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Items: 1 to 50 of 56

1.

Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress.

Lee VS, Halabi CM, Broekelmann TJ, Trackman PC, Stitziel NO, Mecham RP.

JCI Insight. 2019 Jun 18;5. pii: 127748. doi: 10.1172/jci.insight.127748.

2.

Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis.

Huang LH, Zinselmeyer BH, Chang CH, Saunders BT, Elvington A, Baba O, Broekelmann TJ, Qi L, Rueve JS, Swartz MA, Kim BS, Mecham RP, Wiig H, Thomas MJ, Sorci-Thomas MG, Randolph GJ.

Cell Metab. 2019 Feb 5;29(2):475-487.e7. doi: 10.1016/j.cmet.2018.10.006. Epub 2018 Nov 8.

PMID:
30415924
3.

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells.

Onken MD, Makepeace CM, Kaltenbronn KM, Kanai SM, Todd TD, Wang S, Broekelmann TJ, Rao PK, Cooper JA, Blumer KJ.

Sci Signal. 2018 Sep 4;11(546). pii: eaao6852. doi: 10.1126/scisignal.aao6852.

4.

Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.

Craft CS, Broekelmann TJ, Mecham RP.

Matrix Biol. 2018 Oct;71-72:100-111. doi: 10.1016/j.matbio.2018.03.006. Epub 2018 Mar 7. Review.

PMID:
29524629
5.

Contribution of metabolic disease to bone fragility in MAGP1-deficient mice.

Turecamo SE, Walji TA, Broekelmann TJ, Williams JW, Ivanov S, Wee NK, Procknow JD, McManus MR, Randolph GJ, Scheller EL, Mecham RP, Craft CS.

Matrix Biol. 2018 Apr;67:1-14. doi: 10.1016/j.matbio.2018.02.022. Epub 2018 Mar 5.

6.

Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness.

Knutsen RH, Beeman SC, Broekelmann TJ, Liu D, Tsang KM, Kovacs A, Ye L, Danback JR, Watson A, Wardlaw A, Wagenseil JE, Garbow JR, Shoykhet M, Kozel BA.

Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H18-H32. doi: 10.1152/ajpheart.00683.2017. Epub 2018 Mar 2.

7.

Measurement of elastin, collagen, and total protein levels in tissues.

Stoilov I, Starcher BC, Mecham RP, Broekelmann TJ.

Methods Cell Biol. 2018;143:133-146. doi: 10.1016/bs.mcb.2017.08.008. Epub 2017 Nov 6.

PMID:
29310774
8.

Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.

Halabi CM, Broekelmann TJ, Lin M, Lee VS, Chu ML, Mecham RP.

Sci Adv. 2017 May 3;3(5):e1602532. doi: 10.1126/sciadv.1602532. eCollection 2017 May.

9.

Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine.

Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, Mecham RP, Schwartz MA, Niklason LE, White ES.

Biomaterials. 2016 Sep;102:220-30. doi: 10.1016/j.biomaterials.2016.06.025. Epub 2016 Jun 16.

10.

Sterilization of Lung Matrices by Supercritical Carbon Dioxide.

Balestrini JL, Liu A, Gard AL, Huie J, Blatt KM, Schwan J, Zhao L, Broekelmann TJ, Mecham RP, Wilcox EC, Niklason LE.

Tissue Eng Part C Methods. 2016 Mar;22(3):260-9. doi: 10.1089/ten.TEC.2015.0449. Epub 2016 Jan 29.

11.

Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness.

Halabi CM, Broekelmann TJ, Knutsen RH, Ye L, Mecham RP, Kozel BA.

Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H1008-16. doi: 10.1152/ajpheart.00288.2015. Epub 2015 Jul 31.

12.

Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.

Combs MD, Knutsen RH, Broekelmann TJ, Toennies HM, Brett TJ, Miller CA, Kober DL, Craft CS, Atkinson JJ, Shipley JM, Trask BC, Mecham RP.

J Biol Chem. 2013 Oct 4;288(40):28869-80. doi: 10.1074/jbc.M113.497727. Epub 2013 Aug 20.

13.

Zap70 inhibits Syk-mediated osteoclast function.

Zou W, Croke M, Fukunaga T, Broekelmann TJ, Mecham RP, Teitelbaum SL.

J Cell Biochem. 2013 Aug;114(8):1871-8. doi: 10.1002/jcb.24531.

14.

Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner.

Zhu T, Chappel JC, Hsu FF, Turk J, Aurora R, Hyrc K, De Camilli P, Broekelmann TJ, Mecham RP, Teitelbaum SL, Zou W.

J Biol Chem. 2013 Feb 22;288(8):5268-77. doi: 10.1074/jbc.M112.446054. Epub 2013 Jan 7.

15.

Paxillin contracts the osteoclast cytoskeleton.

Zou W, Deselm CJ, Broekelmann TJ, Mecham RP, Vande Pol S, Choi K, Teitelbaum SL.

J Bone Miner Res. 2012 Dec;27(12):2490-500. doi: 10.1002/jbmr.1706.

16.

Cardiac specific ATP-sensitive K+ channel (KATP) overexpression results in embryonic lethality.

Toib A, Zhang HX, Broekelmann TJ, Hyrc KL, Guo Q, Chen F, Remedi MS, Nichols CG.

J Mol Cell Cardiol. 2012 Sep;53(3):437-45. doi: 10.1016/j.yjmcc.2012.07.001. Epub 2012 Jul 13.

17.

Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa.

Sugitani H, Hirano E, Knutsen RH, Shifren A, Wagenseil JE, Ciliberto C, Kozel BA, Urban Z, Davis EC, Broekelmann TJ, Mecham RP.

J Biol Chem. 2012 Jun 22;287(26):22055-67. doi: 10.1074/jbc.M111.327940. Epub 2012 May 9.

18.

Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation.

Kozel BA, Knutsen RH, Ye L, Ciliberto CH, Broekelmann TJ, Mecham RP.

J Biol Chem. 2011 Dec 30;286(52):44926-36. doi: 10.1074/jbc.M111.274779. Epub 2011 Nov 2.

19.

Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.

Craft CS, Broekelmann TJ, Zou W, Chappel JC, Teitelbaum SL, Mecham RP.

J Cell Biochem. 2012 Jan;113(1):93-9. doi: 10.1002/jcb.23331.

20.

Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding.

Akhtar K, Broekelmann TJ, Song H, Turk J, Brett TJ, Mecham RP, Adair-Kirk TL.

J Biol Chem. 2011 Apr 15;286(15):13574-82. doi: 10.1074/jbc.M110.192088. Epub 2011 Feb 14.

21.

Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro.

Akhtar K, Broekelmann TJ, Miao M, Keeley FW, Starcher BC, Pierce RA, Mecham RP, Adair-Kirk TL.

J Biol Chem. 2010 Nov 26;285(48):37396-404. doi: 10.1074/jbc.M110.126789. Epub 2010 Sep 16.

22.

Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas.

Yuan L, Holmes TC, Watts RE, Khosla C, Broekelmann TJ, Mecham R, Zheng H, Izaguirre EW, Rich KM.

J Neurooncol. 2011 Jun;103(2):207-19. doi: 10.1007/s11060-010-0379-2. Epub 2010 Sep 8.

23.

Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts.

Zou W, Zhu T, Craft CS, Broekelmann TJ, Mecham RP, Teitelbaum SL.

J Cell Sci. 2010 Sep 1;123(Pt 17):2955-63. doi: 10.1242/jcs.069872.

24.

Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling.

Craft CS, Zou W, Watkins M, Grimston S, Brodt MD, Broekelmann TJ, Weinbaum JS, Teitelbaum SL, Pierce RA, Civitelli R, Silva MJ, Mecham RP.

J Biol Chem. 2010 Jul 30;285(31):23858-67. doi: 10.1074/jbc.M110.113019. Epub 2010 May 25.

25.

Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.

Weinbaum JS, Broekelmann TJ, Pierce RA, Werneck CC, Segade F, Craft CS, Knutsen RH, Mecham RP.

J Biol Chem. 2008 Sep 12;283(37):25533-43. doi: 10.1074/jbc.M709962200. Epub 2008 Jul 14.

26.

Modification and functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin.

Broekelmann TJ, Ciliberto CH, Shifren A, Mecham RP.

Matrix Biol. 2008 Sep;27(7):631-9. doi: 10.1016/j.matbio.2008.06.001. Epub 2008 Jun 17.

27.

Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.

Werneck CC, Vicente CP, Weinberg JS, Shifren A, Pierce RA, Broekelmann TJ, Tollefsen DM, Mecham RP.

Blood. 2008 Apr 15;111(8):4137-44. doi: 10.1182/blood-2007-07-101733. Epub 2008 Feb 15.

28.

Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils.

Mydel P, Shipley JM, Adair-Kirk TL, Kelley DG, Broekelmann TJ, Mecham RP, Senior RM.

J Biol Chem. 2008 Apr 11;283(15):9513-22. doi: 10.1074/jbc.M706239200. Epub 2008 Jan 4.

29.

Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice.

McLaughlin PJ, Chen Q, Horiguchi M, Starcher BC, Stanton JB, Broekelmann TJ, Marmorstein AD, McKay B, Mecham R, Nakamura T, Marmorstein LY.

Mol Cell Biol. 2006 Mar;26(5):1700-9.

30.

The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers.

Thomassin L, Werneck CC, Broekelmann TJ, Gleyzal C, Hornstra IK, Mecham RP, Sommer P.

J Biol Chem. 2005 Dec 30;280(52):42848-55. Epub 2005 Oct 26.

31.

Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain.

Broekelmann TJ, Kozel BA, Ishibashi H, Werneck CC, Keeley FW, Zhang L, Mecham RP.

J Biol Chem. 2005 Dec 9;280(49):40939-47. Epub 2005 Sep 27.

32.

Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2.

Werneck CC, Trask BC, Broekelmann TJ, Trask TM, Ritty TM, Segade F, Mecham RP.

J Biol Chem. 2004 May 28;279(22):23045-51. Epub 2004 Mar 24.

33.

Fibrillin-1 and -2 contain heparin-binding sites important for matrix deposition and that support cell attachment.

Ritty TM, Broekelmann TJ, Werneck CC, Mecham RP.

Biochem J. 2003 Oct 15;375(Pt 2):425-32.

34.

A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis.

Adair-Kirk TL, Atkinson JJ, Broekelmann TJ, Doi M, Tryggvason K, Miner JH, Mecham RP, Senior RM.

J Immunol. 2003 Jul 1;171(1):398-406.

35.

Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms.

Segade F, Trask BC, Broekelmann TJ, Pierce RA, Mecham RP.

J Biol Chem. 2002 Mar 29;277(13):11050-7. Epub 2002 Jan 16.

36.

Processing of type II procollagen amino propeptide by matrix metalloproteinases.

Fukui N, McAlinden A, Zhu Y, Crouch E, Broekelmann TJ, Mecham RP, Sandell LJ.

J Biol Chem. 2002 Jan 18;277(3):2193-201. Epub 2001 Nov 8.

37.

Revised genomic structure of the human MAGP1 gene and identification of alternate transcripts in human and mouse tissues.

Segade F, Broekelmann TJ, Pierce RA, Mecham RP.

Matrix Biol. 2000 Dec;19(7):671-82.

PMID:
11102756
38.
39.

Identification of tropoelastin as a ligand for the 65-kD FK506-binding protein, FKBP65, in the secretory pathway.

Davis EC, Broekelmann TJ, Ozawa Y, Mecham RP.

J Cell Biol. 1998 Jan 26;140(2):295-303.

40.

Elastin degradation by matrix metalloproteinases. Cleavage site specificity and mechanisms of elastolysis.

Mecham RP, Broekelmann TJ, Fliszar CJ, Shapiro SD, Welgus HG, Senior RM.

J Biol Chem. 1997 Jul 18;272(29):18071-6.

41.

Neuronal production of fibronectin in the cerebral cortex during migration and layer formation is unique to specific cortical domains.

Sheppard AM, Brunstrom JE, Thornton TN, Gerfen RW, Broekelmann TJ, McDonald JA, Pearlman AL.

Dev Biol. 1995 Dec;172(2):504-18.

42.

The mitogenic effects of the B beta chain of fibrinogen are mediated through cell surface calreticulin.

Gray AJ, Park PW, Broekelmann TJ, Laurent GJ, Reeves JT, Stenmark KR, Mecham RP.

J Biol Chem. 1995 Nov 3;270(44):26602-6.

44.

Binding and degradation of elastin by the staphylolytic enzyme lysostaphin.

Park PW, Senior RM, Griffin GL, Broekelmann TJ, Mudd MS, Mecham RP.

Int J Biochem Cell Biol. 1995 Feb;27(2):139-46.

PMID:
7767782
45.

Growth factor and procollagen type I gene expression in human liver disease.

Malizia G, Brunt EM, Peters MG, Rizzo A, Broekelmann TJ, McDonald JA.

Gastroenterology. 1995 Jan;108(1):145-56.

PMID:
7806036
46.

Characterization of integrins in cultured human renal cortical tubule epithelial cells.

Simon EE, Liu CH, Das M, Nigam S, Broekelmann TJ, McDonald JA.

Am J Physiol. 1994 Oct;267(4 Pt 2):F612-23.

PMID:
7943359
47.

Degradation of entactin by matrix metalloproteinases. Susceptibility to matrilysin and identification of cleavage sites.

Sires UI, Griffin GL, Broekelmann TJ, Mecham RP, Murphy G, Chung AE, Welgus HG, Senior RM.

J Biol Chem. 1993 Jan 25;268(3):2069-74.

48.

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

Broekelmann TJ, Limper AH, Colby TV, McDonald JA.

Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6642-6.

49.

Analysis of local mRNA expression for extracellular matrix proteins and growth factors using in situ hybridization in fibroproliferative lung disorders.

Limper AH, Broekelmann TJ, Colby TV, Malizia G, McDonald JA.

Chest. 1991 Mar;99(3 Suppl):55S-56S. No abstract available.

PMID:
1997276
50.

The fibronectin receptor is organized by extracellular matrix fibronectin: implications for oncogenic transformation and for cell recognition of fibronectin matrices.

Roman J, LaChance RM, Broekelmann TJ, Kennedy CJ, Wayner EA, Carter WG, McDonald JA.

J Cell Biol. 1989 Jun;108(6):2529-43.

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