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Items: 48

1.

Engineering Synthetic Chromosomes by Sequential Loading of Multiple Genomic Payloads over 100 Kilobase Pairs in Size.

Greene A, Pascarelli K, Broccoli D, Perkins E.

Mol Ther Methods Clin Dev. 2019 Apr 29;13:463-473. doi: 10.1016/j.omtm.2019.04.006. eCollection 2019 Jun 14.

2.

AXL is a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas.

May CD, Garnett J, Ma X, Landers SM, Ingram DR, Demicco EG, Al Sannaa GA, Vu T, Han L, Zhang Y, Kivlin CM, Bolshakov S, Kalam AA, Liu J, Zhou F, Broccoli D, Wang WL, Lazar AJ, Pollock RE, Lev D, Torres KE.

BMC Cancer. 2015 Nov 14;15:901. doi: 10.1186/s12885-015-1916-3.

3.

Predictors of guideline treatment nonadherence and the impact on survival in patients with colorectal cancer.

Hines RB, Barrett A, Twumasi-Ankrah P, Broccoli D, Engelman KK, Baranda J, Ablah EA, Jacobson L, Redmond M, Tu W, Collins TC.

J Natl Compr Canc Netw. 2015 Jan;13(1):51-60.

PMID:
25583769
4.

Differential expression of cysteine dioxygenase 1 in complex karyotype liposarcomas.

Shaker M, Pascarelli KM, Plantinga MJ, Love MA, Lazar AJ, Ingram DR, von Mehren M, Lev D, Kipling D, Broccoli D.

Biomark Cancer. 2014 Apr 6;6:1-10. doi: 10.4137/BIC.S14683. eCollection 2014.

5.

Telomerase suppresses formation of ALT-associated single-stranded telomeric C-circles.

Plantinga MJ, Pascarelli KM, Merkel AS, Lazar AJ, von Mehren M, Lev D, Broccoli D.

Mol Cancer Res. 2013 Jun;11(6):557-67. doi: 10.1158/1541-7786.MCR-13-0013. Epub 2013 Mar 15.

6.

Validating a gene expression signature proposed to differentiate liposarcomas that use different telomere maintenance mechanisms.

Doyle KR, Mitchell MA, Roberts CL, James S, Johnson JE, Zhou Y, von Mehren M, Lev D, Kipling D, Broccoli D.

Oncogene. 2012 Jan 12;31(2):265-6; author reply 267-8. doi: 10.1038/onc.2011.225. Epub 2011 Jun 27. No abstract available.

7.

Pleomorphic liposarcoma: clinical observations and molecular variables.

Ghadimi MP, Liu P, Peng T, Bolshakov S, Young ED, Torres KE, Colombo C, Hoffman A, Broccoli D, Hornick JL, Lazar AJ, Pisters P, Pollock RE, Lev D.

Cancer. 2011 Dec 1;117(23):5359-69. doi: 10.1002/cncr.26195. Epub 2011 May 19.

8.

Doxorubicin resistance in a novel in vitro model of human pleomorphic liposarcoma associated with alternative lengthening of telomeres.

Mitchell MA, Johnson JE, Pascarelli K, Beeharry N, Chiourea M, Gagos S, Lev D, von Mehren M, Kipling D, Broccoli D.

Mol Cancer Ther. 2010 Mar;9(3):682-92. doi: 10.1158/1535-7163.MCT-09-0705. Epub 2010 Mar 2.

9.

MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.

Caslini C, Connelly JA, Serna A, Broccoli D, Hess JL.

Mol Cell Biol. 2009 Aug;29(16):4519-26. doi: 10.1128/MCB.00195-09. Epub 2009 Jun 15.

10.

Function, replication and structure of the mammalian telomere.

Broccoli D.

Cytotechnology. 2004 Jun;45(1-2):3-12. doi: 10.1007/s10616-004-5120-6.

11.

Telomeric chromatin: roles in aging, cancer and hereditary disease.

McCord RA, Broccoli D.

Mutat Res. 2008 Dec 1;647(1-2):86-93. doi: 10.1016/j.mrfmmm.2008.08.005. Epub 2008 Aug 20. Review.

PMID:
18778718
12.

The origin recognition complex localizes to telomere repeats and prevents telomere-circle formation.

Deng Z, Dheekollu J, Broccoli D, Dutta A, Lieberman PM.

Curr Biol. 2007 Nov 20;17(22):1989-95.

13.

Whole-genome profiling in liposarcomas reveals genetic alterations common to specific telomere maintenance mechanisms.

Johnson JE, Gettings EJ, Schwalm J, Pei J, Testa JR, Litwin S, von Mehren M, Broccoli D.

Cancer Res. 2007 Oct 1;67(19):9221-8.

14.

Telomere maintenance in sarcomas.

Johnson JE, Broccoli D.

Curr Opin Oncol. 2007 Jul;19(4):377-82. Review.

PMID:
17545803
15.

BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation.

Chen X, Arciero CA, Wang C, Broccoli D, Godwin AK.

Cancer Res. 2006 May 15;66(10):5039-46.

16.

Multiple mechanisms of telomere maintenance exist in liposarcomas.

Johnson JE, Varkonyi RJ, Schwalm J, Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D.

Clin Cancer Res. 2005 Aug 1;11(15):5347-55.

17.

Telomere dynamics in response to chemotherapy.

Beeharry N, Broccoli D.

Curr Mol Med. 2005 Mar;5(2):187-96. Review.

PMID:
15974872
18.

Manipulating mouse telomeres: models of tumorigenesis and aging.

Xin Z, Broccoli D.

Cytogenet Genome Res. 2004;105(2-4):471-8.

PMID:
15237236
19.

p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance.

Razak ZR, Varkonyi RJ, Kulp-McEliece M, Caslini C, Testa JR, Murphy ME, Broccoli D.

Mol Cell Biol. 2004 Jul;24(13):5967-77.

20.

Chromosome 17p13.2 transfer reverts transformation phenotypes and Fas-mediated apoptosis in breast epithelial cells.

Lareef MH, Tahin Q, Song J, Russo IH, Mihaila D, Slater CM, Balsara B, Testa JR, Broccoli D, Grobelny JV, Mor G, Cuthbert A, Russo J.

Mol Carcinog. 2004 Apr;39(4):234-46.

PMID:
15057875
21.

Telomerase is frequently activated in tumors with microsatellite instability.

Ibanez de Caceres I, Frolova N, Varkonyi RJ, Dulaimi E, Meropol NJ, Broccoli D, Cairns P.

Cancer Biol Ther. 2004 Mar;3(3):289-92. Epub 2004 Mar 10.

PMID:
14726659
22.

Measurable immune dysfunction and telomere attrition in long-term allogeneic transplant recipients.

Lewis NL, Mullaney M, Mangan KF, Klumpp T, Rogatko A, Broccoli D.

Bone Marrow Transplant. 2004 Jan;33(1):71-8.

PMID:
14704659
23.

Telomere repeat binding factors TRF1, TRF2, and hRAP1 modulate replication of Epstein-Barr virus OriP.

Deng Z, Atanasiu C, Burg JS, Broccoli D, Lieberman PM.

J Virol. 2003 Nov;77(22):11992-2001.

24.

Telomerase inhibition using azidothymidine in the HT-29 colon cancer cell line.

Brown T, Sigurdson E, Rogatko A, Broccoli D.

Ann Surg Oncol. 2003 Oct;10(8):910-5.

PMID:
14527910
25.

Putative telomere-recruiting domain in the catalytic subunit of human telomerase.

Armbruster BN, Etheridge KT, Broccoli D, Counter CM.

Mol Cell Biol. 2003 May;23(9):3237-46.

26.

Telomere length changes in human cancer.

Broccoli D, Godwin AK.

Methods Mol Med. 2002;68:271-8. No abstract available.

PMID:
11901508
27.

SV40 infection induces telomerase activity in human mesothelial cells.

Foddis R, De Rienzo A, Broccoli D, Bocchetta M, Stekala E, Rizzo P, Tosolini A, Grobelny JV, Jhanwar SC, Pass HI, Testa JR, Carbone M.

Oncogene. 2002 Feb 21;21(9):1434-42.

28.

Telometric: a tool providing simplified, reproducible measurements of telomeric DNA from constant field agarose gels.

Grant JD, Broccoli D, Muquit M, Manion FJ, Tisdall J, Ochs MF.

Biotechniques. 2001 Dec;31(6):1314-6, 1318. No abstract available.

29.

Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway.

Grobelny JV, Kulp-McEliece M, Broccoli D.

Hum Mol Genet. 2001 Sep 1;10(18):1953-61.

PMID:
11555632
30.
31.

Telomere-dependent senescence.

Kipling D, Wynford-Thomas D, Jones CJ, Akbar A, Aspinall R, Bacchetti S, Blasco MA, Broccoli D, DePinho RA, Edwards DR, Effros RB, Harley CB, Lansdorp PM, Linskens MH, Prowse KR, Newbold RF, Olovnikov AM, Parkinson EK, Pawelec G, Pontén J, Shall S, Zijlmans M, Faragher RG.

Nat Biotechnol. 1999 Apr;17(4):313-4. No abstract available.

PMID:
10207859
32.

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.

Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T.

Science. 1999 Feb 26;283(5406):1321-5.

33.

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.

Broccoli D, Smogorzewska A, Chong L, de Lange T.

Nat Genet. 1997 Oct;17(2):231-5.

PMID:
9326950
34.

Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains.

Broccoli D, Chong L, Oelmann S, Fernald AA, Marziliano N, van Steensel B, Kipling D, Le Beau MM, de Lange T.

Hum Mol Genet. 1997 Jan;6(1):69-76.

PMID:
9002672
35.
36.

A human telomeric protein.

Chong L, van Steensel B, Broccoli D, Erdjument-Bromage H, Hanish J, Tempst P, de Lange T.

Science. 1995 Dec 8;270(5242):1663-7.

PMID:
7502076
37.

Telomerase activity in normal and malignant hematopoietic cells.

Broccoli D, Young JW, de Lange T.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9082-6.

38.

Robertsonian metacentrics of the house mouse lose telomeric sequences but retain some minor satellite DNA in the pericentromeric area.

Garagna S, Broccoli D, Redi CA, Searle JB, Cooke HJ, Capanna E.

Chromosoma. 1995 Jul;103(10):685-92.

PMID:
7664615
39.

Effect of telomeres on the interphase location of adjacent regions of the human X chromosome.

Broccoli D, Cooke HJ.

Exp Cell Res. 1994 Jun;212(2):308-13.

PMID:
8187823
40.

Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing.

Bayne RA, Broccoli D, Taggart MH, Thomson EJ, Farr CJ, Cooke HJ.

Hum Mol Genet. 1994 Apr;3(4):539-46.

PMID:
8069295
41.

Aging, healing, and the metabolism of telomeres.

Broccoli D, Cooke H.

Am J Hum Genet. 1993 Apr;52(4):657-60. Review. No abstract available.

42.

Isolation and characterization of a mouse subtelomeric sequence.

Broccoli D, Miller OJ, Miller DA.

Chromosoma. 1992 Apr;101(7):442-7.

PMID:
1618025
43.

Isolation of a variant family of mouse minor satellite DNA that hybridizes preferentially to chromosome 4.

Broccoli D, Trevor KT, Miller OJ, Miller DA.

Genomics. 1991 May;10(1):68-74.

PMID:
2045111
44.

Relationship of mouse minor satellite DNA to centromere activity.

Broccoli D, Miller OJ, Miller DA.

Cytogenet Cell Genet. 1990;54(3-4):182-6.

PMID:
2265565
45.

Sequence of centromere separation: characterization of multicentric chromosomes in a rat cell line.

Broccoli D, Paweletz N, Vig BK.

Chromosoma. 1989 Jun;98(1):13-22.

PMID:
2766876
46.

Centromere separation and aneuploidy: a lesson from multicentric chromosomes.

Vig BK, Paweletz N, Broccoli D.

Prog Clin Biol Res. 1989;318:137-48. Review.

PMID:
2696963
48.

Characterization of kinetochores in multicentric chromosomes.

Zinkowski RP, Vig BK, Broccoli D.

Chromosoma. 1986;94(4):243-8.

PMID:
3539553

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