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Items: 1 to 50 of 111

1.

TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.

Moretto E, Longatti A, Murru L, Chamma I, Sessa A, Zapata J, Hosy E, Sainlos M, Saint-Pol J, Rubinstein E, Choquet D, Broccoli V, Schiavo G, Thoumine O, Passafaro M.

Cell Rep. 2019 Oct 29;29(5):1130-1146.e8. doi: 10.1016/j.celrep.2019.09.051.

2.

dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice.

Colasante G, Lignani G, Brusco S, Di Berardino C, Carpenter J, Giannelli S, Valassina N, Bido S, Ricci R, Castoldi V, Marenna S, Church T, Massimino L, Morabito G, Benfenati F, Schorge S, Leocani L, Kullmann DM, Broccoli V.

Mol Ther. 2019 Sep 3. pii: S1525-0016(19)30401-0. doi: 10.1016/j.ymthe.2019.08.018. [Epub ahead of print]

PMID:
31607539
3.

Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging.

Cozzi A, Orellana DI, Santambrogio P, Rubio A, Cancellieri C, Giannelli S, Ripamonti M, Taverna S, Di Lullo G, Rovida E, Ferrari M, Forni GL, Fiorillo C, Broccoli V, Levi S.

Stem Cell Reports. 2019 Nov 12;13(5):832-846. doi: 10.1016/j.stemcr.2019.09.002. Epub 2019 Oct 3.

4.

SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.

Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, Cattaneo S, Martini D, Gabellini C, Pucci C, Fasciani A, Belli R, Taverna S, Andreazzoli M, Zippo A, Broccoli V.

Neuron. 2019 Oct 23;104(2):271-289.e13. doi: 10.1016/j.neuron.2019.07.013. Epub 2019 Sep 9.

PMID:
31515109
5.

Correction: Magic-Factor 1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis.

Cassano M, Biressi S, Finan A, Benedetti L, Omes C, Boratto R, Martin F, Allegretti M, Broccoli V, Cusella De Angelis G, Comoglio PM, Basilico C, Torrente Y, Michieli P, Cossu G, Sampaolesi M.

PLoS One. 2019 Jul 24;14(7):e0220357. doi: 10.1371/journal.pone.0220357. eCollection 2019.

6.

Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors.

Colasante G, Rubio A, Massimino L, Broccoli V.

Front Neurosci. 2019 Mar 26;13:283. doi: 10.3389/fnins.2019.00283. eCollection 2019. Review.

7.

KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes.

Barbagiovanni G, Germain PL, Zech M, Atashpaz S, Lo Riso P, D'Antonio-Chronowska A, Tenderini E, Caiazzo M, Boesch S, Jech R, Haslinger B, Broccoli V, Stewart AF, Winkelmann J, Testa G.

Cell Rep. 2018 Oct 23;25(4):988-1001. doi: 10.1016/j.celrep.2018.09.067.

8.

Recipes for Making Neurons using Combinatorial Forward Genetics.

Broccoli V, Luoni M.

Cell Stem Cell. 2018 Jul 5;23(1):13-14. doi: 10.1016/j.stem.2018.06.012.

9.

SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.

Piazza R, Magistroni V, Redaelli S, Mauri M, Massimino L, Sessa A, Peronaci M, Lalowski M, Soliymani R, Mezzatesta C, Pirola A, Banfi F, Rubio A, Rea D, Stagno F, Usala E, Martino B, Campiotti L, Merli M, Passamonti F, Onida F, Morotti A, Pavesi F, Bregni M, Broccoli V, Baumann M, Gambacorti-Passerini C.

Nat Commun. 2018 Jun 6;9(1):2192. doi: 10.1038/s41467-018-04462-8.

10.

PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity.

Fruscione F, Valente P, Sterlini B, Romei A, Baldassari S, Fadda M, Prestigio C, Giansante G, Sartorelli J, Rossi P, Rubio A, Gambardella A, Nieus T, Broccoli V, Fassio A, Baldelli P, Corradi A, Zara F, Benfenati F.

Brain. 2018 Apr 1;141(4):1000-1016. doi: 10.1093/brain/awy051.

11.

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson's Disease Models.

Iannielli A, Bido S, Folladori L, Segnali A, Cancellieri C, Maresca A, Massimino L, Rubio A, Morabito G, Caporali L, Tagliavini F, Musumeci O, Gregato G, Bezard E, Carelli V, Tiranti V, Broccoli V.

Cell Rep. 2018 Feb 20;22(8):2066-2079. doi: 10.1016/j.celrep.2018.01.089.

12.

Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.

Sahakyan V, Duelen R, Tam WL, Roberts SJ, Grosemans H, Berckmans P, Ceccarelli G, Pelizzo G, Broccoli V, Deprest J, Luyten FP, Verfaillie CM, Sampaolesi M.

Sci Rep. 2018 Feb 13;8(1):2942. doi: 10.1038/s41598-018-21103-8.

13.

Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery.

Giannelli SG, Luoni M, Castoldi V, Massimino L, Cabassi T, Angeloni D, Demontis GC, Leocani L, Andreazzoli M, Broccoli V.

Hum Mol Genet. 2018 Mar 1;27(5):761-779. doi: 10.1093/hmg/ddx438.

PMID:
29281027
14.

The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.

Sessa A, Ciabatti E, Drechsel D, Massimino L, Colasante G, Giannelli S, Satoh T, Akira S, Guillemot F, Broccoli V.

Cereb Cortex. 2017 Dec 1;27(12):5715. doi: 10.1093/cercor/bhx209. No abstract available.

PMID:
28968796
15.

A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential.

Wang J, Bardelli M, Espinosa DA, Pedotti M, Ng TS, Bianchi S, Simonelli L, Lim EXY, Foglierini M, Zatta F, Jaconi S, Beltramello M, Cameroni E, Fibriansah G, Shi J, Barca T, Pagani I, Rubio A, Broccoli V, Vicenzi E, Graham V, Pullan S, Dowall S, Hewson R, Jurt S, Zerbe O, Stettler K, Lanzavecchia A, Sallusto F, Cavalli A, Harris E, Lok SM, Varani L, Corti D.

Cell. 2017 Sep 21;171(1):229-241.e15. doi: 10.1016/j.cell.2017.09.002.

16.

AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy.

Morabito G, Giannelli SG, Ordazzo G, Bido S, Castoldi V, Indrigo M, Cabassi T, Cattaneo S, Luoni M, Cancellieri C, Sessa A, Bacigaluppi M, Taverna S, Leocani L, Lanciego JL, Broccoli V.

Mol Ther. 2017 Dec 6;25(12):2727-2742. doi: 10.1016/j.ymthe.2017.08.004. Epub 2017 Aug 10.

17.

mSEL-1L deficiency affects vasculogenesis and neural stem cell lineage commitment.

Cardano M, Diaferia GR, Conti L, Baronchelli S, Sessa A, Broccoli V, Barbieri A, De Blasio P, Biunno I.

J Cell Physiol. 2018 Apr;233(4):3152-3163. doi: 10.1002/jcp.26153. Epub 2017 Sep 12.

PMID:
28816361
18.

Reprogramming of somatic cells: iPS and iN cells.

Broccoli V.

Prog Brain Res. 2017;230:53-68. doi: 10.1016/bs.pbr.2016.12.009. Epub 2017 Feb 6.

PMID:
28552235
19.

Human Endometrial Stromal Cells Are Highly Permissive To Productive Infection by Zika Virus.

Pagani I, Ghezzi S, Ulisse A, Rubio A, Turrini F, Garavaglia E, Candiani M, Castilletti C, Ippolito G, Poli G, Broccoli V, Panina-Bordignon P, Vicenzi E.

Sci Rep. 2017 Mar 10;7:44286. doi: 10.1038/srep44286.

20.

Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy.

Meneghini V, Frati G, Sala D, De Cicco S, Luciani M, Cavazzin C, Paulis M, Mentzen W, Morena F, Giannelli S, Sanvito F, Villa A, Bulfone A, Broccoli V, Martino S, Gritti A.

Stem Cells Transl Med. 2017 Feb;6(2):352-368. doi: 10.5966/sctm.2015-0414. Epub 2016 Sep 16.

21.

Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells.

Mazzara PG, Massimino L, Pellegatta M, Ronchi G, Ricca A, Iannielli A, Giannelli SG, Cursi M, Cancellieri C, Sessa A, Del Carro U, Quattrini A, Geuna S, Gritti A, Taveggia C, Broccoli V.

Nat Commun. 2017 Feb 7;8:14088. doi: 10.1038/ncomms14088.

22.

Gene therapy approaches in the non-human primate model of Parkinson's disease.

Pignataro D, Sucunza D, Rico AJ, Dopeso-Reyes IG, Roda E, Rodríguez-Perez AI, Labandeira-Garcia JL, Broccoli V, Kato S, Kobayashi K, Lanciego JL.

J Neural Transm (Vienna). 2018 Mar;125(3):575-589. doi: 10.1007/s00702-017-1681-3. Epub 2017 Jan 27. Review.

PMID:
28130586
23.

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells.

Ghezzi S, Cooper L, Rubio A, Pagani I, Capobianchi MR, Ippolito G, Pelletier J, Meneghetti MCZ, Lima MA, Skidmore MA, Broccoli V, Yates EA, Vicenzi E.

Antiviral Res. 2017 Apr;140:13-17. doi: 10.1016/j.antiviral.2016.12.023. Epub 2017 Jan 5.

PMID:
28063994
24.

Neuroprotection of Brain Cells by Lipoic Acid Treatment after Cellular Stress.

Paradells-Navarro S, Benlloch-Navarro MS, Almansa Frias MI, Garcia-Esparza MA, Broccoli V, Miranda M, Soria JM.

ACS Chem Neurosci. 2017 Mar 15;8(3):569-577. doi: 10.1021/acschemneuro.6b00306. Epub 2016 Dec 9.

PMID:
27935686
25.

Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming.

Rubio A, Luoni M, Giannelli SG, Radice I, Iannielli A, Cancellieri C, Di Berardino C, Regalia G, Lazzari G, Menegon A, Taverna S, Broccoli V.

Sci Rep. 2016 Nov 18;6:37540. doi: 10.1038/srep37540.

26.

MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis.

Vasconcelos FF, Sessa A, Laranjeira C, Raposo AASF, Teixeira V, Hagey DW, Tomaz DM, Muhr J, Broccoli V, Castro DS.

Cell Rep. 2016 Oct 4;17(2):469-483. doi: 10.1016/j.celrep.2016.09.024.

27.

The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.

Sessa A, Ciabatti E, Drechsel D, Massimino L, Colasante G, Giannelli S, Satoh T, Akira S, Guillemot F, Broccoli V.

Cereb Cortex. 2017 Jun 1;27(6):3378-3396. doi: 10.1093/cercor/bhw270. Erratum in: Cereb Cortex. 2017 Dec 1;27(12):5715.

PMID:
27600842
28.

Coenzyme A corrects pathological defects in human neurons of PANK2-associated neurodegeneration.

Orellana DI, Santambrogio P, Rubio A, Yekhlef L, Cancellieri C, Dusi S, Giannelli SG, Venco P, Mazzara PG, Cozzi A, Ferrari M, Garavaglia B, Taverna S, Tiranti V, Broccoli V, Levi S.

EMBO Mol Med. 2016 Oct 4;8(10):1197-1211. doi: 10.15252/emmm.201606391. Print 2016 Oct.

29.

The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations.

Gautier CA, Erpapazoglou Z, Mouton-Liger F, Muriel MP, Cormier F, Bigou S, Duffaure S, Girard M, Foret B, Iannielli A, Broccoli V, Dalle C, Bohl D, Michel PP, Corvol JC, Brice A, Corti O.

Hum Mol Genet. 2016 Jul 15;25(14):2972-2984. Epub 2016 May 19.

PMID:
27206984
30.

MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion.

Mariotti S, Barravecchia I, Vindigni C, Pucci A, Balsamo M, Libro R, Senchenko V, Dmitriev A, Jacchetti E, Cecchini M, Roviello F, Lai M, Broccoli V, Andreazzoli M, Mazzanti CM, Angeloni D.

Oncotarget. 2016 Jan 12;7(2):1808-25. doi: 10.18632/oncotarget.6577.

31.

Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.

Colasante G, Lignani G, Rubio A, Medrihan L, Yekhlef L, Sessa A, Massimino L, Giannelli SG, Sacchetti S, Caiazzo M, Leo D, Alexopoulou D, Dell'Anno MT, Ciabatti E, Orlando M, Studer M, Dahl A, Gainetdinov RR, Taverna S, Benfenati F, Broccoli V.

Cell Stem Cell. 2015 Dec 3;17(6):719-734. doi: 10.1016/j.stem.2015.09.002. Epub 2015 Oct 29.

32.

Histone modifications controlling native and induced neural stem cell identity.

Broccoli V, Colasante G, Sessa A, Rubio A.

Curr Opin Genet Dev. 2015 Oct;34:95-101. doi: 10.1016/j.gde.2015.08.003. Epub 2015 Oct 24. Review.

PMID:
26476692
33.

Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients.

Santambrogio P, Dusi S, Guaraldo M, Rotundo LI, Broccoli V, Garavaglia B, Tiranti V, Levi S.

Neurobiol Dis. 2015 Sep;81:144-53. doi: 10.1016/j.nbd.2015.02.030. Epub 2015 Mar 30.

34.

Overcoming the hurdles for a reproducible generation of human functionally mature reprogrammed neurons.

Broccoli V, Rubio A, Taverna S, Yekhlef L.

Exp Biol Med (Maywood). 2015 Jun;240(6):787-94. doi: 10.1177/1535370215577585. Epub 2015 Mar 18. Review.

35.

Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo.

Pellegrini S, Ungaro F, Mercalli A, Melzi R, Sebastiani G, Dotta F, Broccoli V, Piemonti L, Sordi V.

Acta Diabetol. 2015 Dec;52(6):1025-35. doi: 10.1007/s00592-015-0726-z. Epub 2015 Mar 4.

PMID:
25733399
36.

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.

Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V.

Stem Cell Reports. 2015 Jan 13;4(1):25-36. doi: 10.1016/j.stemcr.2014.12.002. Epub 2014 Dec 31.

37.

Modeling physiological and pathological human neurogenesis in the dish.

Broccoli V, Giannelli SG, Mazzara PG.

Front Neurosci. 2014 Jul 24;8:183. doi: 10.3389/fnins.2014.00183. eCollection 2014. Review.

38.

Remote control of induced dopaminergic neurons in parkinsonian rats.

Dell'Anno MT, Caiazzo M, Leo D, Dvoretskova E, Medrihan L, Colasante G, Giannelli S, Theka I, Russo G, Mus L, Pezzoli G, Gainetdinov RR, Benfenati F, Taverna S, Dityatev A, Broccoli V.

J Clin Invest. 2014 Jul;124(7):3215-29. doi: 10.1172/JCI74664. Epub 2014 Jun 17.

39.

Zrf1 is required to establish and maintain neural progenitor identity.

Aloia L, Di Stefano B, Sessa A, Morey L, Santanach A, Gutierrez A, Cozzuto L, Benitah SA, Graf T, Broccoli V, Di Croce L.

Genes Dev. 2014 Jan 15;28(2):182-97. doi: 10.1101/gad.228510.113.

40.

ARX regulates cortical intermediate progenitor cell expansion and upper layer neuron formation through repression of Cdkn1c.

Colasante G, Simonet JC, Calogero R, Crispi S, Sessa A, Cho G, Golden JA, Broccoli V.

Cereb Cortex. 2015 Feb;25(2):322-35. doi: 10.1093/cercor/bht222. Epub 2013 Aug 22.

41.

Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome.

Cozzi A, Santambrogio P, Privitera D, Broccoli V, Rotundo LI, Garavaglia B, Benz R, Altamura S, Goede JS, Muckenthaler MU, Levi S.

J Exp Med. 2013 Aug 26;210(9):1779-91. doi: 10.1084/jem.20130315. Epub 2013 Aug 12.

42.

Rapid generation of functional dopaminergic neurons from human induced pluripotent stem cells through a single-step procedure using cell lineage transcription factors.

Theka I, Caiazzo M, Dvoretskova E, Leo D, Ungaro F, Curreli S, Managò F, Dell'Anno MT, Pezzoli G, Gainetdinov RR, Dityatev A, Broccoli V.

Stem Cells Transl Med. 2013 Jun;2(6):473-9. doi: 10.5966/sctm.2012-0133. Epub 2013 May 8.

43.

Nuclear receptors: Oxysterols detour to neurodevelopment.

Broccoli V, Caiazzo M.

Nat Chem Biol. 2013 Feb;9(2):70-1. doi: 10.1038/nchembio.1165. No abstract available.

PMID:
23334545
44.

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.

Ricciardi S, Ungaro F, Hambrock M, Rademacher N, Stefanelli G, Brambilla D, Sessa A, Magagnotti C, Bachi A, Giarda E, Verpelli C, Kilstrup-Nielsen C, Sala C, Kalscheuer VM, Broccoli V.

Nat Cell Biol. 2012 Sep;14(9):911-23. doi: 10.1038/ncb2566. Epub 2012 Aug 26.

45.

Transplantation of genetically corrected human iPSC-derived progenitors in mice with limb-girdle muscular dystrophy.

Tedesco FS, Gerli MF, Perani L, Benedetti S, Ungaro F, Cassano M, Antonini S, Tagliafico E, Artusi V, Longa E, Tonlorenzi R, Ragazzi M, Calderazzi G, Hoshiya H, Cappellari O, Mora M, Schoser B, Schneiderat P, Oshimura M, Bottinelli R, Sampaolesi M, Torrente Y, Broccoli V, Cossu G.

Sci Transl Med. 2012 Jun 27;4(140):140ra89. doi: 10.1126/scitranslmed.3003541.

46.

Primary skin fibroblasts as a model of Parkinson's disease.

Auburger G, Klinkenberg M, Drost J, Marcus K, Morales-Gordo B, Kunz WS, Brandt U, Broccoli V, Reichmann H, Gispert S, Jendrach M.

Mol Neurobiol. 2012 Aug;46(1):20-7. doi: 10.1007/s12035-012-8245-1. Epub 2012 Feb 19. Review.

47.

Wnt signaling has opposing roles in the developing and the adult brain that are modulated by Hipk1.

Marinaro C, Pannese M, Weinandy F, Sessa A, Bergamaschi A, Taketo MM, Broccoli V, Comi G, Götz M, Martino G, Muzio L.

Cereb Cortex. 2012 Oct;22(10):2415-27. doi: 10.1093/cercor/bhr320. Epub 2011 Nov 17.

PMID:
22095214
48.

Setting a highway for converting skin into neurons.

Broccoli V, Caiazzo M, Dell'Anno MT.

J Mol Cell Biol. 2011 Dec;3(6):322-3. doi: 10.1093/jmcb/mjr029. Epub 2011 Oct 21.

PMID:
22021656
49.

A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells.

Di Stefano B, Maffioletti SM, Gentner B, Ungaro F, Schira G, Naldini L, Broccoli V.

Stem Cells. 2011 Nov;29(11):1684-95. doi: 10.1002/stem.726.

50.

Site-specific integration and tailoring of cassette design for sustainable gene transfer.

Lombardo A, Cesana D, Genovese P, Di Stefano B, Provasi E, Colombo DF, Neri M, Magnani Z, Cantore A, Lo Riso P, Damo M, Pello OM, Holmes MC, Gregory PD, Gritti A, Broccoli V, Bonini C, Naldini L.

Nat Methods. 2011 Aug 21;8(10):861-9. doi: 10.1038/nmeth.1674.

PMID:
21857672

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