Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 305

1.

A Near-Complete Series of Four Atropisomeric Jozimine A2-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus.

Fayez S, Li J, Feineis D, Aké Assi L, Kaiser M, Brun R, Anany MA, Wajant H, Bringmann G.

J Nat Prod. 2019 Nov 22;82(11):3033-3046. doi: 10.1021/acs.jnatprod.9b00589. Epub 2019 Oct 23.

PMID:
31642313
2.

Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells.

Tshitenge DT, Bruhn T, Feineis D, Schmidt D, Mudogo V, Kaiser M, Brun R, Würthner F, Awale S, Bringmann G.

J Nat Prod. 2019 Nov 22;82(11):3150-3164. doi: 10.1021/acs.jnatprod.9b00755. Epub 2019 Oct 20.

PMID:
31630523
3.

Atroposelective Total Synthesis of the Fourfold ortho-Substituted Naphthyltetrahydroisoquinoline Biaryl O,N-Dimethylhamatine.

Slack ED, Seupel R, Aue DH, Bringmann G, Lipshutz BH.

Chemistry. 2019 Nov 7;25(62):14237-14245. doi: 10.1002/chem.201903832. Epub 2019 Oct 15.

PMID:
31486170
4.

An Unusually Broad Series of Seven Cyclombandakamines, Bridged Dimeric Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ealaensis.

Tshitenge DT, Bruhn T, Feineis D, Mudogo V, Kaiser M, Brun R, Bringmann G.

Sci Rep. 2019 Jul 8;9(1):9812. doi: 10.1038/s41598-019-46336-z.

5.

Dimeric naphthylisoquinoline alkaloids: polyketide-derived axially chiral bioactive quateraryls.

Lombe BK, Feineis D, Bringmann G.

Nat Prod Rep. 2019 Nov 1;36(11):1513-1545. doi: 10.1039/c9np00024k. Epub 2019 May 28.

PMID:
31134266
6.

Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells.

Fayez S, Feineis D, Aké Assi L, Kaiser M, Brun R, Awale S, Bringmann G.

Fitoterapia. 2018 Nov;131:245-259. doi: 10.1016/j.fitote.2018.11.006. Epub 2018 Nov 9.

PMID:
30419265
7.

Ancistrolikokine E3, a 5,8'-Coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/Autophagy Signaling Pathway.

Awale S, Dibwe DF, Balachandran C, Fayez S, Feineis D, Lombe BK, Bringmann G.

J Nat Prod. 2018 Oct 26;81(10):2282-2291. doi: 10.1021/acs.jnatprod.8b00733. Epub 2018 Oct 10.

PMID:
30303002
8.

Ancistroyafungines A-D, 5,8'- and 5,1'-coupled naphthylisoquinoline alkaloids from a Congolese Ancistrocladus species, with antiausterity activities against human PANC-1 pancreatic cancer cells.

Kavatsurwa SM, Lombe BK, Feineis D, Dibwe DF, Maharaj V, Awale S, Bringmann G.

Fitoterapia. 2018 Oct;130:6-16. doi: 10.1016/j.fitote.2018.07.017. Epub 2018 Jul 27.

PMID:
30059720
9.

Ancistrolikokine I and further 5,8'-coupled naphthylisoquinoline alkaloids from the Congolese liana Ancistrocladus likoko and their cytotoxic activities against drug-sensitive and multidrug resistant human leukemia cells.

Fayez S, Feineis D, Mudogo V, Seo EJ, Efferth T, Bringmann G.

Fitoterapia. 2018 Sep;129:114-125. doi: 10.1016/j.fitote.2018.06.009. Epub 2018 Jun 22.

PMID:
29936193
10.

Quality of the antimalarial medicine artemether - lumefantrine in 8 cities of the Democratic Republic of the Congo.

Mufusama JP, Ndjoko Ioset K, Feineis D, Hoellein L, Holzgrabe U, Bringmann G.

Drug Test Anal. 2018 Oct;10(10):1599-1606. doi: 10.1002/dta.2420. Epub 2018 Jul 18.

PMID:
29896850
11.

Capillary zone electrophoresis for the determination of amodiaquine and three of its synthetic impurities in pharmaceutical formulations.

Mufusama JP, Hoellein L, Feineis D, Holzgrabe U, Bringmann G.

Electrophoresis. 2018 Oct;39(20):2530-2539. doi: 10.1002/elps.201800170. Epub 2018 Jun 13.

PMID:
29809275
12.

Mbandakamine-Type Naphthylisoquinoline Dimers and Related Alkaloids from the Central African Liana Ancistrocladus ealaensis with Antiparasitic and Antileukemic Activities.

Tshitenge DT, Feineis D, Mudogo V, Kaiser M, Brun R, Seo EJ, Efferth T, Bringmann G.

J Nat Prod. 2018 Apr 27;81(4):918-933. doi: 10.1021/acs.jnatprod.7b01041. Epub 2018 Mar 21.

PMID:
29560715
13.

Ancistrocyclinones A and B, unprecedented pentacyclic N,C-coupled naphthylisoquinoline alkaloids, from the Chinese liana Ancistrocladus tectorius.

Seupel R, Hemberger Y, Feineis D, Xu M, Seo EJ, Efferth T, Bringmann G.

Org Biomol Chem. 2018 Feb 28;16(9):1581-1590. doi: 10.1039/c7ob03092d.

PMID:
29443340
14.

Antiprotozoal Spirombandakamines A1 and A2, Fused Naphthylisoquinoline Dimers from a Congolese Ancistrocladus Plant.

Lombe BK, Bruhn T, Feineis D, Mudogo V, Brun R, Bringmann G.

Org Lett. 2017 Dec 15;19(24):6740-6743. doi: 10.1021/acs.orglett.7b03473. Epub 2017 Nov 30.

PMID:
29189016
15.

Vibrational spectroscopic characterization of arylisoquinolines by means of Raman spectroscopy and density functional theory calculations.

Domes R, Domes C, Albert CR, Bringmann G, Popp J, Frosch T.

Phys Chem Chem Phys. 2017 Nov 15;19(44):29918-29926. doi: 10.1039/c7cp05415g.

PMID:
29087422
16.

Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line.

Li J, Seupel R, Bruhn T, Feineis D, Kaiser M, Brun R, Mudogo V, Awale S, Bringmann G.

J Nat Prod. 2017 Oct 27;80(10):2807-2817. doi: 10.1021/acs.jnatprod.7b00650. Epub 2017 Oct 18.

PMID:
29043798
17.

1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) Alters Cell Cycle Progression in Human Neuroblastoma Cell Lines.

Sharma RK, Candelario-Jalil E, Feineis D, Bringmann G, Fiebich BL, Akundi RS.

Neurotox Res. 2017 Nov;32(4):649-660. doi: 10.1007/s12640-017-9782-1. Epub 2017 Jul 18.

PMID:
28721631
18.

Antiplasmodial Ealapasamines A-C,'Mixed' Naphthylisoquinoline Dimers from the Central African Liana Ancistrocladus ealaensis.

Tshitenge DT, Feineis D, Mudogo V, Kaiser M, Brun R, Bringmann G.

Sci Rep. 2017 Jul 18;7(1):5767. doi: 10.1038/s41598-017-05719-w.

19.

Antileukemic ancistrobenomine B and related 5,1'-coupled naphthylisoquinoline alkaloids from the Chinese liana Ancistrocladus tectorius.

Bringmann G, Seupel R, Feineis D, Xu M, Zhang G, Kaiser M, Brun R, Seo EJ, Efferth T.

Fitoterapia. 2017 Sep;121:76-85. doi: 10.1016/j.fitote.2017.07.001. Epub 2017 Jul 6.

PMID:
28688886
20.

Metallocorroles as inherently chiral chromophores: resolution and electronic circular dichroism spectroscopy of a tungsten biscorrole.

Schies C, Alemayehu AB, Vazquez-Lima H, Thomas KE, Bruhn T, Bringmann G, Ghosh A.

Chem Commun (Camb). 2017 Jun 1;53(45):6121-6124. doi: 10.1039/c7cc02027a.

PMID:
28530281
21.

Gardenifolins A-H, Scalemic Neolignans from Gardenia ternifolia: Chiral Resolution, Configurational Assignment, and Cytotoxic Activities against the HeLa Cancer Cell Line.

Tshitenge DT, Feineis D, Awale S, Bringmann G.

J Nat Prod. 2017 May 26;80(5):1604-1614. doi: 10.1021/acs.jnatprod.7b00180. Epub 2017 May 10.

PMID:
28488862
22.

Cyclombandakamines A1 and A2, Oxygen-Bridged Naphthylisoquinoline Dimers from a Congolese Ancistrocladus Liana.

Lombe BK, Bruhn T, Feineis D, Mudogo V, Brun R, Bringmann G.

Org Lett. 2017 Mar 17;19(6):1342-1345. doi: 10.1021/acs.orglett.7b00209. Epub 2017 Feb 23.

PMID:
28231014
23.

Dioncophyllines C2, D2, and F and Related Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ileboensis with Potent Activities against Plasmodium falciparum and against Multiple Myeloma and Leukemia Cell Lines.

Li J, Seupel R, Feineis D, Mudogo V, Kaiser M, Brun R, Brünnert D, Chatterjee M, Seo EJ, Efferth T, Bringmann G.

J Nat Prod. 2017 Feb 24;80(2):443-458. doi: 10.1021/acs.jnatprod.6b00967. Epub 2017 Jan 25.

PMID:
28121440
24.

Krishnadimer A, an Axially Chiral Non-biaryl Natural Product: Discovery and Biomimetic Synthesis.

Li WS, Wu J, Li J, Satyanandamurty T, Shen L, Bringmann G.

Org Lett. 2017 Jan 6;19(1):182-185. doi: 10.1021/acs.orglett.6b03479. Epub 2016 Dec 19.

PMID:
27992222
25.

Directed Synthesis of All Four Pure Stereoisomers of the N,C-Coupled Naphthylisoquinoline Alkaloid Ancistrocladinium A.

Seupel R, Hertlein-Amslinger B, Gulder T, Stawski P, Kaiser M, Brun R, Bringmann G.

Org Lett. 2016 Dec 16;18(24):6508-6511. Epub 2016 Dec 1.

PMID:
27978644
26.

Generation of Dicoordinate Boron(I) Units by Fragmentation of a Tetra-Boron(I) Molecular Square.

Arrowsmith M, Auerhammer D, Bertermann R, Braunschweig H, Bringmann G, Celik MA, Dewhurst RD, Finze M, Grüne M, Hailmann M, Hertle T, Krummenacher I.

Angew Chem Int Ed Engl. 2016 Nov 7;55(46):14464-14468. doi: 10.1002/anie.201608429. Epub 2016 Oct 12.

PMID:
27730749
27.

Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from the Chinese liana Ancistrocladus tectorius.

Bringmann G, Seupel R, Feineis D, Zhang G, Xu M, Wu J, Kaiser M, Brun R, Seo EJ, Efferth T.

Fitoterapia. 2016 Dec;115:1-8. doi: 10.1016/j.fitote.2016.09.009. Epub 2016 Sep 19.

PMID:
27646602
28.

Rotationally Hindered Biphenyls and Terphenyls: Synthesis, Molecular Dynamics, and Configurational Assignment.

Goel A, Kumar V, Hemberger Y, Singh FV, Nag P, Knauer M, Kant R, Raghunandan R, Maulik PR, Bringmann G.

J Org Chem. 2016 Nov 18;81(22):10721-10732. Epub 2016 Oct 25.

PMID:
27732783
29.

Axially Chiral Dimeric Naphthalene and Naphthoquinone Metabolites, from Root Cultures of the West African Liana Triphyophyllum peltatum.

Bringmann G, Irmer A, Büttner T, Schaumlöffel A, Zhang G, Seupel R, Feineis D, Fester K.

J Nat Prod. 2016 Aug 26;79(8):2094-103. doi: 10.1021/acs.jnatprod.6b00439. Epub 2016 Jul 20.

PMID:
27438403
30.

The Plant-Derived Naphthoquinone Droserone Inhibits In Vitro Measles Virus Infection.

Lieberherr C, Zhang G, Grafen A, Singethan K, Kendl S, Vogt V, Maier J, Bringmann G, Schneider-Schaulies J.

Planta Med. 2017 Feb;83(3-04):232-238. doi: 10.1055/s-0042-111825. Epub 2016 Jul 15.

PMID:
27420351
31.

Trangmolins A-F with an Unprecedented Structural Plasticity of the Rings A and B: New Insight into Limonoid Biosynthesis.

Li W, Shen L, Bruhn T, Pedpradab P, Wu J, Bringmann G.

Chemistry. 2016 Aug 8;22(33):11719-27. doi: 10.1002/chem.201602230. Epub 2016 Jul 7.

PMID:
27383693
32.

Ancistrotectoquinones A and B, the First Quinoid Naphthylisoquinoline Alkaloids, from the Chinese Liana Ancistrocladus tectorius.

Bringmann G, Xu M, Seupel R, Feineis D, Wu J.

Nat Prod Commun. 2016 Jul;11(7):971-976.

PMID:
30452174
33.

First Atroposelective Total Synthesis of Enantiomerically Pure Ancistrocladidine and Ancistrotectorine.

Bringmann G, Manchala N, Büttner T, Hertlein-Amslinger B, Seupel R.

Chemistry. 2016 Jul 4;22(28):9792-6. doi: 10.1002/chem.201600701. Epub 2016 Jun 6.

PMID:
27273153
34.

HIV-inhibitory michellamine-type dimeric naphthylisoquinoline alkaloids from the Central African liana Ancistrocladus congolensis.

Bringmann G, Steinert C, Feineis D, Mudogo V, Betzin J, Scheller C.

Phytochemistry. 2016 Aug;128:71-81. doi: 10.1016/j.phytochem.2016.04.005. Epub 2016 Apr 29.

PMID:
27137461
35.

Rational quality assessment procedure for less-investigated herbal medicines: Case of a Congolese antimalarial drug with an analytical report.

Tshitenge DT, Ioset KN, Lami JN, Ndelo-di-Phanzu J, Mufusama JP, Bringmann G.

Fitoterapia. 2016 Apr;110:189-95. doi: 10.1016/j.fitote.2016.03.012. Epub 2016 Mar 20.

PMID:
27010420
36.

Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.

Sawatzky E, Wehle S, Kling B, Wendrich J, Bringmann G, Sotriffer CA, Heilmann J, Decker M.

J Med Chem. 2016 Mar 10;59(5):2067-82. doi: 10.1021/acs.jmedchem.5b01674. Epub 2016 Feb 17.

PMID:
26886849
37.

Axial, Helical, and Planar Chirality in Directly Linked Basket-Handle Porphyrin Arrays.

Gehrold AC, Bruhn T, Bringmann G.

J Org Chem. 2016 Feb 5;81(3):1075-88. doi: 10.1021/acs.joc.5b02638. Epub 2016 Jan 12.

PMID:
26731681
38.

Monomeric Chiral and Achiral Basket-Handle Porphyrins: Synthesis, Structural Features, and Arrested Tautomerism.

Gehrold AC, Bruhn T, Schneider H, Radius U, Bringmann G.

J Org Chem. 2015 Dec 18;80(24):12359-78. doi: 10.1021/acs.joc.5b02259. Epub 2015 Nov 13.

PMID:
26556497
39.

Stereoisomeric Composition of Natural Myrtucommulone A.

Hans M, Charpentier M, Huch V, Jauch J, Bruhn T, Bringmann G, Quandt D.

J Nat Prod. 2015 Oct 23;78(10):2381-9. doi: 10.1021/acs.jnatprod.5b00358. Epub 2015 Oct 12.

PMID:
26457652
40.

Highly antiplasmodial non-natural oxidative products of dioncophylline A: synthesis, absolute configuration, and conformational stability.

Hemberger Y, Zhang G, Brun R, Kaiser M, Bringmann G.

Chemistry. 2015 Oct 5;21(41):14507-18. doi: 10.1002/chem.201501657. Epub 2015 Aug 13.

PMID:
26272344
41.

Antiviral Limonoids Including Khayanolides from the Trang Mangrove Plant Xylocarpus moluccensis.

Li W, Jiang Z, Shen L, Pedpradab P, Bruhn T, Wu J, Bringmann G.

J Nat Prod. 2015 Jul 24;78(7):1570-8. doi: 10.1021/acs.jnatprod.5b00151. Epub 2015 Jun 26.

PMID:
26114936
42.

Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression.

Lewis MD, Behrends J, Sá E Cunha C, Mendes AM, Lasitschka F, Sattler JM, Heiss K, Kooij TW, Prudêncio M, Bringmann G, Frischknecht F, Mueller AK.

J Immunol. 2015 May 15;194(10):4860-70. doi: 10.4049/jimmunol.1400863. Epub 2015 Apr 10.

43.

Chiral and achiral basket-handle porphyrins: short synthesis and stereostructures of these versatile building blocks.

Gehrold AC, Bruhn T, Schneider H, Radius U, Bringmann G.

Org Lett. 2015 Jan 16;17(2):210-3. doi: 10.1021/ol503286s. Epub 2015 Jan 5.

PMID:
25556288
44.

Modelling antibiotic and cytotoxic isoquinoline effects in Staphylococcus aureus, Staphylococcus epidermidis and mammalian cells.

Cecil A, Ohlsen K, Menzel T, François P, Schrenzel J, Fischer A, Dörries K, Selle M, Lalk M, Hantzschmann J, Dittrich M, Liang C, Bernhardt J, Ölschläger TA, Bringmann G, Bruhn H, Unger M, Ponte-Sucre A, Lehmann L, Dandekar T.

Int J Med Microbiol. 2015 Jan;305(1):96-109. doi: 10.1016/j.ijmm.2014.11.006. Epub 2014 Nov 27.

PMID:
25500547
45.

Anti-trypanosomal activities and structural chemical properties of selected compound classes.

Ponte-Sucre A, Bruhn H, Schirmeister T, Cecil A, Albert CR, Buechold C, Tischer M, Schlesinger S, Goebel T, Fuß A, Mathein D, Merget B, Sotriffer CA, Stich A, Krohne G, Engstler M, Bringmann G, Holzgrabe U.

Parasitol Res. 2015 Feb;114(2):501-12. doi: 10.1007/s00436-014-4210-4. Epub 2014 Nov 23.

PMID:
25416330
46.

Axially chiral BODIPY DYEmers: an apparent exception to the exciton chirality rule.

Bruhn T, Pescitelli G, Jurinovich S, Schaumlöffel A, Witterauf F, Ahrens J, Bröring M, Bringmann G.

Angew Chem Int Ed Engl. 2014 Dec 22;53(52):14592-5. doi: 10.1002/anie.201408398. Epub 2014 Oct 29.

PMID:
25354119
47.

Nature's lab for derivatization: new and revised structures of a variety of streptophenazines produced by a sponge-derived Streptomyces strain.

Kunz AL, Labes A, Wiese J, Bruhn T, Bringmann G, Imhoff JF.

Mar Drugs. 2014 Mar 25;12(4):1699-714. doi: 10.3390/md12041699.

48.

Decandrinin, an unprecedented C9-spiro-fused 7,8-seco-ent-abietane from the Godavari mangrove Ceriops decandra.

Wang H, Li MY, Katele FZ, Satyanandamurty T, Wu J, Bringmann G.

Beilstein J Org Chem. 2014 Jan 27;10:276-81. doi: 10.3762/bjoc.10.23. eCollection 2014.

49.

C,C- and N,C-coupled dimers of 2-aminotetraphenylporphyrins: regiocontrolled synthesis, spectroscopic properties, and quantum-chemical calculations.

Bruhn T, Witterauf F, Götz DC, Grimmer CT, Würtemberger M, Radius U, Bringmann G.

Chemistry. 2014 Apr 1;20(14):3998-4006. doi: 10.1002/chem.201304169. Epub 2014 Feb 26.

PMID:
24574328
50.

Pestalotiopens A and B: stereochemically challenging flexible sesquiterpene-cyclopaldic acid hybrids from Pestalotiopsis sp.

Hemberger Y, Xu J, Wray V, Proksch P, Wu J, Bringmann G.

Chemistry. 2013 Nov 11;19(46):15556-64. doi: 10.1002/chem.201302204. Epub 2013 Oct 2.

PMID:
24123472

Supplemental Content

Loading ...
Support Center