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Carrier of Wingless (Cow) Regulation of Drosophila Neuromuscular Junction Development.

Kopke DL, Leahy SN, Vita DJ, Lima SC, Newman ZL, Broadie K.

eNeuro. 2020 Mar 10;7(2). pii: ENEURO.0285-19.2020. doi: 10.1523/ENEURO.0285-19.2020. Print 2020 Mar/Apr.


Fragile X Mental Retardation Protein positively regulates PKA anchor Rugose and PKA activity to control actin assembly in learning/memory circuitry.

Sears JC, Choi WJ, Broadie K.

Neurobiol Dis. 2019 Jul;127:53-64. doi: 10.1016/j.nbd.2019.02.004. Epub 2019 Feb 13.


Activity-Dependent Remodeling of Drosophila Olfactory Sensory Neuron Brain Innervation during an Early-Life Critical Period.

Golovin RM, Vest J, Vita DJ, Broadie K.

J Neurosci. 2019 Apr 17;39(16):2995-3012. doi: 10.1523/JNEUROSCI.2223-18.2019. Epub 2019 Feb 12.


BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis.

Kim N, Kim S, Nahm M, Kopke D, Kim J, Cho E, Lee MJ, Lee M, Kim SH, Broadie K, Lee S.

Nat Commun. 2019 Feb 8;10(1):684. doi: 10.1038/s41467-019-08533-2.


Newly Identified Electrically Coupled Neurons Support Development of the Drosophila Giant Fiber Model Circuit.

Kennedy T, Broadie K.

eNeuro. 2018 Dec 14;5(6). pii: ENEURO.0346-18.2018. doi: 10.1523/ENEURO.0346-18.2018. eCollection 2018 Nov-Dec.


Fragile X Mental Retardation Protein Regulates Activity-Dependent Membrane Trafficking and Trans-Synaptic Signaling Mediating Synaptic Remodeling.

Sears JC, Broadie K.

Front Mol Neurosci. 2018 Jan 12;10:440. doi: 10.3389/fnmol.2017.00440. eCollection 2017. Review.


Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis.

Dear ML, Shilts J, Broadie K.

Sci Signal. 2017 Nov 7;10(504). pii: eaan3181. doi: 10.1126/scisignal.aan3181.


Fragile X Mental Retardation Protein Restricts Small Dye Iontophoresis Entry into Central Neurons.

Kennedy T, Broadie K.

J Neurosci. 2017 Oct 11;37(41):9844-9858. doi: 10.1523/JNEUROSCI.0723-17.2017. Epub 2017 Sep 8.


Notum coordinates synapse development via extracellular regulation of Wingless trans-synaptic signaling.

Kopke DL, Lima SC, Alexandre C, Broadie K.

Development. 2017 Oct 1;144(19):3499-3510. doi: 10.1242/dev.148130. Epub 2017 Aug 31.


Multifarious Functions of the Fragile X Mental Retardation Protein.

Davis JK, Broadie K.

Trends Genet. 2017 Oct;33(10):703-714. doi: 10.1016/j.tig.2017.07.008. Epub 2017 Aug 18. Review.


ESCRT-III Membrane Trafficking Misregulation Contributes To Fragile X Syndrome Synaptic Defects.

Vita DJ, Broadie K.

Sci Rep. 2017 Aug 17;7(1):8683. doi: 10.1038/s41598-017-09103-6.


Fragile X Mental Retardation Protein Requirements in Activity-Dependent Critical Period Neural Circuit Refinement.

Doll CA, Vita DJ, Broadie K.

Curr Biol. 2017 Aug 7;27(15):2318-2330.e3. doi: 10.1016/j.cub.2017.06.046. Epub 2017 Jul 27.


Secreted tissue inhibitor of matrix metalloproteinase restricts trans-synaptic signaling to coordinate synaptogenesis.

Shilts J, Broadie K.

J Cell Sci. 2017 Jul 15;130(14):2344-2358. doi: 10.1242/jcs.200808. Epub 2017 Jun 2.


Neural Circuits: Reduced Inhibition in Fragile X Syndrome.

Golovin RM, Broadie K.

Curr Biol. 2017 Apr 24;27(8):R298-R300. doi: 10.1016/j.cub.2017.03.011.


Developmental experience-dependent plasticity in the first synapse of the Drosophila olfactory circuit.

Golovin RM, Broadie K.

J Neurophysiol. 2016 Dec 1;116(6):2730-2738. doi: 10.1152/jn.00616.2016. Epub 2016 Sep 28. Review.


Coordinated movement, neuromuscular synaptogenesis and trans-synaptic signaling defects in Drosophila galactosemia models.

Jumbo-Lucioni PP, Parkinson WM, Kopke DL, Broadie K.

Hum Mol Genet. 2016 Sep 1;25(17):3699-3714. doi: 10.1093/hmg/ddw217. Epub 2016 Jul 27.


Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model.

Parkinson WM, Dookwah M, Dear ML, Gatto CL, Aoki K, Tiemeyer M, Broadie K.

Dis Model Mech. 2016 May 1;9(5):513-27. doi: 10.1242/dmm.022939. Epub 2016 Mar 3.


A fully automated Drosophila olfactory classical conditioning and testing system for behavioral learning and memory assessment.

Jiang H, Hanna E, Gatto CL, Page TL, Bhuva B, Broadie K.

J Neurosci Methods. 2016 Mar 1;261:62-74. doi: 10.1016/j.jneumeth.2015.11.030. Epub 2015 Dec 15.


Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis.

Dear ML, Dani N, Parkinson W, Zhou S, Broadie K.

Development. 2016 Jan 1;143(1):75-87. doi: 10.1242/dev.124461. Epub 2015 Nov 24.


Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory.

Doll CA, Broadie K.

Development. 2015 Apr 1;142(7):1346-56. doi: 10.1242/dev.117127.


Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model.

Jumbo-Lucioni P, Parkinson W, Broadie K.

Dis Model Mech. 2014 Dec;7(12):1365-78. doi: 10.1242/dmm.017137. Epub 2014 Oct 17.


Two protein N-acetylgalactosaminyl transferases regulate synaptic plasticity by activity-dependent regulation of integrin signaling.

Dani N, Zhu H, Broadie K.

J Neurosci. 2014 Sep 24;34(39):13047-65. doi: 10.1523/JNEUROSCI.1484-14.2014.


Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models.

Doll CA, Broadie K.

Front Cell Neurosci. 2014 Feb 7;8:30. doi: 10.3389/fncel.2014.00030. eCollection 2014. Review.


GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model.

Gatto CL, Pereira D, Broadie K.

Neurobiol Dis. 2014 May;65:142-59. doi: 10.1016/j.nbd.2014.01.008. Epub 2014 Jan 12.


N-glycosylation requirements in neuromuscular synaptogenesis.

Parkinson W, Dear ML, Rushton E, Broadie K.

Development. 2013 Dec;140(24):4970-81. doi: 10.1242/dev.099192. Epub 2013 Nov 13.


Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila.

Friedman SH, Dani N, Rushton E, Broadie K.

Dis Model Mech. 2013 Nov;6(6):1400-13. doi: 10.1242/dmm.012229. Epub 2013 Sep 5.


miR-153 regulates SNAP-25, synaptic transmission, and neuronal development.

Wei C, Thatcher EJ, Olena AF, Cha DJ, Perdigoto AL, Marshall AF, Carter BD, Broadie K, Patton JG.

PLoS One. 2013;8(2):e57080. doi: 10.1371/journal.pone.0057080. Epub 2013 Feb 25.


The cell polarity scaffold Lethal Giant Larvae regulates synapse morphology and function.

Staples J, Broadie K.

J Cell Sci. 2013 May 1;126(Pt 9):1992-2003. doi: 10.1242/jcs.120139. Epub 2013 Feb 26.


Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization.

Nahm M, Lee MJ, Parkinson W, Lee M, Kim H, Kim YJ, Kim S, Cho YS, Min BM, Bae YC, Broadie K, Lee S.

Neuron. 2013 Feb 20;77(4):680-95. doi: 10.1016/j.neuron.2012.12.015.


Expression and function of scalloped during Drosophila development.

Guss KA, Benson M, Gubitosi N, Brondell K, Broadie K, Skeath JB.

Dev Dyn. 2013 Jul;242(7):874-85. doi: 10.1002/dvdy.23942. Epub 2013 Jun 3.


A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling.

Dani N, Nahm M, Lee S, Broadie K.

PLoS Genet. 2012;8(11):e1003031. doi: 10.1371/journal.pgen.1003031. Epub 2012 Nov 8.


Jelly Belly trans-synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture.

Rohrbough J, Kent KS, Broadie K, Weiss JB.

Dev Neurobiol. 2013 Mar;73(3):189-208. doi: 10.1002/dneu.22056. Epub 2012 Nov 1.


Matrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome.

Siller SS, Broadie K.

Neural Plast. 2012;2012:124548. doi: 10.1155/2012/124548. Epub 2012 May 20. Review.


Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis.

Rushton E, Rohrbough J, Deutsch K, Broadie K.

Dev Neurobiol. 2012 Aug;72(8):1161-79. doi: 10.1002/dneu.22006. Epub 2012 Jun 25.


In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation.

Coffee RL Jr, Williamson AJ, Adkins CM, Gray MC, Page TL, Broadie K.

Hum Mol Genet. 2012 Feb 15;21(4):900-15. doi: 10.1093/hmg/ddr527. Epub 2011 Nov 11.


Molecular and genetic analysis of the Drosophila model of fragile X syndrome.

Tessier CR, Broadie K.

Results Probl Cell Differ. 2012;54:119-56. doi: 10.1007/978-3-642-21649-7_7.


Extracellular matrix and its receptors in Drosophila neural development.

Broadie K, Baumgartner S, Prokop A.

Dev Neurobiol. 2011 Nov;71(11):1102-30. doi: 10.1002/dneu.20935. Review.


Drosophila modeling of heritable neurodevelopmental disorders.

Gatto CL, Broadie K.

Curr Opin Neurobiol. 2011 Dec;21(6):834-41. doi: 10.1016/j.conb.2011.04.009. Epub 2011 May 17. Review.


Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons.

Gatto CL, Broadie K.

Dev Biol. 2011 Aug 15;356(2):291-307. doi: 10.1016/j.ydbio.2011.05.001. Epub 2011 May 10.


Glycosylated synaptomatrix regulation of trans-synaptic signaling.

Dani N, Broadie K.

Dev Neurobiol. 2012 Jan;72(1):2-21. doi: 10.1002/dneu.20891. Review.


The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling.

Nahm M, Long AA, Paik SK, Kim S, Bae YC, Broadie K, Lee S.

J Cell Biol. 2010 Nov 1;191(3):661-75. doi: 10.1083/jcb.201007086.


Drosophila rolling blackout displays lipase domain-dependent and -independent endocytic functions downstream of dynamin.

Vijayakrishnan N, Phillips SE, Broadie K.

Traffic. 2010 Dec;11(12):1567-78. doi: 10.1111/j.1600-0854.2010.01117.x. Epub 2010 Oct 1.


Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap.

Rohrbough J, Broadie K.

Development. 2010 Oct;137(20):3523-33. doi: 10.1242/dev.047878.


The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons.

Tessier CR, Broadie K.

Neurobiol Dis. 2011 Jan;41(1):147-59. doi: 10.1016/j.nbd.2010.09.002. Epub 2010 Sep 16.


The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy.

Long AA, Mahapatra CT, Woodruff EA 3rd, Rohrbough J, Leung HT, Shino S, An L, Doerge RW, Metzstein MM, Pak WL, Broadie K.

J Cell Sci. 2010 Oct 1;123(Pt 19):3303-15. doi: 10.1242/jcs.069468. Epub 2010 Sep 7.


Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.

Coffee RL Jr, Tessier CR, Woodruff EA 3rd, Broadie K.

Dis Model Mech. 2010 Jul-Aug;3(7-8):471-85. doi: 10.1242/dmm.004598. Epub 2010 May 4.


Structural mass spectrometry analysis of lipid changes in a Drosophila epilepsy model brain.

Kliman M, Vijayakrishnan N, Wang L, Tapp JT, Broadie K, McLean JA.

Mol Biosyst. 2010 Jun;6(6):958-66. doi: 10.1039/b927494d. Epub 2010 Apr 9.

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