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Items: 1 to 50 of 166

1.

Rectus sheath single-injection blocks: a study to quantify local anaesthetic absorption using serial ultrasound measurements and lidocaine serum concentrations.

Primrose M, Al Nebaihi H, Brocks DR, Widder S, Fairey A, Tsui B, Dillane D, Green JS.

J Pharm Pharmacol. 2019 May 27. doi: 10.1111/jphp.13110. [Epub ahead of print]

PMID:
31134628
2.

Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma.

Goeppert B, Toth R, Singer S, Albrecht T, Lipka DB, Lutsik P, Brocks D, Baehr M, Muecke O, Assenov Y, Gu L, Endris V, Stenzinger A, Mehrabi A, Schirmacher P, Plass C, Weichenhan D, Roessler S.

Hepatology. 2019 May;69(5):2091-2106. doi: 10.1002/hep.30493. Epub 2019 Feb 28.

PMID:
30615206
3.

Combination treatment of acute myeloid leukemia cells with DNMT and HDAC inhibitors: predominant synergistic gene downregulation associated with gene body demethylation.

Blagitko-Dorfs N, Schlosser P, Greve G, Pfeifer D, Meier R, Baude A, Brocks D, Plass C, Lübbert M.

Leukemia. 2019 Apr;33(4):945-956. doi: 10.1038/s41375-018-0293-8. Epub 2018 Nov 23.

PMID:
30470836
4.
5.

Examining the relationship between prerequisite grades and types of academic performance in pharmacy school.

Cor MK, Brocks DR.

Curr Pharm Teach Learn. 2018 Jun;10(6):695-700. doi: 10.1016/j.cptl.2018.03.008. Epub 2018 Apr 5.

PMID:
30025768
6.

Dietary-Induced Obesity and Changes in the Biodistribution and Metabolism of Amiodarone in the Rat.

Abdussalam A, Al-Agili M, Al Nebaihi HM, Mayo PR, Gabr RQ, Brocks DR.

J Pharm Sci. 2018 Nov;107(11):2938-2945. doi: 10.1016/j.xphs.2018.06.032. Epub 2018 Jul 12.

PMID:
30017888
7.

Positron Emission Tomography (PET) and Pharmacokinetics: Classical Blood Sampling Versus Image-Derived Analysis of [18F]FAZA and [18F]FDG in a Murine Tumor Bearing Model.

Jans HS, Yang XH, Brocks DR, Kumar P, Wuest M, Wiebe LI.

J Pharm Pharm Sci. 2018;21(1s):32s-47s. doi: 10.18433/jpps29788.

PMID:
29702045
8.

Reactivation of endogenous retroviral elements via treatment with DNMT- and HDAC-inhibitors.

Daskalakis M, Brocks D, Sheng YH, Islam MS, Ressnerova A, Assenov Y, Milde T, Oehme I, Witt O, Goyal A, Kühn A, Hartmann M, Weichenhan D, Jung M, Plass C.

Cell Cycle. 2018;17(7):811-822. doi: 10.1080/15384101.2018.1442623. Epub 2018 Apr 30.

9.

Identification and Characterization of Novel Receptor-Interacting Serine/Threonine-Protein Kinase 2 Inhibitors Using Structural Similarity Analysis.

Salla M, Aguayo-Ortiz R, Danmaliki GI, Zare A, Said A, Moore J, Pandya V, Manaloor R, Fong S, Blankstein AR, Gibson SB, Garcia LR, Meier P, Bhullar KS, Hubbard BP, Fiteh Y, Vliagoftis H, Goping IS, Brocks D, Hwang P, Velázquez-Martínez CA, Baksh S.

J Pharmacol Exp Ther. 2018 May;365(2):354-367. doi: 10.1124/jpet.117.247163. Epub 2018 Mar 19.

PMID:
29555876
10.

Intratumor heterogeneity in epigenetic patterns.

Assenov Y, Brocks D, Gerhäuser C.

Semin Cancer Biol. 2018 Aug;51:12-21. doi: 10.1016/j.semcancer.2018.01.010. Epub 2018 Jan 31. Review.

11.

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

Lipka DB, Witte T, Toth R, Yang J, Wiesenfarth M, Nöllke P, Fischer A, Brocks D, Gu Z, Park J, Strahm B, Wlodarski M, Yoshimi A, Claus R, Lübbert M, Busch H, Boerries M, Hartmann M, Schönung M, Kilik U, Langstein J, Wierzbinska JA, Pabst C, Garg S, Catalá A, De Moerloose B, Dworzak M, Hasle H, Locatelli F, Masetti R, Schmugge M, Smith O, Stary J, Ussowicz M, van den Heuvel-Eibrink MM, Assenov Y, Schlesner M, Niemeyer C, Flotho C, Plass C.

Nat Commun. 2017 Dec 19;8(1):2126. doi: 10.1038/s41467-017-02177-w.

12.

A High-Performance Liquid Chromatography Assay Method for the Determination of Lidocaine in Human Serum.

Al Nebaihi HM, Primrose M, Green JS, Brocks DR.

Pharmaceutics. 2017 Nov 18;9(4). pii: E52. doi: 10.3390/pharmaceutics9040052.

13.

Erratum: DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats.

Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y, Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt O, Lübbert M, Mallm JP, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhäuser C, Oakes CC, Wang T, Plass C.

Nat Genet. 2017 Oct 27;49(11):1661. doi: 10.1038/ng1117-1661c.

PMID:
29074949
14.

Glycemic and Metabolic Effects of Two Long Bouts of Moderate-Intensity Exercise in Men with Normal Glucose Tolerance or Type 2 Diabetes.

Eshghi SR, Fletcher K, Myette-Côté É, Durrer C, Gabr RQ, Little JP, Senior P, Steinback C, Davenport MH, Bell GJ, Brocks DR, Boulé NG.

Front Endocrinol (Lausanne). 2017 Jul 11;8:154. doi: 10.3389/fendo.2017.00154. eCollection 2017.

15.

Comments on "Effects of Obesity and Leptin Deficiency on Morphine Pharmacokinetics in a Mouse Model" by Dalesio et al, Anesth Analg. 2016;123: 1611-1617.

Brocks DR, Davies NM.

Anesth Analg. 2017 Jul;125(1):361. doi: 10.1213/ANE.0000000000002178. No abstract available.

PMID:
28609335
16.

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats.

Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y, Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt O, Lübbert M, Mallm JP, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhäuser C, Oakes CC, Wang T, Plass C.

Nat Genet. 2017 Jul;49(7):1052-1060. doi: 10.1038/ng.3889. Epub 2017 Jun 12. Erratum in: Nat Genet. 2017 Oct 27;49(11):1661.

17.

The Obesogenic Potency of Various High-Caloric Diet Compositions in Male Rats, and Their Effects on Expression of Liver and Kidney Proteins Involved in Drug Elimination.

Abdussalam A, Elshenawy OH, Bin Jardan YA, El-Kadi AOS, Brocks DR.

J Pharm Sci. 2017 Jun;106(6):1650-1658. doi: 10.1016/j.xphs.2017.02.002. Epub 2017 Feb 9.

PMID:
28189626
18.

Pharmacokinetics of metformin in the rat: assessment of the effect of hyperlipidemia and evidence for its metabolism to guanylurea.

Gabr RQ, El-Sherbeni AA, Ben-Eltriki M, El-Kadi AO, Brocks DR.

Can J Physiol Pharmacol. 2017 May;95(5):530-538. doi: 10.1139/cjpp-2016-0329. Epub 2016 Dec 15.

PMID:
28177686
19.

The pharmacokinetics of dronedarone in normolipidemic and hyperlipidemic rats.

Jardan YA, Brocks DR.

Biopharm Drug Dispos. 2016 Sep;37(6):345-51. doi: 10.1002/bdd.2016.

PMID:
27194397
20.

Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells.

Anwar-Mohamed A, El-Sherbeni AA, Hamdy DA, Korashy HM, Brocks DR, El-Kadi AO.

J Pharm Sci. 2016 Mar;105(3):1318-26. doi: 10.1016/j.xphs.2015.12.009. Epub 2016 Feb 6.

PMID:
26886340
21.

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.

Oakes CC, Seifert M, Assenov Y, Gu L, Przekopowitz M, Ruppert AS, Wang Q, Imbusch CD, Serva A, Koser SD, Brocks D, Lipka DB, Bogatyrova O, Weichenhan D, Brors B, Rassenti L, Kipps TJ, Mertens D, Zapatka M, Lichter P, Döhner H, Küppers R, Zenz T, Stilgenbauer S, Byrd JC, Plass C.

Nat Genet. 2016 Mar;48(3):253-64. doi: 10.1038/ng.3488. Epub 2016 Jan 18.

22.

Musical patterns for comparative epigenomics.

Brocks D.

Clin Epigenetics. 2015 Sep 8;7:94. doi: 10.1186/s13148-015-0127-8. eCollection 2015.

23.

Role of Environmental Factors in the Development of Pediatric Eosinophilic Esophagitis.

Slae M, Persad R, Leung AJ, Gabr R, Brocks D, Huynh HQ.

Dig Dis Sci. 2015 Nov;60(11):3364-72. doi: 10.1007/s10620-015-3740-7. Epub 2015 Jun 11.

PMID:
26062820
24.

uSIMPK. An Excel for Windows-based simulation program for instruction of basic pharmacokinetics principles to pharmacy students.

Brocks DR.

Comput Methods Programs Biomed. 2015 Jul;120(3):154-63. doi: 10.1016/j.cmpb.2015.04.006. Epub 2015 Apr 20.

PMID:
25934593
25.

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD.

Nature. 2015 Apr 23;520(7548):549-52. doi: 10.1038/nature14131. Epub 2015 Feb 18.

PMID:
25707806
26.

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing.

Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wünsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C.

Cell Cycle. 2014;13(22):3476-87. doi: 10.4161/15384101.2014.973334.

27.
28.

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.

Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MAG, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A.

Cell Stem Cell. 2014 Oct 2;15(4):507-522. doi: 10.1016/j.stem.2014.07.005. Epub 2014 Aug 21.

29.

Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer.

Brocks D, Assenov Y, Minner S, Bogatyrova O, Simon R, Koop C, Oakes C, Zucknick M, Lipka DB, Weischenfeldt J, Feuerbach L, Cowper-Sal Lari R, Lupien M, Brors B, Korbel J, Schlomm T, Tanay A, Sauter G, Gerhäuser C, Plass C; ICGC Early Onset Prostate Cancer Project.

Cell Rep. 2014 Aug 7;8(3):798-806. doi: 10.1016/j.celrep.2014.06.053. Epub 2014 Jul 24.

30.

Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.

Bierhoff H, Dammert MA, Brocks D, Dambacher S, Schotta G, Grummt I.

Mol Cell. 2014 May 22;54(4):675-82. doi: 10.1016/j.molcel.2014.03.032. Epub 2014 Apr 24.

31.

Effects of serum lipoproteins on cyclosporine A cellular uptake and renal toxicity in vitro.

Brocks DR, Chaudhary HR, Ben-Eltriki M, Elsherbiny ME, El-Kadi AO.

Can J Physiol Pharmacol. 2014 Feb;92(2):140-8. doi: 10.1139/cjpp-2013-0250.

PMID:
24502637
32.

Breast milk concentrations of amiodarone, desethylamiodarone, and bisoprolol following short-term drug exposure: two case reports.

Khurana R, Bin Jardan YA, Wilkie J, Brocks DR.

J Clin Pharmacol. 2014 Jul;54(7):828-31. doi: 10.1002/jcph.272. Epub 2014 Feb 5.

PMID:
24482268
33.

Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia.

Oakes CC, Claus R, Gu L, Assenov Y, Hüllein J, Zucknick M, Bieg M, Brocks D, Bogatyrova O, Schmidt CR, Rassenti L, Kipps TJ, Mertens D, Lichter P, Döhner H, Stilgenbauer S, Byrd JC, Zenz T, Plass C.

Cancer Discov. 2014 Mar;4(3):348-61. doi: 10.1158/2159-8290.CD-13-0349. Epub 2013 Dec 19.

35.

A liquid chromatography-mass spectrometric method for the quantification of azithromycin in human plasma.

Ben-Eltriki M, Somayaji V, Padwal RS, Brocks DR.

Biomed Chromatogr. 2013 Aug;27(8):1012-7. doi: 10.1002/bmc.2896. Epub 2013 Mar 15.

PMID:
23494651
36.

Pharmacokinetic characterization of intravenous cyclosporine treatment for cardioprotection during resuscitation of asphyxiated newborn piglets.

Gill RS, Brocks DR, Churchill T, Lee TF, Bigam DL, Cheung PY.

Pediatr Crit Care Med. 2013 Mar;14(3):e156-62. doi: 10.1097/PCC.0b013e318271f475.

PMID:
23392361
37.

Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes.

Brocks DR, Hamdy DA, Ben-Eltriki M, Patel JP, El-Kadi AO.

J Pharm Sci. 2013 Jan;102(1):262-70. doi: 10.1002/jps.23348. Epub 2012 Nov 6.

PMID:
23132435
38.

The effects of gastric bypass surgery on drug absorption and pharmacokinetics.

Brocks DR, Ben-Eltriki M, Gabr RQ, Padwal RS.

Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1505-19. doi: 10.1517/17425255.2012.722757. Epub 2012 Sep 24. Review.

PMID:
22998066
39.

Cyclosporine treatment reduces oxygen free radical generation and oxidative stress in the brain of hypoxia-reoxygenated newborn piglets.

Gill RS, Lee TF, Liu JQ, Chaudhary H, Brocks DR, Bigam DL, Cheung PY.

PLoS One. 2012;7(7):e40471. doi: 10.1371/journal.pone.0040471. Epub 2012 Jul 9.

40.

Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes.

Patel JP, Hamdy DA, El-Kadi AO, Brocks DR.

Chirality. 2012 Jul;24(7):558-65. doi: 10.1002/chir.22054. Epub 2012 May 16.

PMID:
22589120
41.

Effect of gastric bypass surgery on azithromycin oral bioavailability.

Padwal RS, Ben-Eltriki M, Wang X, Langkaas LA, Sharma AM, Birch DW, Karmali S, Brocks DR.

J Antimicrob Chemother. 2012 Sep;67(9):2203-6. doi: 10.1093/jac/dks177. Epub 2012 May 10.

PMID:
22577100
42.

Encapsulation of P-glycoprotein inhibitors by polymeric micelles can reduce their pharmacokinetic interactions with doxorubicin.

Binkhathlan Z, Shayeganpour A, Brocks DR, Lavasanifar A.

Eur J Pharm Biopharm. 2012 May;81(1):142-8. doi: 10.1016/j.ejpb.2012.02.003. Epub 2012 Feb 14.

PMID:
22361031
44.

Variations in tissue selectivity amongst insulin secretagogues: a systematic review.

Abdelmoneim AS, Hasenbank SE, Seubert JM, Brocks DR, Light PE, Simpson SH.

Diabetes Obes Metab. 2012 Feb;14(2):130-8. doi: 10.1111/j.1463-1326.2011.01496.x. Epub 2011 Nov 3. Review.

PMID:
21923736
45.

Phase 1 trial of everolimus plus sunitinib in patients with metastatic renal cell carcinoma.

Molina AM, Feldman DR, Voss MH, Ginsberg MS, Baum MS, Brocks DR, Fischer PM, Trinos MJ, Patil S, Motzer RJ.

Cancer. 2012 Apr 1;118(7):1868-76. doi: 10.1002/cncr.26429. Epub 2011 Sep 6.

46.

The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition.

Elsherbiny ME, Brocks DR.

Drug Metab Rev. 2011 Nov;43(4):457-75. doi: 10.3109/03602532.2011.596204. Epub 2011 Aug 8. Review.

PMID:
21823901
47.

Effect of hyperlipidemia on ketoconazole-midazolam drug-drug interaction in rat.

Hamdy DA, Brocks DR.

J Pharm Sci. 2011 Nov;100(11):4986-92. doi: 10.1002/jps.22675. Epub 2011 Jun 22.

PMID:
21698600
48.

Metformin and exercise in type 2 diabetes: examining treatment modality interactions.

Boulé NG, Robert C, Bell GJ, Johnson ST, Bell RC, Lewanczuk RZ, Gabr RQ, Brocks DR.

Diabetes Care. 2011 Jul;34(7):1469-74. doi: 10.2337/dc10-2207. Epub 2011 May 20.

49.

Effect of gastric bypass surgery on the absorption and bioavailability of metformin.

Padwal RS, Gabr RQ, Sharma AM, Langkaas LA, Birch DW, Karmali S, Brocks DR.

Diabetes Care. 2011 Jun;34(6):1295-300. doi: 10.2337/dc10-2140. Epub 2011 Apr 8.

50.

A phase 1 study of everolimus and sorafenib for metastatic clear cell renal cell carcinoma.

Harzstark AL, Small EJ, Weinberg VK, Sun J, Ryan CJ, Lin AM, Fong L, Brocks DR, Rosenberg JE.

Cancer. 2011 Sep 15;117(18):4194-200. doi: 10.1002/cncr.25931. Epub 2011 Mar 8.

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