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Intradermal synDNA vaccination generates Leishmania specific T cells in the skin and protection against Leishmania major.

Louis L, Clark M, Wise MC, Glennie N, Wong A, Broderick K, Uzonna J, Weiner DB, Scott P.

Infect Immun. 2019 Jun 10. pii: IAI.00227-19. doi: 10.1128/IAI.00227-19. [Epub ahead of print]


Integration of needle-free jet injection with advanced electroporation delivery enhances the magnitude, kinetics, and persistence of engineered DNA vaccine induced immune responses.

Jiang J, Ramos SJ, Bangalore P, Fisher P, Germar K, Lee BK, Williamson D, Kemme A, Schade E, McCoy J, Muthumani K, Weiner DB, Humeau LM, Broderick KE.

Vaccine. 2019 Jun 27;37(29):3832-3839. doi: 10.1016/j.vaccine.2019.05.054. Epub 2019 Jun 4.


Classification of breast tissue expander infections: Back to the basics.

Kraenzlin FS, Saunders H, Aliu O, Cooney D, Rosson GD, Sacks JM, Broderick K, Manahan MA.

J Surg Oncol. 2019 May 18. doi: 10.1002/jso.25500. [Epub ahead of print]


Immunogenicity of a protective intradermal DNA vaccine against Lassa Virus in Cynomolgus macaques.

Ramos SJ, Jiang J, Banglore P, Cashman KA, Schmaljohn CS, Schultheis K, Pugh H, Nguyen J, Humeau LM, Broderick KE.

Hum Vaccin Immunother. 2019 May 9. doi: 10.1080/21645515.2019.1616499. [Epub ahead of print]


Skeletogenic capacity of human perivascular stem cells obtained via magnetic activated cell sorting.

Meyers CA, Xu J, Zhang L, Chang LL, Wang Y, Asatrian G, Ding C, Yan N, Zou E, Broderick K, Lee M, Péault B, James AW.

Tissue Eng Part A. 2019 Apr 25. doi: 10.1089/ten.TEA.2019.0031. [Epub ahead of print]


In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus.

Esquivel RN, Patel A, Kudchodkar SB, Park DH, Stettler K, Beltramello M, Allen JW, Mendoza J, Ramos S, Choi H, Borole P, Asija K, Bah M, Shaheen S, Chen J, Yan J, Durham AC, Smith TRF, Broderick K, Guibinga G, Muthumani K, Corti D, Humeau L, Weiner DB.

Mol Ther. 2019 May 8;27(5):974-985. doi: 10.1016/j.ymthe.2019.03.005. Epub 2019 Apr 5.


Intradermal SynCon® Ebola GP DNA Vaccine is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers.

Tebas P, Kraynyak KA, Patel A, Maslow JN, Morrow MP, Sylvester AJ, Knoblock D, Gillespie E, Amante D, Racine T, McMullan T, Jeong M, Roberts CC, Park YK, Boyer J, Broderick KE, Kobinger GP, Bagarazzi M, Weiner DB, Sardesai NY, White SM.

J Infect Dis. 2019 Mar 19. pii: jiz132. doi: 10.1093/infdis/jiz132. [Epub ahead of print]


Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation.

Schommer NN, Nguyen J, Yung BS, Schultheis K, Muthumani K, Weiner DB, Humeau L, Broderick KE, Smith TRF.

Hum Gene Ther. 2019 Apr;30(4):523-533. doi: 10.1089/hum.2018.241.


Implementing Our Microsurgical Breast Reconstruction Enhanced Recovery after Surgery Pathway: Consensus Obstacles and Recommendations.

Stone JP, Siotos C, Sarmiento S, Temple-Oberle C, Aliu O, Cooney DS, Broderick KP, Sacks JM, Manahan MA, Rosson GD.

Plast Reconstr Surg Glob Open. 2019 Jan 4;7(1):e1855. doi: 10.1097/GOX.0000000000001855. eCollection 2019 Jan.


COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis.

Zheng Y, Comaills V, Burr R, Boulay G, Miyamoto DT, Wittner BS, Emmons E, Sil S, Koulopoulos MW, Broderick KT, Tai E, Rengarajan S, Kulkarni AS, Shioda T, Wu CL, Ramaswamy S, Ting DT, Toner M, Rivera MN, Maheswaran S, Haber DA.

Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5223-5232. doi: 10.1073/pnas.1819303116. Epub 2019 Feb 28.


A Rising Tide Lifts All Boats: Professors and Leadership in an Academic Department of Emergency Medicine.

Libby AM, Broderick KB, Zane RD.

Acad Emerg Med. 2019 Mar;26(3):350-353. doi: 10.1111/acem.13689. Epub 2019 Feb 19. No abstract available.


Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination.

Schultheis K, Schaefer H, Pugh HM, Yung BS, Oh J, Nguyen J, Humeau L, Broderick KE, Smith TRF.

J Vis Exp. 2019 Jan 20;(143). doi: 10.3791/58595.


Novel IFN-γ ELISpot reveals robust T cell responses elicited after influenza nucleoprotein DNA vaccination in New Zealand White rabbits.

Yung BS, Pugh H, Generotti AA, Phanhthilath N, Schultheis K, Muthumani K, Broderick KE, Smith TRF.

Vaccine. 2019 Feb 8;37(7):903-909. doi: 10.1016/j.vaccine.2019.01.006. Epub 2019 Jan 17.


Evolution of Workforce Diversity in Surgery.

Siotos C, Payne RM, Stone JP, Cui D, Siotou K, Broderick KP, Rosson GD, Cooney CM.

J Surg Educ. 2019 Jul - Aug;76(4):1015-1021. doi: 10.1016/j.jsurg.2018.12.009. Epub 2019 Jan 9.


Relative contributions of adipose-resident CD146+ pericytes and CD34+ adventitial progenitor cells in bone tissue engineering.

Wang Y, Xu J, Chang L, Meyers CA, Zhang L, Broderick K, Lee M, Peault B, James AW.

NPJ Regen Med. 2019 Jan 7;4:1. doi: 10.1038/s41536-018-0063-2. eCollection 2019.


Enhanced Recovery after Surgery Pathway for Microsurgical Breast Reconstruction: A Systematic Review and Meta-Analysis.

Sebai ME, Siotos C, Payne RM, Stone JP, Seal SM, Habibi M, Broderick K, Sacks JM, Manahan MA, Rosson GD.

Plast Reconstr Surg. 2019 Mar;143(3):655-666. doi: 10.1097/PRS.0000000000005300.


Reactor production of promethium-147.

Broderick K, Lusk R, Hinderer J, Griswold J, Boll R, Garland M, Heilbronn L, Mirzadeh S.

Appl Radiat Isot. 2019 Feb;144:54-63. doi: 10.1016/j.apradiso.2018.10.025. Epub 2018 Oct 31.


Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice.

Wang Y, Esquivel R, Flingai S, Schiller ZA, Kern A, Agarwal S, Chu J, Patel A, Sullivan K, Wise MC, Broderick KE, Hu L, Weiner DB, Klempner MS.

J Infect Dis. 2019 Mar 15;219(7):1146-1150. doi: 10.1093/infdis/jiy627.


In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model.

Patel A, Park DH, Davis CW, Smith TRF, Leung A, Tierney K, Bryan A, Davidson E, Yu X, Racine T, Reed C, Gorman ME, Wise MC, Elliott STC, Esquivel R, Yan J, Chen J, Muthumani K, Doranz BJ, Saphire EO, Crowe JE, Broderick KE, Kobinger GP, He S, Qiu X, Kobasa D, Humeau L, Sardesai NY, Ahmed R, Weiner DB.

Cell Rep. 2018 Nov 13;25(7):1982-1993.e4. doi: 10.1016/j.celrep.2018.10.062.


WISP-1 drives bone formation at the expense of fat formation in human perivascular stem cells.

Meyers CA, Xu J, Asatrian G, Ding C, Shen J, Broderick K, Ting K, Soo C, Peault B, James AW.

Sci Rep. 2018 Oct 23;8(1):15618. doi: 10.1038/s41598-018-34143-x.


Protective Efficacy and Long-Term Immunogenicity in Cynomolgus Macaques by Ebola Virus Glycoprotein Synthetic DNA Vaccines.

Patel A, Reuschel EL, Kraynyak KA, Racine T, Park DH, Scott VL, Audet J, Amante D, Wise MC, Keaton AA, Wong G, Villarreal DO, Walters J, Muthumani K, Shedlock DJ, de La Vega MA, Plyler R, Boyer J, Broderick KE, Yan J, Khan AS, Jones S, Bello A, Soule G, Tran KN, He S, Tierney K, Qiu X, Kobinger GP, Sardesai NY, Weiner DB.

J Infect Dis. 2019 Jan 29;219(4):544-555. doi: 10.1093/infdis/jiy537.


Synthetic DNA-Encoded Monoclonal Antibody Delivery of Anti-CTLA-4 Antibodies Induces Tumor Shrinkage In Vivo.

Duperret EK, Trautz A, Stoltz R, Patel A, Wise MC, Perales-Puchalt A, Smith T, Broderick KE, Masteller E, Kim JJ, Humeau L, Muthumani K, Weiner DB.

Cancer Res. 2018 Nov 15;78(22):6363-6370. doi: 10.1158/0008-5472.CAN-18-1429. Epub 2018 Oct 4.


A Synthetic Micro-Consensus DNA Vaccine Generates Comprehensive Influenza A H3N2 Immunity and Protects Mice Against Lethal Challenge by Multiple H3N2 Viruses.

Elliott STC, Keaton AA, Chu JD, Reed CC, Garman B, Patel A, Yan J, Broderick KE, Weiner DB.

Hum Gene Ther. 2018 Sep;29(9):1044-1055. doi: 10.1089/hum.2018.102.


Genome-wide analysis of genes encoding core components of the ubiquitin system in soybean (Glycine max) reveals a potential role for ubiquitination in host immunity against soybean cyst nematode.

Zhang C, Song L, Choudhary MK, Zhou B, Sun G, Broderick K, Giesler L, Zeng L.

BMC Plant Biol. 2018 Jul 18;18(1):149. doi: 10.1186/s12870-018-1365-7.


Delineating the Cellular Mechanisms Associated with Skin Electroporation.

Schultheis K, Smith TRF, Kiosses WB, Kraynyak KA, Wong A, Oh J, Broderick KE.

Hum Gene Ther Methods. 2018 Aug;29(4):177-188. doi: 10.1089/hgtb.2017.105. Epub 2018 Aug 10.


Tumor Site and Breast Cancer Prognosis.

Siotos C, McColl M, Psoter K, Gilmore RC, Sebai ME, Broderick KP, Jacobs LK, Irwin S, Rosson GD, Habibi M.

Clin Breast Cancer. 2018 Oct;18(5):e1045-e1052. doi: 10.1016/j.clbc.2018.05.007. Epub 2018 May 29.


Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques.

Hu X, Lu Z, Valentin A, Rosati M, Broderick KE, Sardesai NY, Marx PA, Mullins JI, Pavlakis GN, Felber BK.

Hum Vaccin Immunother. 2018;14(9):2163-2177. doi: 10.1080/21645515.2018.1489949. Epub 2018 Jul 12.


DNA Vaccine-Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination.

Hu X, Valentin A, Cai Y, Dayton F, Rosati M, Ramírez-Salazar EG, Kulkarni V, Broderick KE, Sardesai NY, Wyatt LS, Earl PL, Moss B, Mullins JI, Pavlakis GN, Felber BK.

Hum Gene Ther. 2018 Sep;29(9):1029-1043. doi: 10.1089/hum.2018.065. Epub 2018 Jun 21.


Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques.

Singh S, Ramírez-Salazar EG, Doueiri R, Valentin A, Rosati M, Hu X, Keele BF, Shen X, Tomaras GD, Ferrari G, LaBranche C, Montefiori DC, Das J, Alter G, Trinh HV, Hamlin C, Rao M, Dayton F, Bear J, Chowdhury B, Alicea C, Lifson JD, Broderick KE, Sardesai NY, Sivananthan SJ, Fox CB, Reed SG, Venzon DJ, Hirsch VM, Pavlakis GN, Felber BK.

J Virol. 2018 Jul 17;92(15). pii: e00281-18. doi: 10.1128/JVI.00281-18. Print 2018 Aug 1.


Collagen deposition in chronic hidradenitis suppurativa: potential role for CD163+ macrophages.

Byrd AS, Kerns ML, Williams DW, Zarif JC, Rosenberg AZ, Delsante M, Liu H, Dillen CA, Maynard JP, Caffrey JA, Sacks JM, Milner SM, Aliu O, Broderick KP, Lew LS, Miller LS, Kang S, Okoye GA.

Br J Dermatol. 2018 Sep;179(3):792-794. doi: 10.1111/bjd.16600. Epub 2018 Jun 29. No abstract available.


Non-organic Vision Loss in the Afghanistan and Iraq Conflicts.

Broderick KM, Ableman TB, Weber ED, Enzenauer RW, Wain HJ, Wroblewski KJ.

Neuroophthalmology. 2017 Mar 30;41(4):175-181. doi: 10.1080/01658107.2017.1295998. eCollection 2017 Aug.


An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer.

Miyamoto DT, Lee RJ, Kalinich M, LiCausi JA, Zheng Y, Chen T, Milner JD, Emmons E, Ho U, Broderick K, Silva E, Javaid S, Kwan TT, Hong X, Dahl DM, McGovern FJ, Efstathiou JA, Smith MR, Sequist LV, Kapur R, Wu CL, Stott SL, Ting DT, Giobbie-Hurder A, Toner M, Maheswaran S, Haber DA.

Cancer Discov. 2018 Mar;8(3):288-303. doi: 10.1158/2159-8290.CD-16-1406. Epub 2018 Jan 4.


DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections.

Elliott STC, Kallewaard NL, Benjamin E, Wachter-Rosati L, McAuliffe JM, Patel A, Smith TRF, Schultheis K, Park DH, Flingai S, Wise MC, Mendoza J, Ramos S, Broderick KE, Yan J, Humeau LM, Sardesai NY, Muthumani K, Zhu Q, Weiner DB.

NPJ Vaccines. 2017 Jul 6;2:18. doi: 10.1038/s41541-017-0020-x. eCollection 2017.


In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine.

Muthumani K, Griffin BD, Agarwal S, Kudchodkar SB, Reuschel EL, Choi H, Kraynyak KA, Duperret EK, Keaton AA, Chung C, Kim YK, Booth SA, Racine T, Yan J, Morrow MP, Jiang J, Lee B, Ramos S, Broderick KE, Reed CC, Khan AS, Humeau L, Ugen KE, Park YK, Maslow JN, Sardesai NY, Joseph Kim J, Kobinger GP, Weiner DB.

NPJ Vaccines. 2016 Nov 10;1:16021. doi: 10.1038/npjvaccines.2016.21. eCollection 2016.


Emergency department naloxone rescue kit dispensing and patient follow-up.

Kaucher KA, Acquisto NM, Broderick KB.

Am J Emerg Med. 2018 Aug;36(8):1503-1504. doi: 10.1016/j.ajem.2017.12.020. Epub 2017 Dec 7. No abstract available.


DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa and Ebola viruses in guinea pigs.

Cashman KA, Wilkinson ER, Wollen SE, Shamblin JD, Zelko JM, Bearss JJ, Zeng X, Broderick KE, Schmaljohn CS.

Hum Vaccin Immunother. 2017 Dec 2;13(12):3010-3019. doi: 10.1080/21645515.2017.1382780. Epub 2017 Nov 14.


Oncoplastic Breast Reconstruction: Should All Patients be Considered?

Habibi M, Broderick KP, Sebai ME, Jacobs LK.

Surg Oncol Clin N Am. 2018 Jan;27(1):167-180. doi: 10.1016/j.soc.2017.07.007. Review.


Adipose tissue: a new target for electroporation-enhanced DNA vaccines.

Fisher PD, Brambila CJ, McCoy JR, Kiosses WB, Mendoza JM, Oh J, Yung BS, Schultheis K, Smith TRF, Broderick KE.

Gene Ther. 2017 Dec;24(12):757-767. doi: 10.1038/gt.2017.96. Epub 2017 Nov 6.


Broad cross-protective anti-hemagglutination responses elicited by influenza microconsensus DNA vaccine.

Yan J, Morrow MP, Chu JS, Racine T, Reed CC, Khan AS, Broderick KE, Kim JJ, Kobinger GP, Sardesai NY, Weiner DB.

Vaccine. 2018 May 24;36(22):3079-3089. doi: 10.1016/j.vaccine.2017.09.086.


A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever.

Cashman KA, Wilkinson ER, Shaia CI, Facemire PR, Bell TM, Bearss JJ, Shamblin JD, Wollen SE, Broderick KE, Sardesai NY, Schmaljohn CS.

Hum Vaccin Immunother. 2017 Dec 2;13(12):2902-2911. doi: 10.1080/21645515.2017.1356500. Epub 2017 Oct 18.


Fidaxomicin versus Vancomycin as a First-Line Treatment for Clostridium difficile-Associated Diarrhea in Specific Patient Populations: A Pharmacoeconomic Evaluation.

Reveles KR, Backo JL, Corvino FA, Zivkovic M, Broderick KC.

Pharmacotherapy. 2017 Dec;37(12):1489-1497. doi: 10.1002/phar.2049. Epub 2017 Nov 27.


An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model.

Patel A, DiGiandomenico A, Keller AE, Smith TRF, Park DH, Ramos S, Schultheis K, Elliott STC, Mendoza J, Broderick KE, Wise MC, Yan J, Jiang J, Flingai S, Khan AS, Muthumani K, Humeau L, Cheng LI, Wachter-Rosati L, Stover CK, Sardesai NY, Weiner DB.

Nat Commun. 2017 Sep 21;8(1):637. doi: 10.1038/s41467-017-00576-7.


Nucleic acid-based vaccines targeting respiratory syncytial virus: Delivering the goods.

Smith TRF, Schultheis K, Broderick KE.

Hum Vaccin Immunother. 2017 Nov 2;13(11):2626-2629. doi: 10.1080/21645515.2017.1363134.


Early Immunomodulatory Effects of Implanted Human Perivascular Stromal Cells During Bone Formation.

Meyers CA, Xu J, Zhang L, Asatrian G, Ding C, Yan N, Broderick K, Sacks J, Goyal R, Zhang X, Ting K, Péault B, Soo C, James AW.

Tissue Eng Part A. 2018 Mar;24(5-6):448-457. doi: 10.1089/ten.TEA.2017.0023. Epub 2017 Aug 15.


HIV Env conserved element DNA vaccine alters immunodominance in macaques.

Hu X, Valentin A, Rosati M, Manocheewa S, Alicea C, Chowdhury B, Bear J, Broderick KE, Sardesai NY, Gall SL, Mullins JI, Pavlakis GN, Felber BK.

Hum Vaccin Immunother. 2017 Dec 2;13(12):2859-2871. doi: 10.1080/21645515.2017.1339852. Epub 2017 Jul 5.


Herpes zoster ophthalmicus and strabismus: a unique cause of secondary Brown syndrome.

Broderick KM, Raymond WR 4th, Boden JH.

J AAPOS. 2017 Aug;21(4):335-337. doi: 10.1016/j.jaapos.2017.06.003. Epub 2017 Jun 15.


Development of an intradermal DNA vaccine delivery strategy to achieve single-dose immunity against respiratory syncytial virus.

Smith TRF, Schultheis K, Morrow MP, Kraynyak KA, McCoy JR, Yim KC, Muthumani K, Humeau L, Weiner DB, Sardesai NY, Broderick KE.

Vaccine. 2017 May 15;35(21):2840-2847. doi: 10.1016/j.vaccine.2017.04.008. Epub 2017 Apr 14.


Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100.

Morrow MP, Kraynyak KA, Sylvester AJ, Shen X, Amante D, Sakata L, Parker L, Yan J, Boyer J, Roh C, Humeau L, Khan AS, Broderick K, Marcozzi-Pierce K, Giffear M, Lee J, Trimble CL, Kim JJ, Sardesai NY, Weiner DB, Bagarazzi ML.

Mol Ther Oncolytics. 2016 Nov 30;3:16025. doi: 10.1038/mto.2016.25. eCollection 2016.


Enhanced Delivery of DNA or RNA Vaccines by Electroporation.

Broderick KE, Humeau LM.

Methods Mol Biol. 2017;1499:193-200.


Characterization of guinea pig T cell responses elicited after EP-assisted delivery of DNA vaccines to the skin.

Schultheis K, Schaefer H, Yung BS, Oh J, Muthumani K, Humeau L, Broderick KE, Smith TR.

Vaccine. 2017 Jan 3;35(1):61-70. doi: 10.1016/j.vaccine.2016.11.052. Epub 2016 Nov 25.

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