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Items: 34


Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates.

Sivanandham R, Brocca-Cofano E, Krampe N, Falwell E, Venkatraman SMK, Ribeiro RM, Apetrei C, Pandrea I.

J Clin Invest. 2018 Nov 1;128(11):5178-5183. doi: 10.1172/JCI99420. Epub 2018 Oct 15.


Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques.

Brocca-Cofano E, Xu C, Wetzel KS, Cottrell ML, Policicchio BB, Raehtz KD, Ma D, Dunsmore T, Haret-Richter GS, Musaitif K, Keele BF, Kashuba AD, Collman RG, Pandrea I, Apetrei C.

J Virol. 2018 Aug 16;92(17). pii: e00576-18. doi: 10.1128/JVI.00576-18. Print 2018 Sep 1.


Pathogenic Correlates of Simian Immunodeficiency Virus-Associated B Cell Dysfunction.

Brocca-Cofano E, Kuhrt D, Siewe B, Xu C, Haret-Richter GS, Craigo J, Labranche C, Montefiori DC, Landay A, Apetrei C, Pandrea I.

J Virol. 2017 Nov 14;91(23). pii: e01051-17. doi: 10.1128/JVI.01051-17. Print 2017 Dec 1.


Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy.

Schechter ME, Andrade BB, He T, Richter GH, Tosh KW, Policicchio BB, Singh A, Raehtz KD, Sheikh V, Ma D, Brocca-Cofano E, Apetrei C, Tracy R, Ribeiro RM, Sher A, Francischetti IMB, Pandrea I, Sereti I.

Sci Transl Med. 2017 Aug 30;9(405). pii: eaam5441. doi: 10.1126/scitranslmed.aam5441.


Modeling aging in HIV infection in nonhuman primates to address an emerging challenge of the post-ART era.

He T, Falwell E, Brocca-Cofano E, Pandrea I.

Curr Opin Virol. 2017 Aug;25:66-75. doi: 10.1016/j.coviro.2017.07.012. Epub 2017 Aug 10. Review.


Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes.

He T, Brocca-Cofano E, Policicchio BB, Sivanandham R, Gautam R, Raehtz KD, Xu C, Pandrea I, Apetrei C.

J Immunol. 2016 Dec 15;197(12):4535-4539. Epub 2016 Nov 11.


Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers.

Policicchio BB, Xu C, Brocca-Cofano E, Raehtz KD, He T, Ma D, Li H, Sivanandham R, Haret-Richter GS, Dunsmore T, Trichel A, Mellors JW, Hahn BH, Shaw GM, Ribeiro RM, Pandrea I, Apetrei C.

PLoS Pathog. 2016 Sep 15;12(9):e1005879. doi: 10.1371/journal.ppat.1005879. eCollection 2016 Sep.


Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques.

Li H, Wang S, Kong R, Ding W, Lee FH, Parker Z, Kim E, Learn GH, Hahn P, Policicchio B, Brocca-Cofano E, Deleage C, Hao X, Chuang GY, Gorman J, Gardner M, Lewis MG, Hatziioannou T, Santra S, Apetrei C, Pandrea I, Alam SM, Liao HX, Shen X, Tomaras GD, Farzan M, Chertova E, Keele BF, Estes JD, Lifson JD, Doms RW, Montefiori DC, Haynes BF, Sodroski JG, Kwong PD, Hahn BH, Shaw GM.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3413-22. doi: 10.1073/pnas.1606636113. Epub 2016 May 31.


Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues.

He T, Brocca-Cofano E, Gillespie DG, Xu C, Stock JL, Ma D, Policicchio BB, Raehtz KD, Rinaldo CR, Apetrei C, Jackson EK, Macatangay BJ, Pandrea I.

J Virol. 2015 Sep;89(18):9616-30. doi: 10.1128/JVI.01196-15. Epub 2015 Jul 15.


Loss of marginal zone B-cells in SHIVSF162P4 challenged rhesus macaques despite control of viremia to low or undetectable levels in chronic infection.

Demberg T, Mohanram V, Musich T, Brocca-Cofano E, McKinnon KM, Venzon D, Robert-Guroff M.

Virology. 2015 Oct;484:323-33. doi: 10.1016/j.virol.2015.06.022. Epub 2015 Jul 4.


Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia.

Gordon SN, Doster MN, Kines RC, Keele BF, Brocca-Cofano E, Guan Y, Pegu P, Liyanage NP, Vaccari M, Cuburu N, Buck CB, Ferrari G, Montefiori D, Piatak M Jr, Lifson JD, Xenophontos AM, Venzon D, Robert-Guroff M, Graham BS, Lowy DR, Schiller JT, Franchini G.

J Immunol. 2014 Dec 15;193(12):6172-83. doi: 10.4049/jimmunol.1401504. Epub 2014 Nov 14.


Immune targeting of PD-1(hi) expressing cells during and after antiretroviral therapy in SIV-infected rhesus macaques.

Vargas-Inchaustegui DA, Xiao P, Hogg AE, Demberg T, McKinnon K, Venzon D, Brocca-Cofano E, Dipasquale J, Lee EM, Hudacik L, Pal R, Sui Y, Berzofsky JA, Liu L, Langermann S, Robert-Guroff M.

Virology. 2013 Dec;447(1-2):274-84. doi: 10.1016/j.virol.2013.09.015. Epub 2013 Oct 9.


Impact of antibody quality and anamnestic response on viremia control post-challenge in a combined Tat/Env vaccine regimen in rhesus macaques.

Demberg T, Brocca-Cofano E, Kuate S, Aladi S, Vargas-Inchaustegui DA, Venzon D, Kalisz I, Kalyanaraman VS, Lee EM, Pal R, DiPasquale J, Ruprecht RM, Montefiori DC, Srivastava I, Barnett SW, Robert-Guroff M.

Virology. 2013 Jun 5;440(2):210-21. doi: 10.1016/j.virol.2013.02.024. Epub 2013 Mar 22.


Increased excitability in tat-transgenic mice: role of tat in HIV-related neurological disorders.

Zucchini S, Pittaluga A, Brocca-Cofano E, Summa M, Fabris M, De Michele R, Bonaccorsi A, Busatto G, Barbanti-Brodano G, Altavilla G, Verlengia G, Cifelli P, Corallini A, Caputo A, Simonato M.

Neurobiol Dis. 2013 Jul;55:110-9. doi: 10.1016/j.nbd.2013.02.004. Epub 2013 Feb 27.


Dynamics of memory B-cell populations in blood, lymph nodes, and bone marrow during antiretroviral therapy and envelope boosting in simian immunodeficiency virus SIVmac251-infected rhesus macaques.

Demberg T, Brocca-Cofano E, Xiao P, Venzon D, Vargas-Inchaustegui D, Lee EM, Kalisz I, Kalyanaraman VS, Dipasquale J, McKinnon K, Robert-Guroff M.

J Virol. 2012 Dec;86(23):12591-604. doi: 10.1128/JVI.00298-12. Epub 2012 Sep 12.


Replicating adenovirus-simian immunodeficiency virus (SIV) recombinant priming and envelope protein boosting elicits localized, mucosal IgA immunity in rhesus macaques correlated with delayed acquisition following a repeated low-dose rectal SIV(mac251) challenge.

Xiao P, Patterson LJ, Kuate S, Brocca-Cofano E, Thomas MA, Venzon D, Zhao J, DiPasquale J, Fenizia C, Lee EM, Kalisz I, Kalyanaraman VS, Pal R, Montefiori D, Keele BF, Robert-Guroff M.

J Virol. 2012 Apr;86(8):4644-57. doi: 10.1128/JVI.06812-11. Epub 2012 Feb 15.


Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA.

Gordon SN, Kines RC, Kutsyna G, Ma ZM, Hryniewicz A, Roberts JN, Fenizia C, Hidajat R, Brocca-Cofano E, Cuburu N, Buck CB, Bernardo ML, Robert-Guroff M, Miller CJ, Graham BS, Lowy DR, Schiller JT, Franchini G.

J Immunol. 2012 Jan 15;188(2):714-23. doi: 10.4049/jimmunol.1101404. Epub 2011 Dec 14.


Vaccine-elicited SIV and HIV envelope-specific IgA and IgG memory B cells in rhesus macaque peripheral blood correlate with functional antibody responses and reduced viremia.

Brocca-Cofano E, McKinnon K, Demberg T, Venzon D, Hidajat R, Xiao P, Daltabuit-Test M, Patterson LJ, Robert-Guroff M.

Vaccine. 2011 Apr 12;29(17):3310-9. doi: 10.1016/j.vaccine.2011.02.066. Epub 2011 Mar 5.


Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.

Patterson LJ, Daltabuit-Test M, Xiao P, Zhao J, Hu W, Wille-Reece U, Brocca-Cofano E, Kalyanaraman VS, Kalisz I, Whitney S, Lee EM, Pal R, Montefiori DC, Dandekar S, Seder R, Roederer M, Wiseman RW, Hirsch V, Robert-Guroff M.

Virology. 2011 Mar 1;411(1):87-102. doi: 10.1016/j.virol.2010.12.033. Epub 2011 Jan 14.


The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice.

Fraternale A, Paoletti MF, Dominici S, Caputo A, Castaldello A, Millo E, Brocca-Cofano E, Smietana M, Clayette P, Oiry J, Benatti U, Magnani M.

Vaccine. 2010 Nov 10;28(48):7676-82. doi: 10.1016/j.vaccine.2010.09.033. Epub 2010 Sep 25.


Multiple vaccine-elicited nonneutralizing antienvelope antibody activities contribute to protective efficacy by reducing both acute and chronic viremia following simian/human immunodeficiency virus SHIV89.6P challenge in rhesus macaques.

Xiao P, Zhao J, Patterson LJ, Brocca-Cofano E, Venzon D, Kozlowski PA, Hidajat R, Demberg T, Robert-Guroff M.

J Virol. 2010 Jul;84(14):7161-73. doi: 10.1128/JVI.00410-10. Epub 2010 May 5.


Interferon regulatory factor-1 acts as a powerful adjuvant in tat DNA based vaccination.

Castaldello A, Sgarbanti M, Marsili G, Brocca-Cofano E, Remoli AL, Caputo A, Battistini A.

J Cell Physiol. 2010 Sep;224(3):702-9. doi: 10.1002/jcp.22169.


Induction of humoral and enhanced cellular immune responses by novel core-shell nanosphere- and microsphere-based vaccine formulations following systemic and mucosal administration.

Caputo A, Castaldello A, Brocca-Cofano E, Voltan R, Bortolazzi F, Altavilla G, Sparnacci K, Laus M, Tondelli L, Gavioli R, Ensoli B.

Vaccine. 2009 Jun 2;27(27):3605-15. doi: 10.1016/j.vaccine.2009.03.047. Epub 2009 Apr 7.


Priming with a very low dose of DNA complexed with cationic block copolymers followed by protein boost elicits broad and long-lasting antigen-specific humoral and cellular responses in mice.

Voltan R, Castaldello A, Brocca-Cofano E, De Michele R, Triulzi C, Altavilla G, Tondelli L, Laus M, Sparnacci K, Reali E, Gavioli R, Ensoli B, Caputo A.

Vaccine. 2009 Jul 16;27(33):4498-507. doi: 10.1016/j.vaccine.2009.05.031. Epub 2009 May 28.


Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge.

Bogers WM, Davis D, Baak I, Kan E, Hofman S, Sun Y, Mortier D, Lian Y, Oostermeijer H, Fagrouch Z, Dubbes R, van der Maas M, Mooij P, Koopman G, Verschoor E, Langedijk JP, Zhao J, Brocca-Cofano E, Robert-Guroff M, Srivastava I, Barnett S, Heeney JL.

Virology. 2008 Dec 20;382(2):217-25. doi: 10.1016/j.virol.2008.09.016. Epub 2008 Oct 22.


Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 DeltaV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin.

Caputo A, Brocca-Cofano E, Castaldello A, Voltan R, Gavioli R, Srivastava IK, Barnett SW, Cafaro A, Ensoli B.

Vaccine. 2008 Feb 26;26(9):1214-27. doi: 10.1016/j.vaccine.2007.12.030. Epub 2008 Jan 15.


Preparation and characterization of innovative protein-coated poly(methylmethacrylate) core-shell nanoparticles for vaccine purposes.

Voltan R, Castaldello A, Brocca-Cofano E, Altavilla G, Caputo A, Laus M, Sparnacci K, Ensoli B, Spaccasassi S, Ballestri M, Tondelli L.

Pharm Res. 2007 Oct;24(10):1870-82. Epub 2007 May 3.


DNA prime and protein boost immunization with innovative polymeric cationic core-shell nanoparticles elicits broad immune responses and strongly enhance cellular responses of HIV-1 tat DNA vaccination.

Castaldello A, Brocca-Cofano E, Voltan R, Triulzi C, Altavilla G, Laus M, Sparnacci K, Ballestri M, Tondelli L, Fortini C, Gavioli R, Ensoli B, Caputo A.

Vaccine. 2006 Jul 17;24(29-30):5655-69. Epub 2006 Jun 2.


Novel biocompatible anionic polymeric microspheres for the delivery of the HIV-1 Tat protein for vaccine application.

Caputo A, Brocca-Cofano E, Castaldello A, De Michele R, Altavilla G, Marchisio M, Gavioli R, Rolen U, Chiarantini L, Cerasi A, Dominici S, Magnani M, Cafaro A, Sparnacci K, Laus M, Tondelli L, Ensoli B.

Vaccine. 2004 Jul 29;22(21-22):2910-24.


Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative.

Richter S, Parolin C, Gatto B, Del Vecchio C, Brocca-Cofano E, Fravolini A, Palù G, Palumbo M.

Antimicrob Agents Chemother. 2004 May;48(5):1895-9.


Prevalence of liver tumours in HIV-1 tat-transgenic mice treated with urethane.

Altavilla G, Caputo A, Trabanelli C, Brocca Cofano E, Sabbioni S, Menegatti MA, Barbanti-Brodano G, Corallini A.

Eur J Cancer. 2004 Jan;40(2):275-83.


Red blood cell-mediated delivery of recombinant HIV-1 Tat protein in mice induces anti-Tat neutralizing antibodies and CTL.

Dominici S, Laguardia ME, Serafini G, Chiarantini L, Fortini C, Tripiciano A, Brocca-Cofano E, Scoglio A, Caputo A, Fiorelli V, Gavioli R, Cafaro A, Ensoli B, Magnani M.

Vaccine. 2003 May 16;21(17-18):2073-81.


Immunization with low doses of HIV-1 tat DNA delivered by novel cationic block copolymers induces CTL responses against Tat.

Caputo A, Gavioli R, Altavilla G, Brocca-Cofano E, Boarini C, Betti M, Castaldello A, Lorenzini F, Micheletti F, Cafaro A, Sparnacci K, Laus M, Tondelli L, Ensoli B.

Vaccine. 2003 Mar 7;21(11-12):1103-11.


Transcription pattern of human herpesvirus 8 open reading frame K3 in primary effusion lymphoma and Kaposi's sarcoma.

Rimessi P, Bonaccorsi A, Stürzl M, Fabris M, Brocca-Cofano E, Caputo A, Melucci-Vigo G, Falchi M, Cafaro A, Cassai E, Ensoli B, Monini P.

J Virol. 2001 Aug;75(15):7161-74.

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