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Items: 1 to 50 of 112

1.

Gluconeogenesis is essential for trypanosome development in the tsetse fly vector.

Wargnies M, Bertiaux E, Cahoreau E, Ziebart N, Crouzols A, Morand P, Biran M, Allmann S, Hubert J, Villafraz O, Millerioux Y, Plazolles N, Asencio C, Rivière L, Rotureau B, Boshart M, Portais JC, Bringaud F.

PLoS Pathog. 2018 Dec 17;14(12):e1007502. doi: 10.1371/journal.ppat.1007502. eCollection 2018 Dec.

2.

Unexpected diversity in eukaryotic transcription revealed by the retrotransposon hotspot family of Trypanosoma brucei.

Florini F, Naguleswaran A, Gharib WH, Bringaud F, Roditi I.

Nucleic Acids Res. 2018 Dec 14. doi: 10.1093/nar/gky1255. [Epub ahead of print]

PMID:
30544263
3.

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction.

Fernandes PM, Kinkead J, McNae IW, Bringaud F, Michels PAM, Walkinshaw MD.

Biochem J. 2019 Jan 18;476(2):179-191. doi: 10.1042/BCJ20180635.

PMID:
30404924
4.

Glycerol supports growth of the Trypanosoma brucei bloodstream forms in the absence of glucose: Analysis of metabolic adaptations on glycerol-rich conditions.

Pineda E, Thonnus M, Mazet M, Mourier A, Cahoreau E, Kulyk H, Dupuy JW, Biran M, Masante C, Allmann S, Rivière L, Rotureau B, Portais JC, Bringaud F.

PLoS Pathog. 2018 Nov 1;14(11):e1007412. doi: 10.1371/journal.ppat.1007412. eCollection 2018 Nov.

5.

De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions.

Millerioux Y, Mazet M, Bouyssou G, Allmann S, Kiema TR, Bertiaux E, Fouillen L, Thapa C, Biran M, Plazolles N, Dittrich-Domergue F, Crouzols A, Wierenga RK, Rotureau B, Moreau P, Bringaud F.

PLoS Pathog. 2018 May 29;14(5):e1007116. doi: 10.1371/journal.ppat.1007116. eCollection 2018 May.

6.

The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.

Marchese L, Nascimento JF, Damasceno FS, Bringaud F, Michels PAM, Silber AM.

Pathogens. 2018 Apr 1;7(2). pii: E36. doi: 10.3390/pathogens7020036. Review.

7.

Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana.

Kovářová J, Pountain AW, Wildridge D, Weidt S, Bringaud F, Burchmore RJS, Achcar F, Barrett MP.

PLoS Pathog. 2018 Mar 19;14(3):e1006953. doi: 10.1371/journal.ppat.1006953. eCollection 2018 Mar.

8.

Identification of the centromeres of Leishmania major: revealing the hidden pieces.

Garcia-Silva MR, Sollelis L, MacPherson CR, Stanojcic S, Kuk N, Crobu L, Bringaud F, Bastien P, Pagès M, Scherf A, Sterkers Y.

EMBO Rep. 2017 Nov;18(11):1968-1977. doi: 10.15252/embr.201744216. Epub 2017 Sep 21.

9.

Metabolic reprogramming during the Trypanosoma brucei life cycle.

Smith TK, Bringaud F, Nolan DP, Figueiredo LM.

Version 2. F1000Res. 2017 May 16 [revised 2017 Jan 1];6. pii: F1000 Faculty Rev-683. doi: 10.12688/f1000research.10342.2. eCollection 2017. Review.

10.

Glycosomes: A comprehensive view of their metabolic roles in T. brucei.

Allmann S, Bringaud F.

Int J Biochem Cell Biol. 2017 Apr;85:85-90. doi: 10.1016/j.biocel.2017.01.015. Epub 2017 Feb 6. Review.

PMID:
28179189
11.

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector.

Mantilla BS, Marchese L, Casas-Sánchez A, Dyer NA, Ejeh N, Biran M, Bringaud F, Lehane MJ, Acosta-Serrano A, Silber AM.

PLoS Pathog. 2017 Jan 23;13(1):e1006158. doi: 10.1371/journal.ppat.1006158. eCollection 2017 Jan.

12.

Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.

Harijan RK, Kiema TR, Syed SM, Qadir I, Mazet M, Bringaud F, Michels PAM, Wierenga RK.

Protein Eng Des Sel. 2017 Mar 1;30(3):225-233. doi: 10.1093/protein/gzw080.

PMID:
28062645
13.

NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms.

Surve SV, Jensen BC, Heestand M, Mazet M, Smith TK, Bringaud F, Parsons M, Schnaufer A.

Mol Biochem Parasitol. 2017 Jan;211:57-61. doi: 10.1016/j.molbiopara.2016.10.001. Epub 2016 Oct 4.

14.

Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids.

Morales J, Hashimoto M, Williams TA, Hirawake-Mogi H, Makiuchi T, Tsubouchi A, Kaga N, Taka H, Fujimura T, Koike M, Mita T, Bringaud F, Concepción JL, Hashimoto T, Embley TM, Nara T.

Proc Biol Sci. 2016 May 11;283(1830). pii: 20160520. doi: 10.1098/rspb.2016.0520.

15.

The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism.

Harijan RK, Mazet M, Kiema TR, Bouyssou G, Alexson SE, Bergmann U, Moreau P, Michels PA, Bringaud F, Wierenga RK.

Proteins. 2016 Aug;84(8):1075-96. doi: 10.1002/prot.25054. Epub 2016 May 9.

PMID:
27093562
16.

Mitochondrial pyruvate carrier in Trypanosoma brucei.

Štáfková J, Mach J, Biran M, Verner Z, Bringaud F, Tachezy J.

Mol Microbiol. 2016 May;100(3):442-56. doi: 10.1111/mmi.13325. Epub 2016 Feb 10.

17.

Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism.

Jackson AP, Otto TD, Aslett M, Armstrong SD, Bringaud F, Schlacht A, Hartley C, Sanders M, Wastling JM, Dacks JB, Acosta-Serrano A, Field MC, Ginger ML, Berriman M.

Curr Biol. 2016 Jan 25;26(2):161-172. doi: 10.1016/j.cub.2015.11.055. Epub 2015 Dec 24. Review.

18.

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose.

Creek DJ, Mazet M, Achcar F, Anderson J, Kim DH, Kamour R, Morand P, Millerioux Y, Biran M, Kerkhoven EJ, Chokkathukalam A, Weidt SK, Burgess KE, Breitling R, Watson DG, Bringaud F, Barrett MP.

PLoS Pathog. 2015 Mar 16;11(3):e1004689. doi: 10.1371/journal.ppat.1004689. eCollection 2015 Mar.

19.

Combining reverse genetics and nuclear magnetic resonance-based metabolomics unravels trypanosome-specific metabolic pathways.

Bringaud F, Biran M, Millerioux Y, Wargnies M, Allmann S, Mazet M.

Mol Microbiol. 2015 Jun;96(5):917-26. doi: 10.1111/mmi.12990. Epub 2015 Apr 7. Review.

20.

Triacylglycerol Storage in Lipid Droplets in Procyclic Trypanosoma brucei.

Allmann S, Mazet M, Ziebart N, Bouyssou G, Fouillen L, Dupuy JW, Bonneu M, Moreau P, Bringaud F, Boshart M.

PLoS One. 2014 Dec 10;9(12):e114628. doi: 10.1371/journal.pone.0114628. eCollection 2014.

21.

Identification and analysis of ingi-related retroposons in the trypanosomatid genomes.

Bringaud F, Rogers M, Ghedin E.

Methods Mol Biol. 2015;1201:109-22. doi: 10.1007/978-1-4939-1438-8_6.

PMID:
25388110
22.

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.

Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F.

Nucleic Acids Res. 2015 Jan;43(Database issue):D637-44. doi: 10.1093/nar/gku944. Epub 2014 Oct 9.

23.

Contribution of pyruvate phosphate dikinase in the maintenance of the glycosomal ATP/ADP balance in the Trypanosoma brucei procyclic form.

Deramchia K, Morand P, Biran M, Millerioux Y, Mazet M, Wargnies M, Franconi JM, Bringaud F.

J Biol Chem. 2014 Jun 20;289(25):17365-78. doi: 10.1074/jbc.M114.567230. Epub 2014 May 2.

24.

The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants.

Porcel BM, Denoeud F, Opperdoes F, Noel B, Madoui MA, Hammarton TC, Field MC, Da Silva C, Couloux A, Poulain J, Katinka M, Jabbari K, Aury JM, Campbell DA, Cintron R, Dickens NJ, Docampo R, Sturm NR, Koumandou VL, Fabre S, Flegontov P, Lukeš J, Michaeli S, Mottram JC, Szöőr B, Zilberstein D, Bringaud F, Wincker P, Dollet M.

PLoS Genet. 2014 Feb 6;10(2):e1004007. doi: 10.1371/journal.pgen.1004007. eCollection 2014 Feb.

25.

Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viability.

Mazet M, Morand P, Biran M, Bouyssou G, Courtois P, Daulouède S, Millerioux Y, Franconi JM, Vincendeau P, Moreau P, Bringaud F.

PLoS Negl Trop Dis. 2013 Dec 19;7(12):e2587. doi: 10.1371/journal.pntd.0002587. eCollection 2013.

26.

Characterization of two mitochondrial flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenases in Trypanosoma brucei.

Škodová I, Verner Z, Bringaud F, Fabian P, Lukeš J, Horváth A.

Eukaryot Cell. 2013 Dec;12(12):1664-73. doi: 10.1128/EC.00152-13. Epub 2013 Oct 18.

27.

The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control.

Millerioux Y, Ebikeme C, Biran M, Morand P, Bouyssou G, Vincent IM, Mazet M, Riviere L, Franconi JM, Burchmore RJ, Moreau P, Barrett MP, Bringaud F.

Mol Microbiol. 2013 Oct;90(1):114-29. doi: 10.1111/mmi.12351. Epub 2013 Aug 25.

28.

Regulation of Trypanosoma brucei Total and Polysomal mRNA during Development within Its Mammalian Host.

Capewell P, Monk S, Ivens A, Macgregor P, Fenn K, Walrad P, Bringaud F, Smith TK, Matthews KR.

PLoS One. 2013 Jun 26;8(6):e67069. doi: 10.1371/journal.pone.0067069. Print 2013.

29.

Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux.

Allmann S, Morand P, Ebikeme C, Gales L, Biran M, Hubert J, Brennand A, Mazet M, Franconi JM, Michels PA, Portais JC, Boshart M, Bringaud F.

J Biol Chem. 2013 Jun 21;288(25):18494-505. doi: 10.1074/jbc.M113.462978. Epub 2013 May 10.

30.

Flux Analysis of the Trypanosoma brucei Glycolysis Based on a Multiobjective-Criteria Bioinformatic Approach.

Ghozlane A, Bringaud F, Soueidan H, Dutour I, Jourdan F, Thébault P.

Adv Bioinformatics. 2012;2012:159423. doi: 10.1155/2012/159423. Epub 2012 Oct 13.

31.

Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei.

Peña-Diaz P, Pelosi L, Ebikeme C, Colasante C, Gao F, Bringaud F, Voncken F.

J Biol Chem. 2012 Dec 7;287(50):41861-74. doi: 10.1074/jbc.M112.404699. Epub 2012 Oct 16.

32.

The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets.

Godel C, Kumar S, Koutsovoulos G, Ludin P, Nilsson D, Comandatore F, Wrobel N, Thompson M, Schmid CD, Goto S, Bringaud F, Wolstenholme A, Bandi C, Epe C, Kaminsky R, Blaxter M, Mäser P.

FASEB J. 2012 Nov;26(11):4650-61. doi: 10.1096/fj.12-205096. Epub 2012 Aug 13.

33.

Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti.

Cornillot E, Hadj-Kaddour K, Dassouli A, Noel B, Ranwez V, Vacherie B, Augagneur Y, Brès V, Duclos A, Randazzo S, Carcy B, Debierre-Grockiego F, Delbecq S, Moubri-Ménage K, Shams-Eldin H, Usmani-Brown S, Bringaud F, Wincker P, Vivarès CP, Schwarz RT, Schetters TP, Krause PJ, Gorenflot A, Berry V, Barbe V, Ben Mamoun C.

Nucleic Acids Res. 2012 Oct;40(18):9102-14. doi: 10.1093/nar/gks700. Epub 2012 Jul 24.

34.

Isotopic profiling of ¹³C-labeled biological samples by two-dimensional heteronuclear J-resolved nuclear magnetic resonance spectroscopy.

Cahoreau E, Peyriga L, Hubert J, Bringaud F, Massou S, Portais JC.

Anal Biochem. 2012 Aug 15;427(2):158-63. doi: 10.1016/j.ab.2012.05.021. Epub 2012 May 29.

PMID:
22658961
35.

ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma.

Millerioux Y, Morand P, Biran M, Mazet M, Moreau P, Wargnies M, Ebikeme C, Deramchia K, Gales L, Portais JC, Boshart M, Franconi JM, Bringaud F.

J Biol Chem. 2012 May 18;287(21):17186-97. doi: 10.1074/jbc.M112.355404. Epub 2012 Apr 2.

36.

Multiple roles of proline transport and metabolism in trypanosomatids.

Bringaud F, Barrett MP, Zilberstein D.

Front Biosci (Landmark Ed). 2012 Jan 1;17:349-74. Review.

PMID:
22201748
37.

When, how and why glycolysis became compartmentalised in the Kinetoplastea. A new look at an ancient organelle.

Gualdrón-López M, Brennand A, Hannaert V, Quiñones W, Cáceres AJ, Bringaud F, Concepción JL, Michels PA.

Int J Parasitol. 2012 Jan;42(1):1-20. doi: 10.1016/j.ijpara.2011.10.007. Epub 2011 Nov 22. Review.

PMID:
22142562
38.

The characterization and evolutionary relationships of a trypanosomal thiolase.

Mazet M, Harijan RK, Kiema TR, Haapalainen AM, Morand P, Morales J, Bringaud F, Wierenga RK, Michels PA.

Int J Parasitol. 2011 Oct;41(12):1273-83. doi: 10.1016/j.ijpara.2011.07.009. Epub 2011 Aug 26.

PMID:
21907205
39.

TSIDER1, a short and non-autonomous Salivarian trypanosome-specific retroposon related to the ingi6 subclade.

Bringaud F, Berriman M, Hertz-Fowler C.

Mol Biochem Parasitol. 2011 Sep;179(1):30-6. doi: 10.1016/j.molbiopara.2011.05.007. Epub 2011 Jun 1.

40.

Transketolase in Trypanosoma brucei.

Stoffel SA, Alibu VP, Hubert J, Ebikeme C, Portais JC, Bringaud F, Schweingruber ME, Barrett MP.

Mol Biochem Parasitol. 2011 Sep;179(1):1-7. doi: 10.1016/j.molbiopara.2011.04.006. Epub 2011 May 12.

PMID:
21570429
41.

Ablation of succinate production from glucose metabolism in the procyclic trypanosomes induces metabolic switches to the glycerol 3-phosphate/dihydroxyacetone phosphate shuttle and to proline metabolism.

Ebikeme C, Hubert J, Biran M, Gouspillou G, Morand P, Plazolles N, Guegan F, Diolez P, Franconi JM, Portais JC, Bringaud F.

J Biol Chem. 2010 Oct 15;285(42):32312-24. doi: 10.1074/jbc.M110.124917. Epub 2010 Aug 11.

42.

Acetate and succinate production in amoebae, helminths, diplomonads, trichomonads and trypanosomatids: common and diverse metabolic strategies used by parasitic lower eukaryotes.

Bringaud F, Ebikeme C, Boshart M.

Parasitology. 2010 Aug;137(9):1315-31. doi: 10.1017/S0031182009991843. Epub 2009 Dec 23. Review.

PMID:
20028611
43.

Alanine aminotransferase of Trypanosoma brucei--a key role in proline metabolism in procyclic life forms.

Spitznagel D, Ebikeme C, Biran M, Nic a' Bháird N, Bringaud F, Henehan GT, Nolan DP.

FEBS J. 2009 Dec;276(23):7187-99. doi: 10.1111/j.1742-4658.2009.07432.x. Epub 2009 Nov 6.

44.

Trypanosomatid genomes contain several subfamilies of ingi-related retroposons.

Bringaud F, Berriman M, Hertz-Fowler C.

Eukaryot Cell. 2009 Oct;8(10):1532-42. doi: 10.1128/EC.00183-09. Epub 2009 Aug 7.

45.

Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes.

Rivière L, Moreau P, Allmann S, Hahn M, Biran M, Plazolles N, Franconi JM, Boshart M, Bringaud F.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12694-9. doi: 10.1073/pnas.0903355106. Epub 2009 Jul 22.

46.

Organization and evolution of two SIDER retroposon subfamilies and their impact on the Leishmania genome.

Smith M, Bringaud F, Papadopoulou B.

BMC Genomics. 2009 May 22;10:240. doi: 10.1186/1471-2164-10-240.

47.

A kinetoplastid BRCA2 interacts with DNA replication protein CDC45.

Oyola SO, Bringaud F, Melville SE.

Int J Parasitol. 2009 Jan;39(1):59-69. doi: 10.1016/j.ijpara.2008.07.002. Epub 2008 Aug 3.

PMID:
18723021
48.

Role of transposable elements in trypanosomatids.

Bringaud F, Ghedin E, El-Sayed NM, Papadopoulou B.

Microbes Infect. 2008 May;10(6):575-81. doi: 10.1016/j.micinf.2008.02.009. Epub 2008 Feb 21. Review.

PMID:
18467144
49.

Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei.

Coustou V, Biran M, Breton M, Guegan F, Rivière L, Plazolles N, Nolan D, Barrett MP, Franconi JM, Bringaud F.

J Biol Chem. 2008 Jun 13;283(24):16342-54. doi: 10.1074/jbc.M709592200. Epub 2008 Apr 22.

50.

N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift.

Ebikeme CE, Peacock L, Coustou V, Riviere L, Bringaud F, Gibson WC, Barrett MP.

Parasitology. 2008 Apr;135(5):585-94. doi: 10.1017/S0031182008004241. Epub 2008 Mar 27.

PMID:
18371239

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