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Items: 1 to 50 of 72

1.

Autophagy facilitates the release of immunogenic signals following chemotherapy in 3D models of mesothelioma.

Follo C, Cheng Y, Richards WG, Bueno R, Broaddus VC.

Mol Carcinog. 2019 Oct;58(10):1754-1769. doi: 10.1002/mc.23050. Epub 2019 Jun 19.

PMID:
31215708
2.

Inhibition of autophagy initiation potentiates chemosensitivity in mesothelioma.

Follo C, Cheng Y, Richards WG, Bueno R, Broaddus VC.

Mol Carcinog. 2018 Mar;57(3):319-332. doi: 10.1002/mc.22757. Epub 2017 Nov 14.

PMID:
29073722
3.

Autophagy initiation correlates with the autophagic flux in 3D models of mesothelioma and with patient outcome.

Follo C, Barbone D, Richards WG, Bueno R, Broaddus VC.

Autophagy. 2016 Jul 2;12(7):1180-94. doi: 10.1080/15548627.2016.1173799. Epub 2016 Apr 20.

4.

Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma.

Barbone D, Van Dam L, Follo C, Jithesh PV, Zhang SD, Richards WG, Bueno R, Fennell DA, Broaddus VC.

PLoS One. 2016 Mar 16;11(3):e0150044. doi: 10.1371/journal.pone.0150044. eCollection 2016.

5.

Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models.

Barbone D, Follo C, Echeverry N, Gerbaudo VH, Klabatsa A, Bueno R, Felley-Bosco E, Broaddus VC.

PLoS One. 2015 Aug 18;10(8):e0134825. doi: 10.1371/journal.pone.0134825. eCollection 2015.

6.

Medical Subspecialty Textbooks in the 21st Century. Essential or Headed for Extinction?

Broaddus VC, Grippi MA.

Ann Am Thorac Soc. 2015 Aug;12(8):1113-5. doi: 10.1513/AnnalsATS.201506-335OI.

PMID:
26177458
7.

Inflammatory Cytokines Contribute to Asbestos-Induced Injury of Mesothelial Cells.

Acencio MM, Soares B, Marchi E, Silva CS, Teixeira LR, Broaddus VC.

Lung. 2015 Oct;193(5):831-7. doi: 10.1007/s00408-015-9744-4. Epub 2015 Jun 10.

PMID:
26059286
8.

Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors.

Echeverry N, Ziltener G, Barbone D, Weder W, Stahel RA, Broaddus VC, Felley-Bosco E.

Cell Death Dis. 2015 May 7;6:e1757. doi: 10.1038/cddis.2015.124.

9.

BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma.

Busacca S, Chacko AD, Klabatsa A, Arthur K, Sheaff M, Barbone D, Mutti L, Gunasekharan VK, Gorski JJ, El-Tanani M, Broaddus VC, Gaudino G, Fennell DA.

PLoS One. 2013 Jun 7;8(6):e65489. doi: 10.1371/journal.pone.0065489. Print 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/90879c69-ebc5-40b2-9926-4a00e4f9e055. Barbone, Dario [added]; Mutti, Luciano [added].

10.

Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression.

Barbone D, Cheung P, Battula S, Busacca S, Gray SG, Longley DB, Bueno R, Sugarbaker DJ, Fennell DA, Broaddus VC.

PLoS One. 2012;7(12):e52753. doi: 10.1371/journal.pone.0052753. Epub 2012 Dec 26.

11.

Ligation of CM1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with EGFR mutation.

Lee HK, Park GB, Kim YS, Song H, Broaddus VC, Hur DY.

Int J Oncol. 2013 Feb;42(2):469-77. doi: 10.3892/ijo.2012.1731. Epub 2012 Dec 7.

12.

Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent.

Hurwitz JL, Stasik I, Kerr EM, Holohan C, Redmond KM, McLaughlin KM, Busacca S, Barbone D, Broaddus VC, Gray SG, O'Byrne KJ, Johnston PG, Fennell DA, Longley DB.

Eur J Cancer. 2012 May;48(7):1096-107. doi: 10.1016/j.ejca.2011.11.009. Epub 2011 Dec 10.

PMID:
22154545
13.

Rapid generation of in vitro multicellular spheroids for the study of monoclonal antibody therapy.

Phung YT, Barbone D, Broaddus VC, Ho M.

J Cancer. 2011;2:507-14. Epub 2011 Oct 13.

14.

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance.

Barbone D, Ryan JA, Kolhatkar N, Chacko AD, Jablons DM, Sugarbaker DJ, Bueno R, Letai AG, Coussens LM, Fennell DA, Broaddus VC.

Cell Death Dis. 2011 Jun 23;2:e174. doi: 10.1038/cddis.2011.58.

15.

Non-neoplastic and neoplastic pleural endpoints following fiber exposure.

Broaddus VC, Everitt JI, Black B, Kane AB.

J Toxicol Environ Health B Crit Rev. 2011;14(1-4):153-78. doi: 10.1080/10937404.2011.556049. Review.

16.

Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas.

Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J.

Cancer Res. 2011 Apr 1;71(7):2428-32. doi: 10.1158/0008-5472.CAN-10-3484. Epub 2011 Mar 29.

17.

The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy.

Xiang X, Phung Y, Feng M, Nagashima K, Zhang J, Broaddus VC, Hassan R, Fitzgerald D, Ho M.

PLoS One. 2011 Jan 31;6(1):e14640. doi: 10.1371/journal.pone.0014640.

18.

Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma.

Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B.

Cancer Res. 2009 Feb 15;69(4):1570-7. doi: 10.1158/0008-5472.CAN-08-1363. Epub 2009 Feb 3.

19.

Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids.

Yang TM, Barbone D, Fennell DA, Broaddus VC.

Am J Respir Cell Mol Biol. 2009 Jul;41(1):14-23. doi: 10.1165/rcmb.2008-0320OC. Epub 2008 Dec 18.

20.

mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.

Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC.

Am J Respir Cell Mol Biol. 2008 Nov;39(5):576-83. doi: 10.1165/rcmb.2007-0460OC. Epub 2008 May 29.

21.

Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids.

Barbone D, Yang TM, Morgan JR, Gaudino G, Broaddus VC.

J Biol Chem. 2008 May 9;283(19):13021-30. doi: 10.1074/jbc.M709698200. Epub 2008 Mar 13.

22.

Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies.

An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura SL, Broaddus VC, Liu B.

Mol Cancer Ther. 2008 Mar;7(3):569-78. doi: 10.1158/1535-7163.MCT-07-2132. Epub 2008 Mar 4.

23.
24.

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.

Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL.

J Clin Invest. 2007 Nov;117(11):3551-62.

25.

Malignant mesothelioma cells are rapidly sensitized to TRAIL-induced apoptosis by low-dose anisomycin via Bim.

Abayasiriwardana KS, Barbone D, Kim KU, Vivo C, Lee KK, Dansen TB, Hunt AE, Evan GI, Broaddus VC.

Mol Cancer Ther. 2007 Oct;6(10):2766-76.

26.

Pleural mesothelial cells mediate inflammatory and profibrotic responses in talc-induced pleurodesis.

Acencio MM, Vargas FS, Marchi E, Carnevale GG, Teixeira LR, Antonangelo L, Broaddus VC.

Lung. 2007 Dec;185(6):343-8. Epub 2007 Oct 12.

PMID:
17932716
27.

Eighth international mesothelioma interest group.

Carbone M, Albelda SM, Broaddus VC, Flores RM, Hillerdal G, Jaurand MC, Kjaerheim K, Pass HI, Robinson B, Tsao A.

Oncogene. 2007 Oct 25;26(49):6959-67. Epub 2007 May 14.

PMID:
17496929
28.
29.

A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance.

Kim KU, Wilson SM, Abayasiriwardana KS, Collins R, Fjellbirkeland L, Xu Z, Jablons DM, Nishimura SL, Broaddus VC.

Am J Respir Cell Mol Biol. 2005 Dec;33(6):541-8. Epub 2005 Aug 25.

30.

Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and DNA damage.

Broaddus VC, Dansen TB, Abayasiriwardana KS, Wilson SM, Finch AJ, Swigart LB, Hunt AE, Evan GI.

J Biol Chem. 2005 Apr 1;280(13):12486-93. Epub 2004 Dec 22.

31.

Malignant mesothelioma as both a challenge and an opportunity.

Mutti L, Broaddus VC.

Oncogene. 2004 Dec 9;23(57):9155-61.

PMID:
15516978
32.

Mesothelial cell proliferation and apoptosis.

Leard LE, Broaddus VC.

Respirology. 2004 Aug;9(3):292-9. Review.

PMID:
15362999
33.

H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis.

Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus VC.

Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L448-53. Epub 2004 Apr 30.

34.

Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue.

Fjellbirkeland L, Cambier S, Broaddus VC, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura SL.

Am J Pathol. 2003 Aug;163(2):533-42.

35.

Workshop on lung disease and the environment: where do we go from here?

Crapo JD, Broaddus VC, Brody AR, Malindzak G, Samet J, Wright JR; American Thoracic Society.

Am J Respir Crit Care Med. 2003 Jul 15;168(2):250-4. Review. No abstract available.

PMID:
12851246
37.

The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1.

Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL.

J Cell Biol. 2002 Apr 29;157(3):493-507. Epub 2002 Apr 22.

38.

Tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines.

Liu W, Bodle E, Chen JY, Gao M, Rosen GD, Broaddus VC.

Am J Respir Cell Mol Biol. 2001 Jul;25(1):111-8.

PMID:
11472983
39.

Diuresis and transudative effusions--changing the rules of the game.

Broaddus VC.

Am J Med. 2001 Jun 15;110(9):732-5. No abstract available.

PMID:
11403759
40.

Apoptosis and asbestos-induced disease: Is there a connection?

Broaddus VC.

J Lab Clin Med. 2001 May;137(5):314-5. No abstract available.

PMID:
11329527
41.

A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth.

Cambier S, Mu DZ, O'Connell D, Boylen K, Travis W, Liu WH, Broaddus VC, Nishimura SL.

Cancer Res. 2000 Dec 15;60(24):7084-93.

42.

Vitronectin adsorption to chrysotile asbestos increases fiber phagocytosis and toxicity for mesothelial cells.

Wu J, Liu W, Koenig K, Idell S, Broaddus VC.

Am J Physiol Lung Cell Mol Physiol. 2000 Nov;279(5):L916-23.

43.

Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage, and apoptosis in mesothelial cells.

Liu W, Ernst JD, Broaddus VC.

Am J Respir Cell Mol Biol. 2000 Sep;23(3):371-8.

PMID:
10970829
44.

DNA breakage in asbestos-treated normal and transformed (TSV40) rat pleural mesothelial cells.

Levresse V, Renier A, Levy F, Broaddus VC, Jaurand M.

Mutagenesis. 2000 May;15(3):239-44.

PMID:
10792017
45.

Mesothelial cell apoptosis is confirmed in vivo by morphological change in cytokeratin distribution.

Marchi E, Liu W, Broaddus VC.

Am J Physiol Lung Cell Mol Physiol. 2000 Mar;278(3):L528-35.

46.

Asbestos upregulates expression of the urokinase-type plasminogen activator receptor on mesothelial cells.

Perkins RC, Broaddus VC, Shetty S, Hamilton S, Idell S.

Am J Respir Cell Mol Biol. 1999 Nov;21(5):637-46.

PMID:
10536123
47.

The effects of two antiinflammatory pretreatments on bacterial-induced lung injury.

Miyazaki H, Broaddus VC, Wiener-Kronish JP, Sawa T, Pittet JF, Kravchenko V, Mathison JC, Nishizawa H, Hattori S, Yamakawa T, Yamada H, Kudoh I.

Anesthesiology. 1999 Jun;90(6):1650-62.

PMID:
10360864
48.

Resistance of pleural mesothelioma cell lines to apoptosis: relation to expression of Bcl-2 and Bax.

Narasimhan SR, Yang L, Gerwin BI, Broaddus VC.

Am J Physiol. 1998 Jul;275(1):L165-71. doi: 10.1152/ajplung.1998.275.1.L165.

PMID:
9688948
49.

Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells.

Ernst JD, Yang L, Rosales JL, Broaddus VC.

Anal Biochem. 1998 Jun 15;260(1):18-23.

PMID:
9648647
50.

Asbestos-induced pleural disease.

Nishimura SL, Broaddus VC.

Clin Chest Med. 1998 Jun;19(2):311-29. Review.

PMID:
9646983

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