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Items: 8

1.

Identification and circumvention of bottlenecks in CYP21A2-mediated premedrol production using recombinant Escherichia coli.

König L, Brixius-Anderko S, Milhim M, Tavouli-Abbas D, Hutter MC, Hannemann F, Bernhardt R.

Biotechnol Bioeng. 2019 Dec 8. doi: 10.1002/bit.27246. [Epub ahead of print]

PMID:
31814109
2.

HIV Drug Efavirenz Inhibits CYP21A2 Activity with Possible Clinical Implications.

Malikova J, Zingg T, Fingerhut R, Sluka S, Grössl M, Brixius-Anderko S, Bernhardt R, McDougall J, Pandey AV, Flück CE.

Horm Res Paediatr. 2019;91(4):262-270. doi: 10.1159/000500522. Epub 2019 Jun 28.

PMID:
31256164
3.

Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.

Brixius-Anderko S, Scott EE.

J Biol Chem. 2019 Jan 11;294(2):453-460. doi: 10.1074/jbc.RA118.006214. Epub 2018 Nov 13.

4.

CYP17A1 inhibitor abiraterone, an anti-prostate cancer drug, also inhibits the 21-hydroxylase activity of CYP21A2.

Malikova J, Brixius-Anderko S, Udhane SS, Parween S, Dick B, Bernhardt R, Pandey AV.

J Steroid Biochem Mol Biol. 2017 Nov;174:192-200. doi: 10.1016/j.jsbmb.2017.09.007. Epub 2017 Sep 8.

PMID:
28893623
5.

Biotransformation of the mineralocorticoid receptor antagonists spironolactone and canrenone by human CYP11B1 and CYP11B2: Characterization of the products and their influence on mineralocorticoid receptor transactivation.

Schiffer L, Müller AR, Hobler A, Brixius-Anderko S, Zapp J, Hannemann F, Bernhardt R.

J Steroid Biochem Mol Biol. 2016 Oct;163:68-76. doi: 10.1016/j.jsbmb.2016.04.004. Epub 2016 Apr 25.

PMID:
27125452
6.

An indole-deficient Escherichia coli strain improves screening of cytochromes P450 for biotechnological applications.

Brixius-Anderko S, Hannemann F, Ringle M, Khatri Y, Bernhardt R.

Biotechnol Appl Biochem. 2017 May;64(3):315-326. doi: 10.1002/bab.1488. Epub 2017 Mar 28.

PMID:
26913738
7.

Metabolism of Oral Turinabol by Human Steroid Hormone-Synthesizing Cytochrome P450 Enzymes.

Schiffer L, Brixius-Anderko S, Hannemann F, Zapp J, Neunzig J, Thevis M, Bernhardt R.

Drug Metab Dispos. 2016 Feb;44(2):227-37. doi: 10.1124/dmd.115.066829. Epub 2015 Dec 9.

PMID:
26658226
8.

A CYP21A2 based whole-cell system in Escherichia coli for the biotechnological production of premedrol.

Brixius-Anderko S, Schiffer L, Hannemann F, Janocha B, Bernhardt R.

Microb Cell Fact. 2015 Sep 15;14:135. doi: 10.1186/s12934-015-0333-2.

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