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Items: 1 to 50 of 97


Self-organizing neuruloids model developmental aspects of Huntington's disease in the ectodermal compartment.

Haremaki T, Metzger JJ, Rito T, Ozair MZ, Etoc F, Brivanlou AH.

Nat Biotechnol. 2019 Sep 9. doi: 10.1038/s41587-019-0237-5. [Epub ahead of print]


Mapping cell migrations and fates in a gastruloid model to the human primitive streak.

Martyn I, Siggia ED, Brivanlou AH.

Development. 2019 Sep 12;146(17). pii: dev179564. doi: 10.1242/dev.179564.


A 3D model of a human epiblast reveals BMP4-driven symmetry breaking.

Simunovic M, Metzger JJ, Etoc F, Yoney A, Ruzo A, Martyn I, Croft G, You DS, Brivanlou AH, Siggia ED.

Nat Cell Biol. 2019 Jul;21(7):900-910. doi: 10.1038/s41556-019-0349-7. Epub 2019 Jul 1.


Chick Models and Human-Chick Organizer Grafts.

Martyn I, Kanno TY, Brivanlou AH.

Methods Mol Biol. 2019;2005:77-89. doi: 10.1007/978-1-4939-9524-0_6.


A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells.

Martyn I, Brivanlou AH, Siggia ED.

Development. 2019 Mar 25;146(6). pii: dev172791. doi: 10.1242/dev.172791.


Author Correction: Self-organization of a human organizer by combined Wnt and Nodal signalling.

Martyn I, Kanno TY, Ruzo A, Siggia ED, Brivanlou AH.

Nature. 2018 Dec;564(7735):E10. doi: 10.1038/s41586-018-0583-3.


WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.

Yoney A, Etoc F, Ruzo A, Carroll T, Metzger JJ, Martyn I, Li S, Kirst C, Siggia ED, Brivanlou AH.

Elife. 2018 Oct 12;7. pii: e38279. doi: 10.7554/eLife.38279.


Synthetic embryology: controlling geometry to model early mammalian development.

Metzger JJ, Simunovic M, Brivanlou AH.

Curr Opin Genet Dev. 2018 Oct;52:86-91. doi: 10.1016/j.gde.2018.06.006. Epub 2018 Jun 27. Review.


hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate.

Ozair MZ, Kirst C, van den Berg BL, Ruzo A, Rito T, Brivanlou AH.

Cell Stem Cell. 2018 Jul 5;23(1):60-73.e6. doi: 10.1016/j.stem.2018.05.024. Epub 2018 Jun 21.



Brivanlou AH.

Curr Top Dev Biol. 2018;129:xi-xiii. doi: 10.1016/S0070-2153(18)30058-9. No abstract available.


Self-organization of a human organizer by combined Wnt and Nodal signalling.

Martyn I, Kanno TY, Ruzo A, Siggia ED, Brivanlou AH.

Nature. 2018 Jun;558(7708):132-135. doi: 10.1038/s41586-018-0150-y. Epub 2018 May 23. Erratum in: Nature. 2018 Dec;564(7735):E10.


Chromosomal instability during neurogenesis in Huntington's disease.

Ruzo A, Croft GF, Metzger JJ, Galgoczi S, Gerber LJ, Pellegrini C, Wang H Jr, Fenner M, Tse S, Marks A, Nchako C, Brivanlou AH.

Development. 2018 Jan 29;145(2). pii: dev156844. doi: 10.1242/dev.156844.


At Last: Gene Editing in Human Embryos to Understand Human Development.

Ruzo A, Brivanlou AH.

Cell Stem Cell. 2017 Nov 2;21(5):564-565. doi: 10.1016/j.stem.2017.10.008.


Role of MicroRNAs in Zygotic Genome Activation: Modulation of mRNA During Embryogenesis.

Rosa A, Brivanlou AH.

Methods Mol Biol. 2017;1605:31-43. doi: 10.1007/978-1-4939-6988-3_3. Review.


Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis.

Simunovic M, Brivanlou AH.

Development. 2017 Mar 15;144(6):976-985. doi: 10.1242/dev.143529. Review.


Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.

Qi Y, Zhang XJ, Renier N, Wu Z, Atkin T, Sun Z, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, Ganat Y, Azevedo R, Zeltner N, Brivanlou AH, Karayiorgou M, Gogos J, Tomishima M, Tessier-Lavigne M, Shi SH, Studer L.

Nat Biotechnol. 2017 Feb;35(2):154-163. doi: 10.1038/nbt.3777. Epub 2017 Jan 23.


A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization.

Etoc F, Metzger J, Ruzo A, Kirst C, Yoney A, Ozair MZ, Brivanlou AH, Siggia ED.

Dev Cell. 2016 Nov 7;39(3):302-315. doi: 10.1016/j.devcel.2016.09.016. Epub 2016 Oct 13.


Self-organization of human embryonic stem cells on micropatterns.

Deglincerti A, Etoc F, Guerra MC, Martyn I, Metzger J, Ruzo A, Simunovic M, Yoney A, Brivanlou AH, Siggia E, Warmflash A.

Nat Protoc. 2016 Nov;11(11):2223-2232. doi: 10.1038/nprot.2016.131. Epub 2016 Oct 13.


Self-organization of the in vitro attached human embryo.

Deglincerti A, Croft GF, Pietila LN, Zernicka-Goetz M, Siggia ED, Brivanlou AH.

Nature. 2016 May 12;533(7602):251-4. doi: 10.1038/nature17948. Epub 2016 May 4.


Self-Organization of Spatial Patterning in Human Embryonic Stem Cells.

Deglincerti A, Etoc F, Ozair MZ, Brivanlou AH.

Curr Top Dev Biol. 2016;116:99-113. doi: 10.1016/bs.ctdb.2015.11.010. Epub 2016 Feb 2. Review.


Human SCNT Gets a Boost from Histone Demethylation.

Deglincerti A, Brivanlou AH.

Cell Stem Cell. 2015 Dec 3;17(6):641-642. doi: 10.1016/j.stem.2015.11.014.


Huntingtin is required for ciliogenesis and neurogenesis during early Xenopus development.

Haremaki T, Deglincerti A, Brivanlou AH.

Dev Biol. 2015 Dec 15;408(2):305-15. doi: 10.1016/j.ydbio.2015.07.013. Epub 2015 Jul 17.


Coco is a dual activity modulator of TGFβ signaling.

Deglincerti A, Haremaki T, Warmflash A, Sorre B, Brivanlou AH.

Development. 2015 Aug 1;142(15):2678-85. doi: 10.1242/dev.122358. Epub 2015 Jun 26.


Discovery of novel isoforms of huntingtin reveals a new hominid-specific exon.

Ruzo A, Ismailoglu I, Popowski M, Haremaki T, Croft GF, Deglincerti A, Brivanlou AH.

PLoS One. 2015 May 26;10(5):e0127687. doi: 10.1371/journal.pone.0127687. eCollection 2015.


The generation of sex cells.

Deglincerti A, Brivanlou AH.

Cell Res. 2015 Mar;25(3):267-8. doi: 10.1038/cr.2015.18. Epub 2015 Feb 20.


Encoding of temporal signals by the TGF-β pathway and implications for embryonic patterning.

Sorre B, Warmflash A, Brivanlou AH, Siggia ED.

Dev Cell. 2014 Aug 11;30(3):334-42. doi: 10.1016/j.devcel.2014.05.022. Epub 2014 Jul 24.


A method to recapitulate early embryonic spatial patterning in human embryonic stem cells.

Warmflash A, Sorre B, Etoc F, Siggia ED, Brivanlou AH.

Nat Methods. 2014 Aug;11(8):847-54. doi: 10.1038/nmeth.3016. Epub 2014 Jun 29.


Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells.

Ismailoglu I, Chen Q, Popowski M, Yang L, Gross SS, Brivanlou AH.

Dev Biol. 2014 Jul 15;391(2):230-40. doi: 10.1016/j.ydbio.2014.04.005. Epub 2014 Apr 26.


miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells.

Rosa A, Papaioannou MD, Krzyspiak JE, Brivanlou AH.

Dev Biol. 2014 Jul 1;391(1):81-8. doi: 10.1016/j.ydbio.2014.03.020. Epub 2014 Apr 4.


Coco regulates dorsoventral specification of germ layers via inhibition of TGFβ signalling.

Bates TJ, Vonica A, Heasman J, Brivanlou AH, Bell E.

Development. 2013 Oct;140(20):4177-81. doi: 10.1242/dev.095521. Epub 2013 Sep 11.


Neural induction and early patterning in vertebrates.

Ozair MZ, Kintner C, Brivanlou AH.

Wiley Interdiscip Rev Dev Biol. 2013 Jul;2(4):479-98. doi: 10.1002/wdev.90. Epub 2012 Oct 15. Review.


Regulatory non-coding RNAs in pluripotent stem cells.

Rosa A, Brivanlou AH.

Int J Mol Sci. 2013 Jul 11;14(7):14346-73. doi: 10.3390/ijms140714346. Review.


Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.

Whitman M, Rosen V, Brivanlou AH, Groppe JC, Sebald W, Mueller T.

Nat Med. 2013 Jul;19(7):809-10. doi: 10.1038/nm.3080. No abstract available.


SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism.

Ozair MZ, Noggle S, Warmflash A, Krzyspiak JE, Brivanlou AH.

Stem Cells. 2013 Jan;31(1):35-47. doi: 10.1002/stem.1246.


Signaling dynamics and embryonic development.

Warmflash A, Siggia ED, Brivanlou AH.

Cell Cycle. 2012 Oct 1;11(19):3529-30. doi: 10.4161/cc.21964. Epub 2012 Aug 30. No abstract available.


The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites.

Gao H, Chakraborty G, Lee-Lim AP, Mo Q, Decker M, Vonica A, Shen R, Brogi E, Brivanlou AH, Giancotti FG.

Cell. 2012 Aug 17;150(4):764-79. doi: 10.1016/j.cell.2012.06.035. Erratum in: Cell. 2012 Dec 7;151(6):1386-8.


Modulation of FOXD3 activity in human embryonic stem cells directs pluripotency and paraxial mesoderm fates.

Arduini BL, Brivanlou AH.

Stem Cells. 2012 Oct;30(10):2188-98. doi: 10.1002/stem.1200.


The molecular circuitry underlying pluripotency in embryonic stem cells.

Warmflash A, Arduini BL, Brivanlou AH.

Wiley Interdiscip Rev Syst Biol Med. 2012 Sep-Oct;4(5):443-56. doi: 10.1002/wsbm.1182. Epub 2012 Jul 3. Review.


Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4.

Warmflash A, Zhang Q, Sorre B, Vonica A, Siggia ED, Brivanlou AH.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):E1947-56. doi: 10.1073/pnas.1207607109. Epub 2012 Jun 11.


A taste of TGFβ in Tuscany.

Hata A, Brivanlou AH.

Development. 2012 Feb;139(3):449-53. doi: 10.1242/dev.067249.


A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation.

Rosa A, Brivanlou AH.

EMBO J. 2011 Jan 19;30(2):237-48. doi: 10.1038/emboj.2010.319. Epub 2010 Dec 10.


Synthetic mRNAs: powerful tools for reprogramming and differentiation of human cells.

Rosa A, Brivanlou AH.

Cell Stem Cell. 2010 Nov 5;7(5):549-50. doi: 10.1016/j.stem.2010.10.002.


APOBEC2, a selective inhibitor of TGFβ signaling, regulates left-right axis specification during early embryogenesis.

Vonica A, Rosa A, Arduini BL, Brivanlou AH.

Dev Biol. 2011 Feb 1;350(1):13-23. doi: 10.1016/j.ydbio.2010.09.016. Epub 2010 Sep 27.


APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex.

Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou AH, Barres BA, Christiano AM.

Nature. 2010 Apr 15;464(7291):1043-7. doi: 10.1038/nature08875.


MicroRNAs in early vertebrate development.

Rosa A, Brivanlou AH.

Cell Cycle. 2009 Nov 1;8(21):3513-20. Epub 2009 Nov 18. Review.


Scaling of BMP gradients in Xenopus embryos.

Francois P, Vonica A, Brivanlou AH, Siggia ED.

Nature. 2009 Sep 3;461(7260):E1; discussion E2.


An efficient and reversible transposable system for gene delivery and lineage-specific differentiation in human embryonic stem cells.

Lacoste A, Berenshteyn F, Brivanlou AH.

Cell Stem Cell. 2009 Sep 4;5(3):332-42. doi: 10.1016/j.stem.2009.07.011. Erratum in: Cell Stem Cell. 2009 Nov 6;5(5):568.


Bone morphogenetic protein 15 (BMP15) acts as a BMP and Wnt inhibitor during early embryogenesis.

Di Pasquale E, Brivanlou AH.

J Biol Chem. 2009 Sep 18;284(38):26127-36. doi: 10.1074/jbc.M109.036608. Epub 2009 Jun 24.


The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selection.

Rosa A, Spagnoli FM, Brivanlou AH.

Dev Cell. 2009 Apr;16(4):517-27. doi: 10.1016/j.devcel.2009.02.007.

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