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Developing a core outcome set for children with protracted bacterial bronchitis.

Gilchrist FJ, Ali I, Brodlie M, Carroll WD, Kemball B, Walker J, Sinha I.

ERJ Open Res. 2020 Feb 10;6(1). pii: 00344-2019. doi: 10.1183/23120541.00344-2019. eCollection 2020 Jan.


Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age.

Grudzinska FS, Brodlie M, Scholefield BR, Jackson T, Scott A, Thickett DR, Sapey E.

Thorax. 2020 Feb;75(2):164-171. doi: 10.1136/thoraxjnl-2018-212826. Epub 2019 Nov 15.


Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells.

Saint-Criq V, Haq IJ, Gardner AI, Garnett JP, Ward C, Brodlie M, Gray MA.

J Vis Exp. 2019 Jun 13;(148). doi: 10.3791/59815.


Pediatric tracheostomy: A large single-center experience.

Roberts J, Powell J, Begbie J, Siou G, McLarnon C, Welch A, McKean M, Thomas M, Ebdon AM, Moss S, Agbeko RS, Smith JH, Brodlie M, O'Brien C, Powell S.

Laryngoscope. 2019 Jun 28. doi: 10.1002/lary.28160. [Epub ahead of print]


Physiological effects of high-flow nasal cannula therapy in preterm infants.

Liew Z, Fenton AC, Harigopal S, Gopalakaje S, Brodlie M, O'Brien CJ.

Arch Dis Child Fetal Neonatal Ed. 2020 Jan;105(1):87-93. doi: 10.1136/archdischild-2018-316773. Epub 2019 May 23.


Tools and Methods Used for the Assessment of Body Composition in Patients With Cystic Fibrosis: A Systematic Review.

Calella P, Valerio G, Brodlie M, Taylor J, Donini LM, Siervo M.

Nutr Clin Pract. 2019 Oct;34(5):701-714. doi: 10.1002/ncp.10247. Epub 2019 Feb 7.


Risk factors for lung disease progression in children with cystic fibrosis.

Al Momani H, Perry A, Jones R, McDonnell M, Krishnan A, Robertson A, Griffin M, Rutherford R, Brodlie M, Pearson J, Bourke S, Ward C.

Eur Respir J. 2018 Oct 4;52(4). pii: 1801492. doi: 10.1183/13993003.01492-2018. Print 2018 Oct. No abstract available.


A review of adenotonsillar hypertrophy and adenotonsillectomy in children after solid organ transplantation.

Roberts J, Powell J, Mather MW, Powell S, Brodlie M.

Int J Pediatr Otorhinolaryngol. 2018 Nov;114:29-35. doi: 10.1016/j.ijporl.2018.08.020. Epub 2018 Aug 23. Review.


Epidemiology of Nontuberculous Mycobacteria Infection in Children and Young People With Cystic Fibrosis: Analysis of UK Cystic Fibrosis Registry.

Gardner AI, McClenaghan E, Saint G, McNamara PS, Brodlie M, Thomas MF.

Clin Infect Dis. 2019 Feb 15;68(5):731-737. doi: 10.1093/cid/ciy531.


Cystic fibrosis, body composition, and health outcomes: a systematic review.

Calella P, Valerio G, Brodlie M, Donini LM, Siervo M.

Nutrition. 2018 Nov;55-56:131-139. doi: 10.1016/j.nut.2018.03.052. Epub 2018 Apr 6.


NonTuberculous Mycobacteria infection and lung transplantation in cystic fibrosis: a worldwide survey of clinical practice.

Tissot A, Thomas MF, Corris PA, Brodlie M.

BMC Pulm Med. 2018 May 22;18(1):86. doi: 10.1186/s12890-018-0635-3.


Sphingolipids as targets for inhalation treatment of cystic fibrosis.

Becker KA, Riethmüller J, Seitz AP, Gardner A, Boudreau R, Kamler M, Kleuser B, Schuchman E, Caldwell CC, Edwards MJ, Grassmé H, Brodlie M, Gulbins E.

Adv Drug Deliv Rev. 2018 Aug;133:66-75. doi: 10.1016/j.addr.2018.04.015. Epub 2018 Apr 24. Review.


Association between body composition and pulmonary function in children and young people with cystic fibrosis.

Calella P, Valerio G, Thomas M, McCabe H, Taylor J, Brodlie M, Siervo M.

Nutrition. 2018 Apr;48:73-76. doi: 10.1016/j.nut.2017.10.026. Epub 2017 Dec 5.


Endothelial cell damage in idiopathic pneumonia syndrome.

Altmann T, Slack J, Slatter MA, O'Brien C, Cant A, Thomas M, Brodlie M, Annavarapu S, Gennery AR.

Bone Marrow Transplant. 2018 Apr;53(4):515-518. doi: 10.1038/s41409-017-0042-z. Epub 2018 Jan 15. No abstract available.


Corrigendum for: Congenital Lung Agenesis: Incidence and Outcome in the North of England.

Thomas M, Robertson N, Miller N, Rankin J, McKean M, Brodlie M.

Birth Defects Res. 2017 Sep 1;109(15):1237. doi: 10.1002/bdr2.1120. No abstract available.


Should we use montelukast in wheezy children?

Haq I, Harris C, Taylor J, McKean MC, Brodlie M.

Arch Dis Child. 2017 Nov;102(11):997-998. doi: 10.1136/archdischild-2017-312655. Epub 2017 Aug 5. No abstract available.


Ataluren in cystic fibrosis: development, clinical studies and where are we now?

Zainal Abidin N, Haq IJ, Gardner AI, Brodlie M.

Expert Opin Pharmacother. 2017 Sep;18(13):1363-1371. doi: 10.1080/14656566.2017.1359255. Epub 2017 Aug 1. Review.


Characterisation of eppin function: expression and activity in the lung.

Scott A, Glasgow A, Small D, Carlile S, McCrudden M, McLean D, Brown R, Doherty D, Lundy FT, Hamid UI, O'Kane CM, McAuley DF, Brodlie M, Tunney M, Elborn JS, Irwin CR, Timson DJ, Taggart CC, Weldon S.

Eur Respir J. 2017 Jul 13;50(1). pii: 1601937. doi: 10.1183/13993003.01937-2016. Print 2017 Jul.


β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections.

Grassmé H, Henry B, Ziobro R, Becker KA, Riethmüller J, Gardner A, Seitz AP, Steinmann J, Lang S, Ward C, Schuchman EH, Caldwell CC, Kamler M, Edwards MJ, Brodlie M, Gulbins E.

Cell Host Microbe. 2017 Jun 14;21(6):707-718.e8. doi: 10.1016/j.chom.2017.05.001. Epub 2017 May 25.


How to use nasal nitric oxide in a child with suspected primary ciliary dyskinesia.

Simpson K, Brodlie M.

Arch Dis Child Educ Pract Ed. 2017 Dec;102(6):314-318. doi: 10.1136/archdischild-2016-311468. Epub 2017 May 11.


CK2 is a key regulator of SLC4A2-mediated Cl-/HCO3- exchange in human airway epithelia.

Ibrahim SH, Turner MJ, Saint-Criq V, Garnett J, Haq IJ, Brodlie M, Ward C, Borgo C, Salvi M, Venerando A, Gray MA.

Pflugers Arch. 2017 Sep;469(9):1073-1091. doi: 10.1007/s00424-017-1981-3. Epub 2017 Apr 28.


Nontuberculous mycobacteria in gastrostomy fed patients with cystic fibrosis.

Al-Momani H, Perry A, Jones R, Bourke S, Doe S, Perry J, Anderson A, Forrest T, Forrest I, Griffin M, Brodlie M, Pearson J, Ward C.

Sci Rep. 2017 Apr 24;7:46546. doi: 10.1038/srep46546.


Congenital Lung Agenesis: Incidence and Outcome in the North of England.

Robertson N, Miller N, Rankin J, McKean M, Brodlie M, Thomas M.

Birth Defects Res. 2017 Jul 3;109(11):857-859. doi: 10.1002/bdr2.1011. Epub 2017 Apr 12. Erratum in: Birth Defects Res. 2017 Sep 1;109 (15):1237.


Successful outcome following pneumonectomy in a teenage boy with cystic fibrosis: a case report.

Liew Z, Mallikarjuna S, Hasan A, Gould FK, Bunn S, Thomas MF, Lordan JL, O'Brien C, Brodlie M.

BMC Pulm Med. 2017 Jan 13;17(1):17. doi: 10.1186/s12890-016-0350-x.


Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion.

Garnett JP, Kalsi KK, Sobotta M, Bearham J, Carr G, Powell J, Brodlie M, Ward C, Tarran R, Baines DL.

Sci Rep. 2016 Nov 29;6:37955. doi: 10.1038/srep37955.


Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation.

Zeybel GL, Pearson JP, Krishnan A, Bourke SJ, Doe S, Anderson A, Faruqi S, Morice AH, Jones R, McDonnell M, Zeybel M, Dettmar PW, Brodlie M, Ward C.

J Cyst Fibros. 2017 Jan;16(1):124-131. doi: 10.1016/j.jcf.2016.07.004. Epub 2016 Jul 27.


IL-22 exacerbates weight loss in a murine model of chronic pulmonary Pseudomonas aeruginosa infection.

Bayes HK, Ritchie ND, Ward C, Corris PA, Brodlie M, Evans TJ.

J Cyst Fibros. 2016 Nov;15(6):759-768. doi: 10.1016/j.jcf.2016.06.008. Epub 2016 Jul 1.


Microbiological profiles of sputum and gastric juice aspirates in Cystic Fibrosis patients.

Al-Momani H, Perry A, Stewart CJ, Jones R, Krishnan A, Robertson AG, Bourke S, Doe S, Cummings SP, Anderson A, Forrest T, Griffin SM, Brodlie M, Pearson J, Ward C.

Sci Rep. 2016 Jun 1;6:26985. doi: 10.1038/srep26985.


A multifunctional bispecific antibody against Pseudomonas aeruginosa as a potential therapeutic strategy.

Haq IJ, Gardner A, Brodlie M.

Ann Transl Med. 2016 Jan;4(1):12. doi: 10.3978/j.issn.2305-5839.2015.10.10. No abstract available.


Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets.

Haq IJ, Gray MA, Garnett JP, Ward C, Brodlie M.

Thorax. 2016 Mar;71(3):284-7. doi: 10.1136/thoraxjnl-2015-207588. Epub 2015 Dec 30. Review.


Leukotriene receptor antagonists as maintenance or intermittent treatment in pre-school children with episodic viral wheeze.

Brodlie M, Gupta A, Rodriguez-Martinez CE, Castro-Rodriguez JA, Ducharme FM, McKean MC.

Paediatr Respir Rev. 2016 Jan;17:57-9. doi: 10.1016/j.prrv.2015.10.007. Epub 2015 Nov 10. Review. No abstract available.


Bile acid aspiration in people with cystic fibrosis before and after lung transplantation.

Brodlie M, Aseeri A, Lordan JL, Robertson AG, McKean MC, Corris PA, Griffin SM, Manning NJ, Pearson JP, Ward C.

Eur Respir J. 2015 Dec;46(6):1820-3. doi: 10.1183/13993003.00891-2015. Epub 2015 Oct 22. No abstract available.


Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children.

Brodlie M, Gupta A, Rodriguez-Martinez CE, Castro-Rodriguez JA, Ducharme FM, McKean MC.

Cochrane Database Syst Rev. 2015 Oct 19;(10):CD008202. doi: 10.1002/14651858.CD008202.pub2. Review.


Targeted therapies to improve CFTR function in cystic fibrosis.

Brodlie M, Haq IJ, Roberts K, Elborn JS.

Genome Med. 2015 Sep 24;7:101. doi: 10.1186/s13073-015-0223-6. Review.


A novel culture medium for isolation of rapidly-growing mycobacteria from the sputum of patients with cystic fibrosis.

Preece CL, Perry A, Gray B, Kenna DT, Jones AL, Cummings SP, Robb A, Thomas MF, Brodlie M, O'Brien CJ, Bourke SJ, Perry JD.

J Cyst Fibros. 2016 Mar;15(2):186-91. doi: 10.1016/j.jcf.2015.05.002. Epub 2015 May 20.


The evidence for high flow nasal cannula devices in infants.

Haq I, Gopalakaje S, Fenton AC, McKean MC, J O'Brien C, Brodlie M.

Paediatr Respir Rev. 2014 Jun;15(2):124-34. doi: 10.1016/j.prrv.2013.12.002. Epub 2013 Dec 17. Review.


Elevated paracellular glucose flux across cystic fibrosis airway epithelial monolayers is an important factor for Pseudomonas aeruginosa growth.

Garnett JP, Gray MA, Tarran R, Brodlie M, Ward C, Baker EH, Baines DL.

PLoS One. 2013 Oct 4;8(10):e76283. doi: 10.1371/journal.pone.0076283. eCollection 2013.


Aspiration and allograft injury secondary to gastroesophageal reflux occur in the immediate post-lung transplantation period (prospective clinical trial).

Griffin SM, Robertson AG, Bredenoord AJ, Brownlee IA, Stovold R, Brodlie M, Forrest I, Dark JH, Pearson JP, Ward C.

Ann Surg. 2013 Nov;258(5):705-11; discussion 711-2. doi: 10.1097/SLA.0b013e3182a6589b.


Are the enzymatic methods currently being used to measure bronchoalveolar lavage bile salt levels fit for purpose?

Parikh S, Brownlee IA, Robertson AG, Manning NT, Johnson GE, Brodlie M, Corris PA, Ward C, Pearson JP.

J Heart Lung Transplant. 2013 Apr;32(4):418-23. doi: 10.1016/j.healun.2012.12.008. Epub 2013 Feb 4.


TNFα from classically activated macrophages accentuates epithelial to mesenchymal transition in obliterative bronchiolitis.

Borthwick LA, Corris PA, Mahida R, Walker A, Gardner A, Suwara M, Johnson GE, Moisey EJ, Brodlie M, Ward C, Perry JD, De Soyza A, Mann DA, Fisher AJ.

Am J Transplant. 2013 Mar;13(3):621-33. doi: 10.1111/ajt.12065. Epub 2013 Jan 17.


Oesophageal foreign body presenting with stridor associated with feeding.

Liew Z, McKean MC, Townshend J, O'Brien CJ, Brodlie M.

Arch Dis Child. 2013 May;98(5):384-5. doi: 10.1136/archdischild-2012-303230. Epub 2013 Jan 17. No abstract available.


Vitamin D in children with cystic fibrosis.

Brodlie M, Orchard WA, Reeks GA, Pattman S, McCabe H, O'Brien CJ, Thomas MF, Spencer DA.

Arch Dis Child. 2012 Nov;97(11):982-4. doi: 10.1136/archdischild-2011-301398. Epub 2012 Aug 4.


The oral corticosteroid-sparing effect of omalizumab in children with severe asthma.

Brodlie M, McKean MC, Moss S, Spencer DA.

Arch Dis Child. 2012 Jul;97(7):604-9. doi: 10.1136/archdischild-2011-301570. Epub 2012 Jun 9.


The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.

Gardner A, Fisher AJ, Richter C, Johnson GE, Moisey EJ, Brodlie M, Ward C, Krippner-Heidenreich A, Mann DA, Borthwick LA.

Am J Pathol. 2012 Jun;180(6):2293-308. doi: 10.1016/j.ajpath.2012.02.022. Epub 2012 Apr 21.


Childhood cough.

Brodlie M, Graham C, McKean MC.

BMJ. 2012 Mar 6;344:e1177. doi: 10.1136/bmj.e1177. Review. No abstract available.


Bile acids are present in the lower airways of people with cystic fibrosis.

Aseeri A, Brodlie M, Lordan J, Corris P, Pearson J, Ward C, Manning N.

Am J Respir Crit Care Med. 2012 Feb 15;185(4):463. No abstract available.


Interleukin-17 and cystic fibrosis lung disease.

Brodlie M, Corris PA, Lordan J, Ward C.

Am J Respir Crit Care Med. 2012 Jan 1;185(1):108-9; author reply 109-10. No abstract available.


Use of somatostatin analogues to treat chylothorax in a child with Generalised Lymphatic Dysplasia.

Brodlie M, Abdelgalil S, Mansour S, Spencer DA.

Respir Med Case Rep. 2012;5:76-7. doi: 10.1016/j.rmedc.2011.07.005. Epub 2011 Oct 1.


Mitochondrial respiratory chain disease in children undergoing cardiac transplantation: a prospective study.

Bates MG, Nesbitt V, Kirk R, He L, Blakely EL, Alston CL, Brodlie M, Hasan A, Taylor RW, McFarland R.

Int J Cardiol. 2012 Mar 8;155(2):305-6. doi: 10.1016/j.ijcard.2011.11.063. Epub 2011 Dec 20. No abstract available.


Is CFTR-delF508 really absent from the apical membrane of the airway epithelium?

Borthwick LA, Botha P, Verdon B, Brodlie MJ, Gardner A, Bourn D, Johnson GE, Gray MA, Fisher AJ.

PLoS One. 2011;6(8):e23226. doi: 10.1371/journal.pone.0023226. Epub 2011 Aug 3.

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