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Levofloxacin versus placebo for the treatment of latent tuberculosis among contacts of patients with multidrug-resistant tuberculosis (the VQUIN MDR trial): a protocol for a randomised controlled trial.

Fox GJ, Nguyen CB, Nguyen TA, Tran PT, Marais BJ, Graham SM, Nguyen BH, Velen K, Dowdy DW, Mason P, Britton WJ, Behr MA, Benedetti A, Menzies D, Nguyen VN, Marks GB.

BMJ Open. 2020 Jan 2;10(1):e033945. doi: 10.1136/bmjopen-2019-033945.


Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo.

Stifter SA, Bhattacharyya N, Sawyer AJ, Cootes TA, Stambas J, Doyle SE, Feigenbaum L, Paul WE, Britton WJ, Sher A, Feng CG.

Cell Rep. 2019 Dec 10;29(11):3539-3550.e4. doi: 10.1016/j.celrep.2019.11.021.


Management of Australian Adults with Bronchiectasis in Tertiary Care: Evidence-Based or Access-Driven?

Visser SK, Bye PTP, Fox GJ, Burr LD, Chang AB, Holmes-Liew CL, King P, Middleton PG, Maguire GP, Smith D, Thomson RM, Stroil-Salama E, Britton WJ, Morgan LC.

Lung. 2019 Dec;197(6):803-810. doi: 10.1007/s00408-019-00280-x. Epub 2019 Nov 5.


Community-wide Screening for Tuberculosis in a High-Prevalence Setting.

Marks GB, Nguyen NV, Nguyen PTB, Nguyen TA, Nguyen HB, Tran KH, Nguyen SV, Luu KB, Tran DTT, Vo QTN, Le OTT, Nguyen YH, Do VQ, Mason PH, Nguyen VT, Ho J, Sintchenko V, Nguyen LN, Britton WJ, Fox GJ.

N Engl J Med. 2019 Oct 3;381(14):1347-1357. doi: 10.1056/NEJMoa1902129.


Inhalable combination powder formulations of phage and ciprofloxacin for P. aeruginosa respiratory infections.

Lin Y, Chang RYK, Britton WJ, Morales S, Kutter E, Li J, Chan HK.

Eur J Pharm Biopharm. 2019 Sep;142:543-552. doi: 10.1016/j.ejpb.2019.08.004. Epub 2019 Aug 6.


Mucosal Vaccination with a Self-Adjuvanted Lipopeptide Is Immunogenic and Protective against Mycobacterium tuberculosis.

Ashhurst AS, McDonald DM, Hanna CC, Stanojevic VA, Britton WJ, Payne RJ.

J Med Chem. 2019 Sep 12;62(17):8080-8089. doi: 10.1021/acs.jmedchem.9b00832. Epub 2019 Aug 16.


Australian adults with bronchiectasis: The first report from the Australian Bronchiectasis Registry.

Visser SK, Bye PTP, Fox GJ, Burr LD, Chang AB, Holmes-Liew CL, King P, Middleton PG, Maguire GP, Smith D, Thomson RM, Stroil-Salama E, Britton WJ, Morgan LC.

Respir Med. 2019 Aug;155:97-103. doi: 10.1016/j.rmed.2019.07.016. Epub 2019 Jul 16.


CXCR6-Deficiency Improves the Control of Pulmonary Mycobacterium tuberculosis and Influenza Infection Independent of T-Lymphocyte Recruitment to the Lungs.

Ashhurst AS, Flórido M, Lin LCW, Quan D, Armitage E, Stifter SA, Stambas J, Britton WJ.

Front Immunol. 2019 Mar 7;10:339. doi: 10.3389/fimmu.2019.00339. eCollection 2019.


The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets.

Black HD, Xu W, Hortle E, Robertson SI, Britton WJ, Kaur A, New EJ, Witting PK, Chami B, Oehlers SH.

Free Radic Biol Med. 2019 May 1;135:157-166. doi: 10.1016/j.freeradbiomed.2019.03.010. Epub 2019 Mar 14.


Thrombocyte Inhibition Restores Protective Immunity to Mycobacterial Infection in Zebrafish.

Hortle E, Johnson KE, Johansen MD, Nguyen T, Shavit JA, Britton WJ, Tobin DM, Oehlers SH.

J Infect Dis. 2019 Jul 2;220(3):524-534. doi: 10.1093/infdis/jiz110.


Deciphering protective immunity against tuberculosis: implications for vaccine development.

Counoupas C, Triccas JA, Britton WJ.

Expert Rev Vaccines. 2019 Apr;18(4):353-364. doi: 10.1080/14760584.2019.1585246. Epub 2019 Mar 4.


Household contact investigation for the detection of tuberculosis in Vietnam: economic evaluation of a cluster-randomised trial.

Lung T, Marks GB, Nhung NV, Anh NT, Hoa NLP, Anh LTN, Hoa NB, Britton WJ, Bestrashniy J, Jan S, Fox GJ.

Lancet Glob Health. 2019 Mar;7(3):e376-e384. doi: 10.1016/S2214-109X(18)30520-5.


Jet nebulization of bacteriophages with different tail morphologies - Structural effects.

Leung SSY, Carrigy NB, Vehring R, Finlay WH, Morales S, Carter EA, Britton WJ, Kutter E, Chan HK.

Int J Pharm. 2019 Jan 10;554:322-326. doi: 10.1016/j.ijpharm.2018.11.026. Epub 2018 Nov 13.


Synergy of nebulized phage PEV20 and ciprofloxacin combination against Pseudomonas aeruginosa.

Lin Y, Chang RYK, Britton WJ, Morales S, Kutter E, Chan HK.

Int J Pharm. 2018 Nov 15;551(1-2):158-165. doi: 10.1016/j.ijpharm.2018.09.024. Epub 2018 Sep 14.


Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility.

Johansen MD, Hortle E, Kasparian JA, Romero A, Novoa B, Figueras A, Britton WJ, de Silva K, Purdie AC, Oehlers SH.

Fish Shellfish Immunol. 2018 Dec;83:238-242. doi: 10.1016/j.fsi.2018.09.037. Epub 2018 Sep 13.


Post-treatment Mortality Among Patients With Tuberculosis: A Prospective Cohort Study of 10 964 Patients in Vietnam.

Fox GJ, Nguyen VN, Dinh NS, Nghiem LPH, Le TNA, Nguyen TA, Nguyen BH, Nguyen HD, Tran NB, Nguyen TL, Le TN, Nguyen VH, Phan TL, Nguyen KC, Ho J, Pham DC, Britton WJ, Bestrashniy JRBM, Marks GB.

Clin Infect Dis. 2019 Apr 8;68(8):1359-1366. doi: 10.1093/cid/ciy665.


Pulmonary immunization with a recombinant influenza A virus vaccine induces lung-resident CD4+ memory T cells that are associated with protection against tuberculosis.

Flórido M, Muflihah H, Lin LCW, Xia Y, Sierro F, Palendira M, Feng CG, Bertolino P, Stambas J, Triccas JA, Britton WJ.

Mucosal Immunol. 2018 Nov;11(6):1743-1752. doi: 10.1038/s41385-018-0065-9. Epub 2018 Aug 16.


Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models.

Johansen MD, Kasparian JA, Hortle E, Britton WJ, Purdie AC, Oehlers SH.

Dev Comp Immunol. 2018 Nov;88:169-172. doi: 10.1016/j.dci.2018.07.022. Epub 2018 Jul 21.


Recurrence of tuberculosis among patients following treatment completion in eight provinces of Vietnam: A nested case-control study.

Bestrashniy JRBM, Nguyen VN, Nguyen TL, Pham TL, Nguyen TA, Pham DC, Nghiem LPH, Le TNA, Nguyen BH, Nguyen KC, Nguyen HD, Buu TN, Le TN, Nguyen VH, Dinh NS, Britton WJ, Marks GB, Fox GJ.

Int J Infect Dis. 2018 Sep;74:31-37. doi: 10.1016/j.ijid.2018.06.013. Epub 2018 Jun 23.


Cohort profile: The Childhood Asthma Prevention Study (CAPS).

Garden FL, Toelle BG, Mihrshahi S, Webb KL, Almqvist C, Tovey ER, Brew BK, Ayer JG, Skilton MR, Jones G, Ferreira MAR, Cowie CT, Weber-Chrysochoou C, Britton WJ, Celermajer DS, Leeder SR, Peat JK, Marks GB.

Int J Epidemiol. 2018 Dec 1;47(6):1736-1736k. doi: 10.1093/ije/dyy078. No abstract available.


Identification of a plasma microRNA profile in untreated pulmonary tuberculosis patients that is modulated by anti-mycobacterial therapy.

Barry SE, Ellis M, Yang Y, Guan G, Wang X, Britton WJ, Saunders BM.

J Infect. 2018 Oct;77(4):341-348. doi: 10.1016/j.jinf.2018.03.006. Epub 2018 May 7.


Protective efficacy of recombinant BCG over-expressing protective, stage-specific antigens of Mycobacterium tuberculosis.

Counoupas C, Pinto R, Nagalingam G, Britton WJ, Triccas JA.

Vaccine. 2018 May 3;36(19):2619-2629. doi: 10.1016/j.vaccine.2018.03.066. Epub 2018 Apr 5.


Sequential pulmonary immunization with heterologous recombinant influenza A virus tuberculosis vaccines protects against murine M. tuberculosis infection.

Muflihah H, Flórido M, Lin LCW, Xia Y, Triccas JA, Stambas J, Britton WJ.

Vaccine. 2018 Apr 25;36(18):2462-2470. doi: 10.1016/j.vaccine.2018.03.037. Epub 2018 Mar 27.


CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti-PD-1 Treatment.

Edwards J, Wilmott JS, Madore J, Gide TN, Quek C, Tasker A, Ferguson A, Chen J, Hewavisenti R, Hersey P, Gebhardt T, Weninger W, Britton WJ, Saw RPM, Thompson JF, Menzies AM, Long GV, Scolyer RA, Palendira U.

Clin Cancer Res. 2018 Jul 1;24(13):3036-3045. doi: 10.1158/1078-0432.CCR-17-2257. Epub 2018 Mar 29.


Childhood fish oil supplementation modifies associations between traffic related air pollution and allergic sensitisation.

Hansell AL, Bakolis I, Cowie CT, Belousova EG, Ng K, Weber-Chrysochoou C, Britton WJ, Leeder SR, Tovey ER, Webb KL, Toelle BG, Marks GB.

Environ Health. 2018 Mar 27;17(1):27. doi: 10.1186/s12940-018-0370-5.


PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection.

Ashhurst AS, Parumasivam T, Chan JGY, Lin LCW, Flórido M, West NP, Chan HK, Britton WJ.

PLoS One. 2018 Mar 19;13(3):e0194620. doi: 10.1371/journal.pone.0194620. eCollection 2018.


Effect of storage temperature on the stability of spray dried bacteriophage powders.

Leung SSY, Parumasivam T, Nguyen A, Gengenbach T, Carter EA, Carrigy NB, Wang H, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan HK.

Eur J Pharm Biopharm. 2018 Jun;127:213-222. doi: 10.1016/j.ejpb.2018.02.033. Epub 2018 Feb 24.


Total Synthesis of Ecumicin.

Hawkins PME, Giltrap AM, Nagalingam G, Britton WJ, Payne RJ.

Org Lett. 2018 Feb 16;20(4):1019-1022. doi: 10.1021/acs.orglett.7b03967. Epub 2018 Feb 7.


Household-Contact Investigation for Detection of Tuberculosis in Vietnam.

Fox GJ, Nhung NV, Sy DN, Hoa NLP, Anh LTN, Anh NT, Hoa NB, Dung NH, Buu TN, Loi NT, Nhung LT, Hung NV, Lieu PT, Cuong NK, Cuong PD, Bestrashniy J, Britton WJ, Marks GB.

N Engl J Med. 2018 Jan 18;378(3):221-229. doi: 10.1056/NEJMoa1700209.


A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans.

Zhang G, deWeerd NA, Stifter SA, Liu L, Zhou B, Wang W, Zhou Y, Ying B, Hu X, Matthews AY, Ellis M, Triccas JA, Hertzog PJ, Britton WJ, Chen X, Feng CG.

Nat Commun. 2018 Jan 8;9(1):85. doi: 10.1038/s41467-017-02611-z.


Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection.

Counoupas C, Pinto R, Nagalingam G, Britton WJ, Petrovsky N, Triccas JA.

Sci Rep. 2017 Aug 17;7(1):8582. doi: 10.1038/s41598-017-09119-y.


A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment.

Sierro F, Evrard M, Rizzetto S, Melino M, Mitchell AJ, Florido M, Beattie L, Walters SB, Tay SS, Lu B, Holz LE, Roediger B, Wong YC, Warren A, Ritchie W, McGuffog C, Weninger W, Le Couteur DG, Ginhoux F, Britton WJ, Heath WR, Saunders BM, McCaughan GW, Luciani F, MacDonald KPA, Ng LG, Bowen DG, Bertolino P.

Immunity. 2017 Aug 15;47(2):374-388.e6. doi: 10.1016/j.immuni.2017.07.018.


Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis-Induced Inflammation.

Nagalingam G, Vinuesa CG, Britton WJ, Saunders BM.

J Immunol. 2017 Sep 1;199(5):1796-1804. doi: 10.4049/jimmunol.1602069. Epub 2017 Jul 26.


Anti-Tuberculosis Bacteriophage D29 Delivery with a Vibrating Mesh Nebulizer, Jet Nebulizer, and Soft Mist Inhaler.

Carrigy NB, Chang RY, Leung SSY, Harrison M, Petrova Z, Pope WH, Hatfull GF, Britton WJ, Chan HK, Sauvageau D, Finlay WH, Vehring R.

Pharm Res. 2017 Oct;34(10):2084-2096. doi: 10.1007/s11095-017-2213-4. Epub 2017 Jun 23.


Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.

Tran AT, Watson EE, Pujari V, Conroy T, Dowman LJ, Giltrap AM, Pang A, Wong WR, Linington RG, Mahapatra S, Saunders J, Charman SA, West NP, Bugg TD, Tod J, Dowson CG, Roper DI, Crick DC, Britton WJ, Payne RJ.

Nat Commun. 2017 Mar 1;8:14414. doi: 10.1038/ncomms14414.


Effects of storage conditions on the stability of spray dried, inhalable bacteriophage powders.

Leung SSY, Parumasivam T, Gao FG, Carter EA, Carrigy NB, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan HK.

Int J Pharm. 2017 Apr 15;521(1-2):141-149. doi: 10.1016/j.ijpharm.2017.01.060. Epub 2017 Feb 3.


Inhalation of Respirable Crystalline Rifapentine Particles Induces Pulmonary Inflammation.

Parumasivam T, Ashhurst AS, Nagalingam G, Britton WJ, Chan HK.

Mol Pharm. 2017 Jan 3;14(1):328-335. doi: 10.1021/acs.molpharmaceut.6b00905. Epub 2016 Dec 15.


Mycobacterium tuberculosis Infection Manipulates the Glycosylation Machinery and the N-Glycoproteome of Human Macrophages and Their Microparticles.

Hare NJ, Lee LY, Loke I, Britton WJ, Saunders BM, Thaysen-Andersen M.

J Proteome Res. 2017 Jan 6;16(1):247-263. doi: 10.1021/acs.jproteome.6b00685. Epub 2016 Nov 4.


Mycobacterium tuberculosis components expressed during chronic infection of the lung contribute to long-term control of pulmonary tuberculosis in mice.

Counoupas C, Pinto R, Nagalingam G, Hill-Cawthorne GA, Feng CG, Britton WJ, Triccas JA.

NPJ Vaccines. 2016 Sep 15;1:16012. doi: 10.1038/npjvaccines.2016.12. eCollection 2016.


Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs.

Woon HG, Braun A, Li J, Smith C, Edwards J, Sierro F, Feng CG, Khanna R, Elliot M, Bell A, Hislop AD, Tangye SG, Rickinson AB, Gebhardt T, Britton WJ, Palendira U.

PLoS Pathog. 2016 Aug 19;12(8):e1005799. doi: 10.1371/journal.ppat.1005799. eCollection 2016 Aug.


Influence of phthiocerol dimycocerosate on CD4(+) T cell priming and persistence during Mycobacterium tuberculosis infection.

Pinto R, Nambiar JK, Leotta L, Counoupas C, Britton WJ, Triccas JA.

Tuberculosis (Edinb). 2016 Jul;99:25-30. doi: 10.1016/ Epub 2016 Apr 4.


In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment.

Parumasivam T, Chan JG, Pang A, Quan DH, Triccas JA, Britton WJ, Chan HK.

Eur J Pharm Biopharm. 2016 Oct;107:205-14. doi: 10.1016/j.ejpb.2016.07.014. Epub 2016 Jul 12.


Comparable CD4 and CD8 T cell responses and cytokine release after at-birth and delayed BCG immunisation in infants born in Australia.

Ritz N, Casalaz D, Donath S, Tebruegge M, Dutta B, Connell TG, Robins-Browne R, Britton WJ, Hanekom WA, Curtis N.

Vaccine. 2016 Jul 29;34(35):4132-4139. doi: 10.1016/j.vaccine.2016.06.077. Epub 2016 Jul 5.


Dry powder inhalable formulations for anti-tubercular therapy.

Parumasivam T, Chang RY, Abdelghany S, Ye TT, Britton WJ, Chan HK.

Adv Drug Deliv Rev. 2016 Jul 1;102:83-101. doi: 10.1016/j.addr.2016.05.011. Epub 2016 May 17. Review.


Total Synthesis of Teixobactin.

Giltrap AM, Dowman LJ, Nagalingam G, Ochoa JL, Linington RG, Britton WJ, Payne RJ.

Org Lett. 2016 Jun 3;18(11):2788-91. doi: 10.1021/acs.orglett.6b01324. Epub 2016 May 18.


Rifapentine-loaded PLGA microparticles for tuberculosis inhaled therapy: Preparation and in vitro aerosol characterization.

Parumasivam T, Leung SS, Quan DH, Triccas JA, Britton WJ, Chan HK.

Eur J Pharm Sci. 2016 Jun 10;88:1-11. doi: 10.1016/j.ejps.2016.03.024. Epub 2016 Apr 2.


Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections.

Leung SS, Parumasivam T, Gao FG, Carrigy NB, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan HK.

Pharm Res. 2016 Jun;33(6):1486-96. doi: 10.1007/s11095-016-1892-6. Epub 2016 Feb 29.


In Vitro Evaluation of Inhalable Verapamil-Rifapentine Particles for Tuberculosis Therapy.

Parumasivam T, Chan JG, Pang A, Quan DH, Triccas JA, Britton WJ, Chan HK.

Mol Pharm. 2016 Mar 7;13(3):979-89. doi: 10.1021/acs.molpharmaceut.5b00833. Epub 2016 Feb 12.


Functional Interplay between Type I and II Interferons Is Essential to Limit Influenza A Virus-Induced Tissue Inflammation.

Stifter SA, Bhattacharyya N, Pillay R, Flórido M, Triccas JA, Britton WJ, Feng CG.

PLoS Pathog. 2016 Jan 5;12(1):e1005378. doi: 10.1371/journal.ppat.1005378. eCollection 2016 Jan.


Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon inducible proteins including ISG15.

Hare NJ, Chan B, Chan E, Kaufman KL, Britton WJ, Saunders BM.

Proteomics. 2015 Sep;15(17):3020-9. doi: 10.1002/pmic.201400610. Epub 2015 Jul 3.


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