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Items: 1 to 50 of 84

1.

Signs of stabilisation and stable coexistence.

Broekman MJE, Muller-Landau HC, Visser MD, Jongejans E, Wright SJ, de Kroon H.

Ecol Lett. 2019 Nov;22(11):1957-1975. doi: 10.1111/ele.13349. Epub 2019 Jul 21. Review.

PMID:
31328414
2.

Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk.

Moeckel D, Jeong SS, Sun X, Broekman MJ, Nguyen A, Drosopoulos JH, Marcus AJ, Robson SC, Chen R, Abendschein D.

Sci Transl Med. 2014 Aug 6;6(248):248ra105. doi: 10.1126/scitranslmed.3009246.

3.

CD39 expression on T lymphocytes correlates with severity of disease in patients with chronic lymphocytic leukemia.

Pulte D, Furman RR, Broekman MJ, Drosopoulos JH, Ballard HS, Olson KE, Kizer JR, Marcus AJ.

Clin Lymphoma Myeloma Leuk. 2011 Aug;11(4):367-72. doi: 10.1016/j.clml.2011.06.005.

4.

Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2.

He KL, Sui G, Xiong H, Broekman MJ, Huang B, Marcus AJ, Hajjar KA.

J Biol Chem. 2011 Apr 29;286(17):15428-39. doi: 10.1074/jbc.M110.185058. Epub 2010 Nov 29.

5.

Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis.

Jacovina AT, Deora AB, Ling Q, Broekman MJ, Almeida D, Greenberg CB, Marcus AJ, Smith JD, Hajjar KA.

J Clin Invest. 2009 Nov;119(11):3384-94. doi: 10.1172/JCI39591. Epub 2009 Oct 19.

6.

P2X(1) receptor inhibition and soluble CD39 administration as novel approaches to widen the cardiovascular therapeutic window.

Fung CY, Marcus AJ, Broekman MJ, Mahaut-Smith MP.

Trends Cardiovasc Med. 2009 Jan;19(1):1-5. doi: 10.1016/j.tcm.2009.01.005. Review.

7.

Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39.

Hyman MC, Petrovic-Djergovic D, Visovatti SH, Liao H, Yanamadala S, Bouïs D, Su EJ, Lawrence DA, Broekman MJ, Marcus AJ, Pinsky DJ.

J Clin Invest. 2009 May;119(5):1136-49. doi: 10.1172/JCI36433. Epub 2009 Apr 20.

8.

Targeted deletion of ectonucleoside triphosphate diphosphohydrolase 1/CD39 leads to desensitization of pre- and postsynaptic purinergic P2 receptors.

Schaefer U, Machida T, Broekman MJ, Marcus AJ, Levi R.

J Pharmacol Exp Ther. 2007 Sep;322(3):1269-77. Epub 2007 Jun 12.

PMID:
17565006
9.

CD39/NTPDase-1 activity and expression in normal leukocytes.

Pulte ED, Broekman MJ, Olson KE, Drosopoulos JH, Kizer JR, Islam N, Marcus AJ.

Thromb Res. 2007;121(3):309-17. Epub 2007 Jun 7.

10.

CD39 activity correlates with stage and inhibits platelet reactivity in chronic lymphocytic leukemia.

Pulte D, Olson KE, Broekman MJ, Islam N, Ballard HS, Furman RR, Olson AE, Marcus AJ.

J Transl Med. 2007 May 4;5:23.

11.

Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.

Kopp HG, Hooper AT, Broekman MJ, Avecilla ST, Petit I, Luo M, Milde T, Ramos CA, Zhang F, Kopp T, Bornstein P, Jin DK, Marcus AJ, Rafii S.

J Clin Invest. 2006 Dec;116(12):3277-91.

12.

Aspirin therapy for inhibition of platelet reactivity in the presence of erythrocytes in patients with vascular disease.

Santos MT, Vallés J, Aznar J, Lago A, Sanchez E, Cosin J, Moscardó A, Piñón M, Broekman MJ, Marcus AJ.

J Lab Clin Med. 2006 May;147(5):220-7.

13.

Effects of SolCD39, a novel inhibitor of Platelet Aggregation, on Platelet Deposition and Aggregation after PTCA in a Porcine Model.

Buergler JM, Maliszewski CR, Broekman MJ, Kaluza GL, Schulz DG, Marcus AJ, Raizner AE, Kleiman NS, Ali NM.

J Thromb Thrombolysis. 2005 Apr;19(2):115-22.

PMID:
16052302
14.

The ratio of ADP- to ATP-ectonucleotidase activity is reduced in patients with coronary artery disease.

El-Omar MM, Islam N, Broekman MJ, Drosopoulos JH, Roa DC, Lorin JD, Sedlis SP, Olson KE, Pulte ED, Marcus AJ.

Thromb Res. 2005;116(3):199-206. Epub 2004 Dec 21.

PMID:
15935828
15.

Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection.

Marcus AJ, Broekman MJ, Drosopoulos JH, Olson KE, Islam N, Pinsky DJ, Levi R.

Semin Thromb Hemost. 2005 Apr;31(2):234-46. Review.

PMID:
15852226
16.

Ectonucleoside triphosphate diphosphohydrolase 1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis.

Machida T, Heerdt PM, Reid AC, Schäfer U, Silver RB, Broekman MJ, Marcus AJ, Levi R.

J Pharmacol Exp Ther. 2005 May;313(2):570-7. Epub 2005 Jan 12.

PMID:
15647328
17.

Heterologous cell-cell interactions: thromboregulation, cerebroprotection and cardioprotection by CD39 (NTPDase-1).

Marcus AJ, Broekman MJ, Drosopoulos JH, Islam N, Pinsky DJ, Sesti C, Levi R.

J Thromb Haemost. 2003 Dec;1(12):2497-509. Review. Erratum in: J Thromb Haemost. 2004 Apr;2(4):682.

18.

Ectonucleotidase in sympathetic nerve endings modulates ATP and norepinephrine exocytosis in myocardial ischemia.

Sesti C, Koyama M, Broekman MJ, Marcus AJ, Levi R.

J Pharmacol Exp Ther. 2003 Jul;306(1):238-44. Epub 2003 Apr 3.

PMID:
12676879
19.

Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases.

Marcus AJ, Broekman MJ, Drosopoulos JH, Islam N, Pinsky DJ, Sesti C, Levi R.

J Pharmacol Exp Ther. 2003 Apr;305(1):9-16. Review.

PMID:
12649347
20.

Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Wood E, Broekman MJ, Kirley TL, Diani-Moore S, Tickner M, Drosopoulos JH, Islam N, Park JI, Marcus AJ, Rifkind AB.

Arch Biochem Biophys. 2002 Nov 1;407(1):49-62.

PMID:
12392715
21.

COX inhibitors and thromboregulation.

Marcus AJ, Broekman MJ, Pinsky DJ.

N Engl J Med. 2002 Sep 26;347(13):1025-6. Review. No abstract available.

PMID:
12324561
22.

Role of extracellular ATP metabolism in regulation of platelet reactivity.

Birk AV, Broekman MJ, Gladek EM, Robertson HD, Drosopoulos JH, Marcus AJ, Szeto HH.

J Lab Clin Med. 2002 Sep;140(3):166-75.

PMID:
12271274
23.

Platelet-erythrocyte interactions enhance alpha(IIb)beta(3) integrin receptor activation and P-selectin expression during platelet recruitment: down-regulation by aspirin ex vivo.

Vallés J, Santos MT, Aznar J, Martínez M, Moscardó A, Piñón M, Broekman MJ, Marcus AJ.

Blood. 2002 Jun 1;99(11):3978-84.

PMID:
12010797
24.

Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain.

Pinsky DJ, Broekman MJ, Peschon JJ, Stocking KL, Fujita T, Ramasamy R, Connolly ES Jr, Huang J, Kiss S, Zhang Y, Choudhri TF, McTaggart RA, Liao H, Drosopoulos JH, Price VL, Marcus AJ, Maliszewski CR.

J Clin Invest. 2002 Apr;109(8):1031-40.

25.

Role of a novel soluble nucleotide phospho-hydrolase from sheep plasma in inhibition of platelet reactivity: hemostasis, thrombosis, and vascular biology.

Birk AV, Bubman D, Broekman MJ, Robertson HD, Drosopoulos JH, Marcus AJ, Szeto HH.

J Lab Clin Med. 2002 Feb;139(2):116-24.

PMID:
11919550
26.

EctoNucleotidase in cardiac sympathetic nerve endings modulates ATP-mediated feedback of norepinephrine release.

Sesti C, Broekman MJ, Drosopoulos JH, Islam N, Marcus AJ, Levi R.

J Pharmacol Exp Ther. 2002 Feb;300(2):605-11.

PMID:
11805223
27.

Inhibition of platelet recruitment by endothelial cell CD39/ecto-ADPase: significance for occlusive vascular diseases.

Marcus AJ, Broekman MJ, Drosopoulos JH, Pinsky DJ, Islam N, Maliszewsk CR.

Ital Heart J. 2001 Nov;2(11):824-30.

PMID:
11770867
28.

Participation of tyrosine phosphorylation in cytoskeletal reorganization, alpha(IIb)beta(3) integrin receptor activation, and aspirin-insensitive mechanisms of thrombin-stimulated human platelets.

Santos MT, Moscardó A, Vallés J, Martínez M, Piñón M, Aznar J, Broekman MJ, Marcus AJ.

Circulation. 2000 Oct 17;102(16):1924-30.

PMID:
11034940
29.

Site-directed mutagenesis of human endothelial cell ecto-ADPase/soluble CD39: requirement of glutamate 174 and serine 218 for enzyme activity and inhibition of platelet recruitment.

Drosopoulos JH, Broekman MJ, Islam N, Maliszewski CR, Gayle RB 3rd, Marcus AJ.

Biochemistry. 2000 Jun 13;39(23):6936-43.

PMID:
10841775
30.

Aspirin analogs as antithrombotic agents.

Marcus AJ, Broekman MJ.

J Lab Clin Med. 1998 Dec;132(6):446-7. Review. No abstract available.

PMID:
9851731
31.

Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39.

Gayle RB 3rd, Maliszewski CR, Gimpel SD, Schoenborn MA, Caspary RG, Richards C, Brasel K, Price V, Drosopoulos JH, Islam N, Alyonycheva TN, Broekman MJ, Marcus AJ.

J Clin Invest. 1998 May 1;101(9):1851-9.

33.

The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

Marcus AJ, Broekman MJ, Drosopoulos JH, Islam N, Alyonycheva TN, Safier LB, Hajjar KA, Posnett DN, Schoenborn MA, Schooley KA, Gayle RB, Maliszewski CR.

J Clin Invest. 1997 Mar 15;99(6):1351-60.

34.

Prothrombotic effects of erythrocytes on platelet reactivity. Reduction by aspirin.

Santos MT, Valles J, Aznar J, Marcus AJ, Broekman MJ, Safier LB.

Circulation. 1997 Jan 7;95(1):63-8.

PMID:
8994418
35.

Cell-free hemoglobin as an oxygen carrier removes nitric oxide, resulting in defective thromboregulation.

Marcus AJ, Broekman MJ.

Circulation. 1996 Jan 15;93(2):208-9. No abstract available.

PMID:
8548889
36.

Human mononuclear cells express 12-LX: coordinated mRNA regulation with 5-LX and FLAP genes.

Kaminski WE, Jendraschak E, Baumann K, Kiefl R, Fischer S, Marcus AJ, Broekman MJ, von Schacky C.

Blood. 1996 Jan 1;87(1):331-40.

PMID:
8547660
37.

Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions.

Marcus AJ, Safier LB, Broekman MJ, Islam N, Fliessbach JH, Hajjar KA, Kaminski WE, Jendraschak E, Silverstein RL, von Schacky C.

Thromb Haemost. 1995 Jul;74(1):213-7. Review.

PMID:
8578460
38.

Calreticulin, an antithrombotic agent which binds to vitamin K-dependent coagulation factors, stimulates endothelial nitric oxide production, and limits thrombosis in canine coronary arteries.

Kuwabara K, Pinsky DJ, Schmidt AM, Benedict C, Brett J, Ogawa S, Broekman MJ, Marcus AJ, Sciacca RR, Michalak M, et al.

J Biol Chem. 1995 Apr 7;270(14):8179-87.

39.

Principles of thromboregulation: control of platelet reactivity in vascular disease.

Marcus AJ, Safier LB, Kaminski WE, Islam N, Hajjar KA, Jendraschak E, Silverstein RL, Broekman MJ, von Schacky C, Fliessbach JH.

Adv Prostaglandin Thromboxane Leukot Res. 1995;23:413-8. Review. No abstract available.

PMID:
7732885
40.

Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway.

Pinsky DJ, Oz MC, Koga S, Taha Z, Broekman MJ, Marcus AJ, Liao H, Naka Y, Brett J, Cannon PJ, et al.

J Clin Invest. 1994 May;93(5):2291-7.

41.

Downregulation of human platelet reactivity by neutrophils. Participation of lipoxygenase derivatives and adhesive proteins.

Valles J, Santos MT, Marcus AJ, Safier LB, Broekman MJ, Islam N, Ullman HL, Aznar J.

J Clin Invest. 1993 Sep;92(3):1357-65.

42.

Dietary n-3 fatty acids accelerate catabolism of leukotriene B4 in human granulocytes.

von Schacky C, Kiefl R, Marcus AJ, Broekman MJ, Kaminski WE.

Biochim Biophys Acta. 1993 Feb 10;1166(1):20-4.

PMID:
8381674
43.

Homogenization by nitrogen cavitation technique applied to platelet subcellular fractionation.

Broekman MJ.

Methods Enzymol. 1992;215:21-32. No abstract available.

PMID:
1435322
44.

Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells.

Marcus AJ, Safier LB, Hajjar KA, Ullman HL, Islam N, Broekman MJ, Eiroa AM.

J Clin Invest. 1991 Nov;88(5):1690-6.

46.

Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment.

Valles J, Santos MT, Aznar J, Marcus AJ, Martinez-Sales V, Portoles M, Broekman MJ, Safier LB.

Blood. 1991 Jul 1;78(1):154-62.

PMID:
1712639
47.

Enhancement of platelet reactivity and modulation of eicosanoid production by intact erythrocytes. A new approach to platelet activation and recruitment.

Santos MT, Valles J, Marcus AJ, Safier LB, Broekman MJ, Islam N, Ullman HL, Eiroa AM, Aznar J.

J Clin Invest. 1991 Feb;87(2):571-80.

48.
49.

Albumin redirects platelet eicosanoid metabolism toward 12(S)-hydroxyeicosatetraenoic acid.

Broekman MJ, Eiroa AM, Marcus AJ.

J Lipid Res. 1989 Dec;30(12):1925-32.

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