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Items: 1 to 50 of 72

1.

Design, synthesis and biological evaluation of inhibitors of cathepsin K on dedifferentiated chondrocytes.

Yuan XY, Ren Z, Wu Y, Bougault C, Brizuela L, Magne D, Buchet R, Mebarek S.

Bioorg Med Chem. 2019 Mar 15;27(6):1034-1042. doi: 10.1016/j.bmc.2019.02.003. Epub 2019 Feb 2.

PMID:
30773420
2.

Pyrocarbon versus cobalt-chromium in the context of spherical interposition implants: an in vitro study on cultured chondrocytes.

Hannoun A, Ouenzerfi G, Brizuela L, Mebarek S, Bougault C, Hassler M, Berthier Y, Trunfio-Sfarghiu AM.

Eur Cell Mater. 2019 Jan 7;37:1-15. doi: 10.22203/eCM.v037a01.

3.

Effects of phospholipase D during cultured osteoblast mineralization and bone formation.

Abdallah D, Skafi N, Hamade E, Borel M, Reibel S, Vitale N, El Jamal A, Bougault C, Laroche N, Vico L, Badran B, Hussein N, Magne D, Buchet R, Brizuela L, Mebarek S.

J Cell Biochem. 2019 Apr;120(4):5923-5935. doi: 10.1002/jcb.27881. Epub 2018 Oct 15.

PMID:
30320913
4.

Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease.

Skafi N, Abdallah D, Soulage C, Reibel S, Vitale N, Hamade E, Faour W, Magne D, Badran B, Hussein N, Buchet R, Brizuela L, Mebarek S.

J Cell Physiol. 2019 Apr;234(4):4825-4839. doi: 10.1002/jcp.27281. Epub 2018 Sep 12.

PMID:
30207376
5.

Multi-scale mechanical characterization of prostate cancer cell lines: Relevant biological markers to evaluate the cell metastatic potential.

Zouaoui J, Trunfio-Sfarghiu AM, Brizuela L, Piednoir A, Maniti O, Munteanu B, Mebarek S, Girard-Egrot A, Landoulsi A, Granjon T.

Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3109-3119. doi: 10.1016/j.bbagen.2017.09.003. Epub 2017 Sep 9.

PMID:
28899829
6.

Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis.

Bougault C, El Jamal A, Briolay A, Mebarek S, Boutet MA, Garraud T, Le Goff B, Blanchard F, Magne D, Brizuela L.

Bone. 2017 Oct;103:150-158. doi: 10.1016/j.bone.2017.07.002. Epub 2017 Jul 3.

PMID:
28684192
7.

Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer.

Bouquerel P, Gstalder C, Müller D, Laurent J, Brizuela L, Sabbadini RA, Malavaud B, Pyronnet S, Martineau Y, Ader I, Cuvillier O.

Oncogenesis. 2016 Mar 14;5:e209. doi: 10.1038/oncsis.2016.13.

8.

Impact of supramolecular interactions of dextran-β-cyclodextrin polymers on invertase activity in freeze-dried systems.

Santagapita PR, Mazzobre MF, Buera MP, Ramirez HL, Brizuela LG, Corti HR, Villalonga R.

Biotechnol Prog. 2015 May-Jun;31(3):791-8. doi: 10.1002/btpr.2067. Epub 2015 Mar 28.

PMID:
25736897
9.

Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1.

Aliouane L, Chao S, Brizuela L, Pfund E, Cuvillier O, Jean L, Renard PY, Lequeux T.

Bioorg Med Chem. 2014 Sep 1;22(17):4955-60. doi: 10.1016/j.bmc.2014.06.038. Epub 2014 Jun 27.

PMID:
25047939
10.

Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells.

Brizuela L, Martin C, Jeannot P, Ader I, Gstalder C, Andrieu G, Bocquet M, Laffosse JM, Gomez-Brouchet A, Malavaud B, Sabbadini RA, Cuvillier O.

Mol Oncol. 2014 Oct;8(7):1181-95. doi: 10.1016/j.molonc.2014.04.001. Epub 2014 Apr 13.

11.

Hypoxia, therapeutic resistance, and sphingosine 1-phosphate.

Cuvillier O, Ader I, Bouquerel P, Brizuela L, Gstalder C, Malavaud B.

Adv Cancer Res. 2013;117:117-41. doi: 10.1016/B978-0-12-394274-6.00005-4. Review.

PMID:
23290779
12.

First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.

Brizuela L, Ader I, Mazerolles C, Bocquet M, Malavaud B, Cuvillier O.

Mol Cancer Ther. 2012 Sep;11(9):1841-51. doi: 10.1158/1535-7163.MCT-12-0227. Epub 2012 Jul 10.

13.

The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.

Haschemi A, Kosma P, Gille L, Evans CR, Burant CF, Starkl P, Knapp B, Haas R, Schmid JA, Jandl C, Amir S, Lubec G, Park J, Esterbauer H, Bilban M, Brizuela L, Pospisilik JA, Otterbein LE, Wagner O.

Cell Metab. 2012 Jun 6;15(6):813-26. doi: 10.1016/j.cmet.2012.04.023.

14.

Biochemical methods for quantifying sphingolipids: ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate.

Brizuela L, Cuvillier O.

Methods Mol Biol. 2012;874:1-20. doi: 10.1007/978-1-61779-800-9_1.

PMID:
22528435
15.

Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection.

Albert FW, Hodges E, Jensen JD, Besnier F, Xuan Z, Rooks M, Bhattacharjee A, Brizuela L, Good JM, Green RE, Burbano HA, Plyusnina IZ, Trut L, Andersson L, Schöneberg T, Carlborg O, Hannon GJ, Pääbo S.

Heredity (Edinb). 2011 Sep;107(3):205-14. doi: 10.1038/hdy.2011.4. Epub 2011 Feb 9.

16.

FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.

Pchejetski D, Bohler T, Brizuela L, Sauer L, Doumerc N, Golzio M, Salunkhe V, Teissié J, Malavaud B, Waxman J, Cuvillier O.

Cancer Res. 2010 Nov 1;70(21):8651-61. doi: 10.1158/0008-5472.CAN-10-1388. Epub 2010 Oct 19.

17.

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.

Qi HH, Sarkissian M, Hu GQ, Wang Z, Bhattacharjee A, Gordon DB, Gonzales M, Lan F, Ongusaha PP, Huarte M, Yaghi NK, Lim H, Garcia BA, Brizuela L, Zhao K, Roberts TM, Shi Y.

Nature. 2010 Jul 22;466(7305):503-7. doi: 10.1038/nature09261. Epub 2010 Jul 11.

18.

The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.

Brizuela L, Dayon A, Doumerc N, Ader I, Golzio M, Izard JC, Hara Y, Malavaud B, Cuvillier O.

FASEB J. 2010 Oct;24(10):3882-94. doi: 10.1096/fj.10-160838. Epub 2010 Jun 3.

PMID:
20522783
19.

Targeted investigation of the Neandertal genome by array-based sequence capture.

Burbano HA, Hodges E, Green RE, Briggs AW, Krause J, Meyer M, Good JM, Maricic T, Johnson PL, Xuan Z, Rooks M, Bhattacharjee A, Brizuela L, Albert FW, de la Rasilla M, Fortea J, Rosas A, Lachmann M, Hannon GJ, Pääbo S.

Science. 2010 May 7;328(5979):723-5. doi: 10.1126/science.1188046.

20.

Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting.

Rosa-Rosa JM, Gracia-Aznárez FJ, Hodges E, Pita G, Rooks M, Xuan Z, Bhattacharjee A, Brizuela L, Silva JM, Hannon GJ, Benitez J.

PLoS One. 2010 Apr 2;5(4):e9976. doi: 10.1371/journal.pone.0009976.

21.

Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting.

Cuvillier O, Ader I, Bouquerel P, Brizuela L, Malavaud B, Mazerolles C, Rischmann P.

Curr Mol Pharmacol. 2010 Jun;3(2):53-65. Review.

PMID:
20302564
22.

Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease.

Gangoiti P, Camacho L, Arana L, Ouro A, Granado MH, Brizuela L, Casas J, Fabriás G, Abad JL, Delgado A, Gómez-Muñoz A.

Prog Lipid Res. 2010 Oct;49(4):316-34. doi: 10.1016/j.plipres.2010.02.004. Epub 2010 Mar 1. Review.

PMID:
20193711
23.

Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes.

Gresham D, Curry B, Ward A, Gordon DB, Brizuela L, Kruglyak L, Botstein D.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1482-7. doi: 10.1073/pnas.0913883107. Epub 2010 Jan 8.

24.

Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival.

Dayon A, Brizuela L, Martin C, Mazerolles C, Pirot N, Doumerc N, Nogueira L, Golzio M, Teissié J, Serre G, Rischmann P, Malavaud B, Cuvillier O.

PLoS One. 2009 Nov 26;4(11):e8048. doi: 10.1371/journal.pone.0008048.

25.

High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.

Hodges E, Smith AD, Kendall J, Xuan Z, Ravi K, Rooks M, Zhang MQ, Ye K, Bhattacharjee A, Brizuela L, McCombie WR, Wigler M, Hannon GJ, Hicks JB.

Genome Res. 2009 Sep;19(9):1593-605. doi: 10.1101/gr.095190.109. Epub 2009 Jul 6.

26.

Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing.

Hodges E, Rooks M, Xuan Z, Bhattacharjee A, Benjamin Gordon D, Brizuela L, Richard McCombie W, Hannon GJ.

Nat Protoc. 2009;4(6):960-74. doi: 10.1038/nprot.2009.68. Epub 2009 May 28.

27.

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.

Guillermet-Guibert J, Davenne L, Pchejetski D, Saint-Laurent N, Brizuela L, Guilbeau-Frugier C, Delisle MB, Cuvillier O, Susini C, Bousquet C.

Mol Cancer Ther. 2009 Apr;8(4):809-20. doi: 10.1158/1535-7163.MCT-08-1096.

28.

Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.

Ader I, Brizuela L, Bouquerel P, Malavaud B, Cuvillier O.

Cancer Res. 2008 Oct 15;68(20):8635-42. doi: 10.1158/0008-5472.CAN-08-0917.

29.

Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets.

Johnson DS, Li W, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P, Koch CM, Dunham I, Bieda M, Xu X, Farnham PJ, Kapranov P, Nix DA, Gingeras TR, Zhang X, Holster H, Jiang N, Green RD, Song JS, McCuine SA, Anton E, Nguyen L, Trinklein ND, Ye Z, Ching K, Hawkins D, Ren B, Scacheri PC, Rozowsky J, Karpikov A, Euskirchen G, Weissman S, Gerstein M, Snyder M, Yang A, Moqtaderi Z, Hirsch H, Shulha HP, Fu Y, Weng Z, Struhl K, Myers RM, Lieb JD, Liu XS.

Genome Res. 2008 Mar;18(3):393-403. doi: 10.1101/gr.7080508. Epub 2008 Feb 7.

30.

Structure/function relationships of several biopolymers as related to invertase stability in dehydrated systems.

Santagapita PR, Brizuela LG, Mazzobre MF, Ramirez HL, Corti HR, Santana RV, Buera MP.

Biomacromolecules. 2008 Feb;9(2):741-7. doi: 10.1021/bm7012108. Epub 2008 Jan 12.

PMID:
18189362
31.

Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways.

Brizuela L, Rábano M, Gangoiti P, Narbona N, Macarulla JM, Trueba M, Gómez-Muñoz A.

J Lipid Res. 2007 Oct;48(10):2264-74. Epub 2007 Jul 3.

32.

A full-genomic sequence-verified protein-coding gene collection for Francisella tularensis.

Murthy T, Rolfs A, Hu Y, Shi Z, Raphael J, Moreira D, Kelley F, McCarron S, Jepson D, Taycher E, Zuo D, Mohr SE, Fernandez M, Brizuela L, LaBaer J.

PLoS One. 2007 Jun 27;2(6):e577.

33.

Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide.

Gomez-Brouchet A, Pchejetski D, Brizuela L, Garcia V, Altié MF, Maddelein ML, Delisle MB, Cuvillier O.

Mol Pharmacol. 2007 Aug;72(2):341-9. Epub 2007 May 23.

PMID:
17522181
34.

Screens using RNAi and cDNA expression as surrogates for genetics in mammalian tissue culture cells.

Pearlberg J, Degot S, Endege W, Park J, Davies J, Gelfand E, Sawyer J, Conery A, Doench J, Li W, Gonzalez L, Boyce FM, Brizuela L, Labaer J, Grueneberg D, Harlow E.

Cold Spring Harb Symp Quant Biol. 2005;70:449-59.

PMID:
16869783
35.

Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion.

Brizuela L, Rábano M, Peña A, Gangoiti P, Macarulla JM, Trueba M, Gómez-Muñoz A.

J Lipid Res. 2006 Jun;47(6):1238-49. Epub 2006 Mar 22.

36.

Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors.

Rossi KA, Markwalder JA, Seitz SP, Chang CH, Cox S, Boisclair MD, Brizuela L, Brenner SL, Stouten PF.

J Comput Aided Mol Des. 2005 Feb;19(2):111-22.

PMID:
16075305
37.

Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.

Park J, Hu Y, Murthy TV, Vannberg F, Shen B, Rolfs A, Hutti JE, Cantley LC, Labaer J, Harlow E, Brizuela L.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8114-9. Epub 2005 May 31.

38.

The Pseudomonas aeruginosa PA01 gene collection.

Labaer J, Qiu Q, Anumanthan A, Mar W, Zuo D, Murthy TV, Taycher H, Halleck A, Hainsworth E, Lory S, Brizuela L.

Genome Res. 2004 Oct;14(10B):2190-200.

39.

High-throughput generation of P. falciparum functional molecules by recombinational cloning.

Aguiar JC, LaBaer J, Blair PL, Shamailova VY, Koundinya M, Russell JA, Huang F, Mar W, Anthony RM, Witney A, Caruana SR, Brizuela L, Sacci JB Jr, Hoffman SL, Carucci DJ.

Genome Res. 2004 Oct;14(10B):2076-82.

40.

Angiotensin II-stimulated cortisol secretion is mediated by phospholipase D.

Rábano M, Peña A, Brizuela L, Macarulla JM, Gómez-Muñoz A, Trueba M.

Mol Cell Endocrinol. 2004 Jul 30;222(1-2):9-20.

PMID:
15249121
41.
42.

Sphingosine-1-phosphate stimulates cortisol secretion.

Rábano M, Peña A, Brizuela L, Marino A, Macarulla JM, Trueba M, Gómez-Muñoz A.

FEBS Lett. 2003 Jan 30;535(1-3):101-5.

43.

The FLEXGene repository: exploiting the fruits of the genome projects by creating a needed resource to face the challenges of the post-genomic era.

Brizuela L, Richardson A, Marsischky G, Labaer J.

Arch Med Res. 2002 Jul-Aug;33(4):318-24. Review.

PMID:
12234520
44.

FLEXGene repository: from sequenced genomes to gene repositories for high-throughput functional biology and proteomics.

Brizuela L, Braun P, LaBaer J.

Mol Biochem Parasitol. 2001 Dec;118(2):155-65. Review.

PMID:
11738706
45.

Identification of selective inhibitors of cyclin dependent kinase 4.

Carini DJ, Kaltenbach RF, Liu J, Benfield PA, Boylan J, Boisclair M, Brizuela L, Burton CR, Cox S, Grafstrom R, Harrison BA, Harrison K, Akamike E, Markwalder JA, Nakano Y, Seitz SP, Sharp DM, Trainor GL, Sielecki TM.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2209-11.

PMID:
11514172
46.

SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4.

Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, Glass S, Parsons T, Copeland RA, Auger KR, Benfield P, Brizuela L, Rolfe M.

Oncogene. 2000 Jul 20;19(31):3529-36.

47.

Structure-activity relationship studies of flavopiridol analogues.

Murthi KK, Dubay M, McClure C, Brizuela L, Boisclair MD, Worland PJ, Mansuri MM, Pal K.

Bioorg Med Chem Lett. 2000 May 15;10(10):1037-41.

PMID:
10843211
48.

Mechanism of Cdk2/Cyclin E inhibition by p27 and p27 phosphorylation.

Xu X, Nakano T, Wick S, Dubay M, Brizuela L.

Biochemistry. 1999 Jul 6;38(27):8713-22.

PMID:
10393546
49.

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.

Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ, Serrano M, Brenner SL, Blundell TL, Laue ED.

Nature. 1998 Sep 17;395(6699):244-50. Erratum in: Nature 1998 Nov 26;396(6709):390.

PMID:
9751051
50.

Structure of the cyclin-dependent kinase inhibitor p19Ink4d.

Luh FY, Archer SJ, Domaille PJ, Smith BO, Owen D, Brotherton DH, Raine AR, Xu X, Brizuela L, Brenner SL, Laue ED.

Nature. 1997 Oct 30;389(6654):999-1003.

PMID:
9353127

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