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Items: 1 to 50 of 280

1.

Enhanced Sequence Coverage of Large Proteins by Combining Ultraviolet Photodissociation with Proton Transfer Reactions.

Sanders J, Mullen C, Watts E, Holden D, Syka JE, Schwartz JC, Brodbelt JS.

Anal Chem. 2019 Nov 26. doi: 10.1021/acs.analchem.9b04026. [Epub ahead of print]

PMID:
31769661
2.

Enhanced Characterization of Membrane Protein Complexes by Ultraviolet Photodissociation Mass Spectrometry.

Sipe SN, Patrick JW, Laganowsky A, Brodbelt JS.

Anal Chem. 2019 Nov 25. doi: 10.1021/acs.analchem.9b03689. [Epub ahead of print]

PMID:
31765130
3.

Footprints of Nanoscale DNA-Silver Cluster Chromophores via Activated-Electron Photodetachment Mass Spectrometry.

Blevins MS, Kim D, Crittenden CM, Hong S, Yeh HC, Petty JT, Brodbelt JS.

ACS Nano. 2019 Nov 27. doi: 10.1021/acsnano.9b06470. [Epub ahead of print]

PMID:
31755695
4.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

Kim JJ, Lee SY, Gong F, Battenhouse AM, Boutz DR, Bashyal A, Refvik ST, Chiang CM, Xhemalce B, Paull TT, Brodbelt JS, Marcotte EM, Miller KM.

Genes Dev. 2019 Dec 1;33(23-24):1751-1774. doi: 10.1101/gad.331231.119. Epub 2019 Nov 21.

PMID:
31753913
5.

Ion Activation Methods for Peptides and Proteins.

Macias LA, Santos IC, Brodbelt JS.

Anal Chem. 2019 Nov 12. doi: 10.1021/acs.analchem.9b04859. [Epub ahead of print] No abstract available.

PMID:
31665881
6.

Ubiquitin receptors are required for substrate-mediated activation of the proteasome's unfolding ability.

Cundiff MD, Hurley CM, Wong JD, Boscia JA 4th, Bashyal A, Rosenberg J, Reichard EL, Nassif ND, Brodbelt JS, Kraut DA.

Sci Rep. 2019 Oct 10;9(1):14506. doi: 10.1038/s41598-019-50857-y.

7.

Mapping RNAPII CTD Phosphorylation Reveals That the Identity and Modification of Seventh Heptad Residues Direct Tyr1 Phosphorylation.

Burkholder NT, Sipe SN, Escobar EE, Venkatramani M, Irani S, Yang W, Wu H, Matthews WM, Brodbelt JS, Zhang Y.

ACS Chem Biol. 2019 Oct 18;14(10):2264-2275. doi: 10.1021/acschembio.9b00610. Epub 2019 Oct 7.

PMID:
31553563
8.

Hybrid 193 nm Ultraviolet Photodissociation Mass Spectrometry Localizes Cardiolipin Unsaturations.

Macias LA, Feider CL, Eberlin LS, Brodbelt JS.

Anal Chem. 2019 Oct 1;91(19):12509-12516. doi: 10.1021/acs.analchem.9b03278. Epub 2019 Sep 18.

PMID:
31490676
9.

Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb.

Mayfield JE, Irani S, Escobar EE, Zhang Z, Burkholder NT, Robinson MR, Mehaffey MR, Sipe SN, Yang W, Prescott NA, Kathuria KR, Liu Z, Brodbelt JS, Zhang Y.

Elife. 2019 Aug 6;8. pii: e48725. doi: 10.7554/eLife.48725.

10.

Top-Down Characterization of Lipooligosaccharides from Antibiotic-Resistant Bacteria.

Klein DR, Powers MJ, Trent MS, Brodbelt JS.

Anal Chem. 2019 Aug 6;91(15):9608-9615. doi: 10.1021/acs.analchem.9b00940. Epub 2019 Jul 26.

PMID:
31305072
11.

Total Synthesis of an Immunogenic Trehalose Phospholipid from Salmonella Typhi and Elucidation of Its sn-Regiochemistry by Mass Spectrometry.

Mishra VK, Buter J, Blevins MS, Witte MD, Van Rhijn I, Moody DB, Brodbelt JS, Minnaard AJ.

Org Lett. 2019 Jul 5;21(13):5126-5131. doi: 10.1021/acs.orglett.9b01725. Epub 2019 Jun 20.

12.

A Lysine-Targeted Affinity Label for Serine-β-Lactamase Also Covalently Modifies New Delhi Metallo-β-lactamase-1 (NDM-1).

Thomas PW, Cammarata M, Brodbelt JS, Monzingo AF, Pratt RF, Fast W.

Biochemistry. 2019 Jun 25;58(25):2834-2843. doi: 10.1021/acs.biochem.9b00393. Epub 2019 Jun 7.

PMID:
31145588
13.

Localization of Cyclopropane Modifications in Bacterial Lipids via 213 nm Ultraviolet Photodissociation Mass Spectrometry.

Blevins MS, Klein DR, Brodbelt JS.

Anal Chem. 2019 May 21;91(10):6820-6828. doi: 10.1021/acs.analchem.9b01038. Epub 2019 May 3.

PMID:
31026154
14.

Impact of charge state on 193 nm ultraviolet photodissociation of protein complexes.

Sipe SN, Brodbelt JS.

Phys Chem Chem Phys. 2019 May 8;21(18):9265-9276. doi: 10.1039/c9cp01144g.

PMID:
31016301
15.

Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.

Irani S, Sipe SN, Yang W, Burkholder NT, Lin B, Sim K, Matthews WL, Brodbelt JS, Zhang Y.

J Biol Chem. 2019 May 24;294(21):8592-8605. doi: 10.1074/jbc.RA119.007697. Epub 2019 Apr 10.

PMID:
30971428
16.

Structural Characterization of Glycosaminoglycan Carbohydrates Using Ultraviolet Photodissociation.

Klein DR, Leach FE 3rd, Amster IJ, Brodbelt JS.

Anal Chem. 2019 May 7;91(9):6019-6026. doi: 10.1021/acs.analchem.9b00521. Epub 2019 Apr 11.

PMID:
30932467
17.

Colistin heteroresistance in Enterobacter cloacae is regulated by PhoPQ-dependent 4-amino-4-deoxy-l-arabinose addition to lipid A.

Kang KN, Klein DR, Kazi MI, Guérin F, Cattoir V, Brodbelt JS, Boll JM.

Mol Microbiol. 2019 Jun;111(6):1604-1616. doi: 10.1111/mmi.14240. Epub 2019 Apr 10.

18.

Characterization of Antigenic Oligosaccharides from Gram-Negative Bacteria via Activated Electron Photodetachment Mass Spectrometry.

Crittenden CM, Escobar EE, Williams PE, Sanders JD, Brodbelt JS.

Anal Chem. 2019 Apr 2;91(7):4672-4679. doi: 10.1021/acs.analchem.9b00048. Epub 2019 Mar 15.

PMID:
30844257
19.

Top-Down Analysis of Proteins in Low Charge States.

Bashyal A, Sanders JD, Holden DD, Brodbelt JS.

J Am Soc Mass Spectrom. 2019 Apr;30(4):704-717. doi: 10.1007/s13361-019-02146-1. Epub 2019 Feb 22.

PMID:
30796622
20.

A Focus Honoring Carol Robinson's Election to the National Academy of Sciences.

Brodbelt JS, Russell DH.

J Am Soc Mass Spectrom. 2019 Jan;30(1):1-3. doi: 10.1007/s13361-018-2096-6. No abstract available. Erratum in: J Am Soc Mass Spectrom. 2019 Mar;30(3):561.

PMID:
30430435
21.

Structural and Functional Studies of a gem-Dimethylating Methyltransferase from a trans-Acyltransferase Assembly Line.

Meinke JL, Mehaffey MR, Wagner DT, Sun N, Zhang Z, Brodbelt JS, Keatinge-Clay AT.

ACS Chem Biol. 2018 Dec 21;13(12):3306-3314. doi: 10.1021/acschembio.8b00733. Epub 2018 Nov 9.

22.

Desorption Electrospray Ionization Coupled with Ultraviolet Photodissociation for Characterization of Phospholipid Isomers in Tissue Sections.

Klein DR, Feider CL, Garza KY, Lin JQ, Eberlin LS, Brodbelt JS.

Anal Chem. 2018 Sep 4;90(17):10100-10104. doi: 10.1021/acs.analchem.8b03026. Epub 2018 Aug 13.

23.

Extensive Characterization of Heavily Modified Histone Tails by 193 nm Ultraviolet Photodissociation Mass Spectrometry via a Middle-Down Strategy.

Greer SM, Sidoli S, Coradin M, Schack Jespersen M, Schwämmle V, Jensen ON, Garcia BA, Brodbelt JS.

Anal Chem. 2018 Sep 4;90(17):10425-10433. doi: 10.1021/acs.analchem.8b02320. Epub 2018 Aug 16.

24.

Multistage Ultraviolet Photodissociation Mass Spectrometry To Characterize Single Amino Acid Variants of Human Mitochondrial BCAT2.

Mehaffey MR, Sanders JD, Holden DD, Nilsson CL, Brodbelt JS.

Anal Chem. 2018 Aug 21;90(16):9904-9911. doi: 10.1021/acs.analchem.8b02099. Epub 2018 Aug 1.

25.

Towards mapping electrostatic interactions between Kdo2-lipid A and cationic antimicrobial peptides via ultraviolet photodissociation mass spectrometry.

Crittenden CM, Morrison LJ, Fitzpatrick MD, Myers AP, Novelli ET, Rosenberg J, Akin LD, Srinivasa V, Shear JB, Brodbelt JS.

Analyst. 2018 Jul 23;143(15):3607-3618. doi: 10.1039/c8an00652k.

26.

Implementation of Fragment Ion Protection (FIP) during Ultraviolet Photodissociation (UVPD) Mass Spectrometry.

Holden DD, Sanders JD, Weisbrod CR, Mullen C, Schwartz JC, Brodbelt JS.

Anal Chem. 2018 Jul 17;90(14):8583-8591. doi: 10.1021/acs.analchem.8b01723. Epub 2018 Jul 6.

PMID:
29927232
27.

Characterization of Disulfide Linkages in Proteins by 193 nm Ultraviolet Photodissociation (UVPD) Mass Spectrometry.

Quick MM, Crittenden CM, Rosenberg JA, Brodbelt JS.

Anal Chem. 2018 Jul 17;90(14):8523-8530. doi: 10.1021/acs.analchem.8b01556. Epub 2018 Jun 28.

28.

Mapping phosphate modifications of substituted lipid A via a targeted MS3 CID/UVPD strategy.

Crittenden CM, Herrera CM, Williams PE, Ricci DP, Swem LR, Trent MS, Brodbelt JS.

Analyst. 2018 Jun 25;143(13):3091-3099. doi: 10.1039/c8an00561c.

29.

Custom selenoprotein production enabled by laboratory evolution of recoded bacterial strains.

Thyer R, Shroff R, Klein DR, d'Oelsnitz S, Cotham VC, Byrom M, Brodbelt JS, Ellington AD.

Nat Biotechnol. 2018 Aug;36(7):624-631. doi: 10.1038/nbt.4154. Epub 2018 Jun 4.

30.

Desorption Electrospray Ionization Mass Spectrometry Imaging of Proteins Directly from Biological Tissue Sections.

Garza KY, Feider CL, Klein DR, Rosenberg JA, Brodbelt JS, Eberlin LS.

Anal Chem. 2018 Jul 3;90(13):7785-7789. doi: 10.1021/acs.analchem.8b00967. Epub 2018 Jun 15.

31.

PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata.

Parsley NC, Kirkpatrick CL, Crittenden CM, Rad JG, Hoskin DW, Brodbelt JS, Hicks LM.

Phytochemistry. 2018 Aug;152:61-70. doi: 10.1016/j.phytochem.2018.04.014. Epub 2018 May 21.

32.

Expanding the Scope of Cross-Link Identifications by Incorporating Collisional Activated Dissociation and Ultraviolet Photodissociation Methods.

Cammarata MB, Macias LA, Rosenberg J, Bolufer A, Brodbelt JS.

Anal Chem. 2018 Jun 5;90(11):6385-6389. doi: 10.1021/acs.analchem.7b04009. Epub 2018 May 11.

33.

Directed Evolution of Heterologous tRNAs Leads to Reduced Dependence on Post-transcriptional Modifications.

Baldridge KC, Jora M, Maranhao AC, Quick MM, Addepalli B, Brodbelt JS, Ellington AD, Limbach PA, Contreras LM.

ACS Synth Biol. 2018 May 18;7(5):1315-1327. doi: 10.1021/acssynbio.7b00421. Epub 2018 Apr 25.

PMID:
29694026
34.

UV-POSIT: Web-Based Tools for Rapid and Facile Structural Interpretation of Ultraviolet Photodissociation (UVPD) Mass Spectra.

Rosenberg J, Parker WR, Cammarata MB, Brodbelt JS.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1323-1326. doi: 10.1007/s13361-018-1918-x. Epub 2018 Apr 6.

35.

Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer.

Sanders JD, Grinfeld D, Aizikov K, Makarov A, Holden DD, Brodbelt JS.

Anal Chem. 2018 May 1;90(9):5896-5902. doi: 10.1021/acs.analchem.8b00724. Epub 2018 Apr 18.

PMID:
29608288
36.

Extending Proteome Coverage by Combining MS/MS Methods and a Modified Bioinformatics Platform Adapted for Database Searching of Positive and Negative Polarity 193 nm Ultraviolet Photodissociation Mass Spectra.

Greer SM, Bern M, Becker C, Brodbelt JS.

J Proteome Res. 2018 Apr 6;17(4):1340-1347. doi: 10.1021/acs.jproteome.7b00673. Epub 2018 Mar 2.

PMID:
29480007
37.

Top-Down Characterization of Heavily Modified Histones Using 193 nm Ultraviolet Photodissociation Mass Spectrometry.

Greer SM, Brodbelt JS.

J Proteome Res. 2018 Mar 2;17(3):1138-1145. doi: 10.1021/acs.jproteome.7b00801. Epub 2018 Jan 31.

PMID:
29343059
38.

Tracking the Catalytic Cycle of Adenylate Kinase by Ultraviolet Photodissociation Mass Spectrometry.

Mehaffey MR, Cammarata MB, Brodbelt JS.

Anal Chem. 2018 Jan 2;90(1):839-846. doi: 10.1021/acs.analchem.7b03591. Epub 2017 Dec 15.

39.

Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7.

Bergstrom A, Katko A, Adkins Z, Hill J, Cheng Z, Burnett M, Yang H, Aitha M, Mehaffey MR, Brodbelt JS, Tehrani KHME, Martin NI, Bonomo RA, Page RC, Tierney DL, Fast W, Wright GD, Crowder MW.

ACS Infect Dis. 2018 Feb 9;4(2):135-145. doi: 10.1021/acsinfecdis.7b00106. Epub 2017 Nov 9.

40.

Integrating Carbamylation and Ultraviolet Photodissociation Mass Spectrometry for Middle-Down Proteomics.

Sanders JD, Greer SM, Brodbelt JS.

Anal Chem. 2017 Nov 7;89(21):11772-11778. doi: 10.1021/acs.analchem.7b03396. Epub 2017 Oct 26.

PMID:
29035051
41.

Pinpointing Double Bond and sn-Positions in Glycerophospholipids via Hybrid 193 nm Ultraviolet Photodissociation (UVPD) Mass Spectrometry.

Williams PE, Klein DR, Greer SM, Brodbelt JS.

J Am Chem Soc. 2017 Nov 8;139(44):15681-15690. doi: 10.1021/jacs.7b06416. Epub 2017 Oct 25.

42.

Characterization of hydrogen bonding motifs in proteins: hydrogen elimination monitoring by ultraviolet photodissociation mass spectrometry.

Morrison LJ, Chai W, Rosenberg JA, Henkelman G, Brodbelt JS.

Phys Chem Chem Phys. 2017 Aug 2;19(30):20057-20074. doi: 10.1039/c7cp04073c.

43.

Middle-Down 193-nm Ultraviolet Photodissociation for Unambiguous Antibody Identification and its Implications for Immunoproteomic Analysis.

Cotham VC, Horton AP, Lee J, Georgiou G, Brodbelt JS.

Anal Chem. 2017 Jun 20;89(12):6498-6504. doi: 10.1021/acs.analchem.7b00564. Epub 2017 May 26.

PMID:
28517930
44.

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain.

Portz B, Lu F, Gibbs EB, Mayfield JE, Rachel Mehaffey M, Zhang YJ, Brodbelt JS, Showalter SA, Gilmour DS.

Nat Commun. 2017 May 12;8:15231. doi: 10.1038/ncomms15231.

45.

Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates.

Cammarata M, Thyer R, Lombardo M, Anderson A, Wright D, Ellington A, Brodbelt JS.

Chem Sci. 2017 May 1;8(5):4062-4072. doi: 10.1039/c6sc05235e. Epub 2017 Mar 28.

46.

High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer.

Cleland TP, DeHart CJ, Fellers RT, VanNispen AJ, Greer JB, LeDuc RD, Parker WR, Thomas PM, Kelleher NL, Brodbelt JS.

J Proteome Res. 2017 May 5;16(5):2072-2079. doi: 10.1021/acs.jproteome.7b00043. Epub 2017 Apr 19.

47.

Modulation of Protein Fragmentation Through Carbamylation of Primary Amines.

Greer SM, Holden DD, Fellers R, Kelleher NL, Brodbelt JS.

J Am Soc Mass Spectrom. 2017 Aug;28(8):1587-1599. doi: 10.1007/s13361-017-1648-5. Epub 2017 Apr 3.

48.

SITS Derivatization of Peptides to Enhance 266 nm Ultraviolet Photodissociation (UVPD).

Quick MM, Mehaffey MR, Johns RW, Parker WR, Brodbelt JS.

J Am Soc Mass Spectrom. 2017 Jul;28(7):1462-1472. doi: 10.1007/s13361-017-1650-y. Epub 2017 Mar 17.

PMID:
28315237
49.

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM.

Genes Dev. 2017 Feb 1;31(3):260-274. doi: 10.1101/gad.292516.116. Epub 2017 Feb 27.

50.

Comprehensive de Novo Peptide Sequencing from MS/MS Pairs Generated through Complementary Collision Induced Dissociation and 351 nm Ultraviolet Photodissociation.

Horton AP, Robotham SA, Cannon JR, Holden DD, Marcotte EM, Brodbelt JS.

Anal Chem. 2017 Mar 21;89(6):3747-3753. doi: 10.1021/acs.analchem.7b00130. Epub 2017 Mar 8.

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