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Items: 19


A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues.

Behera RK, Mlynek KD, Linz MS, Brinsmade SR.

J Vis Exp. 2019 Feb 19;(144). doi: 10.3791/59055.


Guanine Limitation Results in CodY-Dependent and -Independent Alteration of Staphylococcus aureus Physiology and Gene Expression.

King AN, Borkar SA, Samuels DJ, Batz Z, Bulock LL, Sadykov MR, Bayles KW, Brinsmade SR.

J Bacteriol. 2018 Jun 25;200(14). pii: e00136-18. doi: 10.1128/JB.00136-18. Print 2018 Jul 15.


Nutritional Regulation of the Sae Two-Component System by CodY in Staphylococcus aureus.

Mlynek KD, Sause WE, Moormeier DE, Sadykov MR, Hill KR, Torres VJ, Bayles KW, Brinsmade SR.

J Bacteriol. 2018 Mar 26;200(8). pii: e00012-18. doi: 10.1128/JB.00012-18. Print 2018 Apr 15.


Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide.

Kaiser JC, King AN, Grigg JC, Sheldon JR, Edgell DR, Murphy MEP, Brinsmade SR, Heinrichs DE.

PLoS Genet. 2018 Jan 22;14(1):e1007159. doi: 10.1371/journal.pgen.1007159. eCollection 2018 Jan.


A Tandem Liquid Chromatography-Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus.

Samuels DJ, Wang Z, Rhee KY, Brinsmade SR.

J Vis Exp. 2017 Mar 28;(121). doi: 10.3791/55558.


CodY, a master integrator of metabolism and virulence in Gram-positive bacteria.

Brinsmade SR.

Curr Genet. 2017 Jun;63(3):417-425. doi: 10.1007/s00294-016-0656-5. Epub 2016 Oct 15. Review.


A spectrum of CodY activities drives metabolic reorganization and virulence gene expression in Staphylococcus aureus.

Waters NR, Samuels DJ, Behera RK, Livny J, Rhee KY, Sadykov MR, Brinsmade SR.

Mol Microbiol. 2016 Aug;101(3):495-514. doi: 10.1111/mmi.13404. Epub 2016 Jun 10.


Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB.

Belitsky BR, Brinsmade SR, Sonenshein AL.

PLoS Genet. 2015 Oct 16;11(10):e1005600. doi: 10.1371/journal.pgen.1005600. eCollection 2015 Oct.


Genome Sequence of the Clinical Isolate Staphylococcus aureus subsp. aureus Strain UAMS-1.

Sassi M, Sharma D, Brinsmade SR, Felden B, Augagneur Y.

Genome Announc. 2015 Feb 12;3(1). pii: e01584-14. doi: 10.1128/genomeA.01584-14.


Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY.

Brinsmade SR, Alexander EL, Livny J, Stettner AI, Segrรจ D, Rhee KY, Sonenshein AL.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8227-32. doi: 10.1073/pnas.1321308111. Epub 2014 May 19.


GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes.

Kriel A, Brinsmade SR, Tse JL, Tehranchi AK, Bittner AN, Sonenshein AL, Wang JD.

J Bacteriol. 2014 Jan;196(1):189-201. doi: 10.1128/JB.00918-13. Epub 2013 Oct 25.


Dissecting complex metabolic integration provides direct genetic evidence for CodY activation by guanine nucleotides.

Brinsmade SR, Sonenshein AL.

J Bacteriol. 2011 Oct;193(20):5637-48. doi: 10.1128/JB.05510-11. Epub 2011 Aug 19.


Involvement of protein acetylation in glucose-induced transcription of a stress-responsive promoter.

Lima BP, Antelmann H, Gronau K, Chi BK, Becher D, Brinsmade SR, Wolfe AJ.

Mol Microbiol. 2011 Sep;81(5):1190-204. doi: 10.1111/j.1365-2958.2011.07742.x. Epub 2011 Jul 28.


Regulation of CodY activity through modulation of intracellular branched-chain amino acid pools.

Brinsmade SR, Kleijn RJ, Sauer U, Sonenshein AL.

J Bacteriol. 2010 Dec;192(24):6357-68. doi: 10.1128/JB.00937-10. Epub 2010 Oct 8.


In vivo and in vitro analyses of single-amino acid variants of the Salmonella enterica phosphotransacetylase enzyme provide insights into the function of its N-terminal domain.

Brinsmade SR, Escalante-Semerena JC.

J Biol Chem. 2007 Apr 27;282(17):12629-40. Epub 2007 Mar 5. Erratum in: J Biol Chem. 2007 Jun 1;282(22):16712.


Mutation of phosphotransacetylase but not isocitrate lyase reduces the virulence of Salmonella enterica serovar Typhimurium in mice.

Kim YR, Brinsmade SR, Yang Z, Escalante-Semerena J, Fierer J.

Infect Immun. 2006 Apr;74(4):2498-502.


The eutD gene of Salmonella enterica encodes a protein with phosphotransacetylase enzyme activity.

Brinsmade SR, Escalante-Semerena JC.

J Bacteriol. 2004 Mar;186(6):1890-2.


The crystal structure of phosphonate-inhibited D-Ala-D-Ala peptidase reveals an analogue of a tetrahedral transition state.

Silvaggi NR, Anderson JW, Brinsmade SR, Pratt RF, Kelly JA.

Biochemistry. 2003 Feb 11;42(5):1199-208.


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