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Items: 1 to 50 of 79

1.

Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70.

Li T, Hodgson JW, Petruk S, Mazo A, Brock HW.

Epigenetics Chromatin. 2017 Sep 19;10(1):43. doi: 10.1186/s13072-017-0151-3.

2.

Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation.

Petruk S, Cai J, Sussman R, Sun G, Kovermann SK, Mariani SA, Calabretta B, McMahon SB, Brock HW, Iacovitti L, Mazo A.

Mol Cell. 2017 Apr 20;66(2):247-257.e5. doi: 10.1016/j.molcel.2017.03.006. Epub 2017 Apr 11.

3.

Chromatin proteins and RNA are associated with DNA during all phases of mitosis.

L Black K, Petruk S, Fenstermaker TK, Hodgson JW, Caplan JL, Brock HW, Mazo A.

Cell Discov. 2016 Oct 25;2:16038. eCollection 2016.

4.

Detection of RNA-DNA association by a proximity ligation-based method.

Petruk S, Fenstermaker TK, Black KL, Brock HW, Mazo A.

Sci Rep. 2016 Jun 3;6:27313. doi: 10.1038/srep27313.

5.

Drosophila Cyclin G and epigenetic maintenance of gene expression during development.

Dupont CA, Dardalhon-Cuménal D, Kyba M, Brock HW, Randsholt NB, Peronnet F.

Epigenetics Chromatin. 2015 May 7;8:18. doi: 10.1186/s13072-015-0008-6. eCollection 2015.

6.

Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication.

Petruk S, Black KL, Kovermann SK, Brock HW, Mazo A.

Nat Commun. 2013;4:2841. doi: 10.1038/ncomms3841.

7.

Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.

Yasunaga S, Ohtsubo M, Ohno Y, Saeki K, Kurogi T, Tanaka-Okamoto M, Ishizaki H, Shirai M, Mihara K, Brock HW, Miyoshi J, Takihara Y.

Mol Cell Biol. 2013 Feb;33(4):644-60. doi: 10.1128/MCB.00974-12. Epub 2012 Dec 3.

8.

TrxG and PcG proteins but not methylated histones remain associated with DNA through replication.

Petruk S, Sedkov Y, Johnston DM, Hodgson JW, Black KL, Kovermann SK, Beck S, Canaani E, Brock HW, Mazo A.

Cell. 2012 Aug 31;150(5):922-33. doi: 10.1016/j.cell.2012.06.046. Epub 2012 Aug 23.

9.

Transcription-independent function of Polycomb group protein PSC in cell cycle control.

Mohd-Sarip A, Lagarou A, Doyen CM, van der Knaap JA, Aslan Ü, Bezstarosti K, Yassin Y, Brock HW, Demmers JA, Verrijzer CP.

Science. 2012 May 11;336(6082):744-7. doi: 10.1126/science.1215927. Epub 2012 Apr 5.

10.

Are polycomb group bodies gene silencing factories?

Hodgson JW, Brock HW.

Cell. 2011 Jan 21;144(2):170-1. doi: 10.1016/j.cell.2011.01.006.

11.

Cell cycle defects in polyhomeotic mutants are caused by abrogation of the DNA damage checkpoint.

Beck SA, Falconer E, Catching A, Hodgson JW, Brock HW.

Dev Biol. 2010 Mar 15;339(2):320-8. doi: 10.1016/j.ydbio.2009.12.031. Epub 2010 Jan 4.

12.

Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.

Fisher CL, Pineault N, Brookes C, Helgason CD, Ohta H, Bodner C, Hess JL, Humphries RK, Brock HW.

Blood. 2010 Jan 7;115(1):38-46. doi: 10.1182/blood-2009-07-230698. Epub 2009 Oct 27.

13.

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.

Fisher CL, Lee I, Bloyer S, Bozza S, Chevalier J, Dahl A, Bodner C, Helgason CD, Hess JL, Humphries RK, Brock HW.

Dev Biol. 2010 Jan 1;337(1):9-15. doi: 10.1016/j.ydbio.2009.10.004. Epub 2009 Oct 13.

14.

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).

Sinclair DA, Syrzycka M, Macauley MS, Rastgardani T, Komljenovic I, Vocadlo DJ, Brock HW, Honda BM.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13427-32. doi: 10.1073/pnas.0904638106. Epub 2009 Jul 28.

15.

Regulatory noncoding RNAs at Hox loci.

Brock HW, Hodgson JW, Petruk S, Mazo A.

Biochem Cell Biol. 2009 Feb;87(1):27-34. doi: 10.1139/O08-108. Review.

PMID:
19234521
16.

The Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein.

Hallson G, Syrzycka M, Beck SA, Kennison JA, Dorsett D, Page SL, Hunter SM, Keall R, Warren WD, Brock HW, Sinclair DA, Honda BM.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12405-10. doi: 10.1073/pnas.0801698105. Epub 2008 Aug 19.

17.

Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.

Kim K, Choi J, Heo K, Kim H, Levens D, Kohno K, Johnson EM, Brock HW, An W.

J Biol Chem. 2008 Apr 4;283(14):9113-26. doi: 10.1074/jbc.M708205200. Epub 2008 Feb 7.

18.

Transcriptional interference: an unexpected layer of complexity in gene regulation.

Mazo A, Hodgson JW, Petruk S, Sedkov Y, Brock HW.

J Cell Sci. 2007 Aug 15;120(Pt 16):2755-61. Review.

19.

A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos.

Petruk S, Sedkov Y, Brock HW, Mazo A.

RNA Biol. 2007 Jan-Mar;4(1):1-6. Epub 2007 Apr 16.

PMID:
17568198
20.

Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference.

Petruk S, Sedkov Y, Riley KM, Hodgson J, Schweisguth F, Hirose S, Jaynes JB, Brock HW, Mazo A.

Cell. 2006 Dec 15;127(6):1209-21.

21.

Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family.

Fisher CL, Randazzo F, Humphries RK, Brock HW.

Gene. 2006 Mar 15;369:109-18. Epub 2006 Jan 18.

PMID:
16412590
22.

Polycomb group mutants exhibit mitotic defects in syncytial cell cycles of Drosophila embryos.

O'Dor E, Beck SA, Brock HW.

Dev Biol. 2006 Feb 15;290(2):312-22. Epub 2006 Jan 4.

23.
24.

MLL associates specifically with a subset of transcriptionally active target genes.

Milne TA, Dou Y, Martin ME, Brock HW, Roeder RG, Hess JL.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14765-70. Epub 2005 Sep 30.

25.

Maintenance of gene expression patterns.

Brock HW, Fisher CL.

Dev Dyn. 2005 Mar;232(3):633-55. Review.

26.

Mutational analysis of the N-terminus in Schistocerca gregaria ion-transport peptide expressed in Drosophila Kc1 cells.

Zhao Y, Meredith J, Brock HW, Phillips JE.

Arch Insect Biochem Physiol. 2005 Jan;58(1):27-38.

PMID:
15599935
27.
28.

Dimerization of MLL fusion proteins immortalizes hematopoietic cells.

Martin ME, Milne TA, Bloyer S, Galoian K, Shen W, Gibbs D, Brock HW, Slany R, Hess JL.

Cancer Cell. 2003 Sep;4(3):197-207.

29.

Identification and characterization of polyhomeotic PREs and TREs.

Bloyer S, Cavalli G, Brock HW, Dura JM.

Dev Biol. 2003 Sep 15;261(2):426-42.

30.

A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11.

Fisher CL, Berger J, Randazzo F, Brock HW.

Gene. 2003 Mar 13;306:115-26.

PMID:
12657473
31.

MLL targets SET domain methyltransferase activity to Hox gene promoters.

Milne TA, Briggs SD, Brock HW, Martin ME, Gibbs D, Allis CD, Hess JL.

Mol Cell. 2002 Nov;10(5):1107-17.

33.

Tantalus, a novel ASX-interacting protein with tissue-specific functions.

Dietrich BH, Moore J, Kyba M, dosSantos G, McCloskey F, Milne TA, Brock HW, Krause HM.

Dev Biol. 2001 Jun 15;234(2):441-53.

34.

The Polycomb group--no longer an exclusive club?

Brock HW, van Lohuizen M.

Curr Opin Genet Dev. 2001 Apr;11(2):175-81. Review.

PMID:
11250141
35.

Mutational analysis of the C-terminus in ion transport peptide (ITP) expressed in Drosophila Kc1 cells.

Wang YJ, Zhao Y, Meredith J, Phillips JE, Theilmann DA, Brock HW.

Arch Insect Biochem Physiol. 2000 Nov;45(3):129-38.

PMID:
11169752
36.

A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro.

Tomotsune D, Takihara Y, Berger J, Duhl D, Joo S, Kyba M, Shirai M, Ohta H, Matsuda Y, Honda BM, Simon J, Shimada K, Brock HW, Randazzo F.

Differentiation. 1999 Dec;65(4):229-39.

PMID:
10653359
37.

Analysis of an insect neuropeptide, Schistocerca gregaria ion transport peptide (ITP), expressed in insect cell systems.

Pfeifer TA, Hegedus D, Wang YJ, Zhao Y, Meredith J, Brock HW, Phillips JE, Grigliatti TA, Theilmann DA.

Arch Insect Biochem Physiol. 1999 Dec;42(4):245-52.

PMID:
10578114
38.

The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34.

Berger J, Kurahashi H, Takihara Y, Shimada K, Brock HW, Randazzo F.

Gene. 1999 Sep 3;237(1):185-91.

PMID:
10524249
40.

Occurrence of ion transport peptide (ITP) and ion transport-like peptide (ITP-L) in orthopteroids.

Macins A, Meredith J, Zhao Y, Brock HW, Phillips JE.

Arch Insect Biochem Physiol. 1999;40(2):107-18.

PMID:
10077829
41.

Suppressors of position-effect variegation in Drosophila melanogaster affect expression of the heterochromatic gene light in the absence of a chromosome rearrangement.

Clegg NJ, Honda BM, Whitehead IP, Grigliatti TA, Wakimoto B, Brock HW, Lloyd VK, Sinclair DA.

Genome. 1998 Aug;41(4):495-503.

PMID:
9796098
42.

The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals.

Stankunas K, Berger J, Ruse C, Sinclair DA, Randazzo F, Brock HW.

Development. 1998 Oct;125(20):4055-66.

43.

Expression of Schistocerca gregaria ion transport peptide (ITP) and its homologue (ITP-L) in a baculovirus/insect cell system.

Ring M, Meredith J, Wiens C, Macins A, Brock HW, Phillips JE, Theilmann DA.

Insect Biochem Mol Biol. 1998 Jan;28(1):51-8.

PMID:
9612936
44.

Characterization of a Drosophila homologue of the 160-kDa subunit of the cleavage and polyadenylation specificity factor CPSF.

Salinas CA, Sinclair DA, O'Hare K, Brock HW.

Mol Gen Genet. 1998 Apr;257(6):672-80.

PMID:
9604891
45.

The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.

Sinclair DA, Milne TA, Hodgson JW, Shellard J, Salinas CA, Kyba M, Randazzo F, Brock HW.

Development. 1998 Apr;125(7):1207-16.

46.

RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian Polycomb group complexes.

Hashimoto N, Brock HW, Nomura M, Kyba M, Hodgson J, Fujita Y, Takihara Y, Shimada K, Higashinakagawa T.

Biochem Biophys Res Commun. 1998 Apr 17;245(2):356-65.

PMID:
9571155
47.
48.
49.

Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.

Sinclair DA, Clegg NJ, Antonchuk J, Milne TA, Stankunas K, Ruse C, Grigliatti TA, Kassis JA, Brock HW.

Genetics. 1998 Jan;148(1):211-20.

50.

A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions.

Peterson AJ, Kyba M, Bornemann D, Morgan K, Brock HW, Simon J.

Mol Cell Biol. 1997 Nov;17(11):6683-92.

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