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Items: 1 to 50 of 276

1.

Everolimus, letrozole, and metformin in women with advanced or recurrent endometrioid endometrial cancer: A multi-center, single arm, phase II study.

Soliman PT, Westin SN, Iglesias DA, Fellman BM, Ying Y, Zhang Q, Yates MS, Broaddus RR, Slomovitz BM, Lu KH, Coleman RL.

Clin Cancer Res. 2019 Oct 18. pii: clincanres.0471.2019. doi: 10.1158/1078-0432.CCR-19-0471. [Epub ahead of print]

PMID:
31628143
2.

Correction: A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory.

Arango NP, Brusco L, Shaw KRM, Chen K, Eterovic AK, Holla V, Johnson A, Litzenburger B, Khotskaya YB, Sanchez N, Bailey A, Zheng X, Horombe C, Kopetz S, Farhangfar CJ, Routbort M, Broaddus R, Bernstam EV, Mendelsohn J, Mills GB, Meric-Bernstam F.

Oncotarget. 2019 Aug 27;10(50):5254. doi: 10.18632/oncotarget.27176. eCollection 2019 Aug 27.

3.

Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland.

Bell D, Ferrarotto R, Liang L, Goepfert RP, Li J, Ning J, Broaddus R, Weber RS, El-Naggar AK.

Virchows Arch. 2019 Aug 19. doi: 10.1007/s00428-019-02640-7. [Epub ahead of print]

PMID:
31423558
4.

G-protein coupled receptor 64 (GPR64) acts as a tumor suppressor in endometrial cancer.

Ahn JI, Yoo JY, Kim TH, Kim YI, Broaddus RR, Ahn JY, Lim JM, Jeong JW.

BMC Cancer. 2019 Aug 14;19(1):810. doi: 10.1186/s12885-019-5998-1.

5.

Genetic profiling as a clinical tool in advanced parathyroid carcinoma.

Kutahyalioglu M, Nguyen HT, Kwatampora L, Clarke C, Silva A, Ibrahim E, Waguespack SG, Cabanillas ME, Jimenez C, Hu MI, Sherman SI, Kopetz S, Broaddus R, Dadu R, Wanland K, Williams M, Zafereo M, Perrier N, Busaidy NL.

J Cancer Res Clin Oncol. 2019 Aug;145(8):1977-1986. doi: 10.1007/s00432-019-02945-9. Epub 2019 Jul 15.

PMID:
31309300
6.

Fasting Reduces Intestinal Radiotoxicity, Enabling Dose-Escalated Radiation Therapy for Pancreatic Cancer.

de la Cruz Bonilla M, Stemler KM, Jeter-Jones S, Fujimoto TN, Molkentine J, Asencio Torres GM, Zhang X, Broaddus RR, Taniguchi CM, Piwnica-Worms H.

Int J Radiat Oncol Biol Phys. 2019 Nov 1;105(3):537-547. doi: 10.1016/j.ijrobp.2019.06.2533. Epub 2019 Jul 2.

PMID:
31271824
7.

Endometrial cancer with cervical extension in an obese patient: options for surgery versus combined chemoradiotherapy and extra-fascial hysterectomy.

Kassab C, Ramirez PT, Jhingran A, Bhosale P, Broaddus R.

Int J Gynecol Cancer. 2019 Jun;29(5):976-980. doi: 10.1136/ijgc-2019-000587. No abstract available.

PMID:
31155519
8.

Adjuvant combined-modality therapy for stage IIIC endometrioid and non-endometrioid endometrial cancer.

Chapman BV, Swanick CW, Ning MS, Allen PK, Soliman PT, Westin SN, Pardeshi V, Broaddus RR, Lu KH, Jhingran A, Eifel PJ, Klopp AH.

Gynecol Oncol. 2019 Jul;154(1):22-28. doi: 10.1016/j.ygyno.2019.05.002. Epub 2019 May 17.

PMID:
31109659
9.

Liquid Biopsy Assay for Lung Carcinoma Using Centrifuged Supernatants from Fine Needle Aspiration Specimens.

Hannigan B, Ye W, Mehrotra M, Lam V, Bolivar A, Zalles S, Barkoh BA, Duose D, Hu PC, Broaddus R, Stewart J, Heymach J, Medeiros LJ, Wistuba I, Luthra R, Roy-Chowdhuri S.

Ann Oncol. 2019 Mar 18. pii: mdz102. doi: 10.1093/annonc/mdz102. [Epub ahead of print]

PMID:
30887015
10.

PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice.

Zuo X, Deguchi Y, Xu W, Liu Y, Li HS, Wei D, Tian R, Chen W, Xu M, Yang Y, Gao S, Jaoude JC, Liu F, Chrieki SP, Moussalli MJ, Gagea M, Sebastian MM, Zheng X, Tan D, Broaddus R, Wang J, Ajami NJ, Swennes AG, Watowich SS, Shureiqi I.

Gastroenterology. 2019 Jul;157(1):163-178. doi: 10.1053/j.gastro.2019.03.018. Epub 2019 Mar 15.

PMID:
30885780
11.

Clinical and molecular characterization of early-onset colorectal cancer.

Willauer AN, Liu Y, Pereira AAL, Lam M, Morris JS, Raghav KPS, Morris VK, Menter D, Broaddus R, Meric-Bernstam F, Hayes-Jordan A, Huh W, Overman MJ, Kopetz S, Loree JM.

Cancer. 2019 Jun 15;125(12):2002-2010. doi: 10.1002/cncr.31994. Epub 2019 Mar 11.

PMID:
30854646
12.

Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.

Genutis LK, Tomsic J, Bundschuh RA, Brock PL, Williams MD, Roychowdhury S, Reeser JW, Frankel WL, Alsomali M, Routbort MJ, Broaddus RR, Wakely PE Jr, Phay JE, Walker CJ, de la Chapelle A.

Thyroid. 2019 Apr;29(4):523-529. doi: 10.1089/thy.2018.0655. Epub 2019 Mar 27.

PMID:
30747051
13.

Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion.

Liu Y, Deguchi Y, Tian R, Wei D, Wu L, Chen W, Xu W, Xu M, Liu F, Gao S, Jaoude JC, Chrieki SP, Moussalli MJ, Gagea M, Morris J, Broaddus RR, Zuo X, Shureiqi I.

Cancer Res. 2019 Mar 1;79(5):954-969. doi: 10.1158/0008-5472.CAN-18-1790. Epub 2019 Jan 24.

PMID:
30679176
14.

Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer.

Blando J, Sharma A, Higa MG, Zhao H, Vence L, Yadav SS, Kim J, Sepulveda AM, Sharp M, Maitra A, Wargo J, Tetzlaff M, Broaddus R, Katz MHG, Varadhachary GR, Overman M, Wang H, Yee C, Bernatchez C, Iacobuzio-Donahue C, Basu S, Allison JP, Sharma P.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1692-1697. doi: 10.1073/pnas.1811067116. Epub 2019 Jan 11.

15.

Targeted next-generation sequencing of endometrial cancer and matched circulating tumor DNA: identification of plasma-based, tumor-associated mutations in early stage patients.

Bolivar AM, Luthra R, Mehrotra M, Chen W, Barkoh BA, Hu P, Zhang W, Broaddus RR.

Mod Pathol. 2019 Mar;32(3):405-414. doi: 10.1038/s41379-018-0158-8. Epub 2018 Oct 12.

16.

Identification of a subset of microsatellite-stable endometrial carcinoma with high PD-L1 and CD8+ lymphocytes.

Crumley S, Kurnit K, Hudgens C, Fellman B, Tetzlaff MT, Broaddus R.

Mod Pathol. 2019 Mar;32(3):396-404. doi: 10.1038/s41379-018-0148-x. Epub 2018 Oct 5.

17.

Outcome analysis of Phase I trial patients with metastatic KRAS and/or TP53 mutant non-small cell lung cancer.

Wang Y, Wang Z, Piha-Paul S, Janku F, Subbiah V, Shi N, Hess K, Broaddus R, Shan B, Naing A, Hong D, Tsimberidou AM, Karp D, Lu C, Papadimitrakopoulou V, Heymach J, Meric-Bernstam F, Fu S.

Oncotarget. 2018 Sep 7;9(70):33258-33270. doi: 10.18632/oncotarget.25947. eCollection 2018 Sep 7.

18.

Prognostic Implications of Mucinous Differentiation in Metastatic Colorectal Carcinoma Can Be Explained by Distinct Molecular and Clinicopathologic Characteristics.

Khan M, Loree JM, Advani SM, Ning J, Li W, Pereira AAL, Lam M, Raghav K, Morris VK, Broaddus R, Maru D, Overman MJ, Kopetz S.

Clin Colorectal Cancer. 2018 Dec;17(4):e699-e709. doi: 10.1016/j.clcc.2018.07.005. Epub 2018 Jul 17.

19.

The ERM family member Merlin is required for endometrial gland morphogenesis.

Lopez EW, Vue Z, Broaddus RR, Behringer RR, Gladden AB.

Dev Biol. 2018 Oct 15;442(2):301-314. doi: 10.1016/j.ydbio.2018.08.006. Epub 2018 Aug 15.

PMID:
30118662
20.

Survival Outcomes by TP53 Mutation Status in Metastatic Breast Cancer.

Meric-Bernstam F, Zheng X, Shariati M, Damodaran S, Wathoo C, Brusco L, Demirhan ME, Tapia C, Eterovic AK, Basho RK, Ueno NT, Janku F, Sahin A, Rodon J, Broaddus R, Kim TB, Mendelsohn J, Mills Shaw KR, Tripathy D, Mills GB, Chen K.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.17.00245. Epub 2018 Apr 25.

21.

Challenges in next generation sequencing analysis of somatic mutations in transplant patients.

Chen H, Luthra R, Patel KP, Routbort M, Rashid A, Roy-Chowdhuri S, Lazar A, Broaddus R, Manekia J, Singh RR, Yemelyanova A.

Cancer Genet. 2018 Oct;226-227:17-22. doi: 10.1016/j.cancergen.2018.04.119. Epub 2018 May 10.

PMID:
30005850
22.

KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary.

Hillman RT, Celestino J, Terranova C, Beird HC, Gumbs C, Little L, Nguyen T, Thornton R, Tippen S, Zhang J, Lu KH, Gershenson DM, Rai K, Broaddus RR, Futreal PA.

Nat Commun. 2018 Jun 27;9(1):2496. doi: 10.1038/s41467-018-04950-x.

23.

MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT.

Yoo JY, Kang HB, Broaddus RR, Risinger JI, Choi KC, Kim TH.

BMC Cancer. 2018 May 29;18(1):605. doi: 10.1186/s12885-018-4502-7.

24.

Nuclear β-catenin localization and mutation of the CTNNB1 gene: a context-dependent association.

Kim G, Kurnit KC, Djordjevic B, Singh C, Munsell MF, Wang WL, Lazar AJ, Zhang W, Broaddus R.

Mod Pathol. 2018 Oct;31(10):1553-1559. doi: 10.1038/s41379-018-0080-0. Epub 2018 May 24.

25.

Predicting high-risk endometrioid carcinomas using proteins.

Du D, Ma W, Yates MS, Chen T, Lu KH, Lu Y, Weinstein JN, Broaddus RR, Mills GB, Liu Y.

Oncotarget. 2018 Apr 13;9(28):19704-19715. doi: 10.18632/oncotarget.24803. eCollection 2018 Apr 13.

26.

Molecular Landscape of ERBB2/ERBB3 Mutated Colorectal Cancer.

Loree JM, Bailey AM, Johnson AM, Yu Y, Wu W, Bristow CA, Davis JS, Shaw KR, Broaddus R, Banks KC, Lanman RB, Meric-Bernstam F, Overman MJ, Kopetz S, Raghav K.

J Natl Cancer Inst. 2018 Dec 1;110(12):1409-1417. doi: 10.1093/jnci/djy067.

27.

Prospective Randomized Biomarker Study of Metformin and Lifestyle Intervention for Prevention in Obese Women at Increased Risk for Endometrial Cancer.

Yates MS, Coletta AM, Zhang Q, Schmandt RE, Medepalli M, Nebgen D, Soletsky B, Milbourne A, Levy E, Fellman B, Urbauer D, Yuan Y, Broaddus RR, Basen-Engquist K, Lu K.

Cancer Prev Res (Phila). 2018 Aug;11(8):477-490. doi: 10.1158/1940-6207.CAPR-17-0398. Epub 2018 May 1.

28.

Molecular Profile of Advanced Thyroid Carcinomas by Next-Generation Sequencing: Characterizing Tumors Beyond Diagnosis for Targeted Therapy.

Chen H, Luthra R, Routbort MJ, Patel KP, Cabanillas ME, Broaddus RR, Williams MD.

Mol Cancer Ther. 2018 Jul;17(7):1575-1584. doi: 10.1158/1535-7163.MCT-17-0871. Epub 2018 Apr 25.

29.

Detection of somatic mutations in cell-free DNA in plasma and correlation with overall survival in patients with solid tumors.

Mehrotra M, Singh RR, Loghavi S, Duose DY, Barkoh BA, Behrens C, Patel KP, Routbort MJ, Kopetz S, Broaddus RR, Medeiros LJ, Wistuba II, Luthra R.

Oncotarget. 2017 Oct 24;9(12):10259-10271. doi: 10.18632/oncotarget.21982. eCollection 2018 Feb 13.

30.

MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques.

Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2806-2811. doi: 10.1073/pnas.1722106115. Epub 2018 Feb 28.

31.

Salvaging the supernatant: next generation cytopathology for solid tumor mutation profiling.

Roy-Chowdhuri S, Mehrotra M, Bolivar AM, Kanagal-Shamanna R, Barkoh BA, Hannigan B, Zalles S, Ye W, Duose D, Broaddus R, Staerkel G, Wistuba I, Medeiros LJ, Luthra R.

Mod Pathol. 2018 Jul;31(7):1036-1045. doi: 10.1038/s41379-018-0006-x. Epub 2018 Feb 20.

32.

Exon 3 mutations of CTNNB1 drive tumorigenesis: a review.

Gao C, Wang Y, Broaddus R, Sun L, Xue F, Zhang W.

Oncotarget. 2017 Nov 24;9(4):5492-5508. doi: 10.18632/oncotarget.23695. eCollection 2018 Jan 12. Review.

33.

Inhibiting Nuclear Phospho-Progesterone Receptor Enhances Antitumor Activity of Onapristone in Uterine Cancer.

Huang Y, Hu W, Huang J, Shen F, Sun Y, Ivan C, Pradeep S, Dood R, Haemmerle M, Jiang D, Mangala LS, Noh K, Hansen JM, Dalton HJ, Previs RA, Nagaraja AS, McGuire M, Jennings NB, Broaddus R, Coleman RL, Sood AK.

Mol Cancer Ther. 2018 Feb;17(2):464-473. doi: 10.1158/1535-7163.MCT-17-0006. Epub 2017 Dec 13.

34.

Treatment of Low-Risk Endometrial Cancer and Complex Atypical Hyperplasia With the Levonorgestrel-Releasing Intrauterine Device.

Pal N, Broaddus RR, Urbauer DL, Balakrishnan N, Milbourne A, Schmeler KM, Meyer LA, Soliman PT, Lu KH, Ramirez PT, Ramondetta L, Bodurka DC, Westin SN.

Obstet Gynecol. 2018 Jan;131(1):109-116. doi: 10.1097/AOG.0000000000002390.

35.

Molecular Modifiers of Hormone Receptor Action: Decreased Androgen Receptor Expression in Mismatch Repair Deficient Endometrial Endometrioid Adenocarcinoma.

Gan Q, Crumley S, Broaddus RR.

Int J Gynecol Pathol. 2019 Jan;38(1):44-51. doi: 10.1097/PGP.0000000000000465.

PMID:
29210800
36.

Loss of polarity alters proliferation and differentiation in low-grade endometrial cancers by disrupting Notch signaling.

Williams E, Villar-Prados A, Bowser J, Broaddus R, Gladden AB.

PLoS One. 2017 Dec 5;12(12):e0189081. doi: 10.1371/journal.pone.0189081. eCollection 2017.

37.

Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes.

Loree JM, Pereira AAL, Lam M, Willauer AN, Raghav K, Dasari A, Morris VK, Advani S, Menter DG, Eng C, Shaw K, Broaddus R, Routbort MJ, Liu Y, Morris JS, Luthra R, Meric-Bernstam F, Overman MJ, Maru D, Kopetz S.

Clin Cancer Res. 2018 Mar 1;24(5):1062-1072. doi: 10.1158/1078-0432.CCR-17-2484. Epub 2017 Nov 27.

38.

Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials.

MacKay HJ, Levine DA, Bae-Jump VL, Bell DW, McAlpine JN, Santin A, Fleming GF, Mutch DG, Nephew KP, Wentzensen N, Goodfellow PJ, Dorigo O, Nijman HW, Broaddus R, Kohn EC.

Oncotarget. 2017 Aug 3;8(48):84579-84594. doi: 10.18632/oncotarget.19961. eCollection 2017 Oct 13. Review.

39.

Initiative for Molecular Profiling and Advanced Cancer Therapy (IMPACT): An MD Anderson Precision Medicine Study.

Tsimberidou AM, Hong DS, Ye Y, Cartwright C, Wheler JJ, Falchook GS, Naing A, Fu S, Piha-Paul S, Janku F, Meric-Bernstam F, Hwu P, Kee B, Kies MS, Broaddus R, Mendelsohn J, Hess KR, Kurzrock R.

JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.17.00002. Epub 2017 Sep 8.

40.

Erratum to: MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis.

Wang Y, Hu L, Ji P, Teng F, Tian W, Liu Y, Cogdell D, Liu J, Sood AK, Broaddus R, Xue F, Zhang W.

J Hematol Oncol. 2017 Oct 6;10(1):163. doi: 10.1186/s13045-017-0525-9. No abstract available.

41.

MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells.

Yoo JY, Yang WS, Lee JH, Kim BG, Broaddus RR, Lim JM, Kim TH, Jeong JW.

Oncogene. 2018 Jan 11;37(2):255-262. doi: 10.1038/onc.2017.335. Epub 2017 Sep 18.

42.

Validation of Immunohistochemical Assays for Integral Biomarkers in the NCI-MATCH EAY131 Clinical Trial.

Khoury JD, Wang WL, Prieto VG, Medeiros LJ, Kalhor N, Hameed M, Broaddus R, Hamilton SR.

Clin Cancer Res. 2018 Feb 1;24(3):521-531. doi: 10.1158/1078-0432.CCR-17-1597. Epub 2017 Aug 24. Review.

43.

Importance of PCR-based Tumor Testing in the Evaluation of Lynch Syndrome-associated Endometrial Cancer.

Bruegl AS, Kernberg A, Broaddus RR.

Adv Anat Pathol. 2017 Nov;24(6):372-378. doi: 10.1097/PAP.0000000000000169. Review.

44.

Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.

Janouskova H, El Tekle G, Bellini E, Udeshi ND, Rinaldi A, Ulbricht A, Bernasocchi T, Civenni G, Losa M, Svinkina T, Bielski CM, Kryukov GV, Cascione L, Napoli S, Enchev RI, Mutch DG, Carney ME, Berchuck A, Winterhoff BJN, Broaddus RR, Schraml P, Moch H, Bertoni F, Catapano CV, Peter M, Carr SA, Garraway LA, Wild PJ, Theurillat JP.

Nat Med. 2017 Sep;23(9):1046-1054. doi: 10.1038/nm.4372. Epub 2017 Aug 14.

45.

Universal Point of Care Testing for Lynch Syndrome in Patients with Upper Tract Urothelial Carcinoma.

Metcalfe MJ, Petros FG, Rao P, Mork ME, Xiao L, Broaddus RR, Matin SF.

J Urol. 2018 Jan;199(1):60-65. doi: 10.1016/j.juro.2017.08.002. Epub 2017 Aug 7.

PMID:
28797715
46.

Study of Preanalytic and Analytic Variables for Clinical Next-Generation Sequencing of Circulating Cell-Free Nucleic Acid.

Mehrotra M, Singh RR, Chen W, Huang RSP, Almohammedsalim AA, Barkoh BA, Simien CM, Hernandez M, Behrens C, Patel KP, Routbort MJ, Broaddus RR, Medeiros LJ, Wistuba II, Kopetz S, Luthra R.

J Mol Diagn. 2017 Jul;19(4):514-524. doi: 10.1016/j.jmoldx.2017.03.003. Epub 2017 May 12.

PMID:
28506684
47.

Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing.

Le Gallo M, Rudd ML, Urick ME, Hansen NF, Zhang S; NISC Comparative Sequencing Program, Lozy F, Sgroi DC, Vidal Bel A, Matias-Guiu X, Broaddus RR, Lu KH, Levine DA, Mutch DG, Goodfellow PJ, Salvesen HB, Mullikin JC, Bell DW.

Cancer. 2017 Sep 1;123(17):3261-3268. doi: 10.1002/cncr.30745. Epub 2017 May 9.

48.

Factors prognostic of survival in advanced-stage uterine serous carcinoma.

Holman LL, Pal N, Iglesias DA, Soliman PT, Balakrishnan N, Klopp A, Broaddus RR, Fleming ND, Munsell MF, Lu KH, Westin SN.

Gynecol Oncol. 2017 Jul;146(1):27-33. doi: 10.1016/j.ygyno.2017.04.018. Epub 2017 Apr 30.

49.

Antiangiogenesis and gene aberration-related therapy may improve overall survival in patients with concurrent KRAS and TP53 hotspot mutant cancer.

Wang Z, Piha-Paul S, Janku F, Subbiah V, Shi N, Gong J, Wathoo C, Shaw K, Hess K, Broaddus R, Naing A, Hong D, Tsimberidou AM, Karp D, Yao J, Meric-Bernstam F, Fu S.

Oncotarget. 2017 May 16;8(20):33796-33806. doi: 10.18632/oncotarget.16840.

50.

A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory.

Arango NP, Brusco L, Mills Shaw KR, Chen K, Eterovic AK, Holla V, Johnson A, Litzenburger B, Khotskaya YB, Sanchez N, Bailey A, Zheng X, Horombe C, Kopetz S, Farhangfar CJ, Routbort M, Broaddus R, Bernstam EV, Mendelsohn J, Mills GB, Meric-Bernstam F.

Oncotarget. 2017 Jun 27;8(26):41806-41814. doi: 10.18632/oncotarget.16018. Erratum in: Oncotarget. 2019 Aug 27;10(50):5254.

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