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New approaches to the study of immune responses in humans.

Brodin P.

Hum Genet. 2020 Feb 10. doi: 10.1007/s00439-020-02129-3. [Epub ahead of print] Review.


Fragment-based optimized EthR inhibitors with in vivo ethionamide boosting activity.

Villemagne B, Machelart A, Tran NC, Flipo M, Moune M, Leroux F, Piveteau C, Wohlkonig A, Wintjens R, Li X, Gref R, Brodin P, Deprez B, Baulard AR, Willand N.

ACS Infect Dis. 2020 Feb 3. doi: 10.1021/acsinfecdis.9b00277. [Epub ahead of print]


Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds.

Moraski GC, Deboosère N, Marshall KL, Weaver HA, Vandeputte A, Hastings C, Woolhiser L, Lenaerts AJ, Brodin P, Miller MJ.

PLoS One. 2020 Jan 6;15(1):e0227224. doi: 10.1371/journal.pone.0227224. eCollection 2020.


Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis.

Levillain F, Kim H, Woong Kwon K, Clark S, Cia F, Malaga W, Lanni F, Brodin P, Gicquel B, Guilhot C, Bancroft GJ, Williams A, Jae Shin S, Poquet Y, Neyrolles O.

Vaccine. 2020 Feb 5;38(6):1416-1423. doi: 10.1016/j.vaccine.2019.11.085. Epub 2019 Dec 18.


A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.

Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P.

Science. 2019 Dec 20;366(6472). pii: eaax9198. doi: 10.1126/science.aax9198.


Cell generation dynamics underlying naive T-cell homeostasis in adult humans.

Mold JE, Réu P, Olin A, Bernard S, Michaëlsson J, Rane S, Yates A, Khosravi A, Salehpour M, Possnert G, Brodin P, Frisén J.

PLoS Biol. 2019 Oct 29;17(10):e3000383. doi: 10.1371/journal.pbio.3000383. eCollection 2019 Oct.


Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls.

Reynaert ML, Dupoiron D, Yeramian E, Marsollier L, Brodin P.

Toxins (Basel). 2019 Sep 4;11(9). pii: E516. doi: 10.3390/toxins11090516. Review.


Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis.

Achten NB, Klingenberg C, Benitz WE, Stocker M, Schlapbach LJ, Giannoni E, Bokelaar R, Driessen GJA, Brodin P, Uthaya S, van Rossum AMC, Plötz FB.

JAMA Pediatr. 2019 Sep 3. doi: 10.1001/jamapediatrics.2019.2825. [Epub ahead of print]


Worms' Antimicrobial Peptides.

Bruno R, Maresca M, Canaan S, Cavalier JF, Mabrouk K, Boidin-Wichlacz C, Olleik H, Zeppilli D, Brodin P, Massol F, Jollivet D, Jung S, Tasiemski A.

Mar Drugs. 2019 Aug 29;17(9). pii: E512. doi: 10.3390/md17090512. Review.



Brodin P, Hoffmann E.

Nat Chem Biol. 2019 Sep;15(9):849-850. doi: 10.1038/s41589-019-0347-x. No abstract available.


Seeking the ultimate challenge.

Brodin P.

Nat Med. 2019 Jul;25(7):1026. doi: 10.1038/s41591-019-0497-0.


Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'.

Landegren N, Rosen LB, Freyhult E, Eriksson D, Fall T, Smith G, Ferre EMN, Brodin P, Sharon D, Snyder M, Lionakis M, Anderson M, Kämpe O.

Elife. 2019 Jun 27;8. pii: e43578. doi: 10.7554/eLife.43578.


A Call for Blood-In Human Immunology.

Brodin P, Duffy D, Quintana-Murci L.

Immunity. 2019 Jun 18;50(6):1335-1336. doi: 10.1016/j.immuni.2019.05.012. No abstract available.


Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate.

Hanoun M, Arnal-Estapé A, Maryanovich M, Zahalka AH, Bergren SK, Chua CW, Leftin A, Brodin PN, Shen MM, Guha C, Frenette PS.

Stem Cell Reports. 2019 Jun 11;12(6):1201-1211. doi: 10.1016/j.stemcr.2019.04.019. Epub 2019 May 23.


Automated Cell Processing for Mass Cytometry Experiments.

Mikes J, Olin A, Lakshmikanth T, Chen Y, Brodin P.

Methods Mol Biol. 2019;1989:111-123. doi: 10.1007/978-1-4939-9454-0_8.


A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation.

Pastor A, Machelart A, Li X, Willand N, Baulard A, Brodin P, Gref R, Desmaële D.

Org Biomol Chem. 2019 May 28;17(20):5129-5137. doi: 10.1039/c9ob00680j. Epub 2019 May 10.


Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters.

Babonneau J, Bréard D, Reynaert ML, Marion E, Guilet D, Saint André JP, Croué A, Brodin P, Richomme P, Marsollier L.

Front Pharmacol. 2019 Apr 12;10:378. doi: 10.3389/fphar.2019.00378. eCollection 2019.


B cell profiling in malaria reveals expansion and remodelling of CD11c+ B cell subsets.

Sundling C, Rönnberg C, Yman V, Asghar M, Jahnmatz P, Lakshmikanth T, Chen Y, Mikes J, Forsell MN, Sondén K, Achour A, Brodin P, Persson KE, Färnert A.

JCI Insight. 2019 Apr 2;5. pii: 126492. doi: 10.1172/jci.insight.126492.


Leucocytosis is associated with retinopathy of prematurity in extremely preterm infants.

Lundgren P, Klevebro S, Brodin P, Smith LEH, Hallberg B, Hellström A.

Acta Paediatr. 2019 Jul;108(7):1357-1358. doi: 10.1111/apa.14798. Epub 2019 Apr 12. No abstract available.


The repertoire of maternal anti-viral antibodies in human newborns.

Pou C, Nkulikiyimfura D, Henckel E, Olin A, Lakshmikanth T, Mikes J, Wang J, Chen Y, Bernhardsson AK, Gustafsson A, Bohlin K, Brodin P.

Nat Med. 2019 Apr;25(4):591-596. doi: 10.1038/s41591-019-0392-8. Epub 2019 Mar 18.


Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication.

Sahuc ME, Sahli R, Rivière C, Pène V, Lavie M, Vandeputte A, Brodin P, Rosenberg AR, Dubuisson J, Ksouri R, Rouillé Y, Sahpaz S, Séron K.

J Virol. 2019 May 1;93(10). pii: e02009-18. doi: 10.1128/JVI.02009-18. Print 2019 May 15.


Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis.

Machelart A, Salzano G, Li X, Demars A, Debrie AS, Menendez-Miranda M, Pancani E, Jouny S, Hoffmann E, Deboosere N, Belhaouane I, Rouanet C, Simar S, Talahari S, Giannini V, Villemagne B, Flipo M, Brosch R, Nesslany F, Deprez B, Muraille E, Locht C, Baulard AR, Willand N, Majlessi L, Gref R, Brodin P.

ACS Nano. 2019 Apr 23;13(4):3992-4007. doi: 10.1021/acsnano.8b07902. Epub 2019 Mar 8.


Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation.

Pauwels AM, Härtlova A, Peltier J, Driege Y, Baudelet G, Brodin P, Trost M, Beyaert R, Hoffmann E.

Mol Cell Proteomics. 2019 May;18(5):909-922. doi: 10.1074/mcp.RA119.001316. Epub 2019 Feb 26.


Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1-infected patients according to antiretroviral therapy initiation.

Bekele Y, Lakshmikanth T, Chen Y, Mikes J, Nasi A, Petkov S, Hejdeman B, Brodin P, Chiodi F.

JCI Insight. 2019 Feb 7;4(3). pii: 125442. doi: 10.1172/jci.insight.125442. [Epub ahead of print]


Mitochondrial Dynamics and Activity in Legionella-Infected Cells.

Song OR, Brodin P, Buchrieser C, Escoll P.

Methods Mol Biol. 2019;1921:205-220. doi: 10.1007/978-1-4939-9048-1_13.


Systems-Level Immune Monitoring by Mass Cytometry.

Lakshmikanth T, Brodin P.

Methods Mol Biol. 2019;1913:33-48. doi: 10.1007/978-1-4939-8979-9_3.


Systems-level patterns emerge.

Brodin P.

Nat Rev Immunol. 2019 Feb;19(2):87-88. doi: 10.1038/s41577-018-0106-3. Review. No abstract available.


B cell alterations during BAFF inhibition with belimumab in SLE.

Ramsköld D, Parodis I, Lakshmikanth T, Sippl N, Khademi M, Chen Y, Zickert A, Mikeš J, Achour A, Amara K, Piehl F, Brodin P, Gunnarsson I, Malmström V.

EBioMedicine. 2019 Feb;40:517-527. doi: 10.1016/j.ebiom.2018.12.035. Epub 2018 Dec 26.


Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture.

Chowdhury P, Sahuc ME, Rouillé Y, Rivière C, Bonneau N, Vandeputte A, Brodin P, Goswami M, Bandyopadhyay T, Dubuisson J, Séron K.

PLoS One. 2018 Nov 28;13(11):e0198226. doi: 10.1371/journal.pone.0198226. eCollection 2018.


Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis.

Tang Q, Ramsköld D, Krystufkova O, Mann HF, Wick C, Dastmalchi M, Lakshmikanth T, Chen Y, Mikes J, Alexanderson H, Achour A, Brodin P, Vencovsky J, Lundberg IE, Malmström V.

Scand J Immunol. 2019 Jan;89(1):e12732. doi: 10.1111/sji.12732. Epub 2018 Dec 9.


The biology of the cell - insights from mass cytometry.

Brodin P.

FEBS J. 2019 Apr;286(8):1514-1522. doi: 10.1111/febs.14693. Epub 2018 Nov 26. Review.


Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria.

Raze D, Verwaerde C, Deloison G, Werkmeister E, Coupin B, Loyens M, Brodin P, Rouanet C, Locht C.

Front Microbiol. 2018 Sep 24;9:2258. doi: 10.3389/fmicb.2018.02258. eCollection 2018.


Continuous Immune Cell Differentiation Inferred From Single-Cell Measurements Following Allogeneic Stem Cell Transplantation.

Chen Y, Lakshmikanth T, Olin A, Mikes J, Remberger M, Brodin P.

Front Mol Biosci. 2018 Sep 12;5:81. doi: 10.3389/fmolb.2018.00081. eCollection 2018.


Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis.

Nguyen PC, Delorme V, Bénarouche A, Guy A, Landry V, Audebert S, Pophillat M, Camoin L, Crauste C, Galano JM, Durand T, Brodin P, Canaan S, Cavalier JF.

Bioorg Chem. 2018 Dec;81:414-424. doi: 10.1016/j.bioorg.2018.08.025. Epub 2018 Aug 29.


The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.

Mori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-Pérez C, Zemanová J, Huszár S, Forbak M, Lane TR, Sabbah M, Deboosere N, Frita R, Vandeputte A, Hoffmann E, Russo R, Connell N, Veilleux C, Jha RK, Kumar P, Freundlich JS, Brodin P, Aínsa JA, Nagaraja V, Maxwell A, Mikušová K, Pasca MR, Ekins S.

Tuberculosis (Edinb). 2018 Sep;112:98-109. doi: 10.1016/ Epub 2018 Aug 11.


Stereotypic Immune System Development in Newborn Children.

Olin A, Henckel E, Chen Y, Lakshmikanth T, Pou C, Mikes J, Gustafsson A, Bernhardsson AK, Zhang C, Bohlin K, Brodin P.

Cell. 2018 Aug 23;174(5):1277-1292.e14. doi: 10.1016/j.cell.2018.06.045.


Synergy between Circular Bacteriocin AS-48 and Ethambutol against Mycobacterium tuberculosis.

Aguilar-Pérez C, Gracia B, Rodrigues L, Vitoria A, Cebrián R, Deboosère N, Song OR, Brodin P, Maqueda M, Aínsa JA.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00359-18. doi: 10.1128/AAC.00359-18. Print 2018 Sep.


Publisher Correction: Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles.

Costa-Gouveia J, Pancani E, Jouny S, Machelart A, Delorme V, Salzano G, Iantomasi R, Piveteau C, Queval CJ, Song OR, Flipo M, Deprez B, Saint-André JP, Hureaux J, Majlessi L, Willand N, Baulard A, Brodin P, Gref R.

Sci Rep. 2018 May 10;8(1):7596. doi: 10.1038/s41598-018-25177-2.


Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors.

Sayes F, Blanc C, Ates LS, Deboosere N, Orgeur M, Le Chevalier F, Gröschel MI, Frigui W, Song OR, Lo-Man R, Brossier F, Sougakoff W, Bottai D, Brodin P, Charneau P, Brosch R, Majlessi L.

Cell Rep. 2018 Apr 24;23(4):1072-1084. doi: 10.1016/j.celrep.2018.03.125.


Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry.

Riva L, Song OR, Prentoe J, Helle F, L'homme L, Gattolliat CH, Vandeputte A, Fénéant L, Belouzard S, Baumert TF, Asselah T, Bukh J, Brodin P, Cocquerel L, Rouillé Y, Dubuisson J.

J Virol. 2018 Apr 27;92(10). pii: e01982-17. doi: 10.1128/JVI.01982-17. Print 2018 May 15.


Rebooting Human Immunology.

Davis MM, Brodin P.

Annu Rev Immunol. 2018 Apr 26;36:843-864. doi: 10.1146/annurev-immunol-042617-053206. Epub 2018 Feb 28. Review.


Proteomics of Mycobacterium Infection: Moving towards a Better Understanding of Pathogen-Driven Immunomodulation.

Hoffmann E, Machelart A, Song OR, Brodin P.

Front Immunol. 2018 Jan 30;9:86. doi: 10.3389/fimmu.2018.00086. eCollection 2018. Review.


Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.

Agudelo LZ, Ferreira DMS, Cervenka I, Bryzgalova G, Dadvar S, Jannig PR, Pettersson-Klein AT, Lakshmikanth T, Sustarsic EG, Porsmyr-Palmertz M, Correia JC, Izadi M, Martínez-Redondo V, Ueland PM, Midttun Ø, Gerhart-Hines Z, Brodin P, Pereira T, Berggren PO, Ruas JL.

Cell Metab. 2018 Feb 6;27(2):378-392.e5. doi: 10.1016/j.cmet.2018.01.004.


Plasmablast antibody repertoires in elderly influenza vaccine responders exhibit restricted diversity but increased breadth of binding across influenza strains.

Ju CH, Blum LK, Kongpachith S, Lingampalli N, Mao R, Brodin P, Dekker CL, Davis MM, Robinson WH.

Clin Immunol. 2018 Aug;193:70-79. doi: 10.1016/j.clim.2018.01.011. Epub 2018 Feb 2.


Host-pathogen systems for early drug discovery against tuberculosis.

Trofimov V, Costa-Gouveia J, Hoffmann E, Brodin P.

Curr Opin Microbiol. 2017 Oct;39:143-151. doi: 10.1016/j.mib.2017.11.017. Epub 2017 Nov 24. Review.


ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton.

Song OR, Queval CJ, Iantomasi R, Delorme V, Marion S, Veyron-Churlet R, Werkmeister E, Popoff M, Ricard I, Jouny S, Deboosere N, Lafont F, Baulard A, Yeramian E, Marsollier L, Hoffmann E, Brodin P.

EMBO Rep. 2018 Jan;19(1):29-42. doi: 10.15252/embr.201744371. Epub 2017 Nov 15.


Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids.

Blanc L, Gilleron M, Prandi J, Song OR, Jang MS, Gicquel B, Drocourt D, Neyrolles O, Brodin P, Tiraby G, Vercellone A, Nigou J.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11205-11210. doi: 10.1073/pnas.1707840114. Epub 2017 Oct 2.


Mass Cytometry Identifies Distinct Lung CD4+ T Cell Patterns in Löfgren's Syndrome and Non-Löfgren's Syndrome Sarcoidosis.

Kaiser Y, Lakshmikanth T, Chen Y, Mikes J, Eklund A, Brodin P, Achour A, Grunewald J.

Front Immunol. 2017 Sep 12;8:1130. doi: 10.3389/fimmu.2017.01130. eCollection 2017.


Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.

Queval CJ, Song OR, Carralot JP, Saliou JM, Bongiovanni A, Deloison G, Deboosère N, Jouny S, Iantomasi R, Delorme V, Debrie AS, Park SJ, Gouveia JC, Tomavo S, Brosch R, Yoshimura A, Yeramian E, Brodin P.

Cell Rep. 2017 Sep 26;20(13):3188-3198. doi: 10.1016/j.celrep.2017.08.101.


Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis.

Nguyen PC, Delorme V, Bénarouche A, Martin BP, Paudel R, Gnawali GR, Madani A, Puppo R, Landry V, Kremer L, Brodin P, Spilling CD, Cavalier JF, Canaan S.

Sci Rep. 2017 Sep 18;7(1):11751. doi: 10.1038/s41598-017-11843-4.

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