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Effect of Recombinant Activated Coagulation Factor VII on Hemorrhage Expansion Among Patients With Spot Sign-Positive Acute Intracerebral Hemorrhage: The SPOTLIGHT and STOP-IT Randomized Clinical Trials.

Gladstone DJ, Aviv RI, Demchuk AM, Hill MD, Thorpe KE, Khoury JC, Sucharew HJ, Al-Ajlan F, Butcher K, Dowlatshahi D, Gubitz G, De Masi S, Hall J, Gregg D, Mamdani M, Shamy M, Swartz RH, Del Campo CM, Cucchiara B, Panagos P, Goldstein JN, Carrozzella J, Jauch EC, Broderick JP, Flaherty ML; SPOTLIGHT and STOP-IT Investigators and Coordinators.

JAMA Neurol. 2019 Aug 19. doi: 10.1001/jamaneurol.2019.2636. [Epub ahead of print]


Patient reported outcomes can improve performance status assessment: a pilot study.

Broderick JE, May M, Schwartz JE, Li M, Mejia A, Nocera L, Kolatkar A, Ueno NT, Yennu S, Lee JSH, Hanlon SE, Cozzens Philips FA, Shahabi C, Kuhn P, Nieva J.

J Patient Rep Outcomes. 2019 Jul 16;3(1):41. doi: 10.1186/s41687-019-0136-z.


The Elusive 5'-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies.

Yang H, McDaniel EC, Impano S, Byer AS, Jodts RJ, Yokoyama K, Broderick WE, Broderick JB, Hoffman BM.

J Am Chem Soc. 2019 Jul 31;141(30):12139-12146. doi: 10.1021/jacs.9b05926. Epub 2019 Jul 22.


Temporal Trends of Sex Differences in Transient Ischemic Attack Incidence Within a Population.

Madsen TE, Khoury JC, Alwell K, Moomaw CJ, Rademacher E, Flaherty ML, Woo D, La Rosa FLR, Mackey J, Martini S, Ferioli S, Adeoye O, Khatri P, Broderick JP, Kissela BM, Kleindorfer D.

J Stroke Cerebrovasc Dis. 2019 Sep;28(9):2468-2474. doi: 10.1016/j.jstrokecerebrovasdis.2019.06.020. Epub 2019 Jul 1.


Efficacy of Home-Based Telerehabilitation vs In-Clinic Therapy for Adults After Stroke: A Randomized Clinical Trial.

Cramer SC, Dodakian L, Le V, See J, Augsburger R, McKenzie A, Zhou RJ, Chiu NL, Heckhausen J, Cassidy JM, Scacchi W, Smith MT, Barrett AM, Knutson J, Edwards D, Putrino D, Agrawal K, Ngo K, Roth EJ, Tirschwell DL, Woodbury ML, Zafonte R, Zhao W, Spilker J, Wolf SL, Broderick JP, Janis S; National Institutes of Health StrokeNet Telerehab Investigators.

JAMA Neurol. 2019 Jun 24. doi: 10.1001/jamaneurol.2019.1604. [Epub ahead of print]


Therapist-assisted online treatment for child conduct problems in rural and urban families: Two randomized controlled trials.

Dadds MR, Thai C, Mendoza Diaz A, Broderick J, Moul C, Tully LA, Hawes DJ, Davies S, Burchfield K, Cane L.

J Consult Clin Psychol. 2019 Aug;87(8):706-719. doi: 10.1037/ccp0000419. Epub 2019 Jun 17.


Common Data Elements for Unruptured Intracranial Aneurysm and Subarachnoid Hemorrhage Clinical Research: Recommendations from the Working Group on Long-Term Therapies.

Wong GKC, Daly JJ, Rhoney DH, Broderick J, Ogilvy C, Roos YB, Siddiqui A, Torner J; Unruptured Intracranial Aneurysm and SAH CDE Project Investigators.

Neurocrit Care. 2019 Jun;30(Suppl 1):79-86. doi: 10.1007/s12028-019-00727-2.


Characterization of the Preprocessed Copper Site Equilibrium in Amine Oxidase and Assignment of the Reactive Copper Site in Topaquinone Biogenesis.

Adelson CN, Johnston EM, Hilmer KM, Watts H, Dey SG, Brown DE, Broderick JB, Shepard EM, Dooley DM, Solomon EI.

J Am Chem Soc. 2019 Jun 5;141(22):8877-8890. doi: 10.1021/jacs.9b01922. Epub 2019 May 28.


Needle-like structures discovered on positively charged lightning branches.

Hare BM, Scholten O, Dwyer J, Trinh TNG, Buitink S, Ter Veen S, Bonardi A, Corstanje A, Falcke H, Hörandel JR, Huege T, Mitra P, Mulrey K, Nelles A, Rachen JP, Rossetto L, Schellart P, Winchen T, Anderson J, Avruch IM, Bentum MJ, Blaauw R, Broderick JW, Brouw WN, Brüggen M, Butcher HR, Ciardi B, Fallows RA, de Geus E, Duscha S, Eislöffel J, Garrett MA, Grießmeier JM, Gunst AW, van Haarlem MP, Hessels JWT, Hoeft M, van der Horst AJ, Iacobelli M, Koopmans LVE, Krankowski A, Maat P, Norden MJ, Paas H, Pandey-Pommier M, Pandey VN, Pekal R, Pizzo R, Reich W, Rothkaehl H, Röttgering HJA, Rowlinson A, Schwarz DJ, Shulevski A, Sluman J, Smirnov O, Soida M, Tagger M, Toribio MC, van Ardenne A, Wijers RAMJ, van Weeren RJ, Wucknitz O, Zarka P, Zucca P.

Nature. 2019 Apr;568(7752):360-363. doi: 10.1038/s41586-019-1086-6. Epub 2019 Apr 17.


Yoga as part of a package of care versus non-standard care for schizophrenia.

Broderick J, Vancampfort D.

Cochrane Database Syst Rev. 2019 Apr 16;4:CD012807. doi: 10.1002/14651858.CD012807.pub2.


Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry.

Robinson TG, Bray BD, Paley L, Sprigg N, Wang X, Arima H, Bath PM, Broderick JP, Durham AC, Kim JS, Lavados PM, Lee TH, Martins S, Nguyen TH, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sharma VK, Wang J, Woodward M, Rudd AG, Chalmers J, S Anderson C; ENCHANTED Investigators and the SSNAP Collaboration.

Int J Stroke. 2019 Apr 8:1747493019841246. doi: 10.1177/1747493019841246. [Epub ahead of print]


eHealth-based intervention to increase physical activity levels in people with cancer: protocol of a feasibility trial in an Irish acute hospital setting.

Haberlin C, Broderick J, Guinan EM, Darker C, Hussey J, O'Donnell DM.

BMJ Open. 2019 Mar 8;9(3):e024999. doi: 10.1136/bmjopen-2018-024999.


Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial.

Anderson CS, Huang Y, Lindley RI, Chen X, Arima H, Chen G, Li Q, Billot L, Delcourt C, Bath PM, Broderick JP, Demchuk AM, Donnan GA, Durham AC, Lavados PM, Lee TH, Levi C, Martins SO, Olavarria VV, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sato S, Sharma VK, Silva F, Song L, Thang NH, Wardlaw JM, Wang JG, Wang X, Woodward M, Chalmers J, Robinson TG; ENCHANTED Investigators and Coordinators.

Lancet. 2019 Mar 2;393(10174):877-888. doi: 10.1016/S0140-6736(19)30038-8. Epub 2019 Feb 7.


Results From DEFUSE 3: Good Collaterals Are Associated With Reduced Ischemic Core Growth but Not Neurologic Outcome

de Havenon A, Mlynash M, Kim-Tenser MA, Lansberg MG, Leslie-Mazwi T, Christensen S, McTaggart RA, Alexander M, Albers G, Broderick J, Marks MP, Heit JJ; DEFUSE 3 Investigators.

Stroke. 2019 Mar;50(3):632-638. doi: 10.1161/STROKEAHA.118.023407.


Association of Thrombectomy With Stroke Outcomes Among Patient Subgroups: Secondary Analyses of the DEFUSE 3 Randomized Clinical Trial.

Lansberg MG, Mlynash M, Hamilton S, Yeatts SD, Christensen S, Kemp S, Lavori PW, Ortega-Gutierrez S, Broderick J, Heit J, Marks MP, Albers GW; DEFUSE 3 Investigators.

JAMA Neurol. 2019 Apr 1;76(4):447-453. doi: 10.1001/jamaneurol.2018.4587.


Response styles confound the age gradient of four health and well-being outcomes.

Stone AA, Schneider S, Junghaenel DU, Broderick JE.

Soc Sci Res. 2019 Feb;78:215-225. doi: 10.1016/j.ssresearch.2018.12.004. Epub 2018 Dec 8.


Changes in mechanical dyssynchrony in severe aortic stenosis patients undergoing transcatheter aortic valve replacement.

Truong V, Mazur W, Magier A, Broderick J, Safdar K, Volz B, Bartone C, Kereiakes DJ, Chung ES.

Echocardiography. 2019 Feb;36(2):243-248. doi: 10.1111/echo.14237. Epub 2019 Jan 9.


Secondary structure analysis of peptides with relevance to iron-sulfur cluster nesting.

Hanscam R, Shepard EM, Broderick JB, Copié V, Szilagyi RK.

J Comput Chem. 2019 Jan 15;40(2):515-526. doi: 10.1002/jcc.25741.


Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms.

Ton QV, Leino D, Mowery SA, Bredemeier NO, Lafontant PJ, Lubert A, Gurung S, Farlow JL, Foroud TM, Broderick J, Sumanas S.

Dis Model Mech. 2018 Dec 12;11(12). pii: dmm033654. doi: 10.1242/dmm.033654.


Abstract 79: Chronic and Acute Hypertension in Ischemic Stroke Are Distinct Markers of Impaired Collateral Circulation.

Liebeskind DS, Ayata C, Brown S, Raychev R, Scalzo F, Broderick JP, Tomsick TA, Cipolla MJ.

Stroke. 2018 Jan 22;49(Suppl_1):A79. doi: 10.1161/str.49.suppl_1.79.


Interferometric spatial frequency modulation imaging.

Worts N, Field J, Bartels R, Jones J, Broderick J, Squier J.

Opt Lett. 2018 Nov 1;43(21):5351-5354. doi: 10.1364/OL.43.005351.


Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily.

Broderick WE, Hoffman BM, Broderick JB.

Acc Chem Res. 2018 Nov 20;51(11):2611-2619. doi: 10.1021/acs.accounts.8b00356. Epub 2018 Oct 15.


Frames of Reference in Self-Reports of Health, Well-being, Fatigue, and Pain: A Qualitative Examination.

Junghaenel DU, Broderick JE, Schneider S, May M, Bolton A, McCarrier KP, Stassek LM, Keithly SC, Stone AA.

Appl Res Qual Life. 2018 Sep;13(3):585-601. doi: 10.1007/s11482-017-9546-3. Epub 2017 Jul 6.


Erratum to "Effects of pulmonary rehabilitation on exercise capacity and disease impact in patients with chronic obstructive pulmonary disease and obesity" [Physiotherapy 104 (June (2)) (2018) 248-250].

Broderick J, Mc Grath C, Cullen K, Talbot D, Gilmor J, Baily-Scanlan M, O'Dwyer T.

Physiotherapy. 2018 Dec;104(4):462. doi: 10.1016/ Epub 2018 Oct 11. No abstract available.


50 years of randomised controlled trials published in the journal Physiotherapy: a review 1967 to 2017.

Kelly G, Reilly A, Moloney H, Moran J, Cunningham C, Broderick J.

Physiotherapy. 2018 Dec;104(4):359-366. doi: 10.1016/ Epub 2018 Aug 24. Review.


The AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke randomized trial: Rationale and methods.

Kamel H, Longstreth WT Jr, Tirschwell DL, Kronmal RA, Broderick JP, Palesch YY, Meinzer C, Dillon C, Ewing I, Spilker JA, Di Tullio MR, Hod EA, Soliman EZ, Chaturvedi S, Moy CS, Janis S, Elkind MS.

Int J Stroke. 2019 Feb;14(2):207-214. doi: 10.1177/1747493018799981. Epub 2018 Sep 10.


3D-printed models optimize preoperative planning for pediatric cardiac tumor debulking.

Riggs KW, Dsouza G, Broderick JT, Moore RA, Morales DLS.

Transl Pediatr. 2018 Jul;7(3):196-202. doi: 10.21037/tp.2018.06.01.


Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data.

Al-Shahi Salman R, Frantzias J, Lee RJ, Lyden PD, Battey TWK, Ayres AM, Goldstein JN, Mayer SA, Steiner T, Wang X, Arima H, Hasegawa H, Oishi M, Godoy DA, Masotti L, Dowlatshahi D, Rodriguez-Luna D, Molina CA, Jang DK, Davalos A, Castillo J, Yao X, Claassen J, Volbers B, Kazui S, Okada Y, Fujimoto S, Toyoda K, Li Q, Khoury J, Delgado P, Sabín JÁ, Hernández-Guillamon M, Prats-Sánchez L, Cai C, Kate MP, McCourt R, Venkatasubramanian C, Diringer MN, Ikeda Y, Worthmann H, Ziai WC, d'Esterre CD, Aviv RI, Raab P, Murai Y, Zazulia AR, Butcher KS, Seyedsaadat SM, Grotta JC, Martí-Fàbregas J, Montaner J, Broderick J, Yamamoto H, Staykov D, Connolly ES, Selim M, Leira R, Moon BH, Demchuk AM, Di Napoli M, Fujii Y, Anderson CS, Rosand J; VISTA-ICH Collaboration; ICH Growth Individual Patient Data Meta-analysis Collaborators.

Lancet Neurol. 2018 Oct;17(10):885-894. doi: 10.1016/S1474-4422(18)30253-9. Epub 2018 Aug 14. Erratum in: Lancet Neurol. 2018 Sep 19;:.


Advance Care Planning Education Sessions During Pulmonary Rehabilitation in Ireland.

Korn B, Bailey-Scanlan M, Ribeiro LH, Broderick J.

J Cardiopulm Rehabil Prev. 2019 Jan;39(1):E8-E10. doi: 10.1097/HCR.0000000000000349.


Mechanistic Studies of Radical SAM Enzymes: Pyruvate Formate-Lyase Activating Enzyme and Lysine 2,3-Aminomutase Case Studies.

Byer AS, McDaniel EC, Impano S, Broderick WE, Broderick JB.

Methods Enzymol. 2018;606:269-318. doi: 10.1016/bs.mie.2018.04.013. Epub 2018 Jul 7.


Is periprocedural sedation during acute stroke therapy associated with poorer functional outcomes?

Nichols C, Carrozzella J, Yeatts S, Tomsick T, Broderick J, Khatri P.

J Neurointerv Surg. 2018 Jul;10(Suppl 1):i40-i43. doi: 10.1136/jnis.2009.001768.rep.


Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits: The PRISMS Randomized Clinical Trial.

Khatri P, Kleindorfer DO, Devlin T, Sawyer RN Jr, Starr M, Mejilla J, Broderick J, Chatterjee A, Jauch EC, Levine SR, Romano JG, Saver JL, Vagal A, Purdon B, Devenport J, Pavlov A, Yeatts SD; PRISMS Investigators.

JAMA. 2018 Jul 10;320(2):156-166. doi: 10.1001/jama.2018.8496.


Endovascular Treatment in the DEFUSE 3 Study.

Marks MP, Heit JJ, Lansberg MG, Kemp S, Christensen S, Derdeyn CP, Rasmussen PA, Zaidat OO, Broderick JP, Yeatts SD, Hamilton S, Mlynash M, Albers GW; DEFUSE 3 Investigators.

Stroke. 2018 Aug;49(8):2000-2003. doi: 10.1161/STROKEAHA.118.022147.


To Treat or Not to Treat?

Levine SR, Weingast SZ, Weedon J, Stefanov DG, Katz P, Hurley D, Kasner SE, Khatri P, Broderick JP, Grotta JC, Feldmann E, Panagos PD, Romano JG, Bianchi R, Meyer BC, Scott PA, Kim D, Balucani C.

Stroke. 2018 Aug;49(8):1933-1938. doi: 10.1161/STROKEAHA.118.020971.


Compositional and structural insights into the nature of the H-cluster precursor on HydF.

Scott AG, Szilagyi RK, Mulder DW, Ratzloff MW, Byer AS, King PW, Broderick WE, Shepard EM, Broderick JB.

Dalton Trans. 2018 Jul 17;47(28):9521-9535. doi: 10.1039/c8dt01654b.


Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis.

Byer AS, Yang H, McDaniel EC, Kathiresan V, Impano S, Pagnier A, Watts H, Denler C, Vagstad AL, Piel J, Duschene KS, Shepard EM, Shields TP, Scott LG, Lilla EA, Yokoyama K, Broderick WE, Hoffman BM, Broderick JB.

J Am Chem Soc. 2018 Jul 18;140(28):8634-8638. doi: 10.1021/jacs.8b04061. Epub 2018 Jul 6.


The use of eHealth to promote physical activity in cancer survivors: a systematic review.

Haberlin C, O'Dwyer T, Mockler D, Moran J, O'Donnell DM, Broderick J.

Support Care Cancer. 2018 Oct;26(10):3323-3336. doi: 10.1007/s00520-018-4305-z. Epub 2018 Jun 16.


Bayesian selective response-adaptive design using the historical control.

Kim MO, Harun N, Liu C, Khoury JC, Broderick JP.

Stat Med. 2018 Nov 20;37(26):3709-3722. doi: 10.1002/sim.7836. Epub 2018 Jun 13.


Prehospital Triage of Acute Ischemic Stroke Patients to an Intravenous tPA-Ready versus Endovascular-Ready Hospital: A Decision Analysis.

Benoit JL, Khatri P, Adeoye OM, Broderick JP, McMullan JT, Scheitz JF, Vagal AS, Eckman MH.

Prehosp Emerg Care. 2018 Nov-Dec;22(6):722-733. doi: 10.1080/10903127.2018.1465500. Epub 2018 May 30.


Haemostatic treatment for intracerebral haemorrhage.

Broderick JP.

Lancet. 2018 May 26;391(10135):2081-2082. doi: 10.1016/S0140-6736(18)31040-7. Epub 2018 May 16. No abstract available.


First Use of HeartMate 3 in a Failing Fontan Circulation.

Lorts A, Villa C, Riggs KW, Broderick J, Morales DLS.

Ann Thorac Surg. 2018 Nov;106(5):e233-e234. doi: 10.1016/j.athoracsur.2018.04.021. Epub 2018 May 9.


Lipid-Lowering Pretreatment and Outcome Following Intravenous Thrombolysis for Acute Ischaemic Stroke: A Post Hoc Analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study Trial.

Minhas JS, Wang X, Arima H, Bath PM, Billot L, Broderick JP, Donnan GA, Kim JS, Lavados PM, Lee TH, Martins SCO, Olavarría VV, Pandian JD, Pontes-Neto OM, Ricci S, Sato S, Sharma VK, Thang NH, Wang JG, Woodward M, Chalmers J, Anderson CS, Robinson TG; ENCHANTED Investigators.

Cerebrovasc Dis. 2018;45(5-6):213-220. doi: 10.1159/000488911. Epub 2018 Apr 27.


PFO Closure for Cryptogenic Stroke.

Mi MY, Block PC, Broderick JP.

N Engl J Med. 2018 Apr 26;378(17):1639-1642. doi: 10.1056/NEJMclde1715853. No abstract available.


A feasibility study of a physiotherapy-led motivational programme to increase physical activity and improve cardiometabolic risk in people with major mental illness.

Waugh A, Crumlish N, Kelleher E, Forde C, Broderick J.

Gen Hosp Psychiatry. 2018 Sep - Oct;54:37-44. doi: 10.1016/j.genhosppsych.2018.03.002. Epub 2018 Mar 13. No abstract available.


Pediatric Stroke Rates Over 17 Years: Report From a Population-Based Study.

Lehman LL, Khoury JC, Taylor JM, Yeramaneni S, Sucharew H, Alwell K, Moomaw CJ, Peariso K, Flaherty M, Khatri P, Broderick JP, Kissela BM, Kleindorfer DO.

J Child Neurol. 2018 Jun;33(7):463-467. doi: 10.1177/0883073818767039. Epub 2018 Apr 19.


Alteplase for the treatment of acute ischemic stroke in patients with low National Institutes of Health Stroke Scale and not clearly disabling deficits (Potential of rtPA for Ischemic Strokes with Mild Symptoms PRISMS): Rationale and design.

Yeatts SD, Broderick JP, Chatterjee A, Jauch EC, Levine SR, Romano JG, Saver JL, Vagal A, Purdon B, Devenport J, Khatri P.

Int J Stroke. 2018 Aug;13(6):654-661. doi: 10.1177/1747493018765269. Epub 2018 Mar 23.


Heritability of circle of Willis variations in families with intracranial aneurysms.

Sánchez van Kammen M, Moomaw CJ, van der Schaaf IC, Brown RD Jr, Woo D, Broderick JP, Mackey JS, Rinkel GJE, Huston J 3rd, Ruigrok YM.

PLoS One. 2018 Jan 29;13(1):e0191974. doi: 10.1371/journal.pone.0191974. eCollection 2018.


Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging.

Albers GW, Marks MP, Kemp S, Christensen S, Tsai JP, Ortega-Gutierrez S, McTaggart RA, Torbey MT, Kim-Tenser M, Leslie-Mazwi T, Sarraj A, Kasner SE, Ansari SA, Yeatts SD, Hamilton S, Mlynash M, Heit JJ, Zaharchuk G, Kim S, Carrozzella J, Palesch YY, Demchuk AM, Bammer R, Lavori PW, Broderick JP, Lansberg MG; DEFUSE 3 Investigators.

N Engl J Med. 2018 Feb 22;378(8):708-718. doi: 10.1056/NEJMoa1713973. Epub 2018 Jan 24.


Psychological stress declines rapidly from age 50 in the United States: Yet another well-being paradox.

Stone AA, Schneider S, Broderick JE.

J Psychosom Res. 2017 Dec;103:22-28. doi: 10.1016/j.jpsychores.2017.09.016. Epub 2017 Oct 3.


Dual antiplatelet therapy in aneurysmal subarachnoid hemorrhage: association with reduced risk of clinical vasospasm and delayed cerebral ischemia.

Nagahama Y, Allan L, Nakagawa D, Zanaty M, Starke RM, Chalouhi N, Jabbour P, Brown RD, Derdeyn CP, Leira EC, Broderick J, Chimowitz M, Torner JC, Hasan D.

J Neurosurg. 2018 Sep;129(3):702-710. doi: 10.3171/2017.5.JNS17831. Epub 2017 Nov 3.


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