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Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis.

Koehler S, Kuczkowski A, Kuehne L, Jüngst C, Hoehne M, Grahammer F, Eddy S, Kretzler M, Beck BB, Höhfeld J, Schermer B, Benzing T, Brinkkoetter PT, Rinschen MM.

J Am Soc Nephrol. 2020 Feb 11. pii: ASN.2019030312. doi: 10.1681/ASN.2019030312. [Epub ahead of print]


Drosophila melanogaster and its nephrocytes: A versatile model for glomerular research.

Odenthal J, Brinkkoetter PT.

Methods Cell Biol. 2019;154:217-240. doi: 10.1016/bs.mcb.2019.03.011. Epub 2019 Apr 30.


Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients.

Brinkkoetter PT, Grundmann F, Ghassabeh PJ, Becker I, Johnsen M, Suaréz V, Schulz RJ, Streichert T, Burst V.

Sci Rep. 2019 Aug 29;9(1):12526. doi: 10.1038/s41598-019-49054-8.


Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics.

Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB.

Cell Rep. 2019 Apr 30;27(5):1551-1566.e5. doi: 10.1016/j.celrep.2019.04.012.


Experimental Models to Study Podocyte Biology: Stock-Taking the Toolbox of Glomerular Research.

Hagmann H, Brinkkoetter PT.

Front Pediatr. 2018 Jul 13;6:193. doi: 10.3389/fped.2018.00193. eCollection 2018. Review.


Protein half-life determines expression of proteostatic networks in podocyte differentiation.

Schroeter CB, Koehler S, Kann M, Schermer B, Benzing T, Brinkkoetter PT, Rinschen MM.

FASEB J. 2018 Sep;32(9):4696-4713. doi: 10.1096/fj.201701307R. Epub 2018 Apr 25.


Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression.

Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT.

FASEB J. 2018 Jan;32(1):208-219. doi: 10.1096/fj.201700309R. Epub 2017 Sep 6.


Prohibitin Signaling at the Kidney Filtration Barrier.

Ising C, Brinkkoetter PT.

Adv Exp Med Biol. 2017;982:563-575. doi: 10.1007/978-3-319-55330-6_29. Review.


Metabolism and homeostasis in the kidney: metabolic regulation through insulin signaling in the kidney.

Kuczkowski A, Brinkkoetter PT.

Cell Tissue Res. 2017 Jul;369(1):199-210. doi: 10.1007/s00441-017-2619-7. Epub 2017 Apr 17. Review.


YAP-mediated mechanotransduction determines the podocyte's response to damage.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkoetter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B.

Sci Signal. 2017 Apr 11;10(474). pii: eaaf8165. doi: 10.1126/scisignal.aaf8165.


Is the Age-Related Decline in Renal Function an Age-Associated Disease or Part of a Normal Aging Process?

Braun F, Brinkkoetter PT.

Gerontology. 2017;63(4):325-326. doi: 10.1159/000456616. Epub 2017 Mar 1. No abstract available.


Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes.

Koehler S, Brähler S, Braun F, Hagmann H, Rinschen MM, Späth MR, Höhne M, Wunderlich FT, Schermer B, Benzing T, Brinkkoetter PT.

Kidney Int. 2017 Jun;91(6):1510-1517. doi: 10.1016/j.kint.2016.12.011. Epub 2017 Feb 7.


Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion.

Koehler S, Brähler S, Kuczkowski A, Binz J, Hackl MJ, Hagmann H, Höhne M, Vogt MC, Wunderlich CM, Wunderlich FT, Schweda F, Schermer B, Benzing T, Brinkkoetter PT.

Sci Rep. 2016 Oct 19;6:35400. doi: 10.1038/srep35400.


Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation.

Rinschen MM, Schroeter CB, Koehler S, Ising C, Schermer B, Kann M, Benzing T, Brinkkoetter PT.

Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C404-17. doi: 10.1152/ajpcell.00121.2016. Epub 2016 Jun 29.


Live or Let Die: Is There any Cell Death in Podocytes?

Braun F, Becker JU, Brinkkoetter PT.

Semin Nephrol. 2016 May;36(3):208-19. doi: 10.1016/j.semnephrol.2016.03.008. Review.


Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F112-9. doi: 10.1152/ajprenal.00171.2016. Epub 2016 Apr 27.


Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.

Ising C, Bharill P, Brinkkoetter S, Brähler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Höhne M, Müller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT.

Am J Pathol. 2016 May;186(5):1128-39. doi: 10.1016/j.ajpath.2015.12.018.


The NF-κB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-κB.

Brähler S, Ising C, Barrera Aranda B, Höhne M, Schermer B, Benzing T, Brinkkoetter PT.

Am J Physiol Renal Physiol. 2015 Oct 1;309(7):F617-26. doi: 10.1152/ajprenal.00059.2015. Epub 2015 Aug 12.


ROS and oxidative stress in CKD patients: is it the mitochondria that keeps CKD patients in bed?

Hagmann H, Brinkkoetter PT.

Nephrol Dial Transplant. 2015 Jun;30(6):867-8. doi: 10.1093/ndt/gfv052. Epub 2015 Mar 2. No abstract available.


Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.

Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT.

EMBO Mol Med. 2015 Mar;7(3):275-87. doi: 10.15252/emmm.201404916.


Cyclin I and p35 determine the subcellular distribution of Cdk5.

Hagmann H, Taniguchi Y, Pippin JW, Kauerz HM, Benzing T, Shankland SJ, Brinkkoetter PT.

Am J Physiol Cell Physiol. 2015 Feb 15;308(4):C339-47. doi: 10.1152/ajpcell.00168.2014. Epub 2014 Dec 10.


Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture.

Rinschen MM, Pahmeyer C, Pisitkun T, Schnell N, Wu X, Maaß M, Bartram MP, Lamkemeyer T, Schermer B, Benzing T, Brinkkoetter PT.

Proteomics. 2015 Apr;15(7):1326-31. doi: 10.1002/pmic.201400235. Epub 2015 Jan 19.


Low-grade proteinuria is highly prevalent in HIV-positive patients on antiretroviral treatment.

Gravemann S, Brinkkoetter PT, Vehreschild JJ, Franke B, Ehren K, Bünemann E, Orbach H, Weiß V, Hellmich M, Benzing T, Fätkenheuer G.

AIDS. 2014 Jul 31;28(12):1783-9. doi: 10.1097/QAD.0000000000000324.


Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier.

Rinschen MM, Wu X, König T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, Benzing T.

J Am Soc Nephrol. 2014 Jul;25(7):1509-22. doi: 10.1681/ASN.2013070760. Epub 2014 Feb 7.


Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination.

Hagmann H, Bossung V, Belaidi AA, Fridman A, Karumanchi SA, Thadhani R, Schermer B, Mallmann P, Schwarz G, Benzing T, Brinkkoetter PT.

PLoS One. 2014 Jan 21;9(1):e85258. doi: 10.1371/journal.pone.0085258. eCollection 2014.


Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane.

Hagmann H, Kuczkowski A, Ruehl M, Lamkemeyer T, Brodesser S, Horke S, Dryer S, Schermer B, Benzing T, Brinkkoetter PT.

FASEB J. 2014 Apr;28(4):1769-79. doi: 10.1096/fj.13-240309. Epub 2014 Jan 13.


The role of the podocyte in albumin filtration.

Brinkkoetter PT, Ising C, Benzing T.

Nat Rev Nephrol. 2013 Jun;9(6):328-36. doi: 10.1038/nrneph.2013.78. Epub 2013 Apr 23. Review.


Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions.

Höhne M, Ising C, Hagmann H, Völker LA, Brähler S, Schermer B, Brinkkoetter PT, Benzing T.

Am J Pathol. 2013 Feb;182(2):332-8. doi: 10.1016/j.ajpath.2012.11.002. Epub 2012 Dec 13.


Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria.

Brähler S, Ising C, Hagmann H, Rasmus M, Hoehne M, Kurschat C, Kisner T, Goebel H, Shankland S, Addicks K, Thaiss F, Schermer B, Pasparakis M, Benzing T, Brinkkoetter PT.

Am J Physiol Renal Physiol. 2012 Nov 15;303(10):F1473-85. doi: 10.1152/ajprenal.00031.2012. Epub 2012 Sep 12.


Plasma leakage through glomerular basement membrane ruptures triggers the proliferation of parietal epithelial cells and crescent formation in non-inflammatory glomerular injury.

Ryu M, Migliorini A, Miosge N, Gross O, Shankland S, Brinkkoetter PT, Hagmann H, Romagnani P, Liapis H, Anders HJ.

J Pathol. 2012 Dec;228(4):482-94. doi: 10.1002/path.4046. Epub 2012 Jul 26.


Effects of donor pre-treatment with dopamine on survival after heart transplantation: a cohort study of heart transplant recipients nested in a randomized controlled multicenter trial.

Benck U, Hoeger S, Brinkkoetter PT, Gottmann U, Doenmez D, Boesebeck D, Lauchart W, Gummert J, Karck M, Lehmkuhl HB, Bittner HB, Zuckermann A, Wagner F, Schulz U, Koch A, Bigdeli AK, Bara C, Hirt S, Berchtold-Herz M, Brose S, Herold U, Boehm J, Welp H, Strecker T, Doesch A, Birck R, Krämer BK, Yard BA, Schnuelle P.

J Am Coll Cardiol. 2011 Oct 18;58(17):1768-77. doi: 10.1016/j.jacc.2011.05.060.


Cyclin I-Cdk5 governs survival in post-mitotic cells.

Brinkkoetter PT, Pippin JW, Shankland SJ.

Cell Cycle. 2010 May;9(9):1729-31. Epub 2010 May 10.


N-octanoyl dopamine, a non-hemodyanic dopamine derivative, for cell protection during hypothermic organ preservation.

Lösel RM, Schnetzke U, Brinkkoetter PT, Song H, Beck G, Schnuelle P, Höger S, Wehling M, Yard BA.

PLoS One. 2010 Mar 16;5(3):e9713. doi: 10.1371/journal.pone.0009713.


Novel siRNA delivery system to target podocytes in vivo.

Hauser PV, Pippin JW, Kaiser C, Krofft RD, Brinkkoetter PT, Hudkins KL, Kerjaschki D, Reiser J, Alpers CE, Shankland SJ.

PLoS One. 2010 Mar 1;5(3):e9463. doi: 10.1371/journal.pone.0009463.


p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo.

Brinkkoetter PT, Wu JS, Ohse T, Krofft RD, Schermer B, Benzing T, Pippin JW, Shankland SJ.

Kidney Int. 2010 Apr;77(8):690-9. doi: 10.1038/ki.2009.548. Epub 2010 Feb 3.


Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells.

Brinkkoetter PT, Olivier P, Wu JS, Henderson S, Krofft RD, Pippin JW, Hockenbery D, Roberts JM, Shankland SJ.

J Clin Invest. 2009 Oct;119(10):3089-101. doi: 10.1172/JCI37978. Epub 2009 Sep 1.


Rosuvastatin protects against podocyte apoptosis in vitro.

Cormack-Aboud FC, Brinkkoetter PT, Pippin JW, Shankland SJ, Durvasula RV.

Nephrol Dial Transplant. 2009 Feb;24(2):404-12. doi: 10.1093/ndt/gfn528. Epub 2008 Sep 27.


Inducible rodent models of acquired podocyte diseases.

Pippin JW, Brinkkoetter PT, Cormack-Aboud FC, Durvasula RV, Hauser PV, Kowalewska J, Krofft RD, Logar CM, Marshall CB, Ohse T, Shankland SJ.

Am J Physiol Renal Physiol. 2009 Feb;296(2):F213-29. doi: 10.1152/ajprenal.90421.2008. Epub 2008 Sep 10. Review.


Hypothermic injury: the mitochondrial calcium, ATP and ROS love-hate triangle out of balance.

Brinkkoetter PT, Song H, Lösel R, Schnetzke U, Gottmann U, Feng Y, Hanusch C, Beck GC, Schnuelle P, Wehling M, van der Woude FJ, Yard BA.

Cell Physiol Biochem. 2008;22(1-4):195-204. doi: 10.1159/000149797. Epub 2008 Jul 25.


Establishment of conditionally immortalized mouse glomerular parietal epithelial cells in culture.

Ohse T, Pippin JW, Vaughan MR, Brinkkoetter PT, Krofft RD, Shankland SJ.

J Am Soc Nephrol. 2008 Oct;19(10):1879-90. doi: 10.1681/ASN.2007101087. Epub 2008 Jul 2.


Donor dopamine treatment limits pulmonary oedema and inflammation in lung allografts subjected to prolonged hypothermia.

Hanusch C, Nowak K, Törlitz P, Gill IS, Song H, Rafat N, Brinkkoetter PT, Leuvenink HG, Van Ackern KC, Yard BA, Beck GC.

Transplantation. 2008 May 27;85(10):1449-55. doi: 10.1097/TP.0b013e31816f220d.


Atorvastatin donor pretreatment prevents ischemia/reperfusion injury in renal transplantation in rats: possible role for aldose-reductase inhibition.

Gottmann U, Brinkkoetter PT, Hoeger S, Gutermann K, Coutinho ZM, Ruf T, Hui S, Liu Z, Schnuelle P, van der Woude FJ, Braun C, Yard BA.

Transplantation. 2007 Sep 27;84(6):755-62.


Darbepoetin alfa protects podocytes from apoptosis in vitro and in vivo.

Logar CM, Brinkkoetter PT, Krofft RD, Pippin JW, Shankland SJ.

Kidney Int. 2007 Aug;72(4):489-98. Epub 2007 Jun 6.


Increased circulating endothelial progenitor cells in septic patients: correlation with survival.

Rafat N, Hanusch C, Brinkkoetter PT, Schulte J, Brade J, Zijlstra JG, van der Woude FJ, van Ackern K, Yard BA, Beck GCh.

Crit Care Med. 2007 Jul;35(7):1677-84.


Reduction of VEGF-A and CTGF expression in diabetic nephropathy is associated with podocyte loss.

Baelde HJ, Eikmans M, Lappin DW, Doran PP, Hohenadel D, Brinkkoetter PT, van der Woude FJ, Waldherr R, Rabelink TJ, de Heer E, Bruijn JA.

Kidney Int. 2007 Apr;71(7):637-45. Epub 2007 Jan 31.


Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis.

Brinkkoetter PT, Gottmann U, Schulte J, van der Woude FJ, Braun C, Yard BA.

Clin Exp Immunol. 2006 Dec;146(3):524-32.


Comparison of early renal function parameters for the prediction of 5-year graft survival after kidney transplantation.

Schnuelle P, Gottmann U, Köppel H, Brinkkoetter PT, Krzossok S, Weiss J, Schmitt W, Yard BA, Schwarzbach MH, Post S, van der Woude FJ, Birck R.

Nephrol Dial Transplant. 2007 Jan;22(1):235-45. Epub 2006 Sep 25.


Hypothermia-induced loss of endothelial barrier function is restored after dopamine pretreatment: role of p42/p44 activation.

Brinkkoetter PT, Beck GC, Gottmann U, Loesel R, Schnetzke U, Rudic B, Hanusch C, Rafat N, Liu Z, Weiss C, Leuvinik HG, Ploeg R, Braun C, Schnuelle P, van der Woude FJ, Yard BA.

Transplantation. 2006 Aug 27;82(4):534-42.


Effect of pre-treatment with catecholamines on cold preservation and ischemia/reperfusion-injury in rats.

Gottmann U, Brinkkoetter PT, Bechtler M, Hoeger S, Karle C, Schaub M, Schnuelle P, Yard B, van der Woude FJ, Braun C.

Kidney Int. 2006 Jul;70(2):321-8. Epub 2006 Jun 7.


Influence of donor pretreatment with dopamine on allogeneic kidney transplantation after prolonged cold storage in rats.

Gottmann U, Notheisen A, Brinkkoetter PT, Yard BA, Waldherr R, Schnuelle P, van der Woude FJ, Braun C.

Transplantation. 2005 May 27;79(10):1344-50.


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