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Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension.

Biancospino M, Buel GR, Niño CA, Maspero E, di Perrotolo RS, Raimondi A, Redlingshöfer L, Weber J, Brodsky FM, Walters KJ, Polo S.

Nat Commun. 2019 Oct 31;10(1):4974. doi: 10.1038/s41467-019-12855-6.


Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese.

Edinburgh RM, Bradley HE, Abdullah NF, Robinson SL, Chrzanowski-Smith OJ, Walhin JP, Joanisse S, Manolopoulos KN, Philp A, Hengist A, Chabowski A, Brodsky FM, Koumanov F, Betts JA, Thompson D, Wallis GA, Gonzalez JT.

J Clin Endocrinol Metab. 2019 Oct 19. pii: dgz104. doi: 10.1210/clinem/dgz104. [Epub ahead of print]


Looking back to traffic forward: A tribute to Thomas Kreis (1952-1998) and his inspiration.

Brodsky FM, Perez F.

Traffic. 2019 Sep 14. doi: 10.1111/tra.12697. [Epub ahead of print] No abstract available.


The AP2 adaptor enhances clathrin coat stiffness.

Lherbette M, Redlingshöfer L, Brodsky FM, Schaap IAT, Dannhauser PN.

FEBS J. 2019 Oct;286(20):4074-4085. doi: 10.1111/febs.14961. Epub 2019 Jul 3.


Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism.

Fumagalli M, Camus SM, Diekmann Y, Burke A, Camus MD, Norman PJ, Joseph A, Abi-Rached L, Benazzo A, Rasteiro R, Mathieson I, Topf M, Parham P, Thomas MG, Brodsky FM.

Elife. 2019 Jun 4;8. pii: e41517. doi: 10.7554/eLife.41517.


CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.

Dannhauser PN, Camus SM, Sakamoto K, Sadacca LA, Torres JA, Camus MD, Briant K, Vassilopoulos S, Rothnie A, Smith CJ, Brodsky FM.

J Biol Chem. 2017 Dec 22;292(51):20834-20844. doi: 10.1074/jbc.M117.816256. Epub 2017 Nov 2.


Clathrin light chains' role in selective endocytosis influences antibody isotype switching.

Wu S, Majeed SR, Evans TM, Camus MD, Wong NM, Schollmeier Y, Park M, Muppidi JR, Reboldi A, Parham P, Cyster JG, Brodsky FM.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9816-21. doi: 10.1073/pnas.1611189113. Epub 2016 Aug 18.


A Distinctive Cytoplasmic Tail Contributes to Low Surface Expression and Intracellular Retention of the Patr-AL MHC Class I Molecule.

Goyos A, Guethlein LA, Horowitz A, Hilton HG, Gleimer M, Brodsky FM, Parham P.

J Immunol. 2015 Oct 15;195(8):3725-36. doi: 10.4049/jimmunol.1500397. Epub 2015 Sep 14.


Unconventional functions for clathrin, ESCRTs, and other endocytic regulators in the cytoskeleton, cell cycle, nucleus, and beyond: links to human disease.

Brodsky FM, Sosa RT, Ybe JA, O'Halloran TJ.

Cold Spring Harb Perspect Biol. 2014 Sep 2;6(9):a017004. doi: 10.1101/cshperspect.a017004. Review.


Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration.

Majeed SR, Vasudevan L, Chen CY, Luo Y, Torres JA, Evans TM, Sharkey A, Foraker AB, Wong NM, Esk C, Freeman TA, Moffett A, Keen JH, Brodsky FM.

Nat Commun. 2014 May 23;5:3891. doi: 10.1038/ncomms4891.


Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization.

Vassilopoulos S, Gentil C, Lainé J, Buclez PO, Franck A, Ferry A, Précigout G, Roth R, Heuser JE, Brodsky FM, Garcia L, Bonne G, Voit T, Piétri-Rouxel F, Bitoun M.

J Cell Biol. 2014 May 12;205(3):377-93. doi: 10.1083/jcb.201309096. Epub 2014 May 5.


The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism.

Sullivan CS, Scheib JL, Ma Z, Dang RP, Schafer JM, Hickman FE, Brodsky FM, Ravichandran KS, Carter BD.

Mol Biol Cell. 2014 Jun 15;25(12):1925-36. doi: 10.1091/mbc.E13-11-0658. Epub 2014 Apr 17.


Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway.

Asensio CS, Sirkis DW, Maas JW Jr, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH.

Dev Cell. 2013 Nov 25;27(4):425-37. doi: 10.1016/j.devcel.2013.10.007. Epub 2013 Nov 7.


The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration.

Hoshino S, Sakamoto K, Vassilopoulos S, Camus SM, Griffin CA, Esk C, Torres JA, Ohkoshi N, Ishii A, Tamaoka A, Funke BH, Kucherlapati R, Margeta M, Rando TA, Brodsky FM.

PLoS One. 2013 Oct 30;8(10):e77787. doi: 10.1371/journal.pone.0077787. eCollection 2013.


Frances Brodsky: so you think you know all about clathrin? Interview by Caitlin Sedwick.

Brodsky F.

J Cell Biol. 2013 Sep 16;202(6):830-1. doi: 10.1083/jcb.2026pi. No abstract available.


A cost-benefit analysis of the physical mechanisms of membrane curvature.

Stachowiak JC, Brodsky FM, Miller EA.

Nat Cell Biol. 2013 Sep;15(9):1019-27. doi: 10.1038/ncb2832. Review.


Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.

Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):E3138-47. doi: 10.1073/pnas.1301440110. Epub 2013 Jul 29.


Anisotropic nanocrystal arrays organized on protein lattices formed by recombinant clathrin fragments.

Hom N, Mehta KR, Chou T, Foraker AB, Brodsky FM, Kirshenbaum K, Montclare JK.

J Mater Chem. 2012 Dec 28;22(44):23335-23339.


Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly.

Young A, Stoilova-McPhie S, Rothnie A, Vallis Y, Harvey-Smith P, Ranson N, Kent H, Brodsky FM, Pearse BM, Roseman A, Smith CJ.

Traffic. 2013 Sep;14(9):987-96. doi: 10.1111/tra.12085. Epub 2013 Jun 20.


A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization.

Bonazzi M, Kühbacher A, Toledo-Arana A, Mallet A, Vasudevan L, Pizarro-Cerdá J, Brodsky FM, Cossart P.

Traffic. 2012 Dec;13(12):1653-66. doi: 10.1111/tra.12009. Epub 2012 Oct 11.


Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.

Foraker AB, Camus SM, Evans TM, Majeed SR, Chen CY, Taner SB, Corrêa IR Jr, Doxsey SJ, Brodsky FM.

J Cell Biol. 2012 Aug 20;198(4):591-605. doi: 10.1083/jcb.201205116. Epub 2012 Aug 13.


Diversity of clathrin function: new tricks for an old protein.

Brodsky FM.

Annu Rev Cell Dev Biol. 2012;28:309-36. doi: 10.1146/annurev-cellbio-101011-155716. Epub 2012 Jul 23. Review.


Evolutionary cell biology: Lessons from diversity.

Brodsky FM, Thattai M, Mayor S.

Nat Cell Biol. 2012 Jun 29;14(7):651. doi: 10.1038/ncb2539.


Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization.

Bonazzi M, Vasudevan L, Mallet A, Sachse M, Sartori A, Prevost MC, Roberts A, Taner SB, Wilbur JD, Brodsky FM, Cossart P.

J Cell Biol. 2011 Oct 31;195(3):525-36. doi: 10.1083/jcb.201105152.


The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.

Stoddart A, Tennant TR, Fernald AA, Anastasi J, Brodsky FM, Le Beau MM.

Oncogene. 2012 Jan 26;31(4):494-506. doi: 10.1038/onc.2011.251. Epub 2011 Jun 27.


Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons.

Shieh JC, Schaar BT, Srinivasan K, Brodsky FM, McConnell SK.

PLoS One. 2011 Mar 22;6(3):e17802. doi: 10.1371/journal.pone.0017802.


Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention.

Taner SB, Pando MJ, Roberts A, Schellekens J, Marsh SG, Malmberg KJ, Parham P, Brodsky FM.

J Immunol. 2011 Jan 1;186(1):62-72. doi: 10.4049/jimmunol.0903657. Epub 2010 Nov 29.


Conformation switching of clathrin light chain regulates clathrin lattice assembly.

Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM.

Dev Cell. 2010 May 18;18(5):841-8. doi: 10.1016/j.devcel.2010.04.007.


Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain.

Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ.

Acta Crystallogr D Biol Crystallogr. 2010 Mar;66(Pt 3):314-8. doi: 10.1107/S0907444909054535. Epub 2010 Feb 12.


[The CHC22 human clathrin heavy chain isoform, intracellular traffic of the glucose transporter GLUT4, and type 2 diabetes].

Vassilopoulos S, Esk C, Hoshino S, Brodsky FM.

Med Sci (Paris). 2010 Jan;26(1):33-6. doi: 10.1051/medsci/201026133. French. No abstract available.


The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.

Esk C, Chen CY, Johannes L, Brodsky FM.

J Cell Biol. 2010 Jan 11;188(1):131-44. doi: 10.1083/jcb.200908057.


Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402.

Sharma D, Bastard K, Guethlein LA, Norman PJ, Yawata N, Yawata M, Pando M, Thananchai H, Dong T, Rowland-Jones S, Brodsky FM, Parham P.

J Immunol. 2009 Oct 1;183(7):4569-82. doi: 10.4049/jimmunol.0901734. Epub 2009 Sep 14.


A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.

Vassilopoulos S, Esk C, Hoshino S, Funke BH, Chen CY, Plocik AM, Wright WE, Kucherlapati R, Brodsky FM.

Science. 2009 May 29;324(5931):1192-6. doi: 10.1126/science.1171529.


Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.

Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM.

J Biol Chem. 2008 Nov 21;283(47):32870-9. doi: 10.1074/jbc.M802863200. Epub 2008 Sep 12.


Evolutionary analysis and molecular dissection of caveola biogenesis.

Kirkham M, Nixon SJ, Howes MT, Abi-Rached L, Wakeham DE, Hanzal-Bayer M, Ferguson C, Hill MM, Fernandez-Rojo M, Brown DA, Hancock JF, Brodsky FM, Parton RG.

J Cell Sci. 2008 Jun 15;121(Pt 12):2075-86. doi: 10.1242/jcs.024588. Epub 2008 May 27.


Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission.

Sowinski S, Jolly C, Berninghausen O, Purbhoo MA, Chauveau A, Köhler K, Oddos S, Eissmann P, Brodsky FM, Hopkins C, Onfelt B, Sattentau Q, Davis DM.

Nat Cell Biol. 2008 Feb;10(2):211-9. doi: 10.1038/ncb1682. Epub 2008 Jan 13.


Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly.

Knuehl C, Chen CY, Manalo V, Hwang PK, Ota N, Brodsky FM.

Traffic. 2006 Dec;7(12):1688-700. Epub 2006 Oct 17.


TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.

Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR.

J Exp Med. 2005 Oct 3;202(7):955-65.


Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution.

Wakeham DE, Abi-Rached L, Towler MC, Wilbur JD, Parham P, Brodsky FM.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7209-14. Epub 2005 May 9.


New faces of the familiar clathrin lattice.

Wilbur JD, Hwang PK, Brodsky FM.

Traffic. 2005 Apr;6(4):346-50. Review.


Plasticity of B cell receptor internalization upon conditional depletion of clathrin.

Stoddart A, Jackson AP, Brodsky FM.

Mol Biol Cell. 2005 May;16(5):2339-48. Epub 2005 Feb 16.


Cell biology: clathrin's Achilles' ankle.

Brodsky FM.

Nature. 2004 Dec 2;432(7017):568-9. No abstract available.


The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization.

Niiro H, Allam A, Stoddart A, Brodsky FM, Marshall AJ, Clark EA.

J Immunol. 2004 Nov 1;173(9):5601-9.


Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.

Towler MC, Gleeson PA, Hoshino S, Rahkila P, Manalo V, Ohkoshi N, Ordahl C, Parton RG, Brodsky FM.

Mol Biol Cell. 2004 Jul;15(7):3181-95. Epub 2004 May 7.


Membrane traffic in skeletal muscle.

Towler MC, Kaufman SJ, Brodsky FM.

Traffic. 2004 Mar;5(3):129-39. Review.


T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization.

Crotzer VL, Mabardy AS, Weiss A, Brodsky FM.

J Exp Med. 2004 Apr 5;199(7):981-91.


Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation.

Wakeham DE, Chen CY, Greene B, Hwang PK, Brodsky FM.

EMBO J. 2003 Oct 1;22(19):4980-90.


The long and short of adaptor appendages.

Knuehl C, Brodsky FM.

Nat Struct Biol. 2003 Aug;10(8):580-2. No abstract available.


Clathrin light and heavy chain interface: alpha-helix binding superhelix loops via critical tryptophans.

Chen CY, Reese ML, Hwang PK, Ota N, Agard D, Brodsky FM.

EMBO J. 2002 Nov 15;21(22):6072-82.

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