Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 140

1.

Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.

Goss CH, Kaneko Y, Khuu L, Anderson GD, Ravishankar S, Aitken ML, Lechtzin N, Zhou G, Czyz DM, McLean K, Olakanmi O, Shuman HA, Teresi M, Wilhelm E, Caldwell E, Salipante SJ, Hornick DB, Siehnel RJ, Becker L, Britigan BE, Singh PK.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaat7520. doi: 10.1126/scitranslmed.aat7520.

PMID:
30257953
2.

In Vitro Efficacy of Free and Nanoparticle Formulations of Gallium(III) meso-Tetraphenylporphyrine against Mycobacterium avium and Mycobacterium abscessus and Gallium Biodistribution in Mice.

Choi SR, Britigan BE, Switzer B, Hoke T, Moran D, Narayanasamy P.

Mol Pharm. 2018 Mar 5;15(3):1215-1225. doi: 10.1021/acs.molpharmaceut.7b01036. Epub 2018 Feb 16.

PMID:
29421865
3.

Pseudomonas Quinolone Signal Induces Oxidative Stress and Inhibits Heme Oxygenase-1 Expression in Lung Epithelial Cells.

Abdalla MY, Hoke T, Seravalli J, Switzer BL, Bavitz M, Fliege JD, Murphy PJ, Britigan BE.

Infect Immun. 2017 Aug 18;85(9). pii: e00176-17. doi: 10.1128/IAI.00176-17. Print 2017 Sep.

4.

Gallium nanoparticles facilitate phagosome maturation and inhibit growth of virulent Mycobacterium tuberculosis in macrophages.

Choi SR, Britigan BE, Moran DM, Narayanasamy P.

PLoS One. 2017 May 18;12(5):e0177987. doi: 10.1371/journal.pone.0177987. eCollection 2017.

5.

Passive transfer of interferon-γ over-expressing macrophages enhances resistance of SCID mice to Mycobacterium tuberculosis infection.

Pasula R, Martin WJ 2nd, Kesavalu BR, Abdalla MY, Britigan BE.

Cytokine. 2017 Jul;95:70-79. doi: 10.1016/j.cyto.2017.02.009. Epub 2017 Feb 24.

PMID:
28237876
6.

Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages.

Choi SR, Britigan BE, Narayanasamy P.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02505-16. doi: 10.1128/AAC.02505-16. Print 2017 Apr.

7.

Airway delivery of interferon-γ overexpressing macrophages confers resistance to Mycobacterium avium infection in SCID mice.

Pasula R, Britigan BE, Kesavalu B, Abdalla MY, Martin WJ 2nd.

Physiol Rep. 2016 Nov;4(21). pii: e13008. Epub 2016 Nov 17.

8.

Gallium Compounds Exhibit Potential as New Therapeutic Agents against Mycobacterium abscessus.

Abdalla MY, Switzer BL, Goss CH, Aitken ML, Singh PK, Britigan BE.

Antimicrob Agents Chemother. 2015 Aug;59(8):4826-34. doi: 10.1128/AAC.00331-15. Epub 2015 Jun 1.

9.
10.

Induction of heme oxygenase-1 contributes to survival of Mycobacterium abscessus in human macrophages-like THP-1 cells.

Abdalla MY, Ahmad IM, Switzer B, Britigan BE.

Redox Biol. 2015;4:328-39. doi: 10.1016/j.redox.2015.01.012. Epub 2015 Jan 20.

11.

Iron acquisition by Mycobacterium tuberculosis residing within myeloid dendritic cells.

Olakanmi O, Kesavalu B, Abdalla MY, Britigan BE.

Microb Pathog. 2013 Dec;65:21-8. doi: 10.1016/j.micpath.2013.09.002. Epub 2013 Sep 22.

PMID:
24067451
12.

Gallium nitrate is efficacious in murine models of tuberculosis and inhibits key bacterial Fe-dependent enzymes.

Olakanmi O, Kesavalu B, Pasula R, Abdalla MY, Schlesinger LS, Britigan BE.

Antimicrob Agents Chemother. 2013 Dec;57(12):6074-80. doi: 10.1128/AAC.01543-13. Epub 2013 Sep 23.

13.

Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitrite.

Reszka KJ, Xiong Y, Sallans L, Pasula R, Olakanmi O, Hassett DJ, Britigan BE.

Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1044-56. doi: 10.1152/ajplung.00172.2011. Epub 2012 Feb 17.

14.

Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria.

Nguyen D, Joshi-Datar A, Lepine F, Bauerle E, Olakanmi O, Beer K, McKay G, Siehnel R, Schafhauser J, Wang Y, Britigan BE, Singh PK.

Science. 2011 Nov 18;334(6058):982-6. doi: 10.1126/science.1211037.

15.

Oxidation of thiols and modification of redox-sensitive signaling in human lung epithelial cells exposed to Pseudomonas pyocyanin.

Ahmad IM, Britigan BE, Abdalla MY.

J Toxicol Environ Health A. 2011;74(1):43-51. doi: 10.1080/15287394.2010.514233.

PMID:
21120747
16.

Airway peroxidases catalyze nitration of the {beta}2-agonist salbutamol and decrease its pharmacological activity.

Reszka KJ, Sallans L, Macha S, Brown K, McGraw DW, Kovacic MB, Britigan BE.

J Pharmacol Exp Ther. 2011 Feb;336(2):440-9. doi: 10.1124/jpet.110.170027. Epub 2010 Oct 25.

17.

Quenching of singlet oxygen by pyocyanin and related phenazines.

Reszka KJ, Bilski PJ, Britigan BE.

Photochem Photobiol. 2010 Jul-Aug;86(4):742-6. doi: 10.1111/j.1751-1097.2010.00728.x. Epub 2010 Apr 16.

PMID:
20408986
18.

Gallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection model.

Olakanmi O, Gunn JS, Su S, Soni S, Hassett DJ, Britigan BE.

Antimicrob Agents Chemother. 2010 Jan;54(1):244-53. doi: 10.1128/AAC.00655-09. Epub 2009 Nov 16.

19.

Peroxidative metabolism of beta2-agonists salbutamol and fenoterol and their analogues.

Reszka KJ, McGraw DW, Britigan BE.

Chem Res Toxicol. 2009 Jun;22(6):1137-50. doi: 10.1021/tx900071f. Erratum in: Chem Res Toxicol. 2009 Aug;22(8):1490.

20.

Airway delivery of silica increases susceptibility to mycobacterial infection in mice: potential role of repopulating macrophages.

Pasula R, Britigan BE, Turner J, Martin WJ 2nd.

J Immunol. 2009 Jun 1;182(11):7102-9. doi: 10.4049/jimmunol.0803642.

21.

Copper egress is induced by PMA in human THP-1 monocytic cell line.

Afton SE, Caruso JA, Britigan BE, Qin Z.

Biometals. 2009 Jun;22(3):531-9. doi: 10.1007/s10534-009-9210-y. Epub 2009 Feb 10.

PMID:
19205902
22.

The peptidoglycan-associated lipoprotein OprL helps protect a Pseudomonas aeruginosa mutant devoid of the transactivator OxyR from hydrogen peroxide-mediated killing during planktonic and biofilm culture.

Panmanee W, Gomez F, Witte D, Pancholi V, Britigan BE, Hassett DJ.

J Bacteriol. 2008 May;190(10):3658-69. doi: 10.1128/JB.00022-08. Epub 2008 Feb 29.

23.

Hepatitis C core protein inhibits induction of heme oxygenase-1 and sensitizes hepatocytes to cytotoxicity.

Wen F, Brown KE, Britigan BE, Schmidt WN.

Cell Biol Toxicol. 2008 Apr;24(2):175-88. Epub 2007 Aug 25.

PMID:
17721824
25.

Inactivation of anthracyclines by serum heme proteins.

Wagner BA, Teesch LM, Buettner GR, Britigan BE, Burns CP, Reszka KJ.

Chem Res Toxicol. 2007 Jun;20(6):920-6. Epub 2007 May 12.

26.

The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity.

Kaneko Y, Thoendel M, Olakanmi O, Britigan BE, Singh PK.

J Clin Invest. 2007 Apr;117(4):877-88. Epub 2007 Mar 15.

27.

Iron acquisition by parasitic protozoa.

Wilson ME, Britigan BE.

Parasitol Today. 1998 Sep;14(9):348-53.

PMID:
17040815
28.

Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages.

Olakanmi O, Schlesinger LS, Britigan BE.

J Leukoc Biol. 2007 Jan;81(1):195-204. Epub 2006 Oct 12.

PMID:
17038583
29.

Nitric oxide decreases the stability of DMPO spin adducts.

Reszka KJ, McCormick ML, Buettner GR, Hart CM, Britigan BE.

Nitric Oxide. 2006 Sep;15(2):133-41. Epub 2006 May 2.

PMID:
16647868
30.

Photosensitized oxidation and inactivation of pyocyanin, a virulence factor of Pseudomonas aeruginosa.

Reszka KJ, Denning GM, Britigan BE.

Photochem Photobiol. 2006 Mar-Apr;82(2):466-73.

PMID:
16613500
31.
32.

Inactivation of anthracyclines by cellular peroxidase.

Reszka KJ, Wagner BA, Teesch LM, Britigan BE, Spitz DR, Burns CP.

Cancer Res. 2005 Jul 15;65(14):6346-53.

33.

Oxidation of anthracyclines by peroxidase metabolites of salicylic Acid.

Reszka KJ, Britigan LH, Britigan BE.

J Pharmacol Exp Ther. 2005 Oct;315(1):283-90. Epub 2005 Jun 28.

34.

Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses.

Abdalla MY, Ahmad IM, Spitz DR, Schmidt WN, Britigan BE.

J Med Virol. 2005 Aug;76(4):489-97.

PMID:
15977232
35.

Modulation of lung epithelial functions by Pseudomonas aeruginosa.

Lau GW, Hassett DJ, Britigan BE.

Trends Microbiol. 2005 Aug;13(8):389-97. Review.

PMID:
15951179
36.

Gallium-inducible transferrin-independent iron acquisition is a property of many cell types: possible role of alterations in the plasma membrane.

Olakanmi O, Stokes JB, Britigan BE.

J Investig Med. 2005 Apr;53(3):143-53. doi: 10.2310/6650.2005.00310.

PMID:
15921034
37.

Effects of peroxidase substrates on the Amplex red/peroxidase assay: antioxidant properties of anthracyclines.

Reszka KJ, Wagner BA, Burns CP, Britigan BE.

Anal Biochem. 2005 Jul 15;342(2):327-37.

PMID:
15913534
38.

Hemin induces active chloride secretion in Caco-2 cells.

Uc A, Husted RF, Giriyappa RL, Britigan BE, Stokes JB.

Am J Physiol Gastrointest Liver Physiol. 2005 Aug;289(2):G202-8. Epub 2005 Mar 31.

39.
40.

Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein.

Abdalla MY, Britigan BE, Wen F, Icardi M, McCormick ML, LaBrecque DR, Voigt M, Brown KE, Schmidt WN.

J Infect Dis. 2004 Sep 15;190(6):1109-18. Epub 2004 Aug 17.

PMID:
15319861
41.

Heme transport exhibits polarity in Caco-2 cells: evidence for an active and membrane protein-mediated process.

Uc A, Stokes JB, Britigan BE.

Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1150-7. Epub 2004 Aug 12.

42.

Acetaminophen stimulates the peroxidative metabolism of anthracyclines.

Reszka KJ, Britigan LH, Rasmussen GT, Wagner BA, Burns CP, Britigan BE.

Arch Biochem Biophys. 2004 Jul 1;427(1):16-29.

PMID:
15178484
43.

Oxidation of pyocyanin, a cytotoxic product from Pseudomonas aeruginosa, by microperoxidase 11 and hydrogen peroxide.

Reszka KJ, O'Malley Y, McCormick ML, Denning GM, Britigan BE.

Free Radic Biol Med. 2004 Jun 1;36(11):1448-59.

PMID:
15135182
44.

Role of thiocyanate, bromide and hypobromous acid in hydrogen peroxide-induced apoptosis.

Wagner BA, Reszka KJ, McCormick ML, Britigan BE, Evig CB, Burns CP.

Free Radic Res. 2004 Feb;38(2):167-75.

PMID:
15104210
45.
46.

Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells.

O'Malley YQ, Reszka KJ, Spitz DR, Denning GM, Britigan BE.

Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L94-103. Epub 2004 Mar 12.

47.
48.

Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1.

Wen F, Abdalla MY, Aloman C, Xiang J, Ahmad IM, Walewski J, McCormick ML, Brown KE, Branch AD, Spitz DR, Britigan BE, Schmidt WN.

J Med Virol. 2004 Feb;72(2):230-40.

PMID:
14695664
49.

The Pseudomonas secretory product pyocyanin inhibits catalase activity in human lung epithelial cells.

O'Malley YQ, Reszka KJ, Rasmussen GT, Abdalla MY, Denning GM, Britigan BE.

Am J Physiol Lung Cell Mol Physiol. 2003 Nov;285(5):L1077-86. Epub 2003 Jul 18.

50.

Oxidation of anthracycline anticancer agents by the peroxidase mimic microperoxidase 11 and hydrogen peroxide.

Reszka KJ, McCormick ML, Britigan BE.

Free Radic Biol Med. 2003 Jul 1;35(1):78-93.

PMID:
12826258

Supplemental Content

Loading ...
Support Center