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Items: 36

1.

Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway.

Stempel M, Chan B, Brinkmann MM.

Med Microbiol Immunol. 2019 Feb 25. doi: 10.1007/s00430-019-00582-0. [Epub ahead of print] Review.

PMID:
30805724
2.

The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection.

Stempel M, Chan B, Juranić Lisnić V, Krmpotić A, Hartung J, Paludan SR, Füllbrunn N, Lemmermann NA, Brinkmann MM.

EMBO J. 2019 Mar 1;38(5). pii: e100983. doi: 10.15252/embj.2018100983. Epub 2019 Jan 29.

3.

Endosomal Toll-Like Receptors 7 and 9 Cooperate in Detection of Murine Gammaherpesvirus 68 Infection.

Bussey KA, Murthy S, Reimer E, Chan B, Hatesuer B, Schughart K, Glaunsinger B, Adler H, Brinkmann MM.

J Virol. 2019 Jan 17;93(3). pii: e01173-18. doi: 10.1128/JVI.01173-18. Print 2019 Feb 1.

PMID:
30429335
4.

Strategies for immune evasion by human tumor viruses.

Bussey KA, Brinkmann MM.

Curr Opin Virol. 2018 Oct;32:30-39. doi: 10.1016/j.coviro.2018.08.015. Epub 2018 Sep 18. Review.

PMID:
30241043
5.

Functional expression of TLR5 of different vertebrate species and diversification in intestinal pathogen recognition.

Faber E, Tedin K, Speidel Y, Brinkmann MM, Josenhans C.

Sci Rep. 2018 Jul 26;8(1):11287. doi: 10.1038/s41598-018-29371-0.

6.

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.

Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E.

Immunity. 2018 May 15;48(5):911-922.e7. doi: 10.1016/j.immuni.2018.04.011.

PMID:
29768176
7.

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein.

Bussey KA, Lau U, Schumann S, Gallo A, Osbelt L, Stempel M, Arnold C, Wissing J, Gad HH, Hartmann R, Brune W, Jänsch L, Whitehouse A, Brinkmann MM.

PLoS Pathog. 2018 Mar 2;14(3):e1006937. doi: 10.1371/journal.ppat.1006937. eCollection 2018 Mar.

8.

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.

Chan B, Gonçalves Magalhães V, Lemmermann NAW, Juranić Lisnić V, Stempel M, Bussey KA, Reimer E, Podlech J, Lienenklaus S, Reddehase MJ, Jonjić S, Brinkmann MM.

PLoS Pathog. 2017 May 25;13(5):e1006382. doi: 10.1371/journal.ppat.1006382. eCollection 2017 May.

9.

A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity.

Thurm C, Poltorak MP, Reimer E, Brinkmann MM, Leichert L, Schraven B, Simeoni L.

Oncotarget. 2017 May 9;8(19):30805-30816. doi: 10.18632/oncotarget.16486.

10.

IRAP+ endosomes restrict TLR9 activation and signaling.

Babdor J, Descamps D, Adiko AC, Tohmé M, Maschalidi S, Evnouchidou I, Vasconcellos LR, De Luca M, Mauvais FX, Garfa-Traore M, Brinkmann MM, Chignard M, Manoury B, Saveanu L.

Nat Immunol. 2017 May;18(5):509-518. doi: 10.1038/ni.3711. Epub 2017 Mar 20.

11.

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages.

Thiel N, Keyser KA, Lemmermann NA, Oduro JD, Wagner K, Elsner C, Halenius A, Lenac Roviš T, Brinkmann MM, Jonjić S, Cicin-Sain L, Messerle M.

PLoS Pathog. 2016 Dec 7;12(12):e1006057. doi: 10.1371/journal.ppat.1006057. eCollection 2016 Dec.

12.

Growing tumors induce a local STING dependent Type I IFN response in dendritic cells.

Andzinski L, Spanier J, Kasnitz N, Kröger A, Jin L, Brinkmann MM, Kalinke U, Weiss S, Jablonska J, Lienenklaus S.

Int J Cancer. 2016 Sep 15;139(6):1350-7. doi: 10.1002/ijc.30159. Epub 2016 May 17.

13.

In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration.

Nocera DA, Roselli E, Araya P, Nuñez NG, Lienenklaus S, Jablonska J, Weiss S, Gatti G, Brinkmann MM, Kröger A, Morón G, Maccioni M.

J Immunol. 2016 Mar 15;196(6):2860-9. doi: 10.4049/jimmunol.1501044. Epub 2016 Feb 15.

14.

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS.

Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1034-43. doi: 10.1073/pnas.1516812113. Epub 2016 Jan 25.

15.

Cytomegalovirus immune evasion of myeloid lineage cells.

Brinkmann MM, Dağ F, Hengel H, Messerle M, Kalinke U, Čičin-Šain L.

Med Microbiol Immunol. 2015 Jun;204(3):367-82. doi: 10.1007/s00430-015-0403-4. Epub 2015 Mar 17. Review.

PMID:
25776081
16.

Age-dependent enterocyte invasion and microcolony formation by Salmonella.

Zhang K, Dupont A, Torow N, Gohde F, Leschner S, Lienenklaus S, Weiss S, Brinkmann MM, Kühnel M, Hensel M, Fulde M, Hornef MW.

PLoS Pathog. 2014 Sep 11;10(9):e1004385. doi: 10.1371/journal.ppat.1004385. eCollection 2014 Sep. Erratum in: PLoS Pathog. 2014 Sep;10(9):e1004476. Gohde, Fredrik [corrected to Gohde, Frederik].

17.

The gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus 68 modulate the Toll-like receptor-induced proinflammatory cytokine response.

Bussey KA, Reimer E, Todt H, Denker B, Gallo A, Konrad A, Ottinger M, Adler H, Stürzl M, Brune W, Brinkmann MM.

J Virol. 2014 Aug;88(16):9245-59. doi: 10.1128/JVI.00841-14. Epub 2014 Jun 4.

18.

Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ.

Trsan T, Busche A, Abram M, Wensveen FM, Lemmermann NA, Arapovic M, Babic M, Tomic A, Golemac M, Brinkmann MM, Jäger W, Oxenius A, Polic B, Krmpotic A, Messerle M, Jonjic S.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16550-5. doi: 10.1073/pnas.1310215110. Epub 2013 Sep 19.

19.

Measurement of mouse cytomegalovirus-induced interferon-β with immortalized luciferase reporter cells.

Scheibe E, Lienenklaus S, May T, Magalhães VG, Weiss S, Brinkmann MM.

Methods Mol Biol. 2013;1064:355-66. doi: 10.1007/978-1-62703-601-6_25.

PMID:
23996270
20.

Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling.

Kim J, Huh J, Hwang M, Kwon EH, Jung DJ, Brinkmann MM, Jang MH, Ploegh HL, Kim YM.

J Immunol. 2013 May 15;190(10):5287-95. doi: 10.4049/jimmunol.1202767. Epub 2013 Apr 12.

21.

Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice.

Avalos AM, Kirak O, Oelkers JM, Pils MC, Kim YM, Ottinger M, Jaenisch R, Ploegh HL, Brinkmann MM.

J Immunol. 2013 Jan 15;190(2):695-702. doi: 10.4049/jimmunol.1202342. Epub 2012 Dec 12.

22.

Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.

Henault J, Martinez J, Riggs JM, Tian J, Mehta P, Clarke L, Sasai M, Latz E, Brinkmann MM, Iwasaki A, Coyle AJ, Kolbeck R, Green DR, Sanjuan MA.

Immunity. 2012 Dec 14;37(6):986-997. doi: 10.1016/j.immuni.2012.09.014. Epub 2012 Dec 6.

23.

Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade.

Fliss PM, Jowers TP, Brinkmann MM, Holstermann B, Mack C, Dickinson P, Hohenberg H, Ghazal P, Brune W.

PLoS Pathog. 2012 Feb;8(2):e1002517. doi: 10.1371/journal.ppat.1002517. Epub 2012 Feb 2.

24.

Granulin is a soluble cofactor for toll-like receptor 9 signaling.

Park B, Buti L, Lee S, Matsuwaki T, Spooner E, Brinkmann MM, Nishihara M, Ploegh HL.

Immunity. 2011 Apr 22;34(4):505-13. doi: 10.1016/j.immuni.2011.01.018. Epub 2011 Apr 14.

25.

Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.

Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Hävemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF.

J Virol. 2010 Aug;84(16):8231-40. doi: 10.1128/JVI.01696-09. Epub 2010 Jun 9.

26.

Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop.

Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A.

J Immunol. 2009 Aug 1;183(3):1569-76. doi: 10.4049/jimmunol.0803899. Epub 2009 Jul 8.

27.

Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus.

Wang L, Pietrek M, Brinkmann MM, Hävemeier A, Fischer I, Hillenbrand B, Dittrich-Breiholz O, Kracht M, Chanas S, Blackbourn DJ, Schulz TF.

J Gen Virol. 2009 May;90(Pt 5):1190-201. doi: 10.1099/vir.0.007971-0. Epub 2009 Mar 4.

PMID:
19264656
28.

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9.

Park B, Brinkmann MM, Spooner E, Lee CC, Kim YM, Ploegh HL.

Nat Immunol. 2008 Dec;9(12):1407-14. doi: 10.1038/ni.1669. Epub 2008 Oct 19.

29.

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.

Kim YM, Brinkmann MM, Paquet ME, Ploegh HL.

Nature. 2008 Mar 13;452(7184):234-8. doi: 10.1038/nature06726. Epub 2008 Feb 27.

PMID:
18305481
30.

TLRs bent into shape.

Kim YM, Brinkmann MM, Ploegh HL.

Nat Immunol. 2007 Jul;8(7):675-7. No abstract available.

PMID:
17579642
31.

Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus.

Wang L, Brinkmann MM, Pietrek M, Ottinger M, Dittrich-Breiholz O, Kracht M, Schulz TF.

J Gen Virol. 2007 Jun;88(Pt 6):1698-707.

PMID:
17485529
32.

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.

Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM.

J Cell Biol. 2007 Apr 23;177(2):265-75.

33.

Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.

Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF.

J Virol. 2007 Jan;81(1):42-58. Epub 2006 Oct 18.

34.

Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrest.

Ottinger M, Christalla T, Nathan K, Brinkmann MM, Viejo-Borbolla A, Schulz TF.

J Virol. 2006 Nov;80(21):10772-86. Epub 2006 Aug 23.

35.

Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae.

Brinkmann MM, Schulz TF.

J Gen Virol. 2006 May;87(Pt 5):1047-74. Review.

PMID:
16603506
36.

Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein.

Brinkmann MM, Glenn M, Rainbow L, Kieser A, Henke-Gendo C, Schulz TF.

J Virol. 2003 Sep;77(17):9346-58.

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