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Items: 1 to 50 of 261

1.

The contribution of reactive oxygen species and p38 mitogen-activated protein kinase to myofilament oxidation and progression of heart failure in rabbits.

Heusch P, Canton M, Aker S, van de Sand A, Konietzka I, Rassaf T, Menazza S, Brodde OE, Di Lisa F, Heusch G, Schulz R.

Br J Pharmacol. 2010 Jul;160(6):1408-16. doi: 10.1111/j.1476-5381.2010.00793.x.

2.

Beta1- and beta2-adrenoceptor polymorphisms and cardiovascular diseases.

Brodde OE.

Fundam Clin Pharmacol. 2008 Apr;22(2):107-25. doi: 10.1111/j.1472-8206.2007.00557.x. Review.

PMID:
18353108
3.
4.

In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the Arg389Gly-beta 1-adrenoceptor polymorphism.

Leineweber K, Bogedain P, Wolf C, Wagner S, Weber M, Jakob HG, Heusch G, Philipp T, Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Jul;375(5):303-9. Epub 2007 Jun 1.

PMID:
17541557
5.

Presynaptic alpha-2C adrenoceptor-mediated control of noradrenaline release in humans: genotype- or age-dependent?

Bruck H, Schwerdtfeger T, Toliat M, Leineweber K, Heusch G, Philipp T, Nürnberg P, Brodde OE.

Clin Pharmacol Ther. 2007 Nov;82(5):525-30. Epub 2007 Apr 4.

PMID:
17410123
6.

Beta-adrenoceptor blocker treatment and the cardiac beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in chronic heart failure.

Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Feb;374(5-6):361-72. Epub 2007 Jan 11. Review.

PMID:
17216434
7.

CaMKII-mediated increased lusitropic responses to beta-adrenoreceptor stimulation in ANP-receptor deficient mice.

Yurukova S, Kilić A, Völker K, Leineweber K, Dybkova N, Maier LS, Brodde OE, Kuhn M.

Cardiovasc Res. 2007 Mar 1;73(4):678-88. Epub 2006 Oct 7.

PMID:
17107670
8.

[Role of the L-arginine/nitric oxide system in the action of nebivolol].

Brodde OE, Philipp T.

Dtsch Med Wochenschr. 2006 Nov 10;131(45):2545-50. Review. German.

PMID:
17091442
9.

Decellularized xenogenic heart valves reveal remodeling and growth potential in vivo.

Erdbrügger W, Konertz W, Dohmen PM, Posner S, Ellerbrok H, Brodde OE, Robenek H, Modersohn D, Pruss A, Holinski S, Stein-Konertz M, Pauli G.

Tissue Eng. 2006 Aug;12(8):2059-68.

PMID:
16968148
10.

Is there a role of the Thr164Ile-beta(2)-adrenoceptor polymorphism for the outcome of chronic heart failure?

Leineweber K, Tenderich G, Wolf C, Wagner S, Zittermann A, Elter-Schulz M, Moog R, Müller N, Jakob HG, Körfer R, Philipp T, Heusch G, Brodde OE.

Basic Res Cardiol. 2006 Nov;101(6):479-84. Epub 2006 Jun 16.

PMID:
16783489
11.

Selective upregulation of beta1-adrenergic receptors and dephosphorylation of troponin I in end-stage heart failure patients supported by ventricular assist devices.

Milting H, Scholz C, Arusoglu L, Freitag M, Cebulla R, Jaquet K, Körfer R, V Lewinski D, Kassner A, Brodde OE, Kögler H, El Banayosy A, Pieske B.

J Mol Cell Cardiol. 2006 Sep;41(3):441-50. Epub 2006 Jun 12.

PMID:
16765375
12.

Cardiac adrenoceptors: physiological and pathophysiological relevance.

Brodde OE, Bruck H, Leineweber K.

J Pharmacol Sci. 2006;100(5):323-37. Epub 2006 Apr 13. Review.

13.
14.

The Arg389Gly beta1-adrenoceptor polymorphism does not affect cardiac effects of exercise after parasympathetic inhibition by atropine.

Leineweber K, Bruck H, Temme T, Heusch G, Philipp T, Brodde OE.

Pharmacogenet Genomics. 2006 Jan;16(1):9-13.

PMID:
16344717
15.

The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity.

Bruck H, Leineweber K, Temme T, Weber M, Heusch G, Philipp T, Brodde OE.

J Am Coll Cardiol. 2005 Dec 6;46(11):2111-5. Epub 2005 Nov 4.

16.

Human beta2-adrenergic receptor gene haplotypes and venodilation in vivo.

Bruck H, Leineweber K, Park J, Weber M, Heusch G, Philipp T, Brodde OE.

Clin Pharmacol Ther. 2005 Sep;78(3):232-8.

PMID:
16153394
17.

G-protein-coupled receptor kinase activity in human heart failure: effects of beta-adrenoceptor blockade.

Leineweber K, Rohe P, Beilfuss A, Wolf C, Sporkmann H, Bruck H, Jakob HG, Heusch G, Philipp T, Brodde OE.

Cardiovasc Res. 2005 Jun 1;66(3):512-9. Epub 2005 Apr 7.

PMID:
15914116
18.

Beta2-adrenoceptor gene polymorphisms.

Brodde OE, Leineweber K.

Pharmacogenet Genomics. 2005 May;15(5):267-75. Review.

PMID:
15864127
19.

Pressure overload and neurohumoral activation differentially affect the myocardial proteome.

Schott P, Singer SS, Kögler H, Neddermeier D, Leineweber K, Brodde OE, Regitz-Zagrosek V, Schmidt B, Dihazi H, Hasenfuss G.

Proteomics. 2005 Apr;5(5):1372-81.

PMID:
15732135
20.

Beta 2-adrenoceptor-mediated intrinsic sympathomimetic activity of carteolol: an in vivo study.

Bruck H, Poller U, Lüssenhop H, Pönicke K, Temme T, Heusch G, Philipp T, Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Nov;370(5):361-8. Epub 2004 Oct 23.

PMID:
15526107
21.

Autonomic receptor systems in the failing and aging human heart: similarities and differences.

Brodde OE, Leineweber K.

Eur J Pharmacol. 2004 Oct 1;500(1-3):167-76. Review.

PMID:
15464030
22.

Beta2-adrenoceptor polymorphisms: relation between in vitro and in vivo phenotypes.

Leineweber K, Brodde OE.

Life Sci. 2004 Apr 23;74(23):2803-14. Review.

PMID:
15072081
23.

Drug-drug interactions of beta-adrenoceptor blockers.

Brodde OE, Kroemer HK.

Arzneimittelforschung. 2003;53(12):814-22. Review.

PMID:
14732961
24.

Beta-adrenoceptor polymorphisms.

Leineweber K, Büscher R, Bruck H, Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):1-22. Epub 2003 Nov 28. Review.

PMID:
14647973
25.

Unchanged G-protein-coupled receptor kinase activity in the aging human heart.

Leineweber K, Klapproth S, Beilfuss A, Silber RE, Heusch G, Philipp T, Brodde OE.

J Am Coll Cardiol. 2003 Oct 15;42(8):1487-92.

26.

The Gly389Arg beta1-adrenergic receptor polymorphism: a predictor of response to beta-blocker treatment?

Brodde OE, Stein CM.

Clin Pharmacol Ther. 2003 Oct;74(4):299-302. Review. No abstract available.

PMID:
14534516
27.

Existence of functional M3-muscarinic receptors in the human heart.

Willmy-Matthes P, Leineweber K, Wangemann T, Silber RE, Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):316-9. Epub 2003 Oct 1.

PMID:
14520506
28.

Genotype-dependent time course of lymphocyte beta 2-adrenergic receptor down-regulation.

Bruck H, Leineweber K, Beilfuss A, Weber M, Heusch G, Philipp T, Brodde OE.

Clin Pharmacol Ther. 2003 Sep;74(3):255-63.

PMID:
12966369
29.

Thr164Ile polymorphism of the human beta2-adrenoceptor exhibits blunted desensitization of cardiac functional responses in vivo.

Bruck H, Leineweber K, Ulrich A, Radke J, Heusch G, Philipp T, Brodde OE.

Am J Physiol Heart Circ Physiol. 2003 Nov;285(5):H2034-8. Epub 2003 Jul 17.

30.

Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat.

Kögler H, Hartmann O, Leineweber K, Nguyen van P, Schott P, Brodde OE, Hasenfuss G.

Circ Res. 2003 Aug 8;93(3):230-7. Epub 2003 Jul 3.

PMID:
12842921
31.

Effects of atropine on human cardiac beta 1- and/or beta 2-adrenoceptor stimulation.

Bruck H, Ulrich A, Gerlach S, Radke J, Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):572-7. Epub 2003 May 21.

PMID:
12759717
32.

Role of beta 1- and beta 2-adrenoceptors in hypertrophic and apoptotic effects of noradrenaline and adrenaline in adult rat ventricular cardiomyocytes.

Pönicke K, Heinroth-Hoffmann I, Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):592-9. Epub 2003 May 15.

PMID:
12750877
33.

Cardiac beta-adrenoceptor changes in monocrotaline-treated rats: differences between membrane preparations from whole ventricles and isolated ventricular cardiomyocytes.

Leineweber K, Seyfarth T, Abraham G, Gerbershagen HP, Heinroth-Hoffmann I, Pönicke K, Brodde OE.

J Cardiovasc Pharmacol. 2003 Mar;41(3):333-42.

PMID:
12605011
34.

The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo.

Bruck H, Leineweber K, Büscher R, Ulrich A, Radke J, Insel PA, Brodde OE.

Pharmacogenetics. 2003 Feb;13(2):59-66.

PMID:
12563174
35.

Demonstration of functional M3-muscarinic receptors in ventricular cardiomyocytes of adult rats.

Pönicke K, Heinroth-Hoffmann I, Brodde OE.

Br J Pharmacol. 2003 Jan;138(1):156-60.

36.

The indirect negative inotropic effect of carbachol in beta1-adrenoceptor antagonist-treated human right atria.

Wangemann T, Giessler C, Willmy-Matthes P, Silber RE, Brodde OE.

Eur J Pharmacol. 2003 Jan 1;458(1-2):163-70.

PMID:
12498921
37.

Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure.

Leineweber K, Brandt K, Wludyka B, Beilfuss A, Pönicke K, Heinroth-Hoffmann I, Brodde OE.

Circ Res. 2002 Nov 29;91(11):1056-62.

PMID:
12456492
38.

Age-dependent changes of cardiac neuronal noradrenaline reuptake transporter (uptake1) in the human heart.

Leineweber K, Wangemann T, Giessler C, Bruck H, Dhein S, Kostelka M, Mohr FW, Silber RE, Brodde OE.

J Am Coll Cardiol. 2002 Oct 16;40(8):1459.

39.

Regulation of equine lymphocyte beta-adrenoceptors under the influence of clenbuterol and dexamethasone.

Abraham G, Brodde OE, Ungemach FR.

Equine Vet J. 2002 Sep;34(6):587-93.

PMID:
12357998
40.

Noradrenaline-induced contraction of human saphenous vein and human internal mammary artery: involvement of different alpha-adrenoceptor subtypes.

Giessler C, Wangemann T, Silber RE, Dhein S, Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2002 Aug;366(2):104-9. Epub 2002 Jun 14.

PMID:
12122495
41.
42.

Changes in alpha(1)-adrenergic vascular reactivity in monocrotaline-treated rats.

Dhein S, Giessler C, Heinroth-Hoffmann I, Leineweber K, Seyfarth T, Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2002 Feb;365(2):87-95. Epub 2001 Dec 20.

PMID:
11819025
43.

Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart.

Brodde OE, Bruck H, Leineweber K, Seyfarth T.

Basic Res Cardiol. 2001 Nov;96(6):528-38. Review.

PMID:
11770070
44.

Cardiac beta-adrenoceptor desensitization due to increased beta-adrenoceptor kinase activity in chronic uremia.

Leineweber K, Heinroth-Hoffmann I, Pönicke K, Abraham G, Osten B, Brodde OE.

J Am Soc Nephrol. 2002 Jan;13(1):117-24.

45.

Noradrenaline-induced increase in protein synthesis in adult rat cardiomyocytes: involvement of only alpha1A-adrenoceptors.

Pönicke K, Schlüter KD, Heinroth-Hoffmann I, Seyfarth T, Goldberg M, Osten B, Piper HM, Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Nov;364(5):444-53.

PMID:
11692228
46.

Enhanced protein phosphorylation in hypertensive hypertrophy.

Bokník P, Heinroth-Hoffmann I, Kirchhefer U, Knapp J, Linck B, Lüss H, Müller T, Schmitz W, Brodde O, Neumann J.

Cardiovasc Res. 2001 Sep;51(4):717-28.

PMID:
11530105
47.

Muscarinic receptors in the mammalian heart.

Dhein S, van Koppen CJ, Brodde OE.

Pharmacol Res. 2001 Sep;44(3):161-82. Review.

PMID:
11529684
48.

Impaired beta-adrenergic control of immune function in patients with chronic heart failure: reversal by beta1-blocker treatment.

Werner C, Werdan K, Pönicke K, Brodde OE.

Basic Res Cardiol. 2001 May-Jun;96(3):290-8.

PMID:
11403423
49.

In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans.

Büscher R, Belger H, Eilmes KJ, Tellkamp R, Radke J, Dhein S, Hoyer PF, Michel MC, Insel PA, Brodde OE.

Pharmacogenetics. 2001 Apr;11(3):199-205.

PMID:
11337935
50.

ET-receptor function in relation to blood pressure in spontaneously hypertensive and aortic-banded rats.

Becker K, Heinroth-Hoffmann I, Pönicke K, Osten B, Brodde OE.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Apr;363(4):439-47.

PMID:
11330338

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