizen EJA, Rutten VPMG.

Vet Immunol Immunopathol. 2018 Dec;206:35-40. doi: 10.1016/j.vetimm.2018.11.009. Epub 2018 Nov 13.


Lactobacillus rhamnosus GG-Derived Soluble Mediators Modulate Adaptive Immune Cells.

Ludwig IS, Broere F, Manurung S, Lambers TT, van der Zee R, van Eden W.

Front Immunol. 2018 Jul 10;9:1546. doi: 10.3389/fimmu.2018.01546. eCollection 2018.


Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design.

de Groot AM, Thanki K, Gangloff M, Falkenberg E, Zeng X, van Bijnen DCJ, van Eden W, Franzyk H, Nielsen HM, Broere F, Gay NJ, Foged C, Sijts AJAM.

Mol Ther Nucleic Acids. 2018 Jun 1;11:159-169. doi: 10.1016/j.omtn.2018.02.003. Epub 2018 Feb 13.


Routing dependent immune responses after experimental R848-adjuvated vaccination.

van Aalst S, Jansen MAA, Ludwig IS, van der Zee R, van Eden W, Broere F.

Vaccine. 2018 Mar 7;36(11):1405-1413. doi: 10.1016/j.vaccine.2018.01.077.


The Immunomodulatory Potential of tolDCs Loaded with Heat Shock Proteins.

van Eden W, Jansen MAA, de Wolf ACM, Ludwig IS, Leufkens P, Broere F.

Front Immunol. 2017 Nov 30;8:1690. doi: 10.3389/fimmu.2017.01690. eCollection 2017. Review.


The Enigma of Heat Shock Proteins in Immune Tolerance.

van Eden W, Jansen MAA, Ludwig I, van Kooten P, van der Zee R, Broere F.

Front Immunol. 2017 Nov 21;8:1599. doi: 10.3389/fimmu.2017.01599. eCollection 2017. Review.


Altered lipid properties of the stratum corneum in Canine Atopic Dermatitis.

Chermprapai S, Broere F, Gooris G, Schlotter YM, Rutten VPMG, Bouwstra JA.

Biochim Biophys Acta Biomembr. 2018 Feb;1860(2):526-533. doi: 10.1016/j.bbamem.2017.11.013. Epub 2017 Nov 22.


T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock Proteins.

Barbera Betancourt A, Lyu Q, Broere F, Sijts A, Rutten VPMG, van Eden W.

Front Immunol. 2017 Oct 26;8:1408. doi: 10.3389/fimmu.2017.01408. eCollection 2017. Review.


Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium.

de Groot AM, Du G, Mönkäre J, Platteel ACM, Broere F, Bouwstra JA, Sijts AJAM.

J Control Release. 2017 Nov 28;266:27-35. doi: 10.1016/j.jconrel.2017.09.017. Epub 2017 Sep 14.


Targeting of tolerogenic dendritic cells towards heat-shock proteins: a novel therapeutic strategy for autoimmune diseases?

Jansen MAA, Spiering R, Broere F, van Laar JM, Isaacs JD, van Eden W, Hilkens CMU.

Immunology. 2018 Jan;153(1):51-59. doi: 10.1111/imm.12811. Epub 2017 Sep 18. Review.


Regulatory T cell frequencies and phenotypes following anti-viral vaccination.

de Wolf ACMT, van Aalst S, Ludwig IS, Bodinham CL, Lewis DJ, van der Zee R, van Eden W, Broere F.

PLoS One. 2017 Jun 28;12(6):e0179942. doi: 10.1371/journal.pone.0179942. eCollection 2017.


Bystander activation of irrelevant CD4+ T cells following antigen-specific vaccination occurs in the presence and absence of adjuvant.

van Aalst S, Ludwig IS, van der Zee R, van Eden W, Broere F.

PLoS One. 2017 May 10;12(5):e0177365. doi: 10.1371/journal.pone.0177365. eCollection 2017.


Dynamics of APC recruitment at the site of injection following injection of vaccine adjuvants.

van Aalst S, Ludwig IS, van Kooten PJS, van der Zee R, van Eden W, Broere F.

Vaccine. 2017 Mar 14;35(12):1622-1629. doi: 10.1016/j.vaccine.2017.02.005. Epub 2017 Feb 17.


Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies.

Lord P, Spiering R, Aguillon JC, Anderson AE, Appel S, Benitez-Ribas D, Ten Brinke A, Broere F, Cools N, Cuturi MC, Diboll J, Geissler EK, Giannoukakis N, Gregori S, van Ham SM, Lattimer S, Marshall L, Harry RA, Hutchinson JA, Isaacs JD, Joosten I, van Kooten C, Lopez Diaz de Cerio A, Nikolic T, Oral HB, Sofronic-Milosavljevic L, Ritter T, Riquelme P, Thomson AW, Trucco M, Vives-Pi M, Martinez-Caceres EM, Hilkens CMU.

PeerJ. 2016 Aug 30;4:e2300. doi: 10.7717/peerj.2300. eCollection 2016.


APL1, an altered peptide ligand derived from human heat-shock protein 60, increases the frequency of Tregs and its suppressive capacity against antigen responding effector CD4 + T cells from rheumatoid arthritis patients.

Barberá A, Lorenzo N, van Kooten P, van Roon J, de Jager W, Prada D, Gómez J, Padrón G, van Eden W, Broere F, Del Carmen Domínguez M.

Cell Stress Chaperones. 2016 Jul;21(4):735-44. doi: 10.1007/s12192-016-0698-0. Epub 2016 May 30.


Generation of the First TCR Transgenic Mouse with CD4(+) T Cells Recognizing an Anti-inflammatory Regulatory T Cell-Inducing Hsp70 Peptide.

Jansen MA, van Herwijnen MJ, van Kooten PJ, Hoek A, van der Zee R, van Eden W, Broere F.

Front Immunol. 2016 Mar 9;7:90. doi: 10.3389/fimmu.2016.00090. eCollection 2016.


Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: enhanced gene silencing and reduced adverse effects in vitro.

Zeng X, de Groot AM, Sijts AJ, Broere F, Oude Blenke E, Colombo S, van Eden W, Franzyk H, Nielsen HM, Foged C.

Nanoscale. 2015 Dec 14;7(46):19687-98. doi: 10.1039/c5nr04807a.


Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells.

Delemarre EM, van den Broek T, Mijnheer G, Meerding J, Wehrens EJ, Olek S, Boes M, van Herwijnen MJ, Broere F, van Royen A, Wulffraat NM, Prakken BJ, Spierings E, van Wijk F.

Blood. 2016 Jan 7;127(1):91-101. doi: 10.1182/blood-2015-06-649145. Epub 2015 Oct 19.


An Arthritis-Suppressive and Treg Cell-Inducing CD4+ T Cell Epitope Is Functional in the Context of HLA-Restricted T Cell Responses.

de Wolf C, van der Zee R, den Braber I, Glant T, Maillère B, Favry E, van Lummel M, Koning F, Hoek A, Ludwig I, van Eden W, Broere F.

Arthritis Rheumatol. 2016 Mar;68(3):639-47. doi: 10.1002/art.39444.


In Vivo Induction of Functionally Suppressive Induced Regulatory T Cells from CD4+CD25- T Cells Using an Hsp70 Peptide.

van Herwijnen MJ, van der Zee R, van Eden W, Broere F.

PLoS One. 2015 Jun 24;10(6):e0128373. doi: 10.1371/journal.pone.0128373. eCollection 2015.


DEC205+ Dendritic Cell-Targeted Tolerogenic Vaccination Promotes Immune Tolerance in Experimental Autoimmune Arthritis.

Spiering R, Margry B, Keijzer C, Petzold C, Hoek A, Wagenaar-Hilbers J, van der Zee R, van Eden W, Kretschmer K, Broere F.

J Immunol. 2015 May 15;194(10):4804-13. doi: 10.4049/jimmunol.1400986. Epub 2015 Apr 10.


Distribution patterns of mucosally applied particles and characterization of the antigen presenting cells.

de Geus ED, Degen WG, van Haarlem DA, Schrier C, Broere F, Vervelde L.

Avian Pathol. 2015;44(3):222-9. doi: 10.1080/03079457.2015.1026797. Epub 2015 Mar 31.


CD4+ and CD8+ skin-associated T lymphocytes in canine atopic dermatitis produce interleukin-13, interleukin-22 and interferon-γ and contain a CD25+ FoxP3+ subset.

Jassies-van der Lee A, Rutten VP, Bruijn J, Willemse T, Broere F.

Vet Dermatol. 2014 Oct;25(5):456-e72. doi: 10.1111/vde.12140. Epub 2014 Jun 10.


Inactivated influenza vaccine adjuvanted with bacterium-like particles induce systemic and mucosal influenza A virus specific T-cell and B-cell responses after nasal administration in a TLR2 dependent fashion.

Keijzer C, Haijema BJ, Meijerhof T, Voorn P, de Haan A, Leenhouts K, van Roosmalen ML, van Eden W, Broere F.

Vaccine. 2014 May 19;32(24):2904-10. doi: 10.1016/j.vaccine.2014.02.019. Epub 2014 Mar 2.


Activated peritoneal cavity B-1a cells possess regulatory B cell properties.

Margry B, Kersemakers SC, Hoek A, Arkesteijn GJ, Wieland WH, van Eden W, Broere F.

PLoS One. 2014 Feb 13;9(2):e88869. doi: 10.1371/journal.pone.0088869. eCollection 2014.


Brief report: Autologous stem cell transplantation restores immune tolerance in experimental arthritis by renewal and modulation of the Teff cell compartment.

Delemarre EM, Roord ST, van den Broek T, Zonneveld-Huijssoon E, de Jager W, Rozemuller H, Martens AC, Broere F, Wulffraat NM, Glant TT, Prakken BJ, van Wijk F.

Arthritis Rheumatol. 2014 Feb;66(2):350-6. doi: 10.1002/art.38261.


The immunostimulatory effect of CpG oligodeoxynucleotides on peripheral blood mononuclear cells of healthy dogs and dogs with atopic dermatitis.

Jassies-van der Lee A, Rutten V, Spiering R, van Kooten P, Willemse T, Broere F.

Vet J. 2014 Apr;200(1):103-8. doi: 10.1016/j.tvjl.2013.12.016. Epub 2013 Dec 21.


T cell recognition of naturally presented epitopes of self-heat shock protein 70.

de Jong H, Koffeman EC, Meerding JM, Scholman RC, Wieten L, de Jager W, Klein M, Otten H, van Wijk F, van der Zee R, Bijlsma JW, Broere F, van Eden W, Prakken BJ.

Cell Stress Chaperones. 2014 Jul;19(4):569-78. doi: 10.1007/s12192-013-0484-1. Epub 2014 Jan 15.


Mesenchymal stem cell therapy in proteoglycan induced arthritis.

Swart JF, de Roock S, Hofhuis FM, Rozemuller H, van den Broek T, Moerer P, Broere F, van Wijk F, Kuis W, Prakken BJ, Martens AC, Wulffraat NM.

Ann Rheum Dis. 2015 Apr;74(4):769-77. doi: 10.1136/annrheumdis-2013-204147. Epub 2014 Jan 6.


Membrane-bound metallothionein 1 of murine dendritic cells promotes the expansion of regulatory T cells in vitro.

Spiering R, Wagenaar-Hilbers J, Huijgen V, van der Zee R, van Kooten PJ, van Eden W, Broere F.

Toxicol Sci. 2014 Mar;138(1):69-75. doi: 10.1093/toxsci/kft268. Epub 2013 Nov 27.


APL-1, an altered peptide ligand derived from human heat-shock protein 60, selectively induces apoptosis in activated CD4+ CD25+ T cells from peripheral blood of rheumatoid arthritis patients.

Barberá A, Lorenzo N, Garrido G, Mazola Y, Falcón V, Torres AM, Hernández MI, Hernández MV, Margry B, de Groot AM, van Roon J, van der Zee R, Broere F, van Eden W, Padrón G, Domínguez Mdel C.

Int Immunopharmacol. 2013 Dec;17(4):1075-83. doi: 10.1016/j.intimp.2013.10.010. Epub 2013 Oct 29.


Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases.

Keijzer C, van der Zee R, van Eden W, Broere F.

Front Immunol. 2013 Aug 20;4:245. doi: 10.3389/fimmu.2013.00245. eCollection 2013.


Heat shock proteins can be targets of regulatory T cells for therapeutic intervention in rheumatoid arthritis.

Van Herwijnen MJ, Van Der Zee R, Van Eden W, Broere F.

Int J Hyperthermia. 2013 Aug;29(5):448-54. doi: 10.3109/02656736.2013.811546. Epub 2013 Jul 17. Review.


Peritoneal cavity B-1a cells promote peripheral CD4+ T-cell activation.

Margry B, Wieland WH, van Kooten PJ, van Eden W, Broere F.

Eur J Immunol. 2013 Sep;43(9):2317-26. doi: 10.1002/eji.201343418. Epub 2013 Jul 3.


Stress proteins are used by the immune system for cognate interactions with anti-inflammatory regulatory T cells.

van Eden W, van Herwijnen M, Wagenaar J, van Kooten P, Broere F, van der Zee R.

FEBS Lett. 2013 Jun 27;587(13):1951-8. doi: 10.1016/j.febslet.2013.05.024. Epub 2013 May 23. Review.


PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3(+) T-cells in vitro.

Keijzer C, Spiering R, Silva AL, van Eden W, Jiskoot W, Vervelde L, Broere F.

J Control Release. 2013 May 28;168(1):35-40. doi: 10.1016/j.jconrel.2013.02.027. Epub 2013 Mar 14.


Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells.

Spiering R, van der Zee R, Wagenaar J, van Eden W, Broere F.

Cell Stress Chaperones. 2013 Jul;18(4):439-46. doi: 10.1007/s12192-012-0397-4. Epub 2012 Dec 27.


Tolerogenic dendritic cells that inhibit autoimmune arthritis can be induced by a combination of carvacrol and thermal stress.

Spiering R, van der Zee R, Wagenaar J, Kapetis D, Zolezzi F, van Eden W, Broere F.

PLoS One. 2012;7(9):e46336. doi: 10.1371/journal.pone.0046336. Epub 2012 Sep 25.


Tandem repeats modify the structure of the canine CD1D gene.

Looringh van Beeck FA, Leegwater PA, Herrmann T, Broere F, Rutten VP, Willemse T, Van Rhijn I.

Anim Genet. 2013 Jun;44(3):352-5. doi: 10.1111/age.12002. Epub 2012 Sep 19.


Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis.

van Herwijnen MJ, Wieten L, van der Zee R, van Kooten PJ, Wagenaar-Hilbers JP, Hoek A, den Braber I, Anderton SM, Singh M, Meiring HD, van Els CA, van Eden W, Broere F.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14134-9. doi: 10.1073/pnas.1206803109. Epub 2012 Aug 13.


Heat shock proteins are therapeutic targets in autoimmune diseases and other chronic inflammatory conditions.

Keijzer C, Wieten L, van Herwijnen M, van der Zee R, Van Eden W, Broere F.

Expert Opin Ther Targets. 2012 Sep;16(9):849-57. doi: 10.1517/14728222.2012.706605. Epub 2012 Jul 16. Review.


The anti-inflammatory mechanisms of Hsp70.

Borges TJ, Wieten L, van Herwijnen MJ, Broere F, van der Zee R, Bonorino C, van Eden W.

Front Immunol. 2012 May 4;3:95. doi: 10.3389/fimmu.2012.00095. eCollection 2012.


A case of mistaken identity: HSPs are no DAMPs but DAMPERs.

van Eden W, Spiering R, Broere F, van der Zee R.

Cell Stress Chaperones. 2012 May;17(3):281-92. doi: 10.1007/s12192-011-0311-5. Epub 2011 Dec 3.

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