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Items: 17


Detection of Plasma Curcuminoids from Dietary Intake of Turmeric-Containing Food in Human Volunteers.

Mahale J, Singh R, Howells LM, Britton RG, Khan SM, Brown K.

Mol Nutr Food Res. 2018 Aug;62(16):e1800267. doi: 10.1002/mnfr.201800267. Epub 2018 Jul 10.


An HPLC-UV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue: Potential for preclinical applications.

Mahale J, Howells LM, Singh R, Britton RG, Cai H, Brown K.

Biomed Chromatogr. 2018 May 9:e4280. doi: 10.1002/bmc.4280. [Epub ahead of print]


Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.

Cai H, Scott E, Kholghi A, Andreadi C, Rufini A, Karmokar A, Britton RG, Horner-Glister E, Greaves P, Jawad D, James M, Howells L, Ognibene T, Malfatti M, Goldring C, Kitteringham N, Walsh J, Viskaduraki M, West K, Miller A, Hemingway D, Steward WP, Gescher AJ, Brown K.

Sci Transl Med. 2015 Jul 29;7(298):298ra117. doi: 10.1126/scitranslmed.aaa7619.


Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms.

Britton RG, Kovoor C, Brown K.

Ann N Y Acad Sci. 2015 Aug;1348(1):124-33. doi: 10.1111/nyas.12796. Epub 2015 Jun 22. Review.


Inhibition of prostate cancer cell growth by 3',4',5'-trimethoxyflavonol (TMFol).

Hill CU, Saad SE, Britton RG, Gescher AJ, Sale S, Brown K, Howells LM.

Cancer Chemother Pharmacol. 2015 Jul;76(1):179-85. doi: 10.1007/s00280-015-2771-2. Epub 2015 May 29.


Resveratrol-sulfates provide an intracellular reservoir for generation of parent resveratrol, which induces autophagy in cancer cells.

Andreadi C, Britton RG, Patel KR, Brown K.

Autophagy. 2014 Mar;10(3):524-5. doi: 10.4161/auto.27593. Epub 2014 Jan 9. Review.


Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence.

Patel KR, Andreadi C, Britton RG, Horner-Glister E, Karmokar A, Sale S, Brown VA, Brenner DE, Singh R, Steward WP, Gescher AJ, Brown K.

Sci Transl Med. 2013 Oct 2;5(205):205ra133. doi: 10.1126/scitranslmed.3005870.


Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.

Irving GR, Howells LM, Sale S, Kralj-Hans I, Atkin WS, Clark SK, Britton RG, Jones DJ, Scott EN, Berry DP, Hemingway D, Miller AS, Brown K, Gescher AJ, Steward WP.

Cancer Prev Res (Phila). 2013 Feb;6(2):119-28. doi: 10.1158/1940-6207.CAPR-12-0281. Epub 2012 Dec 11.


Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.

Britton RG, Horner-Glister E, Pomenya OA, Smith EE, Denton R, Jenkins PR, Steward WP, Brown K, Gescher A, Sale S.

Eur J Med Chem. 2012 Aug;54:952-8. doi: 10.1016/j.ejmech.2012.06.031. Epub 2012 Jun 22.


Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice.

Saad SE, Jones DJ, Norris LM, Horner-Glister E, Patel KR, Britton RG, Steward WP, Gescher AJ, Brown K, Sale S.

Biomed Chromatogr. 2012 Dec;26(12):1559-66. doi: 10.1002/bmc.2732. Epub 2012 Mar 27.


Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

Patel KR, Brown VA, Jones DJ, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K.

Cancer Res. 2010 Oct 1;70(19):7392-9. doi: 10.1158/0008-5472.CAN-10-2027. Epub 2010 Sep 14.


Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue.

Howells LM, Britton RG, Mazzoletti M, Greaves P, Broggini M, Brown K, Steward WP, Gescher AJ, Sale S.

Cancer Prev Res (Phila). 2010 Aug;3(8):929-39. doi: 10.1158/1940-6207.CAPR-09-0236. Epub 2010 Jul 13.


Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone).

Cai H, Sale S, Britton RG, Brown K, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2011 Feb;67(2):255-63. doi: 10.1007/s00280-010-1313-1. Epub 2010 Apr 4.


Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy.

Cai H, Sale S, Schmid R, Britton RG, Brown K, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2009 Aug;2(8):743-50. doi: 10.1158/1940-6207.CAPR-09-0081. Epub 2009 Jul 28.


Synthesis of the flavonoid 3',4',5'-trimethoxyflavonol and its determination in plasma and tissues of mice by HPLC with fluorescence detection.

Britton RG, Fong I, Saad S, Brown K, Steward WP, Gescher A, Sale S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 1;877(10):939-42. doi: 10.1016/j.jchromb.2009.02.043. Epub 2009 Feb 24.


Dose-response relationships for N7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide: evidence for a novel mechanism of endogenous adduct formation.

Marsden DA, Jones DJ, Britton RG, Ognibene T, Ubick E, Johnson GE, Farmer PB, Brown K.

Cancer Res. 2009 Apr 1;69(7):3052-9. doi: 10.1158/0008-5472.CAN-08-4233. Epub 2009 Mar 10.


Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4.

Jenkins PR, Wilson J, Emmerson D, Garcia MD, Smith MR, Gray SJ, Britton RG, Mahale S, Chaudhuri B.

Bioorg Med Chem. 2008 Aug 15;16(16):7728-39. doi: 10.1016/j.bmc.2008.07.002. Epub 2008 Jul 8.


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