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Items: 37

1.

Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

Blokland SLM, Hillen MR, Wichers CGK, Zimmermann M, Kruize AA, Radstake TRDJ, Broen JCA, van Roon JAG.

RMD Open. 2019 Jan 11;5(1):e000701. doi: 10.1136/rmdopen-2018-000701. eCollection 2019. No abstract available.

2.

PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation.

Petrelli A, Mijnheer G, Hoytema van Konijnenburg DP, van der Wal MM, Giovannone B, Mocholi E, Vazirpanah N, Broen JC, Hijnen D, Oldenburg B, Coffer PJ, Vastert SJ, Prakken BJ, Spierings E, Pandit A, Mokry M, van Wijk F.

J Clin Invest. 2018 Oct 1;128(10):4669-4681. doi: 10.1172/JCI96107. Epub 2018 Aug 2.

3.

Telomere quantification in frontal and temporal brain tissue of patients with schizophrenia.

van Mierlo HC, Wichers CGK, He Y, Sneeboer MAM, Radstake TRDJ, Kahn RS, Broen JCA, de Witte LD.

J Psychiatr Res. 2017 Dec;95:231-234. doi: 10.1016/j.jpsychires.2017.09.006. Epub 2017 Sep 7.

PMID:
28910708
4.

Metformin, A New Era for an Old Drug in the Treatment of Immune Mediated Disease?

Schuiveling M, Vazirpanah N, Radstake TRDJ, Zimmermann M, Broen JCA.

Curr Drug Targets. 2018;19(8):945-959. doi: 10.2174/1389450118666170613081730.

PMID:
28606032
5.

Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis.

Rossato M, Affandi AJ, Thordardottir S, Wichers CGK, Cossu M, Broen JCA, Moret FM, Bossini-Castillo L, Chouri E, van Bon L, Wolters F, Marut W, van der Kroef M, Silva-Cardoso S, Bekker CPJ, Dolstra H, van Laar JM, Martin J, van Roon JAG, Reedquist KA, Beretta L, Radstake TRDJ.

Arthritis Rheumatol. 2017 Sep;69(9):1891-1902. doi: 10.1002/art.40163. Epub 2017 Jul 25.

6.

Aberrant leukocyte telomere length in Birdshot Uveitis.

Vazirpanah N, Verhagen FH, Rothova A, Missotten TOAR, van Velthoven M, Den Hollander AI, Hoyng CB, Radstake TRDJ, Broen JCA, Kuiper JJW.

PLoS One. 2017 May 1;12(5):e0176175. doi: 10.1371/journal.pone.0176175. eCollection 2017.

7.

Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout.

Vazirpanah N, Kienhorst LBE, Van Lochem E, Wichers C, Rossato M, Shiels PG, Dalbeth N, Stamp LK, Merriman TR, Janssen M, Radstake TRDJ, Broen JC.

Ann Rheum Dis. 2017 Jul;76(7):1313-1319. doi: 10.1136/annrheumdis-2016-210538. Epub 2017 Mar 27.

PMID:
28347991
8.

Expression of ERAP2 and LST1 is increased before start of therapy in rheumatoid arthritis patients with good clinical response to glucocorticoids.

Fritsch-Stork RD, Silva-Cardoso SC, Groot Koerkamp MJ, Broen JC, Lafeber FF, Bijlsma JW.

Clin Exp Rheumatol. 2016 Jul-Aug;34(4):685-9. Epub 2016 Jun 22.

PMID:
27384923
9.

Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.

van den Broek T, Delemarre EM, Janssen WJ, Nievelstein RA, Broen JC, Tesselaar K, Borghans JA, Nieuwenhuis EE, Prakken BJ, Mokry M, Jansen NJ, van Wijk F.

J Clin Invest. 2016 Mar 1;126(3):1126-36. doi: 10.1172/JCI84997. Epub 2016 Feb 22.

10.

A Promoter Polymorphism in the CD59 Complement Regulatory Protein Gene in Donor Lungs Correlates With a Higher Risk for Chronic Rejection After Lung Transplantation.

Budding K, van de Graaf EA, Kardol-Hoefnagel T, Broen JC, Kwakkel-van Erp JM, Oudijk EJ, van Kessel DA, Hack CE, Otten HG.

Am J Transplant. 2016 Mar;16(3):987-98. doi: 10.1111/ajt.13497. Epub 2015 Oct 30.

11.

Rheumatic Diseases as the Fuel to Inflamm-aging.

Broen JC.

Curr Aging Sci. 2015;8(2):121-2. No abstract available.

PMID:
26282395
12.

Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin-8 (CXCL8), Myeloid-Related Protein 8/Myeloid-Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease.

Kienhorst LB, van Lochem E, Kievit W, Dalbeth N, Merriman ME, Phipps-Green A, Loof A, van Heerde W, Vermeulen S, Stamp LK, van Koolwijk E, de Graaf J, Holzinger D, Roth J, Janssens HJ, Merriman TR, Broen JC, Janssen M, Radstake TR.

Arthritis Rheumatol. 2015 Dec;67(12):3303-13. doi: 10.1002/art.39318.

13.

Inflamm-ageing and Senescence in Gout: The Tale of an Old King's Disease.

Vazirpanah N, Radstake TR, Broen JC.

Curr Aging Sci. 2015;8(2):186-201. Review.

PMID:
26212054
14.

The role of genetics and epigenetics in the pathogenesis of systemic sclerosis.

Broen JC, Radstake TR, Rossato M.

Nat Rev Rheumatol. 2014 Nov;10(11):671-81. doi: 10.1038/nrrheum.2014.128. Epub 2014 Aug 19. Review.

PMID:
25136786
15.

Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder.

Boks MP, van Mierlo HC, Rutten BP, Radstake TR, De Witte L, Geuze E, Horvath S, Schalkwyk LC, Vinkers CH, Broen JC, Vermetten E.

Psychoneuroendocrinology. 2015 Jan;51:506-12. doi: 10.1016/j.psyneuen.2014.07.011. Epub 2014 Jul 23.

PMID:
25129579
16.

Proteomic analysis of plasma identifies the Toll-like receptor agonists S100A8/A9 as a novel possible marker for systemic sclerosis phenotype.

van Bon L, Cossu M, Loof A, Gohar F, Wittkowski H, Vonk M, Roth J, van den Berg W, van Heerde W, Broen JC, Radstake TR.

Ann Rheum Dis. 2014 Aug;73(8):1585-9. doi: 10.1136/annrheumdis-2013-205013. Epub 2014 Apr 9.

PMID:
24718960
17.

Overlapping gene expression profiles indicative of antigen processing and the interferon pathway characterize inflammatory fibrotic skin diseases.

Limpers A, van Royen-Kerkhof A, van Roon JA, Radstake TR, Broen JC.

Expert Rev Clin Immunol. 2014 Feb;10(2):231-41. doi: 10.1586/1744666X.2014.872561. Epub 2014 Jan 2. Review.

PMID:
24382112
18.

Accelerated telomere shortening in rheumatic diseases: cause or consequence?

Dehbi AZ, Radstake TR, Broen JC.

Expert Rev Clin Immunol. 2013 Dec;9(12):1193-204. doi: 10.1586/1744666X.2013.850031. Review.

PMID:
24215409
19.

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.

Martin JE, Assassi S, Diaz-Gallo LM, Broen JC, Simeon CP, Castellvi I, Vicente-Rabaneda E, Fonollosa V, Ortego-Centeno N, González-Gay MA, Espinosa G, Carreira P; Spanish Scleroderma Group; SLEGEN consortium; U.S. Scleroderma GWAS group; BIOLUPUS, Camps M, Sabio JM, D'alfonso S, Vonk MC, Voskuyl AE, Schuerwegh AJ, Kreuter A, Witte T, Riemekasten G, Hunzelmann N, Airo P, Beretta L, Scorza R, Lunardi C, Van Laar J, Chee MM, Worthington J, Herrick A, Denton C, Fonseca C, Tan FK, Arnett F, Zhou X, Reveille JD, Gorlova O, Koeleman BP, Radstake TR, Vyse T, Mayes MD, Alarcón-Riquelme ME, Martin J.

Hum Mol Genet. 2013 Oct 1;22(19):4021-9. doi: 10.1093/hmg/ddt248. Epub 2013 Jun 4.

20.

New insight on the Xq28 association with systemic sclerosis.

Carmona FD, Cénit MC, Diaz-Gallo LM, Broen JC, Simeón CP, Carreira PE, Callejas-Rubio JL, Fonollosa V, López-Longo FJ, González-Gay MA, Hunzelmann N, Riemekasten G, Witte T, Kreuter A, Distler JH, Madhok R, Shiels P, van Laar JM, Schuerwegh AJ, Vonk MC, Voskuyl AE, Fonseca C, Denton CP, Herrick A, Worthington J, Arnett FC, Tan FK, Assassi S, Radstake TR, Mayes MD, Martín J; Spanish Scleroderma Group.

Ann Rheum Dis. 2013 Dec;72(12):2032-8. doi: 10.1136/annrheumdis-2012-202742. Epub 2013 Feb 26.

21.

Heme oxygenase-1 promoter polymorphisms do not influence susceptibility to systemic sclerosis and its clinical phenotypes.

van Bon L, Broen JC, Schijvenaars MM, Rueda B, Simeón CP, Ortego-Centeno N, González-Gay MA, Radstake TR, Hunzelmann N, Riemekasten G, Witte T, Wagener FA, Vonk MC, Coenen MJ, Martin J.

Clin Exp Rheumatol. 2013 Mar-Apr;31(2 Suppl 76):186. Epub 2013 Feb 7. No abstract available.

PMID:
23406650
22.

Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility.

Diaz-Gallo LM, Simeon CP, Broen JC, Ortego-Centeno N, Beretta L, Vonk MC, Carreira PE, Vargas S, Román-Ivorra JA, González-Gay MA, Tolosa C, López-Longo FJ, Espinosa G, Vicente EF, Hesselstrand R, Riemekasten G, Witte T, Distler JH, Voskuyl AE, Schuerwegh AJ, Shiels PG, Nordin A, Padyukov L, Hoffmann-Vold AM, Scorza R, Lunardi C, Airo P, van Laar JM, Hunzelmann N, Gathof BS, Kreuter A, Herrick A, Worthington J, Denton CP, Zhou X, Arnett FC, Fonseca C, Koeleman BP, Assasi S, Radstake TR, Mayes MD, Martín J; Spanish Scleroderma Group.

Ann Rheum Dis. 2013 Jul;72(7):1233-8. doi: 10.1136/annrheumdis-2012-202357. Epub 2012 Nov 21.

23.

Evidence that deletion at FCGR3B is a risk factor for systemic sclerosis.

McKinney C, Broen JC, Vonk MC, Beretta L, Hesselstrand R, Hunzelmann N, Riemekasten G, Scorza R, Simeon CP, Fonollosa V, Carreira PE, Ortego-Centeno N, Gonzalez-Gay MA, Airo P, Coenen M, Martin J, Radstake TR, Merriman TR.

Genes Immun. 2012 Sep;13(6):458-60. doi: 10.1038/gene.2012.15. Epub 2012 May 3.

PMID:
22551723
24.

A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis.

Bossini-Castillo L, Simeon CP, Beretta L, Broen JC, Vonk MC, Ríos-Fernández R, Espinosa G, Carreira P, Camps MT, Castillo MJ, González-Gay MA, Beltrán E, Carmen Freire Md, Narváez J, Tolosa C, Witte T, Kreuter A, Schuerwegh AJ, Hoffmann-Vold AM, Hesselstrand R, Lunardi C, van Laar JM, Chee MM, Herrick A, Koeleman BP, Denton CP, Fonseca C, Radstake TR, Martin J; Spanish Scleroderma Group.

Arthritis Res Ther. 2012 Apr 24;14(2):R85.

25.

Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up.

Martin JE, Broen JC, Carmona FD, Teruel M, Simeon CP, Vonk MC, van 't Slot R, Rodriguez-Rodriguez L, Vicente E, Fonollosa V, Ortego-Centeno N, González-Gay MA, García-Hernández FJ, de la Peña PG, Carreira P; Spanish Scleroderma Group, Voskuyl AE, Schuerwegh AJ, van Riel PL, Kreuter A, Witte T, Riemekasten G, Airo P, Scorza R, Lunardi C, Hunzelmann N, Distler JH, Beretta L, van Laar J, Chee MM, Worthington J, Herrick A, Denton C, Tan FK, Arnett FC, Assassi S, Fonseca C, Mayes MD, Radstake TR, Koeleman BP, Martin J.

Hum Mol Genet. 2012 Jun 15;21(12):2825-35. doi: 10.1093/hmg/dds099. Epub 2012 Mar 9.

26.

Genetics of systemic sclerosis: an update.

Broen JC, Coenen MJ, Radstake TR.

Curr Rheumatol Rep. 2012 Feb;14(1):11-21. doi: 10.1007/s11926-011-0221-7. Review.

27.

Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.

Broen JC, Dieude P, Vonk MC, Beretta L, Carmona FD, Herrick A, Worthington J, Hunzelmann N, Riemekasten G, Kiener H, Scorza R, Simeon CP, Fonollosa V; Spanish Systemic Sclerosis Group, Carreira P, Ortego-Centeno N, Gonzalez-Gay MA, Airo' P, Coenen MJ, Tsang K, Aliprantis AO, Martin J, Allanore Y, Radstake TR.

J Rheumatol. 2012 Jan;39(1):112-8. doi: 10.3899/jrheum.110235. Epub 2011 Nov 1.

PMID:
22045834
28.

The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis.

Martin JE, Carmona FD, Broen JC, Simeón CP, Vonk MC, Carreira P, Ríos-Fernández R, Espinosa G, Vicente-Rabaneda E, Tolosa C, García-Hernández FJ, Castellví I, Fonollosa V, González-Gay MA, Sáez-Comet L, Portales RG, de la Peña PG, Fernández-Castro M, Díaz B, Martínez-Estupiñán L, Coenen M, Voskuyl AE, Schuerwegh AJ, Vanthuyne M, Houssiau F, Smith V, de Keyser F, De Langhe E, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Palm Ø, Chee MM, van Laar JM, Denton C, Herrick A, Worthington J, Koeleman BP, Radstake TR, Fonseca C, Martín J; Spanish Scleroderma Group.

Genes Immun. 2012 Feb;13(2):191-6. doi: 10.1038/gene.2011.72. Epub 2011 Oct 20.

PMID:
22012429
29.

A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators.

Broen JC, Bossini-Castillo L, van Bon L, Vonk MC, Knaapen H, Beretta L, Rueda B, Hesselstrand R, Herrick A, Worthington J, Hunzelman N, Denton CP, Fonseca C, Riemekasten G, Kiener HP, Scorza R, Simeón CP, Ortego-Centeno N, Gonzalez-Gay MA, Airò P, Coenen MJ, Martín J, Radstake TR; Spanish Systemic Sclerosis Group.

Arthritis Rheum. 2012 Jan;64(1):264-71. doi: 10.1002/art.33325.

30.

Deciphering the genetic background of systemic sclerosis.

Broen JC, Coenen MJ, Radstake TR.

Expert Rev Clin Immunol. 2011 Jul;7(4):449-62. doi: 10.1586/eci.11.26. Review.

PMID:
21790288
31.

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.

Gorlova O, Martin JE, Rueda B, Koeleman BP, Ying J, Teruel M, Diaz-Gallo LM, Broen JC, Vonk MC, Simeon CP, Alizadeh BZ, Coenen MJ, Voskuyl AE, Schuerwegh AJ, van Riel PL, Vanthuyne M, van 't Slot R, Italiaander A, Ophoff RA, Hunzelmann N, Fonollosa V, Ortego-Centeno N, González-Gay MA, García-Hernández FJ, González-Escribano MF, Airo P, van Laar J, Worthington J, Hesselstrand R, Smith V, de Keyser F, Houssiau F, Chee MM, Madhok R, Shiels PG, Westhovens R, Kreuter A, de Baere E, Witte T, Padyukov L, Nordin A, Scorza R, Lunardi C, Lie BA, Hoffmann-Vold AM, Palm O, García de la Peña P, Carreira P; Spanish Scleroderma Group, Varga J, Hinchcliff M, Lee AT, Gourh P, Amos CI, Wigley FM, Hummers LK, Nelson JL, Riemekasten G, Herrick A, Beretta L, Fonseca C, Denton CP, Gregersen PK, Agarwal S, Assassi S, Tan FK, Arnett FC, Radstake TR, Mayes MD, Martin J.

PLoS Genet. 2011 Jul;7(7):e1002178. doi: 10.1371/journal.pgen.1002178. Epub 2011 Jul 14. Erratum in: PLoS Genet. 2011 Aug;7(8). doi:10.1371/annotation/3aeebb2e-64e5-4548-8d65-1f2d5dfeb073. PLoS Genet. 2011 Aug;7(8). doi:10.1371/annotation/7a52649c-0942-4bd8-a5d3-3cdacca03cd8. Hummers, J [removed].

32.

How birds of a feather flock together: genetics in autoimmune diseases.

Broen JC, Radstake TR.

Expert Rev Clin Immunol. 2011 Mar;7(2):127-8. doi: 10.1586/eci.11.2. No abstract available.

PMID:
21426248
33.

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort.

Bossini-Castillo L, Broen JC, Simeon CP, Beretta L, Vonk MC, Ortego-Centeno N, Espinosa G, Carreira P, Camps MT, Navarrete N, González-Escribano MF, Vicente-Rabaneda E, Rodríguez L, Tolosa C, Román-Ivorra JA, Gómez-Gracia I, García-Hernández FJ, Castellví I, Gallego M, Fernández-Nebro A, García-Portales R, Egurbide MV, Fonollosa V, de la Peña PG, Pros A, González-Gay MA, Hesselstrand R, Riemekasten G, Witte T, Coenen MJ, Koeleman BP, Houssiau F, Smith V, de Keyser F, Westhovens R, De Langhe E, Voskuyl AE, Schuerwegh AJ, Chee MM, Madhok R, Shiels P, Fonseca C, Denton C, Claes K, Padykov L, Nordin A, Palm O, Lie BA, Airó P, Scorza R, van Laar JM, Hunzelmann N, Kreuter A, Herrick A, Worthington J, Radstake TR, Martín J, Rueda B.

Ann Rheum Dis. 2011 Apr;70(4):638-41. doi: 10.1136/ard.2010.141838. Epub 2010 Dec 27. Erratum in: Ann Rheum Dis. 2011 Aug;70(8):1520.

PMID:
21187296
34.

The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility.

Broen JC, Coenen MJ, Rueda B, Witte T, Padyukov L, Klareskog L, Hesselstrand R, Wuttge DM, Simeon C, Ortego-Centeno N, González-Gay MA, Pros A, Hunzelman N, Riemekasten G, Kreuter A, Vonk M, Scorza R, Beretta L, Airò P, van Riel PL, Kimberly R, Martin J, Edberg J, Radstake TR.

J Rheumatol. 2011 Mar;38(3):446-9. doi: 10.3899/jrheum.100427. Epub 2010 Dec 15. Erratum in: J Rheumatol. 2011 May;38(5):968.

PMID:
21159834
35.

Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis.

Broen JC, Wolvers-Tettero IL, Geurts-van Bon L, Vonk MC, Coenen MJ, Lafyatis R, Radstake TR, Langerak AW.

Ann Rheum Dis. 2010 Dec;69(12):2213-6. doi: 10.1136/ard.2010.129999. Epub 2010 Aug 10.

PMID:
20699236
36.

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.

Radstake TR, Gorlova O, Rueda B, Martin JE, Alizadeh BZ, Palomino-Morales R, Coenen MJ, Vonk MC, Voskuyl AE, Schuerwegh AJ, Broen JC, van Riel PL, van 't Slot R, Italiaander A, Ophoff RA, Riemekasten G, Hunzelmann N, Simeon CP, Ortego-Centeno N, González-Gay MA, González-Escribano MF; Spanish Scleroderma Group, Airo P, van Laar J, Herrick A, Worthington J, Hesselstrand R, Smith V, de Keyser F, Houssiau F, Chee MM, Madhok R, Shiels P, Westhovens R, Kreuter A, Kiener H, de Baere E, Witte T, Padykov L, Klareskog L, Beretta L, Scorza R, Lie BA, Hoffmann-Vold AM, Carreira P, Varga J, Hinchcliff M, Gregersen PK, Lee AT, Ying J, Han Y, Weng SF, Amos CI, Wigley FM, Hummers L, Nelson JL, Agarwal SK, Assassi S, Gourh P, Tan FK, Koeleman BP, Arnett FC, Martin J, Mayes MD.

Nat Genet. 2010 May;42(5):426-9. doi: 10.1038/ng.565. Epub 2010 Apr 11.

37.

TLR2 promotes Th2/Th17 responses via TLR4 and TLR7/8 by abrogating the type I IFN amplification loop.

Wenink MH, Santegoets KC, Broen JC, van Bon L, Abdollahi-Roodsaz S, Popa C, Huijbens R, Remijn T, Lubberts E, van Riel PL, van den Berg WB, Radstake TR.

J Immunol. 2009 Dec 1;183(11):6960-70. doi: 10.4049/jimmunol.0900713. Epub 2009 Nov 13.

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