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Items: 1 to 50 of 139

1.

The molecular clock of Mycobacterium tuberculosis.

Menardo F, Duchêne S, Brites D, Gagneux S.

PLoS Pathog. 2019 Sep 12;15(9):e1008067. doi: 10.1371/journal.ppat.1008067. [Epub ahead of print]

2.

Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues.

Meehan CJ, Goig GA, Kohl TA, Verboven L, Dippenaar A, Ezewudo M, Farhat MR, Guthrie JL, Laukens K, Miotto P, Ofori-Anyinam B, Dreyer V, Supply P, Suresh A, Utpatel C, van Soolingen D, Zhou Y, Ashton PM, Brites D, Cabibbe AM, de Jong BC, de Vos M, Menardo F, Gagneux S, Gao Q, Heupink TH, Liu Q, Loiseau C, Rigouts L, Rodwell TC, Tagliani E, Walker TM, Warren RM, Zhao Y, Zignol M, Schito M, Gardy J, Cirillo DM, Niemann S, Comas I, Van Rie A.

Nat Rev Microbiol. 2019 Sep;17(9):533-545. doi: 10.1038/s41579-019-0214-5. Review.

PMID:
31209399
3.

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions.

Vaz AR, Pinto S, Ezequiel C, Cunha C, Carvalho LA, Moreira R, Brites D.

Front Cell Neurosci. 2019 Apr 9;13:109. doi: 10.3389/fncel.2019.00109. eCollection 2019.

4.

Insights into the genetic diversity of Mycobacterium tuberculosis in Tanzania.

Rutaihwa LK, Sasamalo M, Jaleco A, Hella J, Kingazi A, Kamwela L, Kingalu A, Malewo B, Shirima R, Doetsch A, Feldmann J, Reinhard M, Borrell S, Brites D, Reither K, Doulla B, Fenner L, Gagneux S.

PLoS One. 2019 Apr 12;14(4):e0206334. doi: 10.1371/journal.pone.0206334. eCollection 2019.

5.

Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex.

Loiseau C, Brites D, Moser I, Coll F, Pourcel C, Robbe-Austerman S, Escuyer V, Musser KA, Peacock SJ, Feuerriegel S, Kohl TA, Niemann S, Gagneux S, Köser CU.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00159-19. doi: 10.1128/AAC.00159-19. Print 2019 Jun.

6.

Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability.

Braga C, Vaz AR, Oliveira MC, Matilde Marques M, Moreira R, Brites D, Perry MJ.

Eur J Med Chem. 2019 Jun 15;172:16-25. doi: 10.1016/j.ejmech.2019.03.048. Epub 2019 Mar 22.

PMID:
30939350
7.

Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development.

Borrell S, Trauner A, Brites D, Rigouts L, Loiseau C, Coscolla M, Niemann S, De Jong B, Yeboah-Manu D, Kato-Maeda M, Feldmann J, Reinhard M, Beisel C, Gagneux S.

PLoS One. 2019 Mar 25;14(3):e0214088. doi: 10.1371/journal.pone.0214088. eCollection 2019.

8.

Development of a high throughput methodology to screen cathinones' toxicological impact.

Ferreira C, Vaz AR, Florindo PR, Lopes Á, Brites D, Quintas A.

Forensic Sci Int. 2019 May;298:1-9. doi: 10.1016/j.forsciint.2019.02.022. Epub 2019 Feb 23.

PMID:
30870699
9.

A New Phylogenetic Framework for the Animal-Adapted Mycobacterium tuberculosis Complex.

Brites D, Loiseau C, Menardo F, Borrell S, Boniotti MB, Warren R, Dippenaar A, Parsons SDC, Beisel C, Behr MA, Fyfe JA, Coscolla M, Gagneux S.

Front Microbiol. 2018 Nov 27;9:2820. doi: 10.3389/fmicb.2018.02820. eCollection 2018.

10.

Comparative genomics of Mycobacterium africanum Lineage 5 and Lineage 6 from Ghana suggests distinct ecological niches.

Otchere ID, Coscollá M, Sánchez-Busó L, Asante-Poku A, Brites D, Loiseau C, Meehan C, Osei-Wusu S, Forson A, Laryea C, Yahayah AI, Baddoo A, Ansa GA, Aboagye SY, Asare P, Borrell S, Gehre F, Beckert P, Kohl TA, N'dira S, Beisel C, Antonio M, Niemann S, de Jong BC, Parkhill J, Harris SR, Gagneux S, Yeboah-Manu D.

Sci Rep. 2018 Jul 26;8(1):11269. doi: 10.1038/s41598-018-29620-2.

11.

Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model.

Gomes C, Cunha C, Nascimento F, Ribeiro JA, Vaz AR, Brites D.

Mol Neurobiol. 2019 Mar;56(3):2137-2158. doi: 10.1007/s12035-018-1220-8. Epub 2018 Jul 11.

PMID:
29995256
12.

Tuberculosis outbreak investigation using phylodynamic analysis.

Kühnert D, Coscolla M, Brites D, Stucki D, Metcalfe J, Fenner L, Gagneux S, Stadler T.

Epidemics. 2018 Dec;25:47-53. doi: 10.1016/j.epidem.2018.05.004. Epub 2018 May 22.

13.

Secretome from SH-SY5Y APPSwe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling.

Fernandes A, Ribeiro AR, Monteiro M, Garcia G, Vaz AR, Brites D.

Biochimie. 2018 Dec;155:67-82. doi: 10.1016/j.biochi.2018.05.015. Epub 2018 May 29.

PMID:
29857185
14.

Treemmer: a tool to reduce large phylogenetic datasets with minimal loss of diversity.

Menardo F, Loiseau C, Brites D, Coscolla M, Gygli SM, Rutaihwa LK, Trauner A, Beisel C, Borrell S, Gagneux S.

BMC Bioinformatics. 2018 May 2;19(1):164. doi: 10.1186/s12859-018-2164-8.

15.

Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study.

Figueira I, Tavares L, Jardim C, Costa I, Terrasso AP, Almeida AF, Govers C, Mes JJ, Gardner R, Becker JD, McDougall GJ, Stewart D, Filipe A, Kim KS, Brites D, Brito C, Brito MA, Santos CN.

Eur J Nutr. 2019 Feb;58(1):113-130. doi: 10.1007/s00394-017-1576-y. Epub 2017 Nov 18.

PMID:
29151137
16.

Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment.

Santos G, Barateiro A, Gomes CM, Brites D, Fernandes A.

Neuropharmacology. 2018 Feb;129:69-83. doi: 10.1016/j.neuropharm.2017.11.002. Epub 2017 Nov 8.

PMID:
29126910
17.

The Nature and Evolution of Genomic Diversity in the Mycobacterium tuberculosis Complex.

Brites D, Gagneux S.

Adv Exp Med Biol. 2017;1019:1-26. doi: 10.1007/978-3-319-64371-7_1. Review.

PMID:
29116627
18.

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation.

Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, Fernandes A, Brites D.

Front Aging Neurosci. 2017 Aug 31;9:277. doi: 10.3389/fnagi.2017.00277. eCollection 2017.

19.

Polyphenols journey through blood-brain barrier towards neuronal protection.

Figueira I, Garcia G, Pimpão RC, Terrasso AP, Costa I, Almeida AF, Tavares L, Pais TF, Pinto P, Ventura MR, Filipe A, McDougall GJ, Stewart D, Kim KS, Palmela I, Brites D, Brito MA, Brito C, Santos CN.

Sci Rep. 2017 Sep 13;7(1):11456. doi: 10.1038/s41598-017-11512-6.

20.

Dscam1 in Pancrustacean Immunity: Current Status and a Look to the Future.

Armitage SAO, Kurtz J, Brites D, Dong Y, Du Pasquier L, Wang HC.

Front Immunol. 2017 Jun 9;8:662. doi: 10.3389/fimmu.2017.00662. eCollection 2017.

21.

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage.

Cunha C, Santos C, Gomes C, Fernandes A, Correia AM, Sebastião AM, Vaz AR, Brites D.

Mol Neurobiol. 2018 May;55(5):4207-4224. doi: 10.1007/s12035-017-0631-2. Epub 2017 Jun 13.

PMID:
28612258
22.

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.

Pinto S, Cunha C, Barbosa M, Vaz AR, Brites D.

Front Neurosci. 2017 May 17;11:273. doi: 10.3389/fnins.2017.00273. eCollection 2017.

23.

The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy.

Trauner A, Liu Q, Via LE, Liu X, Ruan X, Liang L, Shi H, Chen Y, Wang Z, Liang R, Zhang W, Wei W, Gao J, Sun G, Brites D, England K, Zhang G, Gagneux S, Barry CE 3rd, Gao Q.

Genome Biol. 2017 Apr 19;18(1):71. doi: 10.1186/s13059-017-1196-0.

24.

The Influence of HIV on the Evolution of Mycobacterium tuberculosis.

Koch AS, Brites D, Stucki D, Evans JC, Seldon R, Heekes A, Mulder N, Nicol M, Oni T, Mizrahi V, Warner DF, Parkhill J, Gagneux S, Martin DP, Wilkinson RJ.

Mol Biol Evol. 2017 Jul 1;34(7):1654-1668. doi: 10.1093/molbev/msx107.

25.

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization.

Cunha C, Gomes C, Vaz AR, Brites D.

Mediators Inflamm. 2016;2016:6986175. doi: 10.1155/2016/6986175. Epub 2016 Dec 21.

26.

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

Stucki D, Brites D, Jeljeli L, Coscolla M, Liu Q, Trauner A, Fenner L, Rutaihwa L, Borrell S, Luo T, Gao Q, Kato-Maeda M, Ballif M, Egger M, Macedo R, Mardassi H, Moreno M, Tudo Vilanova G, Fyfe J, Globan M, Thomas J, Jamieson F, Guthrie JL, Asante-Poku A, Yeboah-Manu D, Wampande E, Ssengooba W, Joloba M, Henry Boom W, Basu I, Bower J, Saraiva M, Vaconcellos SEG, Suffys P, Koch A, Wilkinson R, Gail-Bekker L, Malla B, Ley SD, Beck HP, de Jong BC, Toit K, Sanchez-Padilla E, Bonnet M, Gil-Brusola A, Frank M, Penlap Beng VN, Eisenach K, Alani I, Wangui Ndung'u P, Revathi G, Gehre F, Akter S, Ntoumi F, Stewart-Isherwood L, Ntinginya NE, Rachow A, Hoelscher M, Cirillo DM, Skenders G, Hoffner S, Bakonyte D, Stakenas P, Diel R, Crudu V, Moldovan O, Al-Hajoj S, Otero L, Barletta F, Jane Carter E, Diero L, Supply P, Comas I, Niemann S, Gagneux S.

Nat Genet. 2016 Dec;48(12):1535-1543. doi: 10.1038/ng.3704. Epub 2016 Oct 31.

27.

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

Falcão AS, Carvalho LA, Lidónio G, Vaz AR, Lucas SD, Moreira R, Brites D.

ACS Chem Neurosci. 2017 Jan 18;8(1):89-99. doi: 10.1021/acschemneuro.6b00250. Epub 2016 Nov 15.

PMID:
27797173
28.

Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro.

Pogačnik L, Pirc K, Palmela I, Skrt M, Kim KS, Brites D, Brito MA, Ulrih NP, Silva RF.

Brain Res. 2016 Nov 15;1651:17-26. doi: 10.1016/j.brainres.2016.09.020. Epub 2016 Sep 15.

PMID:
27639810
29.

Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat.

Figueira ME, Oliveira M, Direito R, Rocha J, Alves P, Serra AT, Duarte C, Bronze R, Fernandes A, Brites D, Freitas M, Fernandes E, Sepodes B.

Biomed Pharmacother. 2016 Oct;83:1191-1202. doi: 10.1016/j.biopha.2016.08.040. Epub 2016 Aug 20.

PMID:
27551767
30.

Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?

Pinheiro R, Braga C, Santos G, Bronze MR, Perry MJ, Moreira R, Brites D, Falcão AS.

ACS Chem Neurosci. 2017 Jan 18;8(1):50-59. doi: 10.1021/acschemneuro.6b00169. Epub 2016 Oct 11.

PMID:
27665765
31.

Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation.

Garcia G, Nanni S, Figueira I, Ivanov I, McDougall GJ, Stewart D, Ferreira RB, Pinto P, Silva RF, Brites D, Santos CN.

Food Chem. 2017 Jan 15;215:274-83. doi: 10.1016/j.foodchem.2016.07.128. Epub 2016 Jul 28.

PMID:
27542476
32.

Frailty in mouse ageing: A conceptual approach.

von Zglinicki T, Varela Nieto I, Brites D, Karagianni N, Ortolano S, Georgopoulos S, Cardoso AL, Novella S, Lepperdinger G, Trendelenburg AU, van Os R.

Mech Ageing Dev. 2016 Dec;160:34-40. doi: 10.1016/j.mad.2016.07.004. Epub 2016 Jul 18. Review.

33.

Synaptic Failure: Focus in an Integrative View of ALS.

Casas C, Manzano R, Vaz R, Osta R, Brites D.

Brain Plast. 2016 Jun 29;1(2):159-175. doi: 10.3233/BPL-140001. Review.

34.

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation.

Brites D, Fernandes A.

Front Cell Neurosci. 2015 Dec 17;9:476. doi: 10.3389/fncel.2015.00476. eCollection 2015. Review.

35.

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease.

Barateiro A, Brites D, Fernandes A.

Curr Pharm Des. 2016;22(6):656-79. Review.

PMID:
26635271
36.

Somatic and Germline Diversification of a Putative Immunoreceptor within One Phylum: Dscam in Arthropods.

Brites D, Du Pasquier L.

Results Probl Cell Differ. 2015;57:131-58. doi: 10.1007/978-3-319-20819-0_6. Review.

PMID:
26537380
37.

Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia.

Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D.

Mol Pharmacol. 2016 Jan;89(1):84-93. doi: 10.1124/mol.115.098228. Epub 2015 Oct 19.

38.

S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis.

Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, Fernandes A.

Mol Neurobiol. 2016 Aug;53(6):3976-3991. doi: 10.1007/s12035-015-9336-6. Epub 2015 Jul 17.

PMID:
26184632
39.

Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons.

Ribeiro FF, Neves-Tomé R, Assaife-Lopes N, Santos TE, Silva RF, Brites D, Ribeiro JA, Sousa MM, Sebastião AM.

Brain Struct Funct. 2016 Jun;221(5):2777-99. doi: 10.1007/s00429-015-1072-1. Epub 2015 Jun 12.

PMID:
26068054
40.

Locally Confined Clonal Complexes of Mycobacterium ulcerans in Two Buruli Ulcer Endemic Regions of Cameroon.

Bolz M, Bratschi MW, Kerber S, Minyem JC, Um Boock A, Vogel M, Bayi PF, Junghanss T, Brites D, Harris SR, Parkhill J, Pluschke G, Lamelas Cabello A.

PLoS Negl Trop Dis. 2015 Jun 5;9(6):e0003802. doi: 10.1371/journal.pntd.0003802. eCollection 2015.

41.

Glio-vascular changes during ageing in wild-type and Alzheimer's disease-like APP/PS1 mice.

Janota CS, Brites D, Lemere CA, Brito MA.

Brain Res. 2015 Sep 16;1620:153-68. doi: 10.1016/j.brainres.2015.04.056. Epub 2015 May 9.

42.

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects.

Cardoso FL, Herz J, Fernandes A, Rocha J, Sepodes B, Brito MA, McGavern DB, Brites D.

J Neuroinflammation. 2015 Apr 29;12:82. doi: 10.1186/s12974-015-0299-3.

43.

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study.

Palmela I, Correia L, Silva RF, Sasaki H, Kim KS, Brites D, Brito MA.

Front Neurosci. 2015 Mar 13;9:80. doi: 10.3389/fnins.2015.00080. eCollection 2015.

44.

Co-evolution of Mycobacterium tuberculosis and Homo sapiens.

Brites D, Gagneux S.

Immunol Rev. 2015 Mar;264(1):6-24. doi: 10.1111/imr.12264. Review.

45.

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis.

Silva S, Sepodes B, Rocha J, Direito R, Fernandes A, Brites D, Freitas M, Fernandes E, Bronze MR, Figueira ME.

J Nutr Biochem. 2015 Apr;26(4):360-8. doi: 10.1016/j.jnutbio.2014.11.011. Epub 2014 Dec 30.

PMID:
25620693
46.

Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities.

Brites D, Fernandes A.

Semin Fetal Neonatal Med. 2015 Feb;20(1):14-19. doi: 10.1016/j.siny.2014.12.002. Epub 2014 Dec 19. Review.

PMID:
25534357
47.

Blood-brain barrier and bilirubin: clinical aspects and experimental data.

Brito MA, Palmela I, Cardoso FL, Sá-Pereira I, Brites D.

Arch Med Res. 2014 Nov;45(8):660-76. doi: 10.1016/j.arcmed.2014.11.015. Epub 2014 Dec 1. Review.

PMID:
25475697
48.

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima.

Chipman AD, Ferrier DE, Brena C, Qu J, Hughes DS, Schröder R, Torres-Oliva M, Znassi N, Jiang H, Almeida FC, Alonso CR, Apostolou Z, Aqrawi P, Arthur W, Barna JC, Blankenburg KP, Brites D, Capella-Gutiérrez S, Coyle M, Dearden PK, Du Pasquier L, Duncan EJ, Ebert D, Eibner C, Erikson G, Evans PD, Extavour CG, Francisco L, Gabaldón T, Gillis WJ, Goodwin-Horn EA, Green JE, Griffiths-Jones S, Grimmelikhuijzen CJ, Gubbala S, Guigó R, Han Y, Hauser F, Havlak P, Hayden L, Helbing S, Holder M, Hui JH, Hunn JP, Hunnekuhl VS, Jackson L, Javaid M, Jhangiani SN, Jiggins FM, Jones TE, Kaiser TS, Kalra D, Kenny NJ, Korchina V, Kovar CL, Kraus FB, Lapraz F, Lee SL, Lv J, Mandapat C, Manning G, Mariotti M, Mata R, Mathew T, Neumann T, Newsham I, Ngo DN, Ninova M, Okwuonu G, Ongeri F, Palmer WJ, Patil S, Patraquim P, Pham C, Pu LL, Putman NH, Rabouille C, Ramos OM, Rhodes AC, Robertson HE, Robertson HM, Ronshaugen M, Rozas J, Saada N, Sánchez-Gracia A, Scherer SE, Schurko AM, Siggens KW, Simmons D, Stief A, Stolle E, Telford MJ, Tessmar-Raible K, Thornton R, van der Zee M, von Haeseler A, Williams JM, Willis JH, Wu Y, Zou X, Lawson D, Muzny DM, Worley KC, Gibbs RA, Akam M, Richards S.

PLoS Biol. 2014 Nov 25;12(11):e1002005. doi: 10.1371/journal.pbio.1002005. eCollection 2014 Nov.

49.

Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.

Rocha J, Figueira ME, Barateiro A, Fernandes A, Brites D, Pinto R, Freitas M, Fernandes E, Mota-Filipe H, Sepodes B.

Shock. 2015 Apr;43(4):369-78. doi: 10.1097/SHK.0000000000000298.

PMID:
25394244
50.

Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation.

Rocha J, Eduardo-Figueira M, Barateiro A, Fernandes A, Brites D, Bronze R, Duarte CM, Serra AT, Pinto R, Freitas M, Fernandes E, Silva-Lima B, Mota-Filipe H, Sepodes B.

Basic Clin Pharmacol Toxicol. 2015 May;116(5):398-413. doi: 10.1111/bcpt.12335. Epub 2014 Nov 6.

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