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Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing.

Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ.

Nat Commun. 2018 Jul 6;9(1):2641. doi: 10.1038/s41467-018-05073-z.


Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema.

Borel F, Sun H, Zieger M, Cox A, Cardozo B, Li W, Oliveira G, Davis A, Gruntman A, Flotte TR, Brodsky MH, Hoffman AM, Elmallah MK, Mueller C.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2788-2793. doi: 10.1073/pnas.1713689115. Epub 2018 Feb 16.


motifStack for the analysis of transcription factor binding site evolution.

Ou J, Wolfe SA, Brodsky MH, Zhu LJ.

Nat Methods. 2018 Jan 3;15(1):8-9. doi: 10.1038/nmeth.4555. No abstract available.


A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats.

Qaisar N, Lin S, Ryan G, Yang C, Oikemus SR, Brodsky MH, Bortell R, Mordes JP, Wang JP.

Diabetes. 2017 Jan;66(1):145-157. doi: 10.2337/db16-0462. Epub 2016 Oct 7.


Rapid Screening for CRISPR-Directed Editing of the Drosophila Genome Using white Coconversion.

Ge DT, Tipping C, Brodsky MH, Zamore PD.

G3 (Bethesda). 2016 Oct 13;6(10):3197-3206. doi: 10.1534/g3.116.032557.


DNA-binding-domain fusions enhance the targeting range and precision of Cas9.

Bolukbasi MF, Gupta A, Oikemus S, Derr AG, Garber M, Brodsky MH, Zhu LJ, Wolfe SA.

Nat Methods. 2015 Dec;12(12):1150-6. doi: 10.1038/nmeth.3624. Epub 2015 Oct 19.


CRISPRseek: a bioconductor package to identify target-specific guide RNAs for CRISPR-Cas9 genome-editing systems.

Zhu LJ, Holmes BR, Aronin N, Brodsky MH.

PLoS One. 2014 Sep 23;9(9):e108424. doi: 10.1371/journal.pone.0108424. eCollection 2014.


An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins.

Gupta A, Christensen RG, Bell HA, Goodwin M, Patel RY, Pandey M, Enuameh MS, Rayla AL, Zhu C, Thibodeau-Beganny S, Brodsky MH, Joung JK, Wolfe SA, Stormo GD.

Nucleic Acids Res. 2014 Apr;42(8):4800-12. doi: 10.1093/nar/gku132. Epub 2014 Feb 12.


Simulations of enhancer evolution provide mechanistic insights into gene regulation.

Duque T, Samee MA, Kazemian M, Pham HN, Brodsky MH, Sinha S.

Mol Biol Evol. 2014 Jan;31(1):184-200. doi: 10.1093/molbev/mst170. Epub 2013 Oct 4.


Computational identification of diverse mechanisms underlying transcription factor-DNA occupancy.

Cheng Q, Kazemian M, Pham H, Blatti C, Celniker SE, Wolfe SA, Brodsky MH, Sinha S.

PLoS Genet. 2013;9(8):e1003571. doi: 10.1371/journal.pgen.1003571. Epub 2013 Aug 1.


Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development.

Kazemian M, Pham H, Wolfe SA, Brodsky MH, Sinha S.

Nucleic Acids Res. 2013 Sep;41(17):8237-52. doi: 10.1093/nar/gkt598. Epub 2013 Jul 11.


Global analysis of Drosophila Cys₂-His₂ zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants.

Enuameh MS, Asriyan Y, Richards A, Christensen RG, Hall VL, Kazemian M, Zhu C, Pham H, Cheng Q, Blatti C, Brasefield JA, Basciotta MD, Ou J, McNulty JC, Zhu LJ, Celniker SE, Sinha S, Stormo GD, Brodsky MH, Wolfe SA.

Genome Res. 2013 Jun;23(6):928-40. doi: 10.1101/gr.151472.112. Epub 2013 Mar 7.


Recognition models to predict DNA-binding specificities of homeodomain proteins.

Christensen RG, Enuameh MS, Noyes MB, Brodsky MH, Wolfe SA, Stormo GD.

Bioinformatics. 2012 Jun 15;28(12):i84-9. doi: 10.1093/bioinformatics/bts202.


Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila.

Andersen SL, Kuo HK, Savukoski D, Brodsky MH, Sekelsky J.

PLoS Genet. 2011 Oct;7(10):e1002315. doi: 10.1371/journal.pgen.1002315. Epub 2011 Oct 13.


Genome Surveyor 2.0: cis-regulatory analysis in Drosophila.

Kazemian M, Brodsky MH, Sinha S.

Nucleic Acids Res. 2011 Jul;39(Web Server issue):W79-85. doi: 10.1093/nar/gkr291. Epub 2011 May 18.


FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system.

Zhu LJ, Christensen RG, Kazemian M, Hull CJ, Enuameh MS, Basciotta MD, Brasefield JA, Zhu C, Asriyan Y, Lapointe DS, Sinha S, Wolfe SA, Brodsky MH.

Nucleic Acids Res. 2011 Jan;39(Database issue):D111-7. doi: 10.1093/nar/gkq858. Epub 2010 Nov 19.


Quantitative analysis of the Drosophila segmentation regulatory network using pattern generating potentials.

Kazemian M, Blatti C, Richards A, McCutchan M, Wakabayashi-Ito N, Hammonds AS, Celniker SE, Kumar S, Wolfe SA, Brodsky MH, Sinha S.

PLoS Biol. 2010 Aug 17;8(8). pii: e1000456. doi: 10.1371/journal.pbio.1000456. Erratum in: PLoS Biol. 2013 Oct;11(10). doi: 10.1371/annotation/e38f4ae8-0776-42e6-b912-50800f54436e.


p53 represses class switch recombination to IgG2a through its antioxidant function.

Guikema JE, Schrader CE, Brodsky MH, Linehan EK, Richards A, El Falaky N, Li DH, Sluss HK, Szomolanyi-Tsuda E, Stavnezer J.

J Immunol. 2010 Jun 1;184(11):6177-87. doi: 10.4049/jimmunol.0904085. Epub 2010 May 5. Erratum in: J Immunol. 2011 Nov 1;187(9):4920.


p53-independent apoptosis limits DNA damage-induced aneuploidy.

McNamee LM, Brodsky MH.

Genetics. 2009 Jun;182(2):423-35. doi: 10.1534/genetics.109.102327. Epub 2009 Apr 13.


Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites.

Noyes MB, Christensen RG, Wakabayashi A, Stormo GD, Brodsky MH, Wolfe SA.

Cell. 2008 Jun 27;133(7):1277-89. doi: 10.1016/j.cell.2008.05.023.


Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions.

Mauri F, McNamee LM, Lunardi A, Chiacchiera F, Del Sal G, Brodsky MH, Collavin L.

J Biol Chem. 2008 Jul 25;283(30):20848-56. doi: 10.1074/jbc.M710186200. Epub 2008 May 20.


A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system.

Noyes MB, Meng X, Wakabayashi A, Sinha S, Brodsky MH, Wolfe SA.

Nucleic Acids Res. 2008 May;36(8):2547-60. doi: 10.1093/nar/gkn048. Epub 2008 Mar 10.


Cell-nonautonomous function of ceramidase in photoreceptor homeostasis.

Acharya JK, Dasgupta U, Rawat SS, Yuan C, Sanxaridis PD, Yonamine I, Karim P, Nagashima K, Brodsky MH, Tsunoda S, Acharya U.

Neuron. 2008 Jan 10;57(1):69-79. doi: 10.1016/j.neuron.2007.10.041.


Committee on microbiology and extraneous materials.

Agin JR, Ziemer WA, Newman MC, Guilfoyle DE, Vought K, Ledenbach L, Brodsky MH, Hill W, Rice D, Ferreira JL, Werner BG, Martin BM, Shively R, Marrow T, Phillips RW, Wehling P, Labudde RA; AOAC. Committee on microbiology and extraneous materials.

J AOAC Int. 2006 Nov-Dec;89(6):1700-1. No abstract available.


Epigenetic telomere protection by Drosophila DNA damage response pathways.

Oikemus SR, Queiroz-Machado J, Lai K, McGinnis N, Sunkel C, Brodsky MH.

PLoS Genet. 2006 May;2(5):e71. Epub 2006 May 19.


A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors.

Meng X, Brodsky MH, Wolfe SA.

Nat Biotechnol. 2005 Aug;23(8):988-94. Epub 2005 Jul 24.


Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect.

Oikemus SR, McGinnis N, Queiroz-Machado J, Tukachinsky H, Takada S, Sunkel CE, Brodsky MH.

Genes Dev. 2004 Aug 1;18(15):1850-61. Epub 2004 Jul 15.


Committee on Microbiology and Extraneous Materials.

Agin JR, Abbott DO, Ziemer WA, McClure FD, Ferreira JL, Ledenbach L, Hitchins AD, Hill W, Brodsky MH, Sciacchitano CJ, Guilfoyle DE, Loveys DA.

J AOAC Int. 2004 Jan-Feb;87(1):321-9. No abstract available.


Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage.

Brodsky MH, Weinert BT, Tsang G, Rong YS, McGinnis NM, Golic KG, Rio DC, Rubin GM.

Mol Cell Biol. 2004 Feb;24(3):1219-31.


DNA repair in Drosophila: insights from the Drosophila genome sequence.

Sekelsky JJ, Brodsky MH, Burtis KC.

J Cell Biol. 2000 Jul 24;150(2):F31-6. Review. No abstract available.


Illness outbreak associated with Escherichia coli O157:H7 in Genoa salami. E. coli O157:H7 Working Group.

Williams RC, Isaacs S, Decou ML, Richardson EA, Buffett MC, Slinger RW, Brodsky MH, Ciebin BW, Ellis A, Hockin J.

CMAJ. 2000 May 16;162(10):1409-13.


Drosophila p53 binds a damage response element at the reaper locus.

Brodsky MH, Nordstrom W, Tsang G, Kwan E, Rubin GM, Abrams JM.

Cell. 2000 Mar 31;101(1):103-13.


mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development.

Brodsky MH, Sekelsky JJ, Tsang G, Hawley RS, Rubin GM.

Genes Dev. 2000 Mar 15;14(6):666-78.


Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing.

Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS.

Nucleic Acids Res. 1999 Sep 15;27(18):3762-9.


Comparative evaluation of modified m-FC and m-TEC media for membrane filter enumeration of Escherichia coli in water.

Ciebin BW, Brodsky MH, Eddington R, Horsnell G, Choney A, Palmateer G, Ley A, Joshi R, Shears G.

Appl Environ Microbiol. 1995 Nov;61(11):3940-2.


Delayed-Incubation Method for Microbiological Analysis of Environmental Specimens and Samples.

Brodsky MH, DAVlDSON CA, Dickson JS, Pettis MJ, Tieso TL.

J Food Prot. 1995 Aug;58(8):884-889. doi: 10.4315/0362-028X-58.8.884.


A Retail Survey of Smoked Ready-to-eat Fish to Determine Their Microbiological Quality.

Dodds KL, Brodsky MH, Warburton DW.

J Food Prot. 1992 Mar;55(3):208-210. doi: 10.4315/0362-028X-55.3.208.


Analysis of the site in CD4 that binds to the HIV envelope glycoprotein.

Brodsky MH, Warton M, Myers RM, Littman DR.

J Immunol. 1990 Apr 15;144(8):3078-86.


Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.

Turner JM, Brodsky MH, Irving BA, Levin SD, Perlmutter RM, Littman DR.

Cell. 1990 Mar 9;60(5):755-65.


Nosocomial diarrhea associated with enterotoxigenic Clostridium perfringens infection in dogs.

Kruth SA, Prescott JF, Welch MK, Brodsky MH.

J Am Vet Med Assoc. 1989 Aug 1;195(3):331-4.


Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography.

Yamamoto Y, Brodsky MH, Baker JC, Ames BN.

Anal Biochem. 1987 Jan;160(1):7-13.


Evaluation of the diagnostic application of an enzyme immunoassay for Clostridium perfringens type A enterotoxin.

Jackson SG, Yip-Chuck DA, Brodsky MH.

Appl Environ Microbiol. 1986 Oct;52(4):969-70.


Novobiocin-brilliant green-glucose agar: new medium for isolation of salmonellae.

Devenish JA, Ciebin BW, Brodsky MH.

Appl Environ Microbiol. 1986 Sep;52(3):539-45.


A double antibody sandwich enzyme-immunoassay for Clostridium perfringens type A enterotoxin detection in stool specimens.

Jackson SG, Yip-Chuck DA, Brodsky MH.

J Immunol Methods. 1985 Oct 24;83(1):141-50.


Evaluation of Millipore Swab-Membrane Filter Kits.

Devenish JA, Ciebin BW, Brodsky MH.

J Food Prot. 1985 Oct;48(10):870-874. doi: 10.4315/0362-028X-48.10.870.


Polytope model and the electronic and structural properties of amorphous semiconductors.

Mosseri R, DiVincenzo DP, Sadoc JF, Brodsky MH.

Phys Rev B Condens Matter. 1985 Sep 15;32(6):3974-4000. No abstract available.


Evaluation of the Bacteriological Health Risk of 60-Day Aged Raw Milk Cheddar Cheese.

Brodsky MH.

J Food Prot. 1984 Jul;47(7):530-531. doi: 10.4315/0362-028X-47.7.530.


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