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Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.

Genutis LK, Tomsic J, Bundschuh R, Brock P, Williams MD, Roychowdhury S, Reeser JW, Frankel WL, Alsomali M, Routbort MJ, Broaddus RR, Wakely PE Jr, Phay JE, Walker CJ, de la Chapelle A.

Thyroid. 2019 Feb 12. doi: 10.1089/thy.2018.0655. [Epub ahead of print]


Pleiotropic effects of PPARD accelerate colorectal tumorigenesis, progression, and invasion.

Liu Y, Deguchi Y, Tian R, Wei D, Wu L, Chen W, Xu W, Xu M, Liu F, Gao S, Jaoude JC, Chrieki SP, Moussalli MJ, Gagea M, Morris J, Broaddus RR, Zuo X, Shureiqi I.

Cancer Res. 2019 Jan 24. pii: canres.1790.2018. doi: 10.1158/0008-5472.CAN-18-1790. [Epub ahead of print]


Targeted next-generation sequencing of endometrial cancer and matched circulating tumor DNA: identification of plasma-based, tumor-associated mutations in early stage patients.

Bolivar AM, Luthra R, Mehrotra M, Chen W, Barkoh BA, Hu P, Zhang W, Broaddus RR.

Mod Pathol. 2018 Oct 12. doi: 10.1038/s41379-018-0158-8. [Epub ahead of print]


The ERM family member Merlin is required for endometrial gland morphogenesis.

Lopez EW, Vue Z, Broaddus RR, Behringer RR, Gladden AB.

Dev Biol. 2018 Oct 15;442(2):301-314. doi: 10.1016/j.ydbio.2018.08.006. Epub 2018 Aug 15.


KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary.

Hillman RT, Celestino J, Terranova C, Beird HC, Gumbs C, Little L, Nguyen T, Thornton R, Tippen S, Zhang J, Lu KH, Gershenson DM, Rai K, Broaddus RR, Futreal PA.

Nat Commun. 2018 Jun 27;9(1):2496. doi: 10.1038/s41467-018-04950-x.


MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT.

Yoo JY, Kang HB, Broaddus RR, Risinger JI, Choi KC, Kim TH.

BMC Cancer. 2018 May 29;18(1):605. doi: 10.1186/s12885-018-4502-7.


Predicting high-risk endometrioid carcinomas using proteins.

Du D, Ma W, Yates MS, Chen T, Lu KH, Lu Y, Weinstein JN, Broaddus RR, Mills GB, Liu Y.

Oncotarget. 2018 Apr 13;9(28):19704-19715. doi: 10.18632/oncotarget.24803. eCollection 2018 Apr 13.


Prospective Randomized Biomarker Study of Metformin and Lifestyle Intervention for Prevention in Obese Women at Increased Risk for Endometrial Cancer.

Yates MS, Coletta AM, Zhang Q, Schmandt RE, Medepalli M, Nebgen D, Soletsky B, Milbourne A, Levy E, Fellman B, Urbauer D, Yuan Y, Broaddus RR, Basen-Engquist K, Lu K.

Cancer Prev Res (Phila). 2018 Aug;11(8):477-490. doi: 10.1158/1940-6207.CAPR-17-0398. Epub 2018 May 1.


Molecular Profile of Advanced Thyroid Carcinomas by Next-Generation Sequencing: Characterizing Tumors Beyond Diagnosis for Targeted Therapy.

Chen H, Luthra R, Routbort MJ, Patel KP, Cabanillas ME, Broaddus RR, Williams MD.

Mol Cancer Ther. 2018 Jul;17(7):1575-1584. doi: 10.1158/1535-7163.MCT-17-0871. Epub 2018 Apr 25.


Detection of somatic mutations in cell-free DNA in plasma and correlation with overall survival in patients with solid tumors.

Mehrotra M, Singh RR, Loghavi S, Duose DY, Barkoh BA, Behrens C, Patel KP, Routbort MJ, Kopetz S, Broaddus RR, Medeiros LJ, Wistuba II, Luthra R.

Oncotarget. 2017 Oct 24;9(12):10259-10271. doi: 10.18632/oncotarget.21982. eCollection 2018 Feb 13.


MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques.

Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2806-2811. doi: 10.1073/pnas.1722106115. Epub 2018 Feb 28.


Treatment of Low-Risk Endometrial Cancer and Complex Atypical Hyperplasia With the Levonorgestrel-Releasing Intrauterine Device.

Pal N, Broaddus RR, Urbauer DL, Balakrishnan N, Milbourne A, Schmeler KM, Meyer LA, Soliman PT, Lu KH, Ramirez PT, Ramondetta L, Bodurka DC, Westin SN.

Obstet Gynecol. 2018 Jan;131(1):109-116. doi: 10.1097/AOG.0000000000002390.


Molecular Modifiers of Hormone Receptor Action: Decreased Androgen Receptor Expression in Mismatch Repair Deficient Endometrial Endometrioid Adenocarcinoma.

Gan Q, Crumley S, Broaddus RR.

Int J Gynecol Pathol. 2019 Jan;38(1):44-51. doi: 10.1097/PGP.0000000000000465.


MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells.

Yoo JY, Yang WS, Lee JH, Kim BG, Broaddus RR, Lim JM, Kim TH, Jeong JW.

Oncogene. 2018 Jan 11;37(2):255-262. doi: 10.1038/onc.2017.335. Epub 2017 Sep 18.


Importance of PCR-based Tumor Testing in the Evaluation of Lynch Syndrome-associated Endometrial Cancer.

Bruegl AS, Kernberg A, Broaddus RR.

Adv Anat Pathol. 2017 Nov;24(6):372-378. doi: 10.1097/PAP.0000000000000169. Review.


Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.

Janouskova H, El Tekle G, Bellini E, Udeshi ND, Rinaldi A, Ulbricht A, Bernasocchi T, Civenni G, Losa M, Svinkina T, Bielski CM, Kryukov GV, Cascione L, Napoli S, Enchev RI, Mutch DG, Carney ME, Berchuck A, Winterhoff BJN, Broaddus RR, Schraml P, Moch H, Bertoni F, Catapano CV, Peter M, Carr SA, Garraway LA, Wild PJ, Theurillat JP.

Nat Med. 2017 Sep;23(9):1046-1054. doi: 10.1038/nm.4372. Epub 2017 Aug 14.


Universal Point of Care Testing for Lynch Syndrome in Patients with Upper Tract Urothelial Carcinoma.

Metcalfe MJ, Petros FG, Rao P, Mork ME, Xiao L, Broaddus RR, Matin SF.

J Urol. 2018 Jan;199(1):60-65. doi: 10.1016/j.juro.2017.08.002. Epub 2017 Aug 7.


Study of Preanalytic and Analytic Variables for Clinical Next-Generation Sequencing of Circulating Cell-Free Nucleic Acid.

Mehrotra M, Singh RR, Chen W, Huang RSP, Almohammedsalim AA, Barkoh BA, Simien CM, Hernandez M, Behrens C, Patel KP, Routbort MJ, Broaddus RR, Medeiros LJ, Wistuba II, Kopetz S, Luthra R.

J Mol Diagn. 2017 Jul;19(4):514-524. doi: 10.1016/j.jmoldx.2017.03.003. Epub 2017 May 12.


Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing.

Le Gallo M, Rudd ML, Urick ME, Hansen NF, Zhang S; NISC Comparative Sequencing Program, Lozy F, Sgroi DC, Vidal Bel A, Matias-Guiu X, Broaddus RR, Lu KH, Levine DA, Mutch DG, Goodfellow PJ, Salvesen HB, Mullikin JC, Bell DW.

Cancer. 2017 Sep 1;123(17):3261-3268. doi: 10.1002/cncr.30745. Epub 2017 May 9.


Factors prognostic of survival in advanced-stage uterine serous carcinoma.

Holman LL, Pal N, Iglesias DA, Soliman PT, Balakrishnan N, Klopp A, Broaddus RR, Fleming ND, Munsell MF, Lu KH, Westin SN.

Gynecol Oncol. 2017 Jul;146(1):27-33. doi: 10.1016/j.ygyno.2017.04.018. Epub 2017 Apr 30.


Integrated Molecular Characterization of Uterine Carcinosarcoma.

Cherniack AD, Shen H, Walter V, Stewart C, Murray BA, Bowlby R, Hu X, Ling S, Soslow RA, Broaddus RR, Zuna RE, Robertson G, Laird PW, Kucherlapati R, Mills GB; Cancer Genome Atlas Research Network, Weinstein JN, Zhang J, Akbani R, Levine DA.

Cancer Cell. 2017 Mar 13;31(3):411-423. doi: 10.1016/j.ccell.2017.02.010.


CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence.

Kurnit KC, Kim GN, Fellman BM, Urbauer DL, Mills GB, Zhang W, Broaddus RR.

Mod Pathol. 2017 Jul;30(7):1032-1041. doi: 10.1038/modpathol.2017.15. Epub 2017 Mar 10.


Immune Microenvironment in Microsatellite-Instable Endometrial Cancers: Hereditary or Sporadic Origin Matters.

Pakish JB, Zhang Q, Chen Z, Liang H, Chisholm GB, Yuan Y, Mok SC, Broaddus RR, Lu KH, Yates MS.

Clin Cancer Res. 2017 Aug 1;23(15):4473-4481. doi: 10.1158/1078-0432.CCR-16-2655. Epub 2017 Mar 6.


CD73s protection of epithelial integrity: Thinking beyond the barrier.

Bowser JL, Broaddus RR.

Tissue Barriers. 2016 Aug 19;4(4):e1224963. doi: 10.1080/21688370.2016.1224963. eCollection 2016.


Concurrent fine needle aspirations and core needle biopsies: a comparative study of substrates for next-generation sequencing in solid organ malignancies.

Roy-Chowdhuri S, Chen H, Singh RR, Krishnamurthy S, Patel KP, Routbort MJ, Manekia J, Barkoh BA, Yao H, Sabir S, Broaddus RR, Medeiros LJ, Staerkel G, Stewart J, Luthra R.

Mod Pathol. 2017 Apr;30(4):499-508. doi: 10.1038/modpathol.2016.228. Epub 2017 Jan 13.


A Targeted High-Throughput Next-Generation Sequencing Panel for Clinical Screening of Mutations, Gene Amplifications, and Fusions in Solid Tumors.

Luthra R, Patel KP, Routbort MJ, Broaddus RR, Yau J, Simien C, Chen W, Hatfield DZ, Medeiros LJ, Singh RR.

J Mol Diagn. 2017 Mar;19(2):255-264. doi: 10.1016/j.jmoldx.2016.09.011. Epub 2016 Dec 23.


Clinical Challenges Associated with Universal Screening for Lynch Syndrome-Associated Endometrial Cancer.

Bruegl AS, Ring KL, Daniels M, Fellman BM, Urbauer DL, Broaddus RR.

Cancer Prev Res (Phila). 2017 Feb;10(2):108-115. doi: 10.1158/1940-6207.CAPR-16-0219. Epub 2016 Dec 13.


Intratumoral heterogeneity and chemoresistance in nonseminomatous germ cell tumor of the testis.

Bilen MA, Hess KR, Campbell MT, Wang J, Broaddus RR, Karam JA, Ward JF, Wood CG, Choi SL, Rao P, Zhang M, Naing A, General R, Cauley DH, Lin SH, Logothetis CJ, Pisters LL, Tu SM.

Oncotarget. 2016 Dec 27;7(52):86280-86289. doi: 10.18632/oncotarget.13380.


Germline multi-gene hereditary cancer panel testing in an unselected endometrial cancer cohort.

Ring KL, Bruegl AS, Allen BA, Elkin EP, Singh N, Hartman AR, Daniels MS, Broaddus RR.

Mod Pathol. 2016 Nov;29(11):1381-1389. doi: 10.1038/modpathol.2016.135. Epub 2016 Jul 22.


Prospective evaluation of the molecular effects of metformin on the endometrium in women with newly diagnosed endometrial cancer: A window of opportunity study.

Soliman PT, Zhang Q, Broaddus RR, Westin SN, Iglesias D, Munsell MF, Schmandt R, Yates M, Ramondetta L, Lu KH.

Gynecol Oncol. 2016 Dec;143(3):466-471. doi: 10.1016/j.ygyno.2016.10.011. Epub 2016 Oct 13.


Next-generation sequencing identifies high frequency of mutations in potentially clinically actionable genes in sebaceous carcinoma.

Tetzlaff MT, Singh RR, Seviour EG, Curry JL, Hudgens CW, Bell D, Wimmer DA, Ning J, Czerniak BA, Zhang L, Davies MA, Prieto VG, Broaddus RR, Ram P, Luthra R, Esmaeli B.

J Pathol. 2016 Sep;240(1):84-95. doi: 10.1002/path.4759.


How Do We Make Clinical Molecular Testing for Cancer Standard of Care for Pathology Departments?

Loghavi S, Routbort MJ, Patel KP, Luthra R, Wang WL, Broaddus RR, Davies MA, Lazar AJ.

J Natl Compr Canc Netw. 2016 Jun;14(6):787-92. Review.


Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma.

Djordjevic B, Broaddus RR.

Surg Pathol Clin. 2016 Jun;9(2):289-99. doi: 10.1016/j.path.2016.01.007. Epub 2016 Apr 11. Review.


Identification of Factors Affecting the Success of Next-Generation Sequencing Testing in Solid Tumors.

Goswami RS, Luthra R, Singh RR, Patel KP, Routbort MJ, Aldape KD, Yao H, Dang HD, Barkoh BA, Manekia J, Medeiros LJ, Roy-Chowdhuri S, Stewart J, Broaddus RR, Chen H.

Am J Clin Pathol. 2016 Feb;145(2):222-37. doi: 10.1093/ajcp/aqv023. Epub 2016 Feb 12.


MUC1 stimulates EGFR expression and function in endometrial cancer.

Engel BJ, Bowser JL, Broaddus RR, Carson DD.

Oncotarget. 2016 May 31;7(22):32796-809. doi: 10.18632/oncotarget.8743.


Intratumoral heterogeneity: Role of differentiation in a potentially lethal phenotype of testicular cancer.

Tu SM, Bilen MA, Hess KR, Broaddus RR, Kopetz S, Wei C, Pagliaro LC, Karam JA, Ward JF, Wood CG, Rao P, Tu ZH, General R, Chen AH, Nieto YL, Yeung SC, Lin SH, Logothetis CJ, Pisters LL.

Cancer. 2016 Jun 15;122(12):1836-43. doi: 10.1002/cncr.29996. Epub 2016 Mar 28.


Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity.

McCampbell AS, Mittelstadt ML, Dere R, Kim S, Zhou L, Djordjevic B, Soliman PT, Zhang Q, Wei C, Hursting SD, Lu KH, Broaddus RR, Walker CL.

Curr Mol Med. 2016;16(3):252-65.


Loss of CD73-mediated actin polymerization promotes endometrial tumor progression.

Bowser JL, Blackburn MR, Shipley GL, Molina JG, Dunner K Jr, Broaddus RR.

J Clin Invest. 2016 Jan;126(1):220-38. doi: 10.1172/JCI79380. Epub 2015 Dec 7.


Assessment of BRAF V600E Status in Colorectal Carcinoma: Tissue-Specific Discordances between Immunohistochemistry and Sequencing.

Estrella JS, Tetzlaff MT, Bassett RL Jr, Patel KP, Williams MD, Curry JL, Rashid A, Hamilton SR, Broaddus RR.

Mol Cancer Ther. 2015 Dec;14(12):2887-95. doi: 10.1158/1535-7163.MCT-15-0615. Epub 2015 Oct 5.


Factors affecting the success of next-generation sequencing in cytology specimens.

Roy-Chowdhuri S, Goswami RS, Chen H, Patel KP, Routbort MJ, Singh RR, Broaddus RR, Barkoh BA, Manekia J, Yao H, Medeiros LJ, Staerkel G, Luthra R, Stewart J.

Cancer Cytopathol. 2015 Nov;123(11):659-68. doi: 10.1002/cncy.21597. Epub 2015 Jul 31.


Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma.

Liu Y, Yasukawa M, Chen K, Hu L, Broaddus RR, Ding L, Mardis ER, Spellman P, Levine DA, Mills GB, Shmulevich I, Sood AK, Zhang W.

JAMA Oncol. 2015 Jul;1(4):486-94. doi: 10.1001/jamaoncol.2015.1432.


Intact PTEN Expression by Immunohistochemistry is Associated With Decreased Survival in Advanced Stage Ovarian/Primary Peritoneal High-grade Serous Carcinoma.

Bakkar RM, Xie SS, Urbauer DL, Djordjevic B, Vu K, Broaddus RR.

Int J Gynecol Pathol. 2015 Nov;34(6):497-506. doi: 10.1097/PGP.0000000000000205.


Intratumoral morphologic and molecular heterogeneity of rhabdoid renal cell carcinoma: challenges for personalized therapy.

Singh RR, Murugan P, Patel LR, Voicu H, Yoo SY, Majewski T, Mehrotra M, Wani K, Tannir N, Karam JA, Jonasch E, Wood CG, Creighton CJ, Medeiros LJ, Broaddus RR, Tamboli P, Baggerly KA, Aldape KD, Czerniak B, Luthra R, Sircar K.

Mod Pathol. 2015 Sep;28(9):1225-35. doi: 10.1038/modpathol.2015.68. Epub 2015 Jun 26.


Utility of BRAF V600E Immunohistochemistry Expression Pattern as a Surrogate of BRAF Mutation Status in 154 Patients with Advanced Melanoma.

Tetzlaff MT, Pattanaprichakul P, Wargo J, Fox PS, Patel KP, Estrella JS, Broaddus RR, Williams MD, Davies MA, Routbort MJ, Lazar AJ, Woodman SE, Hwu WJ, Gershenwald JE, Prieto VG, Torres-Cabala CA, Curry JL.

Hum Pathol. 2015 Aug;46(8):1101-10. doi: 10.1016/j.humpath.2015.04.012. Epub 2015 May 6.


PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients.

Westin SN, Ju Z, Broaddus RR, Krakstad C, Li J, Pal N, Lu KH, Coleman RL, Hennessy BT, Klempner SJ, Werner HM, Salvesen HB, Cantley LC, Mills GB, Myers AP.

Mol Oncol. 2015 Oct;9(8):1694-703. doi: 10.1016/j.molonc.2015.04.014. Epub 2015 May 16.


Cytokine stimulation of MUC4 expression in human female reproductive tissue carcinoma cell lines and endometrial cancer.

Chapela PJ, Broaddus RR, Hawkins SM, Lessey BA, Carson DD.

J Cell Biochem. 2015 Nov;116(11):2649-57. doi: 10.1002/jcb.25213.


Defective DNA Mismatch Repair Influences Expression of Endometrial Carcinoma Biomarkers.

Okoye EI, Bruegl AS, Fellman B, Luthra R, Broaddus RR.

Int J Gynecol Pathol. 2016 Jan;35(1):8-15. doi: 10.1097/PGP.0000000000000193.


Use of clinical next-generation sequencing to identify melanomas harboring SMARCB1 mutations.

Stockman DL, Curry JL, Torres-Cabala CA, Watson IR, Siroy AE, Bassett RL, Zou L, Patel KP, Luthra R, Davies MA, Wargo JA, Routbort MA, Broaddus RR, Prieto VG, Lazar AJ, Tetzlaff MT.

J Cutan Pathol. 2015 May;42(5):308-17. doi: 10.1111/cup.12481. Epub 2015 Mar 24.


Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors.

Goswami RS, Patel KP, Singh RR, Meric-Bernstam F, Kopetz ES, Subbiah V, Alvarez RH, Davies MA, Jabbar KJ, Roy-Chowdhuri S, Lazar AJ, Medeiros LJ, Broaddus RR, Luthra R, Routbort MJ.

Clin Cancer Res. 2015 Jun 1;21(11):2644-51. doi: 10.1158/1078-0432.CCR-14-2391. Epub 2015 Feb 18.


Identifying aggressive forms of endometrioid-type endometrial cancer: new insights into molecular subtyping.

Liu Y, Broaddus RR, Zhang W.

Expert Rev Anticancer Ther. 2015 Jan;15(1):1-3. doi: 10.1586/14737140.2015.992420. Epub 2014 Dec 12.

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